{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T14:47:44Z","timestamp":1792248464524,"version":"4.4.0"},"reference-count":62,"publisher":"The Angle Orthodontist (EH Angle Education & Research Foundation)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,11]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objective:<\/jats:title>\n To evaluate the relationship between genetic polymorphism and external apical root resorption.<\/jats:p>\n <\/jats:sec>\n \n Methodology:<\/jats:title>\n The protocol was prepared and registered on PROSPERO. Two reviewers independently conducted a comprehensive literature search. The MEDLINE, Embase, Cochrane, and PubMed databases were searched. In addition, the bibliographies of all relevant articles and textbooks were manually searched.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n Thirteen studies met the inclusion criteria. Four studies were classified as low-quality studies (score <10), and nine studies were classified as high-quality studies.<\/jats:p>\n <\/jats:sec>\n \n Discussion:<\/jats:title>\n The results of the present review suggest that, although some authors have reported that genetic polymorphism may play a role in external apical root resorption, others have not supported this association. Future studies should be more consistent in their research methodologies to determine with clarity whether an association exists.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Future investigations should include larger sample sizes with matching cases\/controls, adjust for confounders, provide power calculation and odds ratios, and report genetic analyses with the Hardy-Weinberg equilibrium. The current investigation suggests guidelines and recommendations for future investigators studying genetic polymorphism in patients undergoing orthodontic treatment.<\/jats:p>\n <\/jats:sec>","DOI":"10.2319\/011916-50.1","type":"journal-article","created":{"date-parts":[[2016,5,5]],"date-time":"2016-05-05T10:12:45Z","timestamp":1462443165000},"page":"1042-1049","source":"Crossref","is-referenced-by-count":14,"title":["Association of genetic polymorphism and external apical root resorption"],"prefix":"10.2319","volume":"86","author":[{"given":"Amir","family":"Aminoshariae","sequence":"first","affiliation":[{"name":"Resident, Department of Orthodontics, Case Western Reserve University, School of Dental Medicine, Cleveland, Ohio."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Aminoshariae","sequence":"additional","affiliation":[{"name":"Associate Professor, Department of Endodontics, Case Western Reserve University, School of Dental Medicine, Cleveland, Ohio."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish","family":"Valiathan","sequence":"additional","affiliation":[{"name":"Associate Professor, Department of Orthodontics, Case Western Reserve University, School of Dental Medicine, Cleveland, Ohio."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.","family":"Kulild","sequence":"additional","affiliation":[{"name":"Professor Emeritus, Department of Endodontics, University of Missouri-Kansas City, School of Dentistry, Kansas City, Mo."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1164","reference":[{"key":"i0003-3219-86-6-1042-b01","series-title":"Am J Orthod Dentofacial Orthop","first-page":"610","article-title":"Association of orthodontic force system and root resorption: a systematic review","volume":"147","author":"Roscoe \n MG,","year":"2015","unstructured":"Roscoe \n MG, \n \n \n Meira \n JB, \n \n \n Cattaneo \n PM. \n \n \n Association of orthodontic force system and root resorption: a systematic review. Am J Orthod Dentofacial Orthop. 2015;147:610\u2013626."},{"key":"i0003-3219-86-6-1042-b02","series-title":"Am J Orthod Dentofacial Orthop","first-page":"301","article-title":"A heritable component for external apical root resorption in patients treated orthodontically","volume":"111","author":"Harris \n EF,","year":"1997","unstructured":"Harris \n EF, \n \n \n Kineret \n SE, \n \n \n Tolley \n EA. \n \n \n A heritable component for external apical root resorption in patients treated orthodontically. Am J Orthod Dentofacial Orthop. 1997;111:301\u2013309."},{"key":"i0003-3219-86-6-1042-b03","series-title":"Aust Orthod J","first-page":"1","article-title":"The genetic contribution to orthodontic root resorption: a retrospective twin study","volume":"20","author":"Ngan \n DC.","year":"2003","unstructured":"Ngan \n DC. \n \n \n The genetic contribution to orthodontic root resorption: a retrospective twin study. Aust Orthod J. 2003;20:1\u20139."