{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T18:59:53Z","timestamp":1790449193691,"version":"4.1.0"},"reference-count":44,"publisher":"The Angle Orthodontist (EH Angle Education & Research Foundation)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,3]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objective:\u2002<\/jats:title>\n To carry out an immunoassay analysis of biomarkers expressed in gingival crevicular fluid (GCF) with the main goal of finding a useful diagnostic pattern to distinguish between resorbing deciduous teeth and nonresorbing controls.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:\u2002<\/jats:title>\n A split-mouth design was used in this study with a total of 22 GCF samples collected from 11 patients in the mixed dentition. For each child, one deciduous molar with radiographic evidence of root resorption was used as the test tooth whereas the contralateral first permanent molar with formed roots was used as the control tooth. Samples were processed with immunoassays using a panel of selected biomarkers including interleukin-1 beta (IL-1b), interleukin-1 receptor antagonist (IL-1RA), nuclear factor kappa B ligand (RANKL), osteoprotegerin (OPG), matrix metalloproteinase-9 (MMP-9), and dentin sialoprotein (DSP).<\/jats:p>\n <\/jats:sec>\n \n Results:\u2002<\/jats:title>\n \n There were no statistically significant differences in levels of IL-1b, OPG, and MMP-9 between test and control sites (\n P<\/jats:italic>\n \u2009>\u2009.05). IL-1RA was the only biomarker to show a significant down-regulation (\n P<\/jats:italic>\n \u200a=\u200a .04) in GCF samples collected from resorbing teeth. RANKL data showed a heavily skewed distribution and was deemed unreliable. Only one deciduous GCF sample had detectable levels of DSP; therefore, no further statistical calculation was applicable because of the limited amount of data for this biomarker.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:\u2002<\/jats:title>\n This study indicated that IL1-RA is down-regulated in GCF from resorbing primary molars, thus suggesting this cytokine as a potential analyte to be included in a panel that can discriminate between resorbing and nonresorbing teeth.<\/jats:p>\n <\/jats:sec>","DOI":"10.2319\/032415-195.1","type":"journal-article","created":{"date-parts":[[2015,7,8]],"date-time":"2015-07-08T09:35:45Z","timestamp":1436348145000},"page":"187-192","source":"Crossref","is-referenced-by-count":19,"title":["Immunoassay analysis of proteins in gingival crevicular fluid samples from resorbing teeth"],"prefix":"10.2319","volume":"86","author":[{"given":"Wellington J.","family":"Rody","sequence":"first","affiliation":[{"name":"Assistant Professor, Department of Orthodontics, College of Dentistry, University of Florida, Gainesville, Fla"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjula","family":"Wijegunasinghe","sequence":"additional","affiliation":[{"name":"Laboratory Assistant, Department of Chemistry, University of Manitoba, Winnipeg MB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Shannon","family":"Holliday","sequence":"additional","affiliation":[{"name":"Associate Professor, Department of Orthodontics, College of Dentistry, University of Florida, Gainesville, Fla"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin P.","family":"McHugh","sequence":"additional","affiliation":[{"name":"Associate Professor, Department of Periodontology, College of Dentistry, University of Florida, Gainesville, Fla"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon M.","family":"Wallet","sequence":"additional","affiliation":[{"name":"Associate Professor, Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, Fla"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1164","reference":[{"key":"i0003-3219-86-2-187-r1","series-title":"Taking Advantage of Emerging Technologies in Clinical Practice","first-page":"223","article-title":"Oral fluid-based diagnostics and applications in orthodontics","author":"Rody\n WJ\n Jr,","year":"2012","unstructured":"Rody\n WJ\n Jr, \n \n Iwasaki\n LR, \n \n Krokhin\n O.