{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:17:53Z","timestamp":1777724273502,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The reduced folate carrier ( RFC1) is a major methotrexate transporter whose impaired function was recognized as a frequent mechanism of antifolate resistance. Recently, a G80A polymorphism has been described in the RFC1. This study evaluated the effect of the G80A polymorphism in the RFC1 gene on survival and risk of relapse of acute lymphoblastic leukemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>Seventy patients with acute lymphoblastic leukemia were genotyped by polymerase chain reaction restriction fragment length polymorphism method. An association between the polymorphism and risk of relapse was found ( P &lt; 0.05). Patients with the G\/A genotype have 3.97 (95% confidence interval, 1.12\u201314.06) and carriers of the A\/A genotype have 7.84 (95% confidence interval, 1.66\u201337.10) higher chance of a relapse. Other variables such as age and leukocyte count were associated ( P &lt; 0.05) with the risk of relapse of disease. Individuals with G\/A or A\/A genotypes had poorer survival (log-rank test, P = &lt; 0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These data suggest a role of the polymorphism G80A in the risk of relapse and the mortality risk in patients with acute lymphoblastic leukemia from the State of Guerrero, Mexico.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2310\/jim.0b013e31826803c1","type":"journal-article","created":{"date-parts":[[2016,5,11]],"date-time":"2016-05-11T09:10:57Z","timestamp":1462957857000},"page":"1064-1067","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Polymorphism G80A in the Reduced Folate Carrier Gene and its Relationship to Survival and Risk of Relapse in Acute Lymphoblastic Leukemia"],"prefix":"10.1177","volume":"60","author":[{"given":"Marco Antonio","family":"Leyva-V\u00e1zquez","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Biomedicine, School of Biological Sciences, Guerrero State University, Chilpancingo, Guerrero"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Organista-Nava","sequence":"additional","affiliation":[{"name":"Institute of Cellular Physiology, National Autonomous University of Mexico (UNAM), University City, DF"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yazm\u00edn","family":"G\u00f3mez-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Institute of Cellular Physiology, National Autonomous University of Mexico (UNAM), University City, DF"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Contreras-Quiroz","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biomedicine, School of Biological Sciences, Guerrero State University, Chilpancingo, Guerrero"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugenia","family":"Flores-Alfaro","sequence":"additional","affiliation":[{"name":"Laboratory of Chronic Degenerative Diseases and Infections, School of Biological Sciences, Guerrero State University, Chilpancingo, Guerrero, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berenice","family":"Illades-Aguiar","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biomedicine, School of Biological Sciences, Guerrero State University, Chilpancingo, Guerrero"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,10,1]]},"reference":[{"key":"bibr1-JIM.0b013e31826803c1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-5-33"},{"key":"bibr2-JIM.0b013e31826803c1","unstructured":"Salud\/INEGI, S.d., Fuente: base de datos de defunciones INEGI\/Secretaria de Salud, Direcci\u00f3n General de Informaci\u00f3n en Salud, M\u00e9xico. Febrary, 2006. Available at: http:\/\/www.inegi.org.mx\/. Accessed April 29, 2008."},{"key":"bibr3-JIM.0b013e31826803c1","first-page":"11","volume":"26","author":"Sierra EE","year":"1999","journal-title":"Semin Oncol"},{"key":"bibr4-JIM.0b013e31826803c1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V100.10.3832"},{"key":"bibr5-JIM.0b013e31826803c1","unstructured":"Seguro-popular: Secretaria de Salud\/ Seguro Popular. August 03, 2007. Available at: http:\/\/seguropopular.col.gob.mx:81\/repss\/protocolos\/6LLAEH.pdf. Accessed May 4, 2009."},{"key":"bibr6-JIM.0b013e31826803c1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2012.447"},{"key":"bibr7-JIM.0b013e31826803c1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20460"},{"key":"bibr8-JIM.0b013e31826803c1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2009.11.027"},{"key":"bibr9-JIM.0b013e31826803c1","unstructured":"INMEGEN. Mapa gen\u00e9tico de los mexicanos. May, 2009 Available at: http:\/\/www.inmegen.gob.mx\/. Accessed June 18, 2009."},{"key":"bibr10-JIM.0b013e31826803c1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0903045106"},{"key":"bibr11-JIM.0b013e31826803c1","doi-asserted-by":"publisher","DOI":"10.1016\/S1096-7192(03)00086-6"},{"key":"bibr12-JIM.0b013e31826803c1","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200309000-00004"},{"key":"bibr13-JIM.0b013e31826803c1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.46.30189"}],"container-title":["Journal of Investigative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2310\/JIM.0b013e31826803c1","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.2310\/JIM.0b013e31826803c1","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2310\/JIM.0b013e31826803c1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:39:31Z","timestamp":1777459171000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.2310\/JIM.0b013e31826803c1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":13,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["10.2310\/JIM.0b013e31826803c1"],"URL":"https:\/\/doi.org\/10.2310\/jim.0b013e31826803c1","relation":{},"ISSN":["1081-5589","1708-8267"],"issn-type":[{"value":"1081-5589","type":"print"},{"value":"1708-8267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10]]}}}