},{"key":"i0003-3219-86-6-1042-b04","series-title":"Histol Histopathol","first-page":"767","article-title":"Interleukin 1 receptor antagonist (IL1RN) genetic variations condition post-orthodontic external root resorption in endodontically-treated teeth","volume":"28","author":"Iglesias-Linares \n A,","year":"2013","unstructured":"Iglesias-Linares \n A, \n \n \n Ya\u00f1ez-Vico \n RM, \n \n \n Ballesta-Mudarra \n S, \n \n et al. \n Interleukin 1 receptor antagonist (IL1RN) genetic variations condition post-orthodontic external root resorption in endodontically-treated teeth. Histol Histopathol. 2013;28:767\u2013773."},{"key":"i0003-3219-86-6-1042-b05","series-title":"J Dent Res","first-page":"356","article-title":"Genetic predisposition to external apical root resorption in orthodontic patients: linkage of chromosome-18 marker","volume":"82","author":"Al-Qawasmi \n RA,","year":"2003","unstructured":"Al-Qawasmi \n RA, \n \n \n Hartsfield \n JJ, \n \n \n Everett \n E, \n \n et al. \n Genetic predisposition to external apical root resorption in orthodontic patients: linkage of chromosome-18 marker. J Dent Res. 2003;82:356\u2013360."},{"key":"i0003-3219-86-6-1042-b06","series-title":"Am J Orthod Dentofacial Orthop","first-page":"542","article-title":"Association of functional gene polymorphism IL-1\u03b2 in patients with external apical root resorption","volume":"136","author":"Lages \n EMB,","year":"2009","unstructured":"Lages \n EMB, \n \n \n Drummond \n AF, \n \n \n Pretti \n H, \n \n et al. \n Association of functional gene polymorphism IL-1\u03b2 in patients with external apical root resorption. Am J Orthod Dentofacial Orthop. 2009;136:542\u2013546."},{"key":"i0003-3219-86-6-1042-b07","series-title":"Oral Dis","first-page":"659","article-title":"Polymorphisms of genes encoding P2X7R, IL-1B, OPG and RANK in orthodontic-induced apical root resorption","volume":"20","author":"Pereira \n S,","year":"2014","unstructured":"Pereira \n S, \n \n \n Lavado \n N, \n \n \n Nogueira \n L, \n \n et al. \n Polymorphisms of genes encoding P2X7R, IL-1B, OPG and RANK in orthodontic-induced apical root resorption. Oral Dis. 2014;20:659\u2013667."},{"key":"i0003-3219-86-6-1042-b08","series-title":"Oral Dis","first-page":"307","article-title":"Osteopontin gene SNPs (rs9138, rs11730582) mediate susceptibility to external root resorption in orthodontic patients","volume":"20","author":"Iglesias-Linares \n A,","year":"2014","unstructured":"Iglesias-Linares \n A, \n \n \n Ya\u00f1ez-Vico \n R, \n \n \n Moreno-Fern\u00e1ndez \n A, \n \n et al. \n Osteopontin gene SNPs (rs9138, rs11730582) mediate susceptibility to external root resorption in orthodontic patients. Oral Dis. 2014;20:307\u2013312."},{"key":"i0003-3219-86-6-1042-b09","series-title":"Orthod Craniofac Res","first-page":"71","article-title":"Genetic and treatment-related risk factors associated with external apical root resorption (EARR) concurrent with orthodontia","volume":"18","author":"Sharab \n L,","year":"2015","unstructured":"Sharab \n L, \n \n \n Morford \n L, \n \n \n Dempsey \n J, \n \n et al. \n Genetic and treatment-related risk factors associated with external apical root resorption (EARR) concurrent with orthodontia. Orthod Craniofac Res. 2015;18:71\u201382."},{"key":"i0003-3219-86-6-1042-b10","series-title":"Genet Mol Res","first-page":"4678","article-title":"Interleukin-1beta+ 3954 polymorphisms and risk of external apical root resorption in orthodontic treatment: a meta-analysis","volume":"12","author":"Wu \n F,","year":"2013","unstructured":"Wu \n F, \n \n \n Wang \n L, \n \n \n Huang \n Y, \n \n et al. \n Interleukin-1beta+ 3954 polymorphisms and risk of external apical root resorption in orthodontic treatment: a meta-analysis. Genet Mol Res. 2013;12:4678\u20134686."},{"key":"i0003-3219-86-6-1042-b11","series-title":"Ann Intern Med","first-page":"264","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"151","author":"Moher \n D,","year":"2009","unstructured":"Moher \n D, \n \n \n Liberati \n A, \n \n \n Tetzlaff \n J, \n \n \n Altman \n DG. \n \n \n Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med. 2009;151:264\u2013269."