{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:51:47Z","timestamp":1790373107728,"version":"4.1.0"},"reference-count":23,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2015,3,13]],"date-time":"2015-03-13T00:00:00Z","timestamp":1426204800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Med Surg"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Rituximab (RTX) is increasingly used for the treatment of pemphigus and pemphigoid disorders. The high cost of RTX frequently limits its use and access.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the health system resources and costs associated with RTX treatment of pemphigus and pemphigoid.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Health system resources and costs attributed to a convenience sample of 89 patients with either pemphigus or pemphigoid were identified, quantified, and valued 6 months prior to and following RTX initiation between May 2006 and August 2012. Overall cohort costs and costs per patient were calculated (2013 Can$).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The overall cohort cost for 6 months pre-RTX was $3.8 million and for 6 months post-RTX was $2.6 million. The average cost per patient decreased from $42,231 to $29,423 (30.3% decrease). The main cost driver was intravenous immunoglobulin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings suggest that RTX is effective in reducing health system resources and the costs associated with the treatment of pemphigus and pemphigoid.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2310\/7750.2014.14092","type":"journal-article","created":{"date-parts":[[2015,3,18]],"date-time":"2015-03-18T15:45:27Z","timestamp":1426693527000},"page":"274-282","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["Cost and Resource Use of Pemphigus and Pemphigoid Disorders Pre- and Post-Rituximab"],"prefix":"10.1177","volume":"19","author":[{"given":"Kara","family":"Heelan","sequence":"first","affiliation":[{"name":"Division of Dermatology, Department of Medicine; Health Outcomes and PharmacoEconomics (HOPE) Research Centre, Sunnybrook Research Institute; Division of Clinical Pharmacology and Toxicology at Sunnybrook, Department of Medicine; and Department of Pharmacology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON; and International Centre for Health Innovation, Richard Ivey School of Business, Western University, London, ON."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shazia","family":"Hassan","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine; Health Outcomes and PharmacoEconomics (HOPE) Research Centre, Sunnybrook Research Institute; Division of Clinical Pharmacology and Toxicology at Sunnybrook, Department of Medicine; and Department of Pharmacology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON; and International Centre for Health Innovation, Richard Ivey School of Business, Western University, London, ON."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Bannon","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine; Health Outcomes and PharmacoEconomics (HOPE) Research Centre, Sunnybrook Research Institute; Division of Clinical Pharmacology and Toxicology at Sunnybrook, Department of Medicine; and Department of Pharmacology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON; and International Centre for Health Innovation, Richard Ivey School of Business, Western University, London, ON."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Knowles","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine; Health Outcomes and PharmacoEconomics (HOPE) Research Centre, Sunnybrook Research Institute; Division of Clinical Pharmacology and Toxicology at Sunnybrook, Department of Medicine; and Department of Pharmacology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON; and International Centre for Health Innovation, Richard Ivey School of Business, Western University, London, ON."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Walsh","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine; Health Outcomes and PharmacoEconomics (HOPE) Research Centre, Sunnybrook Research Institute; Division of Clinical Pharmacology and Toxicology at Sunnybrook, Department of Medicine; and Department of Pharmacology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON; and International Centre for Health Innovation, Richard Ivey School of Business, Western University, London, ON."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil H.","family":"Shear","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine; Health Outcomes and PharmacoEconomics (HOPE) Research Centre, Sunnybrook Research Institute; Division of Clinical Pharmacology and Toxicology at Sunnybrook, Department of Medicine; and Department of Pharmacology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON; and International Centre for Health Innovation, Richard Ivey School of Business, Western University, London, ON."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Mittmann","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine; Health Outcomes and PharmacoEconomics (HOPE) Research Centre, Sunnybrook Research Institute; Division of Clinical Pharmacology and Toxicology at Sunnybrook, Department of Medicine; and Department of Pharmacology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON; and International Centre for Health Innovation, Richard Ivey School of Business, Western University, London, ON."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,3,13]]},"reference":[{"key":"bibr1-7750.2014.14092","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2011.01.013"},{"key":"bibr2-7750.2014.14092","doi-asserted-by":"publisher","DOI":"10.3109\/08916934.2011.606447"},{"key":"bibr3-7750.2014.14092","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1996.03890260105016"},{"key":"bibr4-7750.2014.14092","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-012-0017-3"},{"key":"bibr5-7750.2014.14092","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2008.10.004"},{"key":"bibr6-7750.2014.14092","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2013.784391"},{"key":"bibr7-7750.2014.14092","unstructured":"Bank of Canada. 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