{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T05:46:11Z","timestamp":1792820771486,"version":"4.5.0"},"reference-count":27,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We observed the function of hypothalamic-pituitary-thyroid axis in patients with Alzheimer disease (AD) using a case-control study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The case was a cohort that included 50 patients with AD. For each case subject, 1 control who was of similar age, sex, daily activities (scale of Lawton), sleep quality (Pittsburgh Sleep Quality Index), and depression (15-item Geriatrics Depression Scale) was recruited. Thyrotropin-releasing hormone (TRH), thyroid-stimulating hormone (TSH), total triiodothyronine (TT3), total tetraiodothyronine (TT4), free triiodothyronine (FT3), and free tetraiodothyronine (FT4) were detected using radioimmunity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with the healthy controls, the patients with AD had significantly lower levels of TRH (67.72 \u00b1 18.44 vs 78.64 \u00b1 14.31 pmol\/L; t = 2.078; P = 0.036), TSH (3.89 \u00b1 1.22 vs 4.31 \u00b1 1.07 mIU\/L; t = 2.331; P = 0.024), TT3 (1.44 \u00b1 0.21 vs 1.63 \u00b1 0.19 nmol\/L; t = 3.761; P = 0.018), TT4 (119.71 \u00b1 18.64 nmol\/L vs 129.54 \u00b1 23.17 nmol\/L; t = 1.328; P = 0.044), FT3 (4.01 \u00b1 1.27 vs 5.41 \u00b1 0.99 pmol\/L; t = 4.976; P = 0.008), and FT4 (9.84 \u00b1 1.56 vs 12.96 \u00b1 2.20 pmol\/L; t = 5.381; P = 0.006). In the AD cases, none of the correlations between TRH and TSH, TT3, TT4, FT3, and FT4, and between TSH and TT3, TT4, FT3, FT4 was significant. However, in the healthy controls, TRH was significantly correlated with TSH ( R = 0.020; P = 0.042) and FT4 ( R = 0.015; P = 0.018), and TSH was significantly correlated with TT4 ( R = 0.209; P = 0.017) and FT4 ( R = 0.215; P = 0.009).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Alzheimer disease was associated with abnormal function of the hypothalamic-pituitary-thyroid axis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2310\/jim.0b013e318280aafb","type":"journal-article","created":{"date-parts":[[2016,5,11]],"date-time":"2016-05-11T09:10:57Z","timestamp":1462957857000},"page":"578-581","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":33,"title":["Hypothalamic-Pituitary-Thyroid Axis in Patients with Alzheimer Disease (AD)"],"prefix":"10.1177","volume":"61","author":[{"given":"Li","family":"Yong-Hong","sequence":"first","affiliation":[{"name":"Key Laboratory of Biological Effect of Physical Field and Instrument of Sichuan Provincial Department of Education; Department of Electronic Engineering, Chengdu University of Information Technology, Chengdu, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Xiao-Dong","sequence":"additional","affiliation":[{"name":"Department of Oncology, The Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huang","family":"Chang-Quan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biological Effect of Physical Field and Instrument of Sichuan Provincial Department of Education; Department of Electronic Engineering, Chengdu University of Information Technology, Chengdu, Sichuan, China"},{"name":"Department of Geriatrics, The Third Hospital of Mianyang, Sichuan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Bo","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biological Effect of Physical Field and Instrument of Sichuan Provincial Department of Education; Department of Electronic Engineering, Chengdu University of Information Technology, Chengdu, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Qing-Xiu","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, The Third Hospital of Mianyang, Sichuan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,3,1]]},"reference":[{"key":"bibr1-JIM.0b013e318280aafb","doi-asserted-by":"publisher","DOI":"10.1097\/01.wad.0000213866.86934.7e"},{"key":"bibr2-JIM.0b013e318280aafb","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2006.163.12.2164"},{"key":"bibr3-JIM.0b013e318280aafb","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.20.2651"},{"key":"bibr4-JIM.0b013e318280aafb","doi-asserted-by":"publisher","DOI":"10.1097\/00002093-200607000-00003"},{"key":"bibr5-JIM.0b013e318280aafb","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)92692-1"},{"key":"bibr6-JIM.0b013e318280aafb","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1980.03300490052031"},{"key":"bibr7-JIM.0b013e318280aafb","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.9.1143"},{"key":"bibr8-JIM.0b013e318280aafb","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2003.08.002"},{"key":"bibr9-JIM.0b013e318280aafb","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2005.01.010"},{"key":"bibr10-JIM.0b013e318280aafb","first-page":"60","volume":"32","author":"Luboshitzky R","year":"1996","journal-title":"Isr J Med Sci"},{"key":"bibr11-JIM.0b013e318280aafb","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1999.tb01593.x"},{"key":"bibr12-JIM.0b013e318280aafb","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000128134.84230.9F"},{"key":"bibr13-JIM.0b013e318280aafb","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(95)00489-0"},{"key":"bibr14-JIM.0b013e318280aafb","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2000.01146.x"},{"issue":"2","key":"bibr15-JIM.0b013e318280aafb","first-page":"249","volume":"25","author":"Mazzoccoli G","year":"2011","journal-title":"J Biol Regul Homeost Agents"},{"key":"bibr16-JIM.0b013e318280aafb","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.7.1055"},{"key":"bibr17-JIM.0b013e318280aafb","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030317"},{"key":"bibr18-JIM.0b013e318280aafb","doi-asserted-by":"publisher","DOI":"10.1159\/000087001"},{"key":"bibr19-JIM.0b013e318280aafb","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-870427"},{"issue":"4","key":"bibr20-JIM.0b013e318280aafb","first-page":"531","volume":"101","author":"Lazarus JH","year":"2011","journal-title":"J Thyroid Res"},{"key":"bibr21-JIM.0b013e318280aafb","doi-asserted-by":"publisher","DOI":"10.3329\/jhpn.v29i4.8458"},{"key":"bibr22-JIM.0b013e318280aafb","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.11.6448"},{"key":"bibr23-JIM.0b013e318280aafb","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1834302100"},{"key":"bibr24-JIM.0b013e318280aafb","doi-asserted-by":"publisher","DOI":"10.1038\/nm1234"},{"key":"bibr25-JIM.0b013e318280aafb","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2357-10.2010"},{"key":"bibr26-JIM.0b013e318280aafb","doi-asserted-by":"publisher","DOI":"10.1038\/nn842"},{"key":"bibr27-JIM.0b013e318280aafb","doi-asserted-by":"publisher","DOI":"10.1038\/nm1782"}],"container-title":["Journal of Investigative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2310\/JIM.0b013e318280aafb","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.2310\/JIM.0b013e318280aafb","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2310\/JIM.0b013e318280aafb","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:39:42Z","timestamp":1777459182000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.2310\/JIM.0b013e318280aafb"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.2310\/JIM.0b013e318280aafb"],"URL":"https:\/\/doi.org\/10.2310\/jim.0b013e318280aafb","relation":{},"ISSN":["1081-5589","1708-8267"],"issn-type":[{"value":"1081-5589","type":"print"},{"value":"1708-8267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3]]}}}