\n \n \n Oral fluid-based diagnostics and applications in orthodontics. In: McNamaraJ, ed. Taking Advantage of Emerging Technologies in Clinical Practice. Ann Arbor, MI: University of Michigan; 2012:223\u2013261."},{"key":"i0003-3219-86-2-187-r2","series-title":"Electrophoresis","first-page":"4261","article-title":"Protein microchips in biomedicine and biomarker discovery","volume":"28","author":"Spisak\n S,","year":"2007","unstructured":"Spisak\n S, \n \n Tulassay\n Z, \n \n Molnar\n B, \n \n Guttman\n A.\n \n \n Protein microchips in biomedicine and biomarker discovery. Electrophoresis. 2007;28:4261\u20134273."},{"key":"i0003-3219-86-2-187-r3","series-title":"Cytokine Growth Factor Rev","first-page":"323","article-title":"The balance between IL-1 and IL-1Ra in disease","volume":"13","author":"Arend\n WP.","year":"2002","unstructured":"Arend\n WP.\n \n \n The balance between IL-1 and IL-1Ra in disease. Cytokine Growth Factor Rev. 2002;13:323\u2013340."},{"key":"i0003-3219-86-2-187-r4","series-title":"J Clin Periodontol","first-page":"239","article-title":"The RANKL-OPG system in clinical periodontology","volume":"39","author":"Belibasakis\n GN,","year":"2012","unstructured":"Belibasakis\n GN, \n \n Bostanci\n N.\n \n \n The RANKL-OPG system in clinical periodontology. J Clin Periodontol. 2012;39:239\u2013248."},{"key":"i0003-3219-86-2-187-r5","series-title":"Angle Orthod","first-page":"120","article-title":"Differences in the gingival crevicular fluid composition between adults and adolescents undergoing orthodontic treatment","volume":"84","author":"Rody\n WJ\n Jr,","year":"2014","unstructured":"Rody\n WJ\n Jr, \n \n Wijegunasinghe\n M, \n \n Wiltshire\n WA, \n \n Dufault\n B.\n \n \n Differences in the gingival crevicular fluid composition between adults and adolescents undergoing orthodontic treatment. Angle Orthod. 2014;84:120\u2013126."},{"key":"i0003-3219-86-2-187-r6","series-title":"J Dent Res","first-page":"166","article-title":"Differential expression of RANKL and osteoprotegerin in gingival crevicular fluid of patients with periodontitis","volume":"83","author":"Mogi\n M,","year":"2004","unstructured":"Mogi\n M, \n \n Otogoto\n J, \n \n Ota\n N, \n \n Togari\n A.\n \n \n Differential expression of RANKL and osteoprotegerin in gingival crevicular fluid of patients with periodontitis. J Dent Res. 2004;83:166\u2013169."},{"key":"i0003-3219-86-2-187-r7","series-title":"Adv Clin Chem","first-page":"199","article-title":"Matrix metalloproteinases in biologic samples","volume":"65","author":"Jones\n GT.","year":"2014","unstructured":"Jones\n GT.\n \n \n Matrix metalloproteinases in biologic samples. Adv Clin Chem. 2014;65:199\u2013219."},{"key":"i0003-3219-86-2-187-r8","series-title":"Arch Oral Biol","first-page":"203","article-title":"Biological markers for evaluation of root resorption","volume":"52","author":"Balducci\n L,","year":"2007","unstructured":"Balducci\n L, \n \n Ramachandran\n A, \n \n Hao\n J, \n \n Narayanan\n K, \n \n Evans\n C, \n \n George\n A.\n \n \n Biological markers for evaluation of root resorption. Arch Oral Biol. 2007;52:203\u2013208."},{"key":"i0003-3219-86-2-187-r9","series-title":"Eur J Orthod","first-page":"25","article-title":"Dentine phosphoproteins in gingival crevicular fluid during root resorption","volume":"26","author":"Mah\n J,","year":"2004","unstructured":"Mah\n J, \n \n Prasad\n N.\n \n \n Dentine phosphoproteins in gingival crevicular fluid during root resorption. Eur J Orthod. 2004;26:25\u201330."},{"key":"i0003-3219-86-2-187-r10","series-title":"Eur J Orthod","first-page":"307","article-title":"Identification of dentine sialoprotein in gingival crevicular fluid during physiological root resorption and orthodontic tooth movement","volume":"30","author":"Kereshanan\n S,","year":"2008","unstructured":"Kereshanan\n S, \n \n Stephenson\n P, \n \n Waddington\n R.