{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:18:23Z","timestamp":1777724303193,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study examines plasma interleukin 33 (IL-33) levels in patients with osteonecrosis of the femoral head (ONFH) and explores the possible use of IL-33 as a marker for early diagnosis and progression of ONFH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>One hundred twenty-five ONFH patients and 126 control subjects were recruited for this study. The plasma IL-33 levels were measured using a commercially available enzyme-linked immunosorbent assay kit. Effects of disease stage and risk factors on IL-33 level were also assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Plasma IL-33 levels were significantly higher in the 125 ONFH patients (174.33 [SD, 65.73] pg\/mL) than in the 126 control subjects (90.50 [SD, 25.17] pg\/mL, P &lt; 0.001). Plasma IL-33 levels were significantly higher in patients with stage III\/IV ONFH (184.17 [SD, 43.75] pg\/mL) than in patients with stage I\/II ONFH (158.24 [SD, 50.11] pg\/mL, P &lt; 0.001). There was no significant difference in IL-33 levels between alcohol-induced, idiopathic, and steroid-induced cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Plasma IL-33 may be an alarmin for ONFH, and its levels may be related to disease progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2310\/jim.0000000000000050","type":"journal-article","created":{"date-parts":[[2016,5,11]],"date-time":"2016-05-11T09:10:57Z","timestamp":1462957857000},"page":"635-637","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Plasma Interleukin 33 Level in Patients with Osteonecrosis of Femoral Head"],"prefix":"10.1177","volume":"62","author":[{"given":"Liwen","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Orthopedics, 2nd Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanchun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, 2nd Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangdon","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, 2nd Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, 2nd Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, 2nd Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, 2nd Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinzhang","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, 2nd Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aiyong","family":"He","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, 2nd Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,3,1]]},"reference":[{"key":"bibr1-JIM.0000000000000050","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.10-RAI-0186"},{"key":"bibr2-JIM.0000000000000050","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-013-0338-z"},{"key":"bibr3-JIM.0000000000000050","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2010.11.021"},{"key":"bibr4-JIM.0000000000000050","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.269"},{"key":"bibr5-JIM.0000000000000050","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2011.04.013"},{"key":"bibr6-JIM.0000000000000050","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0812690106"},{"key":"bibr7-JIM.0000000000000050","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.67B1.3155745"},{"key":"bibr8-JIM.0000000000000050","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2010.01.002"},{"key":"bibr9-JIM.0000000000000050","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.090492"},{"key":"bibr10-JIM.0000000000000050","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000096826.67494.38"},{"key":"bibr11-JIM.0000000000000050","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-010-1738-1"},{"key":"bibr12-JIM.0000000000000050","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1003487"},{"key":"bibr13-JIM.0000000000000050","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2009.04.255"},{"key":"bibr14-JIM.0000000000000050","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.09.015"},{"key":"bibr15-JIM.0000000000000050","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0802449"}],"container-title":["Journal of Investigative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2310\/JIM.0000000000000050","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.2310\/JIM.0000000000000050","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2310\/JIM.0000000000000050","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:39:36Z","timestamp":1777459176000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.2310\/JIM.0000000000000050"}},"subtitle":["An Alarmin for Osteonecrosis of the Femoral Head?"],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.2310\/JIM.0000000000000050"],"URL":"https:\/\/doi.org\/10.2310\/jim.0000000000000050","relation":{},"ISSN":["1081-5589","1708-8267"],"issn-type":[{"value":"1081-5589","type":"print"},{"value":"1708-8267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3]]}}}