{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:11:01Z","timestamp":1777723861501,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine"],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Peripheral arterial disease is mainly caused by atherosclerosis and is characterized by decreased circulation, lower blood pressure, and insufficient tissue perfusion in the lower extremities. The hemodynamics of standing and altered gravity environments have been well studied relative to arm blood pressures but are less well understood for ankle pressures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Because regional blood pressure depends, in part, on the gravitational pressure gradient, we hypothesized that artificial gravity exposure on a short-arm centrifuge with the center of rotation above the head would increase blood pressure in the lower extremities. Cardiovascular parameters for 12 healthy subjects were measured during exposure to supine short-arm centrifugation at 20, 25, and 30 revolutions per minute (rpm), corresponding to centripetal accelerations of 0.94, 1.47, and 2.11 Gz at the foot level, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Systolic ankle blood pressure significantly increased at all levels of centrifugation. Ankle-brachial indices (the ratio of systolic ankle to arm blood pressures) increased significantly from 1.17 \u00b1 0.03 to 1.58 \u00b1 0.03 at 0.94 Gz ( P &lt; 0.005), 1.74 \u00b1 0.02 at 1.47 Gz ( P &lt; 0.005), and 1.89 \u00b1 0.06 at 2.11 Gz ( P &lt; 0.005). Systolic arm blood pressure significantly increased at 2.11 Gz, but heart rate did not change significantly. All parameters returned to normal after cessation of centrifugation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We demonstrated that short-radius centrifugation leads to an increase in ankle-brachial indices. This could have potential implications for the treatment of peripheral arterial disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2310\/jim.0b013e3181a1fb82","type":"journal-article","created":{"date-parts":[[2016,5,11]],"date-time":"2016-05-11T09:10:57Z","timestamp":1462957857000},"page":"640-644","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Use of Short-Radius Centrifugation to Augment Ankle-Brachial Indices"],"prefix":"10.1177","volume":"57","author":[{"given":"S. Marlene","family":"Grenon","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada"},{"name":"Man-Vehicle Laboratory, Department of Aeronautics and Astronautics, Massachusetts Institute of Technology, Cambridge, MA"},{"name":"Department of Vascular Surgery, St. Pauls Hospital, University of British Columbia, Vancouver, British Columbia, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime","family":"Mateus","sequence":"additional","affiliation":[{"name":"Man-Vehicle Laboratory, Department of Aeronautics and Astronautics, Massachusetts Institute of Technology, Cambridge, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"York","family":"Hsiang","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravi","family":"Sidhu","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, St. Pauls Hospital, University of British Columbia, Vancouver, British Columbia, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence","family":"Young","sequence":"additional","affiliation":[{"name":"Man-Vehicle Laboratory, Department of Aeronautics and Astronautics, Massachusetts Institute of Technology, Cambridge, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel","family":"Gagnon","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,6,1]]},"reference":[{"key":"bibr1-JIM.0b013e3181a1fb82","first-page":"240","volume-title":"Vascular and Endovascular Surgery, A Comprehensive Review","author":"Eugene Ziegler R","year":"2006","edition":"7"},{"key":"bibr2-JIM.0b013e3181a1fb82","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00198.2003"},{"key":"bibr3-JIM.0b013e3181a1fb82","first-page":"S80","volume":"35","author":"Hargens AR","year":"1992","journal-title":"Physiologist"},{"key":"bibr4-JIM.0b013e3181a1fb82","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200105243442108"},{"key":"bibr5-JIM.0b013e3181a1fb82","first-page":"1072","volume":"78","author":"Baron HC","year":"1978","journal-title":"N Y State J Med"},{"key":"bibr6-JIM.0b013e3181a1fb82","first-page":"289","volume":"45","author":"Baron HC","year":"1979","journal-title":"Am Surg"},{"key":"bibr7-JIM.0b013e3181a1fb82","first-page":"P23","volume":"4","author":"Hastreiter D","year":"1997","journal-title":"J Gravit Physiol"},{"key":"bibr8-JIM.0b013e3181a1fb82","first-page":"129","volume":"78","author":"Edmonds JL","year":"2007","journal-title":"Aviat Space Environ Med"},{"key":"bibr9-JIM.0b013e3181a1fb82","first-page":"S155","volume":"36","author":"Cardus D","year":"1993","journal-title":"Physiologist"},{"key":"bibr10-JIM.0b013e3181a1fb82","doi-asserted-by":"publisher","DOI":"10.1016\/S0094-5765(01)00101-1"},{"key":"bibr11-JIM.0b013e3181a1fb82","first-page":"29","volume":"46","author":"Iwase S","year":"2002","journal-title":"Environ Med"},{"key":"bibr12-JIM.0b013e3181a1fb82","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.90304.2008"},{"key":"bibr13-JIM.0b013e3181a1fb82","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00185.2004"},{"key":"bibr14-JIM.0b013e3181a1fb82","first-page":"1","volume-title":"Circulatory Responses to the Upright Posture","author":"Smith JJ","year":"1990"},{"key":"bibr15-JIM.0b013e3181a1fb82","doi-asserted-by":"publisher","DOI":"10.1006\/mvre.1993.1058"},{"key":"bibr16-JIM.0b013e3181a1fb82","doi-asserted-by":"crossref","unstructured":"Rowell LB. 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