},{"key":"i0003-3219-86-6-1042-b12","series-title":"BMC Med Res Methodol","first-page":"10","article-title":"Development of AMSTAR: a measurement tool to assess the methodological quality of systematic reviews","volume":"7","author":"Shea \n BJ,","year":"2007","unstructured":"Shea \n BJ, \n \n \n Grimshaw \n JM, \n \n \n Wells \n GA, \n \n et al. \n Development of AMSTAR: a measurement tool to assess the methodological quality of systematic reviews. BMC Med Res Methodol. 2007;7:10."},{"key":"i0003-3219-86-6-1042-b13","series-title":"Community Dent Oral Epidemiol","first-page":"193","article-title":"An appraisal of the quality of published qualitative dental research","volume":"39","author":"Masood \n M,","year":"2011","unstructured":"Masood \n M, \n \n \n Thaliath \n ET, \n \n \n Bower \n EJ, \n \n \n Newton \n JT. \n \n \n An appraisal of the quality of published qualitative dental research. Community Dent Oral Epidemiol. 2011;39:193\u2013203."},{"issue":"7650","key":"i0003-3219-86-6-1042-b14","series-title":"BMJ","first-page":"924","article-title":"GRADE: an emerging consensus on rating quality of evidence and strength of recommendations","volume":"336","author":"Guyatt \n GH,","year":"2008","unstructured":"Guyatt \n GH, \n \n \n Oxman \n AD, \n \n \n Vist \n GE, \n \n et al. \n GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ. 2008;336(7650):924\u2013926."},{"key":"i0003-3219-86-6-1042-b15","series-title":"Eur J Clin Invest","first-page":"247","article-title":"STrengthening the REporting of Genetic Association studies (STREGA)\u2013an extension of the STROBE statement","volume":"39","author":"Little \n J,","year":"2009","unstructured":"Little \n J, \n \n \n Higgins \n J, \n \n \n Ioannidis \n J, \n \n et al. \n STrengthening the REporting of Genetic Association studies (STREGA)\u2013an extension of the STROBE statement. Eur J Clin Invest. 2009;39:247\u2013266."},{"key":"i0003-3219-86-6-1042-b16","series-title":"J Clin Epidemiol","first-page":"597","article-title":"Strengthening the reporting of genetic association studies (STREGA)\u2014an extension of the strengthening the reporting of observational studies in epidemiology (STROBE) statement","volume":"62","author":"Little \n J,","year":"2009","unstructured":"Little \n J, \n \n \n Higgins \n JP, \n \n \n Ioannidis \n JP, \n \n et al. \n Strengthening the reporting of genetic association studies (STREGA)\u2014an extension of the strengthening the reporting of observational studies in epidemiology (STROBE) statement. J Clin Epidemiol. 2009;62:597\u2013608, e594."},{"key":"i0003-3219-86-6-1042-b17","series-title":"J Clin Periodontol","first-page":"753","article-title":"Suggested guidelines for systematic reviews of periodontal genetic association studies","volume":"40","author":"Nibali \n L.","year":"2013","unstructured":"Nibali \n L. \n \n \n Suggested guidelines for systematic reviews of periodontal genetic association studies. J Clin Periodontol. 2013;40:753\u2013756."},{"key":"i0003-3219-86-6-1042-b18","series-title":"J Clin Periodontol","first-page":"1095","article-title":"Matrix metalloproteinase-1 promoter-1607 1G\/2G polymorphism and chronic periodontitis susceptibility: a meta-analysis and systematic review","volume":"40","author":"Li \n W,","year":"2013","unstructured":"Li \n W, \n \n \n Xiao \n L, \n \n \n Hu \n J. \n \n \n Matrix metalloproteinase-1 promoter-1607 1G\/2G polymorphism and chronic periodontitis susceptibility: a meta-analysis and systematic review. J Clin Periodontol. 2013;40:1095\u20131103."},{"key":"i0003-3219-86-6-1042-b19","series-title":"J Endod","first-page":"999","article-title":"Association of functional gene polymorphism with apical periodontitis","volume":"41","author":"Aminoshariae \n A,","year":"2015","unstructured":"Aminoshariae \n A, \n \n \n Kulild \n JC. \n \n \n Association of functional gene polymorphism with apical periodontitis. J Endod. 2015:41:999\u20131007."},{"key":"i0003-3219-86-6-1042-b20","series-title":"J Endod","first-page":"283","article-title":"Postorthodontic external root resorption in root-filled teeth is influenced by interleukin-1\u03b2 polymorphism","volume":"38","author":"Iglesias-Linares \n A,","year":"2012","unstructured":"Iglesias-Linares \n A, \n \n \n Ya\u00f1ez-Vico \n R-M, \n \n \n Ortiz-Ariza \n E, \n \n et al. \n Postorthodontic external root resorption in root-filled teeth is influenced by interleukin-1\u03b2 polymorphism. J Endod. 2012;38:283\u2013287."