{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:34:54Z","timestamp":1790030094867,"version":"4.0.1"},"reference-count":32,"publisher":"The Angle Orthodontist (EH Angle Education & Research Foundation)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,11]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objective:<\/jats:title>\n \n To investigate the association between the risk of tooth agenesis and single-nucleotide polymorphisms (SNPs) of\n MSX1 and PAX9<\/jats:italic>\n genes in nonsyndromic cleft patients.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n The subjects were 126 Korean nonsyndromic cleft patients. Tooth agenesis type (TAT) was classified as none (0); cleft area (1); cleft area + other area (2); and other area (3) based on agenesis of the maxillary lateral incisor (MXLI) and another tooth within or outside the cleft area. TAT was further grouped into two subcategories (0 and 1) and four subcategories (0, 1, 2, and 3). Three SNPs of\n MSX1<\/jats:italic>\n and 10 SNPs of\n PAX9<\/jats:italic>\n were investigated using Fisher's exact test and logistic regression analysis.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Although the association between genotype distribution of\n PAX9<\/jats:italic>\n -rs7142363 and TAT was significant (\n P<\/jats:italic>\n < .05 in four subcategories), genotypic odds ratios (GORs) of SNPs in each TAT were not meaningful. However, for\n MSX1-<\/jats:italic>\n rs12532\n and PAX9<\/jats:italic>\n -rs2073247, associations between genotypic distribution and TAT were significant (\n P<\/jats:italic>\n < .01 in four subcategories and\n P<\/jats:italic>\n < .05 in two subcategories;\n P<\/jats:italic>\n < .01 in two subcategories, respectively). In cleft area, GORs of MXLI agenesis in genotypes GA of\n MSX1<\/jats:italic>\n -rs12532 and CT of\n PAX9<\/jats:italic>\n -rs2073247 were increased by 3.14-fold and 4.15-fold compared with genotype GG of\n MSX1-rs12532<\/jats:italic>\n and CC of\n PAX9<\/jats:italic>\n -rs2073247, respectively (\n P<\/jats:italic>\n <. 01;\n P<\/jats:italic>\n < .05). In cleft area + other area, the GOR of agenesis of MXLI and another tooth in genotype AA of\n MSX1-rs12532<\/jats:italic>\n was increased by fivefold compared with genotype GG (\n P<\/jats:italic>\n < .05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n Genetic disturbances of\n MSX1 and PAX9<\/jats:italic>\n genes are associated with tooth agenesis within and outside the cleft area.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.2319\/020513-104.1","type":"journal-article","created":{"date-parts":[[2013,5,29]],"date-time":"2013-05-29T15:28:15Z","timestamp":1369841295000},"page":"1036-1042","source":"Crossref","is-referenced-by-count":23,"title":["Associations between the risk of tooth agenesis and single-nucleotide polymorphisms of MSX1 and PAX9 genes in nonsyndromic cleft patients"],"prefix":"10.2319","volume":"83","author":[{"given":"Yu-Jin","family":"Seo","sequence":"first","affiliation":[{"name":"Graduate student (PhD), Department of Orthodontics, School of Dentistry, Seoul National University, Fellow Doctor, Department of Orthodontics, School of Dentistry, Kyung Hee University, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Wan","family":"Park","sequence":"additional","affiliation":[{"name":"Associate Professor, Department of Medical Genetics, College of Medicine, Hallym University, Chuncheon, Gangwon Province, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Ho","family":"Kim","sequence":"additional","affiliation":[{"name":"Associate Professor and Chair, Department of Orthodontics, The Institute of Oral Health Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Hak","family":"Baek","sequence":"additional","affiliation":[{"name":"Professor, Department of Orthodontics, School of Dentistry, Dental Research Institute, Seoul National University, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1164","reference":[{"key":"i0003-3219-83-6-1036-b01","series-title":"Am J Orthod Dentofacial Orthop","first-page":"11","article-title":"A review of tooth formation in children with cleft lip\/palate","volume":"90","author":"Ranta\n R.","year":"1986","unstructured":"Ranta\n R. \n \n A review of tooth formation in children with cleft lip\/palate. 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Arch Oral Biol. 2005;50:861\u2013871."}],"container-title":["The Angle Orthodontist"],"original-title":[],"link":[{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/view\/journals\/angl\/83\/6\/article-p1036.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/angle-orthodontist\/article-pdf\/83\/6\/1036\/1396258\/020513-104_1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/downloadpdf\/journals\/angl\/83\/6\/article-p1036.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/downloadpdf\/journals\/angl\/83\/6\/article-p1036.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T21:01:12Z","timestamp":1747342872000},"score":1,"resource":{"primary":{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/view\/journals\/angl\/83\/6\/article-p1036.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11]]},"references-count":32,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.2319\/020513-104.1","relation":{},"ISSN":["0003-3219","1945-7103"],"issn-type":[{"value":"0003-3219","type":"print"},{"value":"1945-7103","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11]]}}}