\n \n \n Identification of dentine sialoprotein in gingival crevicular fluid during physiological root resorption and orthodontic tooth movement. Eur J Orthod. 2008;30:307\u2013314."},{"key":"i0003-3219-86-2-187-r11","series-title":"Am J Orthod Dentofacial Orthop","first-page":"787","article-title":"Mass spectrometry analysis of gingival crevicular fluid in the presence of external root resorption","volume":"145","author":"Rody\n WJ\n Jr,","year":"2014","unstructured":"Rody\n WJ\n Jr, \n \n Holliday\n LS, \n \n McHugh\n KP, \n \n Wallet\n SM, \n \n Spicer\n V, \n \n Krokhin\n O.\n \n \n Mass spectrometry analysis of gingival crevicular fluid in the presence of external root resorption. Am J Orthod Dentofacial Orthop. 2014;145:787\u2013798."},{"key":"i0003-3219-86-2-187-r12","series-title":"Med Hypotheses","first-page":"1222","article-title":"Trigger osteoclast formation and activation: molecular treatment strategy of delayed tooth eruption","volume":"69","author":"Hua\n F,","year":"2007","unstructured":"Hua\n F, \n \n Zhang\n L, \n \n Chen\n Z.\n \n \n Trigger osteoclast formation and activation: molecular treatment strategy of delayed tooth eruption. Med Hypotheses. 2007;69:1222\u20131224."},{"key":"i0003-3219-86-2-187-r13","series-title":"Crit Rev Oral Biol Med","first-page":"323","article-title":"Cellular, molecular, and genetic determinants of tooth eruption","volume":"13","author":"Wise\n GE,","year":"2002","unstructured":"Wise\n GE, \n \n Frazier-Bowers\n S, \n \n D'Souza\n RN.\n \n \n Cellular, molecular, and genetic determinants of tooth eruption. Crit Rev Oral Biol Med. 2002;13:323\u2013334."},{"key":"i0003-3219-86-2-187-r14","series-title":"Arch Oral Biol","first-page":"961","article-title":"Implications for tooth eruption of the effect of interleukin-1alpha on nuclear factor-kappaB gene expression in the rat dental follicle","volume":"44","author":"Que\n BG,","year":"1999","unstructured":"Que\n BG, \n \n Lumpkin\n SJ, \n \n Wise\n GE.\n \n \n Implications for tooth eruption of the effect of interleukin-1alpha on nuclear factor-kappaB gene expression in the rat dental follicle. Arch Oral Biol. 1999;44:961\u2013967."},{"key":"i0003-3219-86-2-187-r15","series-title":"Dev Dyn","first-page":"346","article-title":"Tooth eruption molecules enhance MCP-1 gene expression in the dental follicle of the rat","volume":"212","author":"Que\n BG,","year":"1998","unstructured":"Que\n BG, \n \n Wise\n GE.\n \n \n Tooth eruption molecules enhance MCP-1 gene expression in the dental follicle of the rat. Dev Dyn. 1998;212:346\u2013351."},{"key":"i0003-3219-86-2-187-r16","series-title":"Annu Rev Immunol","first-page":"27","article-title":"Interleukin-1 receptor antagonist: role in biology","volume":"16","author":"Arend\n WP,","year":"1998","unstructured":"Arend\n WP, \n \n Malyak\n M, \n \n Guthridge\n CJ, \n \n Gabay\n C.\n \n \n Interleukin-1 receptor antagonist: role in biology. Annu Rev Immunol. 1998;16:27\u201355."},{"key":"i0003-3219-86-2-187-r17","series-title":"Am J Orthod Dentofacial Orthop","first-page":"483","article-title":"Tooth movement and cytokines in gingival crevicular fluid and whole blood in growing and adult subjects","volume":"128","author":"Iwasaki\n LR,","year":"2005","unstructured":"Iwasaki\n LR, \n \n Crouch\n LD, \n \n Tutor\n A, \n et al\n . Tooth movement and cytokines in gingival crevicular fluid and whole blood in growing and adult subjects. Am J Orthod Dentofacial Orthop. 2005;128:483\u2013491."},{"key":"i0003-3219-86-2-187-r18","series-title":"Arch Oral Biol","first-page":"519","article-title":"The effect of IL-1 receptor antagonist on orthodontic tooth movement in mice","volume":"57","author":"Salla\n JT,","year":"2012","unstructured":"Salla\n JT, \n \n Taddei\n SR, \n \n Queiroz-Junior\n CM, \n \n Andrade Junior\n I, \n \n Teixeira\n MM, \n \n Silva\n TA.\n \n \n The effect of IL-1 receptor antagonist on orthodontic tooth movement in mice. Arch