{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:15:00Z","timestamp":1777724100756,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine"],"published-print":{"date-parts":[[2011,6]]},"abstract":"\n Background<\/jats:title>\n Parathyroid hormone (PTH) revealed a positive action on progenitor cells released from bone marrow, and many mechanisms supported PTH as a tool to improve stem cell-based therapy in experimental models of ischemia. Elevated PTH resulted in increased mobilization of progenitors into the peripheral blood of patients affected by untreated primary hyperparathyroidism. A frequent finding in uremic patients is a higher PTH level, and different therapeutic strategies are adopted and implemented to achieve an intermediary PTH level. On the contrary, the amount of progenitors commonly results to be extremely reduced.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n In the present study, we investigated, in a cohort of uremic patients, the effect of different levels of PTH on mobilization of progenitor cell populations.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Eighty patients (26 women, 54 men) were enrolled. Following the Kidney Disease Outcomes Quality Initiative (KDOQI) guidelines, patients were divided in 3 groups for PTH levels: low-PTH group with a PTH level lower than 150 pg\/mL (n = 25), KDOQI-PTH group with a PTH level between 150 and 300 pg\/mL (n = 37), and high-PTH group with a PTH level higher than 300 pg\/mL (n = 18). Patients with high levels of PTH were treated differently to achieve KDOQI targets: 5 received intravenous calcitriol and P binders, 3 received intravenous paracalcitriol, and 10 received cinacalcet. We quantified, by the combination of surface markers (CD45\n +<\/jats:sup>\n , CD34\n +<\/jats:sup>\n , CD31\n +<\/jats:sup>\n , and c-kit\n +<\/jats:sup>\n ), the number of hematopoietic and endothelial progenitor cells.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n High-PTH group demonstrated a significantly higher level of CD45\n +<\/jats:sup>\n \/CD34\n +<\/jats:sup>\n \/c-kit\n +<\/jats:sup>\n with respect to low-PTH and KDOQI-PTH groups (1.02 [SD, 0.12] vs. 0.56 [SD, 0.14] cells\/uL, P < 0.01; and 1.02 [SD, 0.12] vs. 0.46 [SD, 0.20] cells\/uL, P < 0.05). CD45\n +<\/jats:sup>\n \/CD34\n +<\/jats:sup>\n \/CD31\n +<\/jats:sup>\n levels resulted significantly increased in the KDOQI-PTH group compared with those observed in the low- (1.83 [SD, 0.72] vs 1.26 [SD, 0.83] cells\/\u03bcL, P = 0.04) and high-PTH groups (1.83 [SD, 0.72] vs 1.20 [SD, 1.15] cells\/\u03bcL, P = 0.04). Receiver operating characteristic analyses were performed to define the ability of CD45\n +<\/jats:sup>\n \/34\n +<\/jats:sup>\n \/31\n +<\/jats:sup>\n to identify the presence of an optimal PTH status (>150 but <300 pg\/mL) among all hemodialysis patients. The area under the curve of CD45\n +<\/jats:sup>\n \/34\n +<\/jats:sup>\n \/31\n +<\/jats:sup>\n was 0.674 (95% confidence interval [CI], 0.501-0.819) with a best cutoff level of 1.36 cells\/\u03bcL (sensitivity, 80.0; specificity, 59.1; P < 0.05). After 4 months, we demonstrated an increase in endothelial progenitor cell number in 13 patients with secondary hyperparathyroidism that achieved KDOQI targets in PTH levels after pharmacological treatment.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Our data confirm, with acknowledged limitations due to the low number of patients, the effect of PTH on bone marrow-derived progenitor cells emphasizing that, in our cohort, an intermediary PTH level, achieved following specific guidelines, results in an equilibrate balance between different subsets of progenitor cells.<\/jats:p>\n <\/jats:sec>","DOI":"10.2310\/jim.0b013e318214edf8","type":"journal-article","created":{"date-parts":[[2016,5,11]],"date-time":"2016-05-11T09:10:57Z","timestamp":1462957857000},"page":"823-828","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Parathyroid Hormone and Mobilization of Circulating Bone Marrow-Derived Cells in Uremic Patients"],"prefix":"10.1177","volume":"59","author":[{"given":"Giuseppe","family":"Coppolino","sequence":"first","affiliation":[{"name":"U. O. C. di Nefrologia e Dialisi, Azienda Ospedaliera \u201cPugliese-Ciaccio,\u201d Catanzaro, Italy"},{"name":"Department of Internal Medicine, University of Messina, Messina, Italy"},{"name":"U. O. C. di Nefrologia e Dialisi, \u201cMagna Grecia\u201d University of Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Bolignano","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Messina, Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciano","family":"De Paola","sequence":"additional","affiliation":[{"name":"U. O. C. di Nefrologia e Dialisi, Azienda Ospedaliera \u201cPugliese-Ciaccio,\u201d Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Crispino","family":"Giulino","sequence":"additional","affiliation":[{"name":"U. O. C. di Ematologia, Azienda Ospedaliera \u201cPugliese-Ciaccio,\u201d Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ada","family":"Mannella","sequence":"additional","affiliation":[{"name":"U. O. C. di Ematologia, Azienda Ospedaliera \u201cPugliese-Ciaccio,\u201d Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mara","family":"Riccio","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Messina, Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Antonietta","family":"Mascaro","sequence":"additional","affiliation":[{"name":"U. O. C. di Nefrologia e Dialisi, \u201cMagna Grecia\u201d University of Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianmarco","family":"Lombardi","sequence":"additional","affiliation":[{"name":"U. O. C. di Nefrologia e Dialisi, Azienda Ospedaliera \u201cPugliese-Ciaccio,\u201d Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Fuiano","sequence":"additional","affiliation":[{"name":"U. O. C. di Nefrologia e Dialisi, \u201cMagna Grecia\u201d University of Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Lombardi","sequence":"additional","affiliation":[{"name":"U. O. C. di Nefrologia e Dialisi, Azienda Ospedaliera \u201cPugliese-Ciaccio,\u201d Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Buemi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Messina, Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,6,1]]},"reference":[{"key":"bibr1-JIM.0b013e318214edf8","doi-asserted-by":"publisher","DOI":"10.1038\/ncpcardio1214"},{"key":"bibr2-JIM.0b013e318214edf8","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000137877.89448.78"},{"key":"bibr3-JIM.0b013e318214edf8","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2007.10.001"},{"key":"bibr4-JIM.0b013e318214edf8","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2007.03.007"},{"key":"bibr5-JIM.0b013e318214edf8","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2008.03.014"},{"key":"bibr6-JIM.0b013e318214edf8","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V12102131"},{"key":"bibr7-JIM.0b013e318214edf8","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.7.16.2215"},{"key":"bibr8-JIM.0b013e318214edf8","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm931"},{"key":"bibr9-JIM.0b013e318214edf8","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000133488.56221.4a"},{"key":"bibr10-JIM.0b013e318214edf8","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1701397"},{"key":"bibr11-JIM.0b013e318214edf8","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.495"},{"key":"bibr12-JIM.0b013e318214edf8","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2008.02.022"},{"key":"bibr13-JIM.0b013e318214edf8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2005.tb00335.x"},{"issue":"4","key":"bibr14-JIM.0b013e318214edf8","first-page":"463","volume":"22","author":"Allegra 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