},{"key":"i0003-3219-86-6-1042-b21","series-title":"Am J Orthod Dentofacial Orthop","first-page":"339","article-title":"Association analysis of clinical aspects and vitamin D receptor gene polymorphism with external apical root resorption in orthodontic patients","volume":"142","author":"Fontana \n MLSSN,","year":"2012","unstructured":"Fontana \n MLSSN, \n \n \n de Souza \n CM, \n \n \n Bernardino \n JF, \n \n et al. \n Association analysis of clinical aspects and vitamin D receptor gene polymorphism with external apical root resorption in orthodontic patients. Am J Orthod Dentofacial Orthop. 2012;142:339\u2013347."},{"key":"i0003-3219-86-6-1042-b22","series-title":"J Orofac Orthop","first-page":"20","article-title":"Interleukin-1 polymorphisms in relation to external apical root resorption (EARR)","volume":"70","author":"G\u00fclden \n N,","year":"2009","unstructured":"G\u00fclden \n N, \n \n \n Eggermann \n T, \n \n \n Zerres \n K, \n \n et al. \n Interleukin-1 polymorphisms in relation to external apical root resorption (EARR). J Orofac Orthop. 2009;70:20\u201338."},{"key":"i0003-3219-86-6-1042-b23","series-title":"Am J Orthod Dentofacial Orthop","first-page":"242","article-title":"Genetic predisposition to external apical root resorption","volume":"123","author":"Al-Qawasmi \n RA,","year":"2003","unstructured":"Al-Qawasmi \n RA, \n \n \n Hartsfield \n JK, \n \n \n Everett \n ET, \n \n et al. \n Genetic predisposition to external apical root resorption. Am J Orthod Dentofacial Orthop. 2003;123:242\u2013252."},{"issue":"11","key":"i0003-3219-86-6-1042-b24","series-title":"Int Endod J","first-page":"1018","article-title":"Interleukin 1 gene cluster SNPs (rs1800587, rs1143634) influences post-orthodontic root resorption in endodontic and their contralateral vital control teeth differently","volume":"45","author":"Iglesias-Linares \n A,","year":"2012","unstructured":"Iglesias-Linares \n A, \n \n \n Ya\u00f1ez-Vico \n RM, \n \n \n Ballesta \n S, \n \n et al. \n Interleukin 1 gene cluster SNPs (rs1800587, rs1143634) influences post-orthodontic root resorption in endodontic and their contralateral vital control teeth differently. Int Endod J. 2012;45(11):1018\u20131026."},{"key":"i0003-3219-86-6-1042-b25","series-title":"Oral Dis","first-page":"262","article-title":"Izakovicova Holla L. IL1 gene polymorphisms in relation to external apical root resorption concurrent with orthodontia","volume":"19","author":"Linhartova \n P,","year":"2013","unstructured":"Linhartova \n P, \n \n \n Cernochova \n P, \n \n \n Izakovicova Holla L. IL1 gene polymorphisms in relation to external apical root resorption concurrent with orthodontia. Oral Dis. 2013;19:262\u2013270."},{"key":"i0003-3219-86-6-1042-b26","series-title":"Oral Dis","first-page":"198","article-title":"Postorthodontic external root resorption is associated with IL1 receptor antagonist gene variations","volume":"18","author":"Iglesias-Linares \n A,","year":"2012","unstructured":"Iglesias-Linares \n A, \n \n \n Ya\u00f1ez-Vico \n R, \n \n \n Ballesta-Mudarra \n S, \n \n et al. \n Postorthodontic external root resorption is associated with IL1 receptor antagonist gene variations. Oral Dis. 2012;18:198\u2013205."},{"key":"i0003-3219-86-6-1042-b27","series-title":"Arch Oral Biol","first-page":"203","article-title":"Biological markers for evaluation of root resorption","volume":"52","author":"Balducci \n L,","year":"2007","unstructured":"Balducci \n L, \n \n \n Ramachandran \n A, \n \n \n Hao \n J, \n \n et al. \n Biological markers for evaluation of root resorption. Arch Oral Biol. 2007;52:203\u2013208."},{"issue":"5","key":"i0003-3219-86-6-1042-b28","series-title":"Eur J Orthod","first-page":"584","article-title":"Anti-dentine antibodies with root resorption during orthodontic treatment","volume":"33","author":"","year":"2011","unstructured":"de PaulaRamos \n S, \n \n \n Ortolan \n GO, \n \n \n Dos Santos \n LM, \n \n et al. Anti-dentine antibodies with root resorption during orthodontic treatment. Eur J Orthod. 2011;33(5):584\u2013591."},{"key":"i0003-3219-86-6-1042-b29","series-title":"Nature","first-page":"315","article-title":"OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis","volume":"397","author":"Kong \n Y-Y,","year":"1999","unstructured":"Kong \n Y-Y, \n \n \n Yoshida \n H, \n \n \n Sarosi \n I, \n \n et al. \n OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature. 1999;397:315\u2013323."