{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T01:49:13Z","timestamp":1777513753114,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Med Surg"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Laser therapy is a rapidly expanding new treatment modality for onychomycosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To review current and prospective laser systems for the treatment of onychomycosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>We searched the PubMed database, the Food and Drug Administration 510(k) database, ClinicalTrials.gov , and Google Scholar for in vitro studies, peer-reviewed clinical trials, manufacturers' white papers, and registered clinical trials of laser systems indicated for the treatment of onychomycosis. All published clinical trials were assessed on a 20-point methodological quality scale.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We identified three basic science articles, five peer-reviewed articles, three white papers, and four pending clinical trials, as well as numerous gray literature documents. The overall methodological score for the clinical trials was 9.1 \u00b1 1.1, with peer-reviewed studies showing a higher score (9.8 \u00b1 1.5) than white papers (7.5 \u00b1 0.7). We also identified 11 commercial laser device systems of varying global availability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Laser therapy has been tested and approved as a cosmetic treatment only for onychomycosis. It cannot be recommended as a therapeutic intervention to eradicate fungal infection at this time as more rigorous randomized, controlled trials are required to determine if laser therapy is efficacious on par with oral and topical interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2310\/7750.2012.12060","type":"journal-article","created":{"date-parts":[[2018,10,18]],"date-time":"2018-10-18T04:44:29Z","timestamp":1539837869000},"page":"301-307","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Laser Therapy for Onychomycosis"],"prefix":"10.1177","volume":"17","author":[{"given":"Aditya K.","family":"Gupta","sequence":"first","affiliation":[{"name":"From the Division of Dermatology, Department of Medicine, University of Toronto, Toronto, ON, and Mediprobe Research Inc., London, ON"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiona C.","family":"Simpson","sequence":"additional","affiliation":[{"name":"From the Division of Dermatology, Department of Medicine, University of Toronto, Toronto, ON, and Mediprobe Research Inc., London, ON"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,9,1]]},"reference":[{"key":"bibr1-7750.2012.12060","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2012.681779"},{"key":"bibr2-7750.2012.12060","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1972.01620050069017"},{"key":"bibr3-7750.2012.12060","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1995.tb06929.x"},{"key":"bibr4-7750.2012.12060","doi-asserted-by":"publisher","DOI":"10.1080\/13693780601113618"},{"key":"bibr5-7750.2012.12060","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.124699"},{"key":"bibr6-7750.2012.12060","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.02.038"},{"key":"bibr7-7750.2012.12060","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2009.12.006"},{"key":"bibr8-7750.2012.12060","unstructured":"US Food and Drug Adminstration. Guidance documents (Medical devices and radiation-emitting products) > The new 510(k) paradigm - Alternate approaches to demonstrating substantial equivalence in premarket notifications - Final guidance. 1998. Available at: http:\/\/www.fda.gov\/MedicalDevices\/DeviceRegulationandGuidance\/GuidanceDocuments\/ucm080187.htm (accessed June 8, 2012)."},{"key":"bibr9-7750.2012.12060","doi-asserted-by":"publisher","DOI":"10.1007\/s10227-002-0137-y"},{"key":"bibr10-7750.2012.12060","doi-asserted-by":"publisher","DOI":"10.7547\/1000166"},{"key":"bibr11-7750.2012.12060","doi-asserted-by":"publisher","DOI":"10.7547\/1020169"},{"key":"bibr12-7750.2012.12060","volume-title":"Laser treatment for toenail fungus","author":"Harris DM","year":"2009"},{"key":"bibr13-7750.2012.12060","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2011.552616"},{"key":"bibr14-7750.2012.12060","first-page":"1","volume":"2010","author":"Kozarev J","year":"2010","journal-title":"J Laser Health Acad"},{"key":"bibr15-7750.2012.12060","first-page":"S07","volume":"2011","author":"Kozarev J","year":"2011","journal-title":"J Laser Health Acad"},{"key":"bibr16-7750.2012.12060","first-page":"496","volume":"11","author":"Kimura U","year":"2012","journal-title":"J Drugs Dermatol"},{"key":"bibr17-7750.2012.12060","volume-title":"3 month clinical results using sub-millisecond 1064 nm Nd: YAG laser for the treatment of onychomycosis","author":"Weiss D","year":"2011"},{"key":"bibr18-7750.2012.12060","volume-title":"Introducing the Sciton ClearSense accessory featuring the ClearToe treatment for onychomycosis (for non-U.S. customers)","author":"Waibel J","year":"2012"},{"key":"bibr19-7750.2012.12060","volume-title":"Treatment of onychomycosis* with the JOULE ClearSense","author":"Bessinger GT","year":"2012"},{"key":"bibr20-7750.2012.12060","unstructured":"Light Age Inc. 510(k) summary K110370. Q-Clear, Light Age. FDA 510(k) premarket notification database; 2011. Available at: http:\/\/www.accessdata.fda.gov\/cdrh_docs\/pdf11\/K110370.pdf (accessed May 30, 2012)."