{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:29:34Z","timestamp":1785774574966,"version":"3.56.0"},"reference-count":7,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Med Surg"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Recent basic science research has revealed a decreased tissue expression of peroxisome proliferator-activated receptor (PPAR) \u03b3 in lichen planopilaris (LPP). Therefore, thiazolidinediones, being PPAR\u03b3 agonists, could be used to treat LPP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We followed 24 patients with LPP who were treated with oral pioglitazone hydrochloride. Improvement in LPP was defined as a decrease in or disappearance of symptoms and perifollicular erythema in the context of halted spread of old patches.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Twenty of 24 patients were females. The average age was 52.5 years, and ages ranged from 22 to 70 years. Five of 24 patients have achieved remission; improvement was noted in half of the patients; there was no change in 3 patients; and 4 patients discontinued treatment due to side effects. Side effects were mild and included left calf pain, lightheadedness and nausea, dizziness, and hives.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Use of thiazolidinediones might be a new promising venue of LPP treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2310\/7750.2011.11008","type":"journal-article","created":{"date-parts":[[2018,10,18]],"date-time":"2018-10-18T04:43:41Z","timestamp":1539837821000},"page":"97-100","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":44,"title":["Use of Pioglitazone in Patients with Lichen Planopilaris"],"prefix":"10.1177","volume":"16","author":[{"given":"Akerke","family":"Baibergenova","sequence":"first","affiliation":[{"name":"Division of Dermatology, University of Toronto, Sunnybrook Health Sciences Centre, Toronto, ON."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Walsh","sequence":"additional","affiliation":[{"name":"Division of Dermatology, University of Toronto, Sunnybrook Health Sciences Centre, Toronto, ON."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,3,1]]},"reference":[{"key":"bibr1-7750.2011.11008","doi-asserted-by":"publisher","DOI":"10.1016\/j.sder.2008.12.006"},{"key":"bibr2-7750.2011.11008","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.369"},{"key":"bibr3-7750.2011.11008","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2009.283"},{"key":"bibr4-7750.2011.11008","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/961753"},{"key":"bibr5-7750.2011.11008","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2007.03273.x"},{"key":"bibr6-7750.2011.11008","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.08.054"},{"key":"bibr7-7750.2011.11008","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.10.025"}],"container-title":["Journal of Cutaneous Medicine and Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2310\/7750.2011.11008","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2310\/7750.2011.11008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:49:12Z","timestamp":1777391352000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.2310\/7750.2011.11008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3]]},"references-count":7,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["10.2310\/7750.2011.11008"],"URL":"https:\/\/doi.org\/10.2310\/7750.2011.11008","relation":{},"ISSN":["1203-4754","1615-7109"],"issn-type":[{"value":"1203-4754","type":"print"},{"value":"1615-7109","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3]]}}}