},{"key":"i0003-3219-86-6-1042-b30","series-title":"Eur J Oral Sci","first-page":"346","article-title":"Expression and role of RANKL in periodontal ligament cells during physiological root-resorption in human deciduous teeth","volume":"111","author":"Fukushima \n H,","year":"2003","unstructured":"Fukushima \n H, \n \n \n Kajiya \n H, \n \n \n Takada \n K, \n \n \n Okamoto \n F, \n \n \n Okabe \n K. \n \n \n Expression and role of RANKL in periodontal ligament cells during physiological root-resorption in human deciduous teeth. Eur J Oral Sci. 2003;111:346\u2013352."},{"key":"i0003-3219-86-6-1042-b31","series-title":"Am J Orthod Dentofacial Orthop","first-page":"497","article-title":"Expression of mRNA for osteoprotegerin and receptor activator of nuclear factor kappa \u03b2 ligand (RANKL) during root resorption induced by the application of heavy orthodontic forces on rat molars","volume":"128","author":"Low \n E,","year":"2005","unstructured":"Low \n E, \n \n \n Zoellner \n H, \n \n \n Kharbanda \n OP, \n \n \n Darendeliler \n MA. \n \n \n Expression of mRNA for osteoprotegerin and receptor activator of nuclear factor kappa \u03b2 ligand (RANKL) during root resorption induced by the application of heavy orthodontic forces on rat molars. Am J Orthod Dentofacial Orthop. 2005;128:497\u2013503."},{"key":"i0003-3219-86-6-1042-b01","series-title":"Am J Orthod Dentofacial Orthop","first-page":"610","article-title":"Association of orthodontic force system and root resorption: a systematic review","volume":"147","author":"Roscoe \n MG,","year":"2015","unstructured":"Roscoe \n MG, \n \n \n Meira \n JB, \n \n \n Cattaneo \n PM. \n \n \n Association of orthodontic force system and root resorption: a systematic review. Am J Orthod Dentofacial Orthop. 2015;147:610\u2013626."},{"key":"i0003-3219-86-6-1042-b02","series-title":"Am J Orthod Dentofacial Orthop","first-page":"301","article-title":"A heritable component for external apical root resorption in patients treated orthodontically","volume":"111","author":"Harris \n EF,","year":"1997","unstructured":"Harris \n EF, \n \n \n Kineret \n SE, \n \n \n Tolley \n EA. \n \n \n A heritable component for external apical root resorption in patients treated orthodontically. Am J Orthod Dentofacial Orthop. 1997;111:301\u2013309."},{"key":"i0003-3219-86-6-1042-b03","series-title":"Aust Orthod J","first-page":"1","article-title":"The genetic contribution to orthodontic root resorption: a retrospective twin study","volume":"20","author":"Ngan \n DC.","year":"2003","unstructured":"Ngan \n DC. \n \n \n The genetic contribution to orthodontic root resorption: a retrospective twin study. Aust Orthod J. 2003;20:1\u20139."},{"key":"i0003-3219-86-6-1042-b04","series-title":"Histol Histopathol","first-page":"767","article-title":"Interleukin 1 receptor antagonist (IL1RN) genetic variations condition post-orthodontic external root resorption in endodontically-treated teeth","volume":"28","author":"Iglesias-Linares \n A,","year":"2013","unstructured":"Iglesias-Linares \n A, \n \n \n Ya\u00f1ez-Vico \n RM, \n \n \n Ballesta-Mudarra \n S, \n \n et al. \n Interleukin 1 receptor antagonist (IL1RN) genetic variations condition post-orthodontic external root resorption in endodontically-treated teeth. Histol Histopathol. 2013;28:767\u2013773."},{"key":"i0003-3219-86-6-1042-b05","series-title":"J Dent Res","first-page":"356","article-title":"Genetic predisposition to external apical root resorption in orthodontic patients: linkage of chromosome-18 marker","volume":"82","author":"Al-Qawasmi \n RA,","year":"2003","unstructured":"Al-Qawasmi \n RA, \n \n \n Hartsfield \n JJ, \n \n \n Everett \n E, \n \n et al. \n Genetic predisposition to external apical root resorption in orthodontic patients: linkage of chromosome-18 marker. J Dent Res. 2003;82:356\u2013360."},{"key":"i0003-3219-86-6-1042-b06","series-title":"Am J Orthod Dentofacial Orthop","first-page":"542","article-title":"Association of functional gene polymorphism IL-1\u03b2 in patients with external apical root resorption","volume":"136","author":"Lages \n EMB,","year":"2009","unstructured":"Lages \n EMB, \n \n \n Drummond \n AF, \n \n \n Pretti \n H, \n \n et al. \n Association of functional gene polymorphism IL-1\u03b2 in patients with external apical root resorption. Am J Orthod Dentofacial Orthop. 2009;136:542\u2013546."},{"key":"i0003-3219-86-6-1042-b07","series-title":"Oral Dis","first-page":"659","article-title":"Polymorphisms of genes encoding P2X7R, IL-1B, OPG and RANK in orthodontic-induced apical root resorption","volume":"20","author":"Pereira \n S,","year":"2014","unstructured":"Pereira \n S, \n \n \n Lavado \n N, \n \n \n Nogueira \n L, \n \n et al. \n Polymorphisms of genes encoding P2X7R, IL-1B, OPG and RANK in orthodontic-induced apical root resorption. Oral Dis. 2014;20:659\u2013667."