{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T01:49:29Z","timestamp":1777513769475,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Med Surg"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Vemurafenib is an oral BRAF inhibitor recently approved for the treatment of metastatic melanoma. Patients treated with this medication have been reported to have the occurrence of squamous cell carcinoma (SCC) and\/or actinic keratosis (AK).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We report the case of a patient treated with vemurafenib for papillary thyroid carcinoma who subsequently developed multiple SCCs and AK of the skin. The lesions were deemed related to the medication and treated with excision. In addition, subsequent development of SCCs and AK was successfully prevented with a combination of isotretinoin and 5-fluorouracil in this patient. We discuss postulated mechanisms for these findings, as well as potential preventive therapy with the aforementioned combination regimen in patients undergoing treatment with vemurafenib.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2310\/7750.2013.12092","type":"journal-article","created":{"date-parts":[[2018,10,18]],"date-time":"2018-10-18T04:43:10Z","timestamp":1539837790000},"page":"419-422","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Eruptive Squamous Cell Carcinomas after Vemurafenib Therapy"],"prefix":"10.1177","volume":"17","author":[{"given":"Rana","family":"Mays","sequence":"first","affiliation":[{"name":"From the Center for Clinical Studies, Houston, TX; Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX; Department of Dermatology, University of Texas Medical School at Houston, Houston, TX; Department of Dermatology, Tufts Medical Center, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Curry","sequence":"additional","affiliation":[{"name":"From the Center for Clinical Studies, Houston, TX; Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX; Department of Dermatology, University of Texas Medical School at Houston, Houston, TX; Department of Dermatology, Tufts Medical Center, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Kim","sequence":"additional","affiliation":[{"name":"From the Center for Clinical Studies, Houston, TX; Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX; Department of Dermatology, University of Texas Medical School at Houston, Houston, TX; Department of Dermatology, Tufts Medical Center, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"Tsai","sequence":"additional","affiliation":[{"name":"From the Center for Clinical Studies, Houston, TX; Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX; Department of Dermatology, University of Texas Medical School at Houston, Houston, TX; Department of Dermatology, Tufts Medical Center, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Arora","sequence":"additional","affiliation":[{"name":"From the Center for Clinical Studies, Houston, TX; Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX; Department of Dermatology, University of Texas Medical School at Houston, Houston, TX; Department of Dermatology, Tufts Medical Center, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farhan","family":"Khan","sequence":"additional","affiliation":[{"name":"From the Center for Clinical Studies, Houston, TX; Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX; Department of Dermatology, University of Texas Medical School at Houston, Houston, TX; Department of Dermatology, Tufts Medical Center, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marigdalia","family":"Ramirez-Fort","sequence":"additional","affiliation":[{"name":"From the Center for Clinical Studies, Houston, TX; Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX; Department of Dermatology, University of Texas Medical School at Houston, Houston, TX; Department of Dermatology, Tufts Medical Center, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Ciurea","sequence":"additional","affiliation":[{"name":"From the Center for Clinical Studies, Houston, TX; Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX; Department of Dermatology, University of Texas Medical School at Houston, Houston, TX; Department of Dermatology, Tufts Medical Center, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,9,6]]},"reference":[{"key":"bibr1-7750.2013.12092","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103782"},{"key":"bibr2-7750.2013.12092","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2010.165"},{"key":"bibr3-7750.2013.12092","first-page":"308","volume":"10","author":"Lynch MC","year":"2011","journal-title":"J Drugs Dermatol"},{"key":"bibr4-7750.2013.12092","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09290.x"},{"key":"bibr5-7750.2013.12092","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.06.034"},{"key":"bibr6-7750.2013.12092","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.144.6.779"},{"key":"bibr7-7750.2013.12092","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2004.09.022"},{"key":"bibr8-7750.2013.12092","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-07-2001"},{"key":"bibr9-7750.2013.12092","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-2554"},{"key":"bibr10-7750.2013.12092","doi-asserted-by":"publisher","DOI":"10.1038\/nature00766"},{"key":"bibr11-7750.2013.12092","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-1118-3"},{"key":"bibr12-7750.2013.12092","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.18.0786"},{"key":"bibr13-7750.2013.12092","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-009-9073-3"},{"key":"bibr14-7750.2013.12092","doi-asserted-by":"publisher","DOI":"10.1677\/ERC-07-0212"},{"key":"bibr15-7750.2013.12092","doi-asserted-by":"publisher","DOI":"10.1038\/418934a"},{"key":"bibr16-7750.2013.12092","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0711741105"},{"key":"bibr17-7750.2013.12092","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2009.27.15_suppl.9000"},{"key":"bibr18-7750.2013.12092","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.177"},{"key":"bibr19-7750.2013.12092","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.36.7680"},{"key":"bibr20-7750.2013.12092","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2011.29.15_suppl.8520"},{"key":"bibr21-7750.2013.12092","doi-asserted-by":"crossref","unstructured":"Fabricius EM, Kruse-Boitschenko U, Schneeweiss U, Model examination of chemoprevention with retinoids in squamous cell carcinomas of the head and neck region and suitable biomarkers for chemoprevention. 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