{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T20:53:12Z","timestamp":1760820792903,"version":"3.38.0"},"reference-count":20,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p> Physical exercise intervention is known to be crucial in the management of type 2 diabetes mellitus (T2DM). We aimed to evaluate, in patients with T2DM, the effect of regular moderate walking exercise on markers of oxidative stress, lipid metabolism, and inflammation. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> We studied 30 patients with T2DM who walked regularly during the last year and 53 patients with T2DM who did not perform any type of exercise. The patients were evaluated for chemerin, adiponectin, leptin, oxidized low-density lipoprotein, and C-reactive protein (CRP) levels. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> The active T2DM patients showed significantly lower body mass index, as compared with the inactive patients. The active T2DM patients showed significantly lower levels of chemerin and CRP than those of the inactive T2DM patients (CRP lost significance after adjustment for body mass index). The active patients, compared with the inactive, presented a trend toward higher levels of adiponectin and lower values of oxidized low-density lipoprotein. Leptin differed significantly between sexes, and the active women presented a trend toward lower levels as compared with the inactive women. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> In the patients with T2DM, the practice of moderate walking in a regular basis was sufficient to reduce chemerin levels, which suggests that practice of regular physical exercise should be encouraged. <\/jats:p><\/jats:sec>","DOI":"10.2310\/jim.0000000000000025","type":"journal-article","created":{"date-parts":[[2016,5,11]],"date-time":"2016-05-11T13:10:57Z","timestamp":1462972257000},"page":"350-353","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["The Positive Effect of Moderate Walking Exercise on Chemerin Levels in Portuguese Patients with Type 2 Diabetes Mellitus"],"prefix":"10.1177","volume":"62","author":[{"given":"Maria Jo\u00e3o","family":"Neuparth","sequence":"first","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Actividade F\u00edsica, Sa\u00fade e Lazer (CIAFEL), Universidade do Porto, Porto, Portugal"},{"name":"CESPU, Instituto de Investiga\u00e7\u00e3o e Forma\u00e7\u00e3o Avan\u00e7ada em Ci\u00eancias e Tecnologias da Sa\u00fade, Gandra-PRD, Portugal"}]},{"given":"Jorge Brand\u00e3o","family":"Proen\u00e7a","sequence":"additional","affiliation":[{"name":"CESPU, Instituto de Investiga\u00e7\u00e3o e Forma\u00e7\u00e3o Avan\u00e7ada em Ci\u00eancias e Tecnologias da Sa\u00fade, Gandra-PRD, Portugal"}]},{"given":"Alice","family":"Santos-Silva","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Bioqu\u00edmica, Departamento de Ci\u00eancias Biol\u00f3gicas, Faculdade de Farm\u00e1cia (FFUP)"},{"name":"Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto, Portugal."}]},{"given":"Susana","family":"Coimbra","sequence":"additional","affiliation":[{"name":"CESPU, Instituto de Investiga\u00e7\u00e3o e Forma\u00e7\u00e3o Avan\u00e7ada em Ci\u00eancias e Tecnologias da Sa\u00fade, Gandra-PRD, Portugal"},{"name":"Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto, Portugal."}]}],"member":"179","published-online":{"date-parts":[[2023,1,10]]},"reference":[{"key":"bibr1-JIM.0000000000000025","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665109990218"},{"key":"bibr2-JIM.0000000000000025","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2006.00610.x"},{"issue":"5","key":"bibr3-JIM.0000000000000025","volume":"14","author":"Enriori PJ","year":"2006","journal-title":"Obesity (Silver Spring)"},{"key":"bibr4-JIM.0000000000000025","doi-asserted-by":"publisher","DOI":"10.1385\/ENDO:29:1:81"},{"key":"bibr5-JIM.0000000000000025","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-011-0278-9"},{"key":"bibr6-JIM.0000000000000025","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-0175"},{"key":"bibr7-JIM.0000000000000025","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M700793200"},{"key":"bibr8-JIM.0000000000000025","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2011.10.008"},{"key":"bibr9-JIM.0000000000000025","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-1098"},{"journal-title":"Endocrine","year":"2013","author":"Stefanov T","key":"bibr10-JIM.0000000000000025"},{"key":"bibr11-JIM.0000000000000025","doi-asserted-by":"publisher","DOI":"10.5812\/asjsm.34860"},{"key":"bibr12-JIM.0000000000000025","doi-asserted-by":"publisher","DOI":"10.3109\/07853890.2012.727020"},{"key":"bibr13-JIM.0000000000000025","doi-asserted-by":"publisher","DOI":"10.2337\/db09-0277"},{"key":"bibr14-JIM.0000000000000025","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-09-0380"},{"journal-title":"Clin Endocrinol (Oxf)","year":"2013","author":"Kim SH","key":"bibr15-JIM.0000000000000025"},{"key":"bibr16-JIM.0000000000000025","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2011.04.009"},{"key":"bibr17-JIM.0000000000000025","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.20.6.1595"},{"key":"bibr18-JIM.0000000000000025","first-page":"210","volume":"30","author":"Bahceci M","year":"2007","journal-title":"Is adipocyte size associated with inflammation in adults? 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