},{"key":"i0003-3219-86-6-1042-b08","series-title":"Oral Dis","first-page":"307","article-title":"Osteopontin gene SNPs (rs9138, rs11730582) mediate susceptibility to external root resorption in orthodontic patients","volume":"20","author":"Iglesias-Linares \n A,","year":"2014","unstructured":"Iglesias-Linares \n A, \n \n \n Ya\u00f1ez-Vico \n R, \n \n \n Moreno-Fern\u00e1ndez \n A, \n \n et al. \n Osteopontin gene SNPs (rs9138, rs11730582) mediate susceptibility to external root resorption in orthodontic patients. Oral Dis. 2014;20:307\u2013312."},{"key":"i0003-3219-86-6-1042-b09","series-title":"Orthod Craniofac Res","first-page":"71","article-title":"Genetic and treatment-related risk factors associated with external apical root resorption (EARR) concurrent with orthodontia","volume":"18","author":"Sharab \n L,","year":"2015","unstructured":"Sharab \n L, \n \n \n Morford \n L, \n \n \n Dempsey \n J, \n \n et al. \n Genetic and treatment-related risk factors associated with external apical root resorption (EARR) concurrent with orthodontia. Orthod Craniofac Res. 2015;18:71\u201382."},{"key":"i0003-3219-86-6-1042-b10","series-title":"Genet Mol Res","first-page":"4678","article-title":"Interleukin-1beta+ 3954 polymorphisms and risk of external apical root resorption in orthodontic treatment: a meta-analysis","volume":"12","author":"Wu \n F,","year":"2013","unstructured":"Wu \n F, \n \n \n Wang \n L, \n \n \n Huang \n Y, \n \n et al. \n Interleukin-1beta+ 3954 polymorphisms and risk of external apical root resorption in orthodontic treatment: a meta-analysis. Genet Mol Res. 2013;12:4678\u20134686."},{"key":"i0003-3219-86-6-1042-b11","series-title":"Ann Intern Med","first-page":"264","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"151","author":"Moher \n D,","year":"2009","unstructured":"Moher \n D, \n \n \n Liberati \n A, \n \n \n Tetzlaff \n J, \n \n \n Altman \n DG. \n \n \n Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med. 2009;151:264\u2013269."},{"key":"i0003-3219-86-6-1042-b12","series-title":"BMC Med Res Methodol","first-page":"10","article-title":"Development of AMSTAR: a measurement tool to assess the methodological quality of systematic reviews","volume":"7","author":"Shea \n BJ,","year":"2007","unstructured":"Shea \n BJ, \n \n \n Grimshaw \n JM, \n \n \n Wells \n GA, \n \n et al. \n Development of AMSTAR: a measurement tool to assess the methodological quality of systematic reviews. BMC Med Res Methodol. 2007;7:10."},{"key":"i0003-3219-86-6-1042-b13","series-title":"Community Dent Oral Epidemiol","first-page":"193","article-title":"An appraisal of the quality of published qualitative dental research","volume":"39","author":"Masood \n M,","year":"2011","unstructured":"Masood \n M, \n \n \n Thaliath \n ET, \n \n \n Bower \n EJ, \n \n \n Newton \n JT. \n \n \n An appraisal of the quality of published qualitative dental research. Community Dent Oral Epidemiol. 2011;39:193\u2013203."},{"issue":"7650","key":"i0003-3219-86-6-1042-b14","series-title":"BMJ","first-page":"924","article-title":"GRADE: an emerging consensus on rating quality of evidence and strength of recommendations","volume":"336","author":"Guyatt \n GH,","year":"2008","unstructured":"Guyatt \n GH, \n \n \n Oxman \n AD, \n \n \n Vist \n GE, \n \n et al. \n GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ. 2008;336(7650):924\u2013926."},{"key":"i0003-3219-86-6-1042-b15","series-title":"Eur J Clin Invest","first-page":"247","article-title":"STrengthening the REporting of Genetic Association studies (STREGA)\u2013an extension of the STROBE statement","volume":"39","author":"Little \n J,","year":"2009","unstructured":"Little \n J, \n \n \n Higgins \n J, \n \n \n Ioannidis \n J, \n \n et al. \n STrengthening the REporting of Genetic Association studies (STREGA)\u2013an extension of the STROBE statement. Eur J Clin Invest. 2009;39:247\u2013266."},{"key":"i0003-3219-86-6-1042-b16","series-title":"J Clin Epidemiol","first-page":"597","article-title":"Strengthening the reporting of genetic association studies (STREGA)\u2014an extension of the strengthening the reporting of observational studies in epidemiology (STROBE) statement","volume":"62","author":"Little \n J,","year":"2009","unstructured":"Little \n J, \n \n \n Higgins \n JP, \n \n \n Ioannidis \n JP, \n \n et al. \n Strengthening the reporting of genetic association studies (STREGA)\u2014an extension of the strengthening the reporting of observational studies in epidemiology (STROBE) statement. J Clin Epidemiol. 