},{"key":"bibr21-7750.2012.12060","unstructured":"University of California, Irvine. 1320 nm NdYAG laser for improving the appearance of onychomycosis. ClinicalTrials.gov. 2011. Available at: http:\/\/clinicaltrials.gov\/ct2\/show\/NCT01498393 (accessed May 30, 2012)."},{"key":"bibr22-7750.2012.12060","unstructured":"ConBio. Diode laser treatment of onychomycosis. ClinicalTrials.gov; 2011. Available at: http:\/\/clinicaltrials.gov\/ct2\/show\/NCT01452490 (accessed May 30, 2012)."},{"key":"bibr23-7750.2012.12060","unstructured":"Brasilia University Hospital. Erbium-doped yttrium aluminium garnet laser (Erb:YAG) associated with amorolfme lacquer in the treatment of onychomycosis (OnychoLASER). ClinicalTrials.gov; 2012. Available at: http:\/\/clinicaltrials.gov\/ct2\/show\/NCT01528813 (accessed May 30, 2012)."},{"key":"bibr24-7750.2012.12060","unstructured":"Erchonia Corporation. Study of the use of low level laser light therapy to treat toenail fungus. ClinicalTrials.gov; 2012. Available at: http:\/\/clinicaltrials.gov\/ct2\/show\/NCT01534689 (accessed May 30, 2012)."},{"key":"bibr25-7750.2012.12060","unstructured":"Fotona Inc. 510(k) summary K113702. XP Nd:YAG Laser System Family, Fotona Inc. FDA 510(k) premarket notification database; 2012. Available at: http:\/\/www.accessdata.fda.gov\/cdrh_docs\/pdf11\/K113702.pdf (accessed May 30, 2012)."},{"key":"bibr26-7750.2012.12060","unstructured":"Aerolase Inc. Skin tightening and hair removal with LightPodNeo. Available at: http:\/\/www.aerolase.com\/LightPodNeo.html#Specs (accessed: May 30, 2012)."},{"key":"bibr27-7750.2012.12060","unstructured":"Sciton Inc. 510(k) summary K111483. JOULE ClearSense, Sciton Inc. FDA 510(k) premarket notification database; 2011. Available at: http:\/\/www.accessdata.fda.gov\/cdrh_docs\/pdf11\/K111483.pdf (accessed May 30, 2012)."},{"key":"bibr28-7750.2012.12060","unstructured":"PinPointe USA. 510(k) summary K093547. PinPointe FootLaser, PinPointe USA Inc. FDA 510(k) premarket notification database; 2010. Available at: http:\/\/www.accessdata.fda.gov\/cdrh_docs\/pdf9\/K093547.pdf (accessed May 30, 2012)."},{"key":"bibr29-7750.2012.12060","unstructured":"Cutera Inc. 510(k) summary K103626. GenesisPlus, Cutera Inc. FDA 510(k) premarket notification database; 2011. Available at: http:\/\/www.accessdata.fda.gov\/cdrh_docs\/pdfl0\/K103626.pdf (accessed May 30, 2012)."},{"key":"bibr30-7750.2012.12060","unstructured":"New Star Lasers Inc. 510(k) summary K103338. CoolTouch VARIA, New Star Lasers Inc. FDA 510(k) premarket notification database; 2011. Available at: http:\/\/www.accessdata.fda.gov\/cdrh_docs\/pdf6\/K060966.pdf (accessed May 30, 2012)."},{"key":"bibr31-7750.2012.12060","unstructured":"CoolTouch Inc. CoolTouch. Physicians CoolTouch CT3Plus Laser System. CoolTouch CT3Plus laser specifications. Available at: http:\/\/www.cooltouch.com\/CT3Plus_specifications.aspx (accessed May 30, 2012)."},{"key":"bibr32-7750.2012.12060","unstructured":"Alma Lasers. 510(k) summary K113810. Harmony, Alma Lasers Inc. FDA 510(k) premarket notification database; 2012. Available at: http:\/\/www.accessdata.fda.gov\/cdrh_docs\/pdf11\/K113810.pdf (accessed May 30, 2012)."},{"key":"bibr33-7750.2012.12060","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2009.00615.x"},{"key":"bibr34-7750.2012.12060","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-007-0492-4"},{"key":"bibr35-7750.2012.12060","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2009.00672.x"}],"container-title":["Journal of Cutaneous Medicine and Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2310\/7750.2012.12060","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.2310\/7750.2012.12060","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2310\/7750.2012.12060","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:49:49Z","timestamp":1777391389000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.2310\/7750.2012.12060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["10.2310\/7750.2012.12060"],"URL":"https:\/\/doi.org\/10.2310\/7750.2012.12060","relation":{},"ISSN":["1203-4754","1615-7109"],"issn-type":[{"value":"1203-4754","type":"print"},{"value":"1615-7109","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9]]}}}