{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T01:35:11Z","timestamp":1777512911709,"version":"3.51.4"},"reference-count":8,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Med Surg"],"published-print":{"date-parts":[[2014,11]]},"abstract":"\n Background:<\/jats:title>\n Bullous pemphigoid (BP) is an autoimmune polymorphic skin disease characterized by erythematous papules and plaques and tense bullae. A skin biopsy for direct immunofluorescence (DIF) is used to detect autoantibodies and complement proteins.<\/jats:p>\n <\/jats:sec>\n \n Objective:<\/jats:title>\n We sought to determine which location would provide the highest probability of obtaining a positive DIF result.<\/jats:p>\n <\/jats:sec>\n \n Method:<\/jats:title>\n We undertook a retrospective chart review of 1,423 DIF biopsies. Biopsies with a clinical suspicion of BP were designated as either lesional, perilesional, or indeterminate.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n Fifty percent of lesional DIF biopsies were positive, whereas 22% of perilesional and 12% of indeterminate biopsies had a positive DIF result. The odds ratio of a positive DIF from a lesional versus perilesional biopsy site was found to be 3.45 (95% CI 1.44\u20138.29).<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Clinicians are more likely to obtain a positive DIF result from a lesional nonbullous skin biopsy than from a perilesional or normal skin biopsy.<\/jats:p>\n <\/jats:sec>","DOI":"10.2310\/7750.2014.14004","type":"journal-article","created":{"date-parts":[[2015,3,11]],"date-time":"2015-03-11T15:01:24Z","timestamp":1426086084000},"page":"392-396","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Biopsy Location for Direct Immunofluorescence in Patients with Suspected Bullous Pemphigoid Impacts Probability of a Positive Test Result"],"prefix":"10.1177","volume":"18","author":[{"given":"Chris","family":"Sladden","sequence":"first","affiliation":[{"name":"From the Department of Dermatology and Skin Science, University of British Columbia, and Department of Pathology and Laboratory Medicine and Division of Dermatology, Department of Medicine, St. Paul's Hospital, Providence Health Care, Vancouver, BC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark G.","family":"Kirchhof","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology and Skin Science, University of British Columbia, and Department of Pathology and Laboratory Medicine and Division of Dermatology, Department of Medicine, St. Paul's Hospital, Providence Health Care, Vancouver, BC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard I.","family":"Crawford","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology and Skin Science, University of British Columbia, and Department of Pathology and Laboratory Medicine and Division of Dermatology, Department of Medicine, St. Paul's Hospital, Providence Health Care, Vancouver, BC"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,11,1]]},"reference":[{"key":"bibr1-7750.2014.14004","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61140-4"},{"key":"bibr2-7750.2014.14004","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2012.04.002"},{"key":"bibr3-7750.2014.14004","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1998.00271.x"},{"key":"bibr4-7750.2014.14004","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(89)70054-2"},{"key":"bibr5-7750.2014.14004","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1990.tb02139.x"},{"key":"bibr6-7750.2014.14004","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12260627"},{"key":"bibr7-7750.2014.14004","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2011.03.001"},{"key":"bibr8-7750.2014.14004","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(85)80035-9"}],"container-title":["Journal of Cutaneous Medicine and Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2310\/7750.2014.14004","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.2310\/7750.2014.14004","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2310\/7750.2014.14004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:46:17Z","timestamp":1777391177000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.2310\/7750.2014.14004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":8,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["10.2310\/7750.2014.14004"],"URL":"https:\/\/doi.org\/10.2310\/7750.2014.14004","relation":{},"ISSN":["1203-4754","1615-7109"],"issn-type":[{"value":"1203-4754","type":"print"},{"value":"1615-7109","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11]]}}}