{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T02:03:15Z","timestamp":1788141795978,"version":"build-2803163510"},"reference-count":31,"publisher":"The Angle Orthodontist (EH Angle Education & Research Foundation)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Objective:<\/jats:bold>\n                    To evaluate the prevalence of dental anomalies in patients with agenesis of second premolars and compare the findings with the prevalence of these anomalies in the general population.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Materials and Methods:<\/jats:bold>\n                    A Brazilian sample of 203 patients aged 8 to 22 years was selected. All patients presented agenesis of at least one second premolar. Panoramic and periapical radiographs and dental casts were used to analyze the presence of other associated dental anomalies, including agenesis of other permanent teeth, ectopia of unerupted permanent teeth, infraocclusion of deciduous molars, microdontia of maxillary lateral incisors, and supernumerary teeth. The occurrence of these anomalies was compared with occurrence data previously reported for the general population. Statistical testing was performed using the chi-square test (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; .05) and the odds ratio.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    The sample with agenesis of at least one second premolar presented a significantly increased prevalence rate of permanent tooth agenesis (21%), excluding third molars. Among the sample segment aged 14 years or greater (N = 77), occurrence of third-molar agenesis (48%) exceeded twice its normal frequency. Significant increases in occurrence of microdontia of maxillary lateral incisors (20.6%), infraocclusion of deciduous molars (24.6%), and distoangulation of mandibular second premolars (7.8%) were observed. Palatally displaced canine anomaly was also significantly elevated (8.1%).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    The results provide evidence that agenesis of other permanent teeth, microdontia, deciduous molar infraocclusion, and certain dental ectopias are the products of the same genetic mechanisms that cause second-premolar agenesis.\n                  <\/jats:p>","DOI":"10.2319\/021308-87.1","type":"journal-article","created":{"date-parts":[[2008,10,23]],"date-time":"2008-10-23T13:02:49Z","timestamp":1224766969000},"page":"436-441","source":"Crossref","is-referenced-by-count":85,"title":["Increased Occurrence of Dental Anomalies Associated with Second-Premolar Agenesis"],"prefix":"10.2319","volume":"79","author":[{"given":"Daniela G.","family":"Garib","sequence":"first","affiliation":[{"name":"a\u2009Associate Professor, Department of Orthodontics, University of S\u00e3o Paulo City, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheldon","family":"Peck","sequence":"additional","affiliation":[{"name":"b\u2009Clinical Professor, Department of Developmental Biology, Harvard School of Dental Medicine, Boston, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone Carinhena","family":"Gomes","sequence":"additional","affiliation":[{"name":"c\u2009Graduate Student, Department of Orthodontics, University of S\u00e3o Paulo City, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1164","reference":[{"key":"i0003-3219-079-03-0436-b1","series-title":"Odontol Revy","first-page":"1","article-title":"Hypodontia in the permanent dentition.","volume":"7","author":"Grahn\u00e9n, H.","year":"1956","unstructured":"Grahn\u00e9n, H.\n          \n          Hypodontia in the permanent dentition.\n          Odontol Revy\n          1956. 7:1\u2013100."},{"key":"i0003-3219-079-03-0436-b2","series-title":"Swed Dent J Suppl","first-page":"153","article-title":"Hypodontia in twins.","volume":"15","author":"Markovic, M.","year":"1982","unstructured":"Markovic, M.\n          \n          Hypodontia in twins.\n          Swed Dent J Suppl\n          1982. 15:153\u2013162."},{"key":"i0003-3219-079-03-0436-b3","series-title":"Am J Orthod Dentofacial Orthop","first-page":"650","article-title":"The genetics of human tooth agenesis: new discoveries for understanding dental anomalies.","volume":"117","author":"Vastardis, H.","year":"2000","unstructured":"Vastardis, H.\n          \n          The genetics of human tooth agenesis: new discoveries for understanding dental anomalies.\n          Am J Orthod Dentofacial Orthop\n          2000. 117:650\u2013656."},{"key":"i0003-3219-079-03-0436-b4","series-title":"Br J Orthod","first-page":"195","article-title":"The heritability of malocclusion: part 2. The influence of genetics in malocclusion.","volume":"26","author":"Mossey, P. A.","year":"1999","unstructured":"Mossey, P. A.\n          \n          The heritability of malocclusion: part 2. The influence of genetics in malocclusion.\n          Br J Orthod\n          1999. 26:195\u2013203."},{"key":"i0003-3219-079-03-0436-b5","series-title":"Angle Orthod","first-page":"14","article-title":"The relationship between third molar agenesis and reduction in tooth number.","volume":"32","author":"Garn, S. M.","year":"1962","unstructured":"Garn, S. M. and A. B.Lewis. The relationship between third molar agenesis and reduction in tooth number.Angle Orthod1962. 32:14\u201318."},{"key":"i0003-3219-079-03-0436-b6","series-title":"Angle Orthod","first-page":"51","article-title":"The gradient and the pattern of crown-size reduction in simple hypodontia.","volume":"40","author":"Garn, S. M.","year":"1970","unstructured":"Garn, S. M. and A. B.Lewis. 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R.\n          \n          Conservative management of lower second premolar impaction.\n          Aust Dent J\n          2000. 45:279\u2013281."},{"key":"i0003-3219-079-03-0436-b26","series-title":"J Appl Oral Sci","first-page":"431","article-title":"Associated dental anomalies: case report.","volume":"13","author":"Garib, D. G.","year":"2005","unstructured":"Garib, D. G., N. L. M.Zanella, and S.Peck. Associated dental anomalies: case report.J Appl Oral Sci2005. 13:431\u2013436."},{"key":"i0003-3219-079-03-0436-b27","series-title":"Angle Orthod","first-page":"173","article-title":"Uprighting mesially impacted mandibular permanent second molars.","volume":"68","author":"Shapira, Y.","year":"1998","unstructured":"Shapira, Y., G.Borell, O.Nahlieli, and M. M.Kuftinec. 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Early treatment of palatally erupting maxillary canines by extraction of the primary canines.Eur J OrthodNov 1988. 10:283\u2013295."}],"container-title":["The Angle Orthodontist"],"original-title":[],"link":[{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/view\/journals\/angl\/79\/3\/article-p436.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/angle-orthodontist\/article-pdf\/79\/3\/436\/1389113\/021308-87_1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/downloadpdf\/journals\/angl\/79\/3\/article-p436.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/downloadpdf\/journals\/angl\/79\/3\/article-p436.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T20:47:35Z","timestamp":1747342055000},"score":1,"resource":{"primary":{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/view\/journals\/angl\/79\/3\/article-p436.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5]]},"references-count":31,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.2319\/021308-87.1","relation":{},"ISSN":["0003-3219","1945-7103"],"issn-type":[{"value":"0003-3219","type":"print"},{"value":"1945-7103","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5]]}}}