{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T01:49:51Z","timestamp":1777513791755,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Med Surg"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Pegylated interferon-\u03b1 combined with ribavirin is the current standard treatment for chronic hepatitis C virus infection. During interferon and ribavirin therapy, both local and generalized mucocutaneous adverse reactions have been reported. Erythema annulare centrifugum induced by this therapy regimen has not been reported previously.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Report:<\/jats:title>\n                    <jats:p>A 29-year-old woman was referred to our clinic for a 1-week history of slightly pruritic annular erythematous eruptions on the lower extremities and hands. The eruptions had first occured on the hands 3 to 4 days after pegylated interferon-\u03b1-2a plus ribavirin combination therapy for hepatitis C virus infection. Histopathologic examination supported the diagnosis of erythema annulare centrifugum. The lesions completely regressed within 2 weeks after the cessation of treatment but recurred on similar localizations within 24 hours with the same therapy. It was thought that erythema annulare centrifugum was induced by pegylated interferon-\u03b1-2a plus ribavirin combination therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Erythema annulare centrifugum is considered an inflammatory skin disease with unknown etiology. It is thought to represent a hypersensitivity reaction to some triggering factors, including infections, immunologic disorders, malign neoplasms, foods, pregnancy, and drugs. We report the first case of erythema annulare centrifigum induced by pegylated interferon-\u03b1-2a plus ribavirin combination therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2310\/7750.2013.13051","type":"journal-article","created":{"date-parts":[[2018,10,18]],"date-time":"2018-10-18T04:44:37Z","timestamp":1539837877000},"page":"65-68","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Erythema Annulare Centrifugum due to Pegylated Interferon-\u03b1-2a plus Ribavirin Combination Therapy in a Patient with Chronic Hepatitis C Virus Infection"],"prefix":"10.1177","volume":"18","author":[{"given":"M\u00fczeyyen","family":"G\u00f6n\u00fcl","sequence":"first","affiliation":[{"name":"From the Dermatology and Pathology Clinics, Ankara Numune Education and Research Hospital, Sihhiye, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seray K\u00fclc\u00fc","family":"\u00c7akmak","sequence":"additional","affiliation":[{"name":"From the Dermatology and Pathology Clinics, Ankara Numune Education and Research Hospital, Sihhiye, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nimet","family":"\u00d6zcan","sequence":"additional","affiliation":[{"name":"From the Dermatology and Pathology Clinics, Ankara Numune Education and Research Hospital, Sihhiye, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I\u015fil Deniz","family":"O\u01e7uz","sequence":"additional","affiliation":[{"name":"From the Dermatology and Pathology Clinics, Ankara Numune Education and Research Hospital, Sihhiye, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esra","family":"\u00d6zhamam","sequence":"additional","affiliation":[{"name":"From the Dermatology and Pathology Clinics, Ankara Numune Education and Research Hospital, Sihhiye, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,1,1]]},"reference":[{"key":"bibr1-7750.2013.13051","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2006.02941.x"},{"key":"bibr2-7750.2013.13051","first-page":"1","volume":"92","author":"Chou WT","year":"2012","journal-title":"Acta Derm Venereol"},{"key":"bibr3-7750.2013.13051","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2007.00336.x"},{"key":"bibr4-7750.2013.13051","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06931.x"},{"key":"bibr5-7750.2013.13051","doi-asserted-by":"publisher","DOI":"10.1155\/2009\/651952"},{"key":"bibr6-7750.2013.13051","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.135.8.1000"},{"key":"bibr7-7750.2013.13051","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2008.00458.x"},{"key":"bibr8-7750.2013.13051","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.08.006"},{"key":"bibr9-7750.2013.13051","first-page":"422","volume":"122","author":"Guillet MH","year":"1995","journal-title":"Ann Dermatol Venereol"},{"key":"bibr10-7750.2013.13051","first-page":"2217","volume-title":"Dermatology in general medicine","author":"Richardson S","year":"2008","edition":"7"},{"key":"bibr11-7750.2013.13051","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ad.2009.07.015","volume":"101","author":"Coronel-P\u00e9rez IM","year":"2010","journal-title":"Actas Dermosifiliogr"}],"container-title":["Journal of Cutaneous Medicine and Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2310\/7750.2013.13051","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.2310\/7750.2013.13051","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2310\/7750.2013.13051","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:49:59Z","timestamp":1777391399000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.2310\/7750.2013.13051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.2310\/7750.2013.13051"],"URL":"https:\/\/doi.org\/10.2310\/7750.2013.13051","relation":{},"ISSN":["1203-4754","1615-7109"],"issn-type":[{"value":"1203-4754","type":"print"},{"value":"1615-7109","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1]]}}}