2009;62:597\u2013608, e594."},{"key":"i0003-3219-86-6-1042-b17","series-title":"J Clin Periodontol","first-page":"753","article-title":"Suggested guidelines for systematic reviews of periodontal genetic association studies","volume":"40","author":"Nibali \n L.","year":"2013","unstructured":"Nibali \n L. \n \n \n Suggested guidelines for systematic reviews of periodontal genetic association studies. J Clin Periodontol. 2013;40:753\u2013756."},{"key":"i0003-3219-86-6-1042-b18","series-title":"J Clin Periodontol","first-page":"1095","article-title":"Matrix metalloproteinase-1 promoter-1607 1G\/2G polymorphism and chronic periodontitis susceptibility: a meta-analysis and systematic review","volume":"40","author":"Li \n W,","year":"2013","unstructured":"Li \n W, \n \n \n Xiao \n L, \n \n \n Hu \n J. \n \n \n Matrix metalloproteinase-1 promoter-1607 1G\/2G polymorphism and chronic periodontitis susceptibility: a meta-analysis and systematic review. J Clin Periodontol. 2013;40:1095\u20131103."},{"key":"i0003-3219-86-6-1042-b19","series-title":"J Endod","first-page":"999","article-title":"Association of functional gene polymorphism with apical periodontitis","volume":"41","author":"Aminoshariae \n A,","year":"2015","unstructured":"Aminoshariae \n A, \n \n \n Kulild \n JC. \n \n \n Association of functional gene polymorphism with apical periodontitis. J Endod. 2015:41:999\u20131007."},{"key":"i0003-3219-86-6-1042-b20","series-title":"J Endod","first-page":"283","article-title":"Postorthodontic external root resorption in root-filled teeth is influenced by interleukin-1\u03b2 polymorphism","volume":"38","author":"Iglesias-Linares \n A,","year":"2012","unstructured":"Iglesias-Linares \n A, \n \n \n Ya\u00f1ez-Vico \n R-M, \n \n \n Ortiz-Ariza \n E, \n \n et al. \n Postorthodontic external root resorption in root-filled teeth is influenced by interleukin-1\u03b2 polymorphism. J Endod. 2012;38:283\u2013287."},{"key":"i0003-3219-86-6-1042-b21","series-title":"Am J Orthod Dentofacial Orthop","first-page":"339","article-title":"Association analysis of clinical aspects and vitamin D receptor gene polymorphism with external apical root resorption in orthodontic patients","volume":"142","author":"Fontana \n MLSSN,","year":"2012","unstructured":"Fontana \n MLSSN, \n \n \n de Souza \n CM, \n \n \n Bernardino \n JF, \n \n et al. \n Association analysis of clinical aspects and vitamin D receptor gene polymorphism with external apical root resorption in orthodontic patients. Am J Orthod Dentofacial Orthop. 2012;142:339\u2013347."},{"key":"i0003-3219-86-6-1042-b22","series-title":"J Orofac Orthop","first-page":"20","article-title":"Interleukin-1 polymorphisms in relation to external apical root resorption (EARR)","volume":"70","author":"G\u00fclden \n N,","year":"2009","unstructured":"G\u00fclden \n N, \n \n \n Eggermann \n T, \n \n \n Zerres \n K, \n \n et al. \n Interleukin-1 polymorphisms in relation to external apical root resorption (EARR). J Orofac Orthop. 2009;70:20\u201338."},{"key":"i0003-3219-86-6-1042-b23","series-title":"Am J Orthod Dentofacial Orthop","first-page":"242","article-title":"Genetic predisposition to external apical root resorption","volume":"123","author":"Al-Qawasmi \n RA,","year":"2003","unstructured":"Al-Qawasmi \n RA, \n \n \n Hartsfield \n JK, \n \n \n Everett \n ET, \n \n et al. \n Genetic predisposition to external apical root resorption. Am J Orthod Dentofacial Orthop. 2003;123:242\u2013252."},{"issue":"11","key":"i0003-3219-86-6-1042-b24","series-title":"Int Endod J","first-page":"1018","article-title":"Interleukin 1 gene cluster SNPs (rs1800587, rs1143634) influences post-orthodontic root resorption in endodontic and their contralateral vital control teeth differently","volume":"45","author":"Iglesias-Linares \n A,","year":"2012","unstructured":"Iglesias-Linares \n A, \n \n \n Ya\u00f1ez-Vico \n RM, \n \n \n Ballesta \n S, \n \n et al. \n Interleukin 1 gene cluster SNPs (rs1800587, rs1143634) influences post-orthodontic root resorption in endodontic and their contralateral vital control teeth differently. Int Endod J. 2012;45(11):1018\u20131026."