{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:02:54Z","timestamp":1792724574970,"version":"4.5.0"},"reference-count":23,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Several cardiac biomarkers, especially brain natriuretic peptide (BNP) and N-terminal (NT)-proBNP, have been used as predictors of prognosis and negative remodeling in DCM. In the present study, we aimed to evaluate the prognostic value of tenascin-C in dilated cardiomyopathy (DCM) and whether it can be used to determine reverse remodeling in patients with DCM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sixty-six patients with DCM were followed up for 12 months after initiation of medical treatment including carvedilol, ramipril (candesartan if ramipril was not tolerated), spironolactone, and furosemide. Tenascin-C and NT-proBNP measurements and transthoracic echocardiography were performed at baseline and at 12 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At 12 months, a significant improvement in New York Heart Association class (2.57 \u00b1 0.6 vs. 1.87 \u00b1 0.5; P &lt; 0.0001), left ventricular end-diastolic volume (217 \u00b1 47 vs 203 \u00b1 48; P &lt; 0.0001), left ventricular ejection fraction (29.1 \u00b1 5.5 vs 30.9 \u00b1 3.8; P &lt; 0.0001), NT-proBNP (2019 \u00b1 558 vs 1462 \u00b1 805; P &lt; 0.0001), and tenascin-C (76 \u00b1 19 vs 48 \u00b1 28; P &lt; 0.0001) values were observed, compared with baseline. Importantly, decrease in tenascin-C values were correlated with increase in left ventricular ejection fraction. Tenascin-C (odds ratio [OR], 1.896; &lt;95% confidence interval [CI], 1.543\u20132.670; P = 0.02), diabetes mellitus (OR, 2.456; G95% CI, 1.987\u20133.234; P = 0.01) and hypertension (OR: 2.106, &lt;95% CI, 1.876\u20132.897; P = 0.03) were independent predictors of mortality in patients with DCM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Reverse ventricular remodeling obtained with carvedilol, ramipril\/candesartan, and spironolacton is associated with decreases in left ventricular end-diastolic volume, left ventricular end-systolic volume, tenascin-C levels, and NT-proBNP levels. Consequently, tenascin-C may be used to evaluate reverse remodeling in patients with DCM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2310\/jim.0b013e3182880c11","type":"journal-article","created":{"date-parts":[[2016,5,11]],"date-time":"2016-05-11T09:10:57Z","timestamp":1462957857000},"page":"728-732","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Tenascin-C as Predictor of Left Ventricular Remodeling and Mortality in Patients with Dilated Cardiomyopathy"],"prefix":"10.1177","volume":"61","author":[{"given":"Bahadir","family":"Sarli","sequence":"first","affiliation":[{"name":"Departments of Cardiology, Erciyes University School of Medicine, Kayseri, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramazan","family":"Topsakal","sequence":"additional","affiliation":[{"name":"Departments of Cardiology, Erciyes University School of Medicine, Kayseri, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esma G.","family":"Kaya","sequence":"additional","affiliation":[{"name":"Departments of Microbiology, Erciyes University School of Medicine, Kayseri, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmut","family":"Akpek","sequence":"additional","affiliation":[{"name":"Departments of Cardiology, Erciyes University School of Medicine, Kayseri, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yat Yin","family":"Lam","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet G.","family":"Kaya","sequence":"additional","affiliation":[{"name":"Departments of Cardiology, Erciyes University School of Medicine, Kayseri, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,4,1]]},"reference":[{"key":"bibr1-JIM.0b013e3182880c11","doi-asserted-by":"publisher","DOI":"10.1253\/circj.71.327"},{"key":"bibr2-JIM.0b013e3182880c11","volume-title":"2001 Heart and Stroke Statistical Update","author":"American Heart Association","year":"2000"},{"key":"bibr3-JIM.0b013e3182880c11","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.01.023"},{"key":"bibr4-JIM.0b013e3182880c11","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2002.120293"},{"key":"bibr5-JIM.0b013e3182880c11","doi-asserted-by":"publisher","DOI":"10.1097\/MCA.0b013e32831624be"},{"key":"bibr6-JIM.0b013e3182880c11","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2012.02.004"},{"issue":"4","key":"bibr7-JIM.0b013e3182880c11","first-page":"500","volume":"39","author":"Kaya MG","year":"2012","journal-title":"Tex Heart Inst 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