{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:51:49Z","timestamp":1787025109143,"version":"build-2736575974"},"reference-count":84,"publisher":"The Angle Orthodontist (EH Angle Education & Research Foundation)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Objective:<\/jats:bold>\n                    To determine whether orthodontic treatment with removable aligners vs fixed orthodontic appliances is associated with a different frequency of orthodontically induced external apical root resorption (OIEARR) when genetic, radiographic, and clinical factors are accounted for.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Materials and Methods:<\/jats:bold>\n                    Three hundred seventy-two orthodontic patients treated with removable aligners (Invisalign) or fixed appliances were genetically screened for interleukin 1B gene (\n                    <jats:italic>IL1B<\/jats:italic>\n                    ) (\n                    <jats:italic>rs1143634<\/jats:italic>\n                    ), interleukin 1 receptor antagonist gene (\n                    <jats:italic>IL1RN<\/jats:italic>\n                    ) (\n                    <jats:italic>rs419598<\/jats:italic>\n                    ), and osteopontin gene (\n                    <jats:italic>SPP1<\/jats:italic>\n                    ) (\n                    <jats:italic>rs9138\/rs11730582<\/jats:italic>\n                    ). Twelve clinical variables, potentially associated with OIEARR, were also considered. Subjects were divided according to the presence of radiographically determined OIEARR (&gt;2 mm). The association between OIEARR and appliance type, and radiographic, clinical and genetic factors, was assessed using backward stepwise conditional logistic regression. Odds ratios (ORs) and 95% confidence intervals (CIs) were reported.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Reliability of the methods was adequate. Clinical case complexity (American Board of Orthodontics [ABO] Discrepancy Index) (OR: 1.032; 95% CI: 1.005\u20131.061;\n                    <jats:italic>P<\/jats:italic>\n                    = .021) and extent of incisor apical displacement in the sagittal plane (OR: 1.478; 95% CI: 1.285\u20131.699;\n                    <jats:italic>P<\/jats:italic>\n                    = .001) were associated with an increased OIEARR risk. After adjusting for associations between clinical\/radiographic\/genetic factors, there were no statistically significant differences with respect to OIEARR or type of orthodontic appliance used, whether removable aligners or fixed appliances (OR: 1.662; 95% CI: 0.945\u20132.924;\n                    <jats:italic>P<\/jats:italic>\n                    = .078). Only subjects homozygous for the\n                    <jats:italic>T<\/jats:italic>\n                    allele of\n                    <jats:italic>IL1RN<\/jats:italic>\n                    (\n                    <jats:italic>rs419598<\/jats:italic>\n                    ) were more prone to OIEARR during orthodontic treatment (OR: 3.121; CI: 1.93\u20135.03;\n                    <jats:italic>P<\/jats:italic>\n                    &lt; .001).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    A similar OIEARR predisposition was identified using either removable aligners (Invisalign) or fixed appliances.\n                  <\/jats:p>","DOI":"10.2319\/02016-101.1","type":"journal-article","created":{"date-parts":[[2016,8,9]],"date-time":"2016-08-09T11:23:41Z","timestamp":1470741821000},"page":"3-10","source":"Crossref","is-referenced-by-count":65,"title":["Orthodontically induced external apical root resorption in patients treated with fixed appliances vs removable aligners"],"prefix":"10.2319","volume":"87","author":[{"given":"Alejandro","family":"Iglesias-Linares","sequence":"first","affiliation":[{"name":"Associate Professor, Department of Orthodontics, School of Dentistry, Complutense University of Madrid, Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Sonnenberg","sequence":"additional","affiliation":[{"name":"Lecturer, Master's Program in Orthodontics, University of Seville, Seville, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Solano","sequence":"additional","affiliation":[{"name":"Lecturer, Master's Program in Orthodontics, University of Seville, Seville, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa-Maria","family":"Ya\u00f1ez-Vico","sequence":"additional","affiliation":[{"name":"Associate Professor, Department of Orthodontics, School of Dentistry, University of Seville, Seville, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Solano","sequence":"additional","affiliation":[{"name":"Chairman, Department of Orthodontics, School of Dentistry, University of Seville, Seville, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven J","family":"Lindauer","sequence":"additional","affiliation":[{"name":"e\u2009Professor and Chair, Department of Orthodontics, School of Dentistry, Virginia Commonwealth University, Richmond, Va."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Flores-Mir","sequence":"additional","affiliation":[{"name":"Professor and Division Head, Department of Orthodontics, School of Dentistry, University of Alberta, Edmonton, Alberta, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1164","reference":[{"key":"i0003-3219-87-1-3-b01","series-title":"Am J Orthod Dentofacial Orthop","first-page":"462","article-title":"Root resorption associated with orthodontic tooth movement: a systematic review","volume":"137","author":"Weltman \n              B,","year":"2010","unstructured":"Weltman \n              B, \n            \n            \n              Vig \n              K, \n            \n            \n              Fields \n              H, \n            \n            \n              Shanker \n              S, \n            \n            \n              Kaizar \n              E. \n            \n          \n          Root resorption associated with orthodontic tooth movement: a systematic review. 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