},{"key":"i0003-3219-86-6-1042-b25","series-title":"Oral Dis","first-page":"262","article-title":"Izakovicova Holla L. IL1 gene polymorphisms in relation to external apical root resorption concurrent with orthodontia","volume":"19","author":"Linhartova \n P,","year":"2013","unstructured":"Linhartova \n P, \n \n \n Cernochova \n P, \n \n \n Izakovicova Holla L. IL1 gene polymorphisms in relation to external apical root resorption concurrent with orthodontia. Oral Dis. 2013;19:262\u2013270."},{"key":"i0003-3219-86-6-1042-b26","series-title":"Oral Dis","first-page":"198","article-title":"Postorthodontic external root resorption is associated with IL1 receptor antagonist gene variations","volume":"18","author":"Iglesias-Linares \n A,","year":"2012","unstructured":"Iglesias-Linares \n A, \n \n \n Ya\u00f1ez-Vico \n R, \n \n \n Ballesta-Mudarra \n S, \n \n et al. \n Postorthodontic external root resorption is associated with IL1 receptor antagonist gene variations. Oral Dis. 2012;18:198\u2013205."},{"key":"i0003-3219-86-6-1042-b27","series-title":"Arch Oral Biol","first-page":"203","article-title":"Biological markers for evaluation of root resorption","volume":"52","author":"Balducci \n L,","year":"2007","unstructured":"Balducci \n L, \n \n \n Ramachandran \n A, \n \n \n Hao \n J, \n \n et al. \n Biological markers for evaluation of root resorption. Arch Oral Biol. 2007;52:203\u2013208."},{"issue":"5","key":"i0003-3219-86-6-1042-b28","series-title":"Eur J Orthod","first-page":"584","article-title":"Anti-dentine antibodies with root resorption during orthodontic treatment","volume":"33","author":"","year":"2011","unstructured":"de PaulaRamos \n S, \n \n \n Ortolan \n GO, \n \n \n Dos Santos \n LM, \n \n et al. Anti-dentine antibodies with root resorption during orthodontic treatment. Eur J Orthod. 2011;33(5):584\u2013591."},{"key":"i0003-3219-86-6-1042-b29","series-title":"Nature","first-page":"315","article-title":"OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis","volume":"397","author":"Kong \n Y-Y,","year":"1999","unstructured":"Kong \n Y-Y, \n \n \n Yoshida \n H, \n \n \n Sarosi \n I, \n \n et al. \n OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature. 1999;397:315\u2013323."},{"key":"i0003-3219-86-6-1042-b30","series-title":"Eur J Oral Sci","first-page":"346","article-title":"Expression and role of RANKL in periodontal ligament cells during physiological root-resorption in human deciduous teeth","volume":"111","author":"Fukushima \n H,","year":"2003","unstructured":"Fukushima \n H, \n \n \n Kajiya \n H, \n \n \n Takada \n K, \n \n \n Okamoto \n F, \n \n \n Okabe \n K. \n \n \n Expression and role of RANKL in periodontal ligament cells during physiological root-resorption in human deciduous teeth. Eur J Oral Sci. 2003;111:346\u2013352."},{"key":"i0003-3219-86-6-1042-b31","series-title":"Am J Orthod Dentofacial Orthop","first-page":"497","article-title":"Expression of mRNA for osteoprotegerin and receptor activator of nuclear factor kappa \u03b2 ligand (RANKL) during root resorption induced by the application of heavy orthodontic forces on rat molars","volume":"128","author":"Low \n E,","year":"2005","unstructured":"Low \n E, \n \n \n Zoellner \n H, \n \n \n Kharbanda \n OP, \n \n \n Darendeliler \n MA. \n \n \n Expression of mRNA for osteoprotegerin and receptor activator of nuclear factor kappa \u03b2 ligand (RANKL) during root resorption induced by the application of heavy orthodontic forces on rat molars. Am J Orthod Dentofacial Orthop. 2005;128:497\u2013503."}],"container-title":["The Angle Orthodontist"],"original-title":[],"link":[{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/view\/journals\/angl\/86\/6\/article-p1042.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/angle-orthodontist\/article-pdf\/86\/6\/1042\/1603872\/011916-50_1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/downloadpdf\/journals\/angl\/86\/6\/article-p1042.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/downloadpdf\/journals\/angl\/86\/6\/article-p1042.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T15:28:32Z","timestamp":1780068512000},"score":1,"resource":{"primary":{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/view\/journals\/angl\/86\/6\/article-p1042.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":62,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.2319\/011916-50.1","relation":{},"ISSN":["0003-3219","1945-7103"],"issn-type":[{"value":"0003-3219","type":"print"},{"value":"1945-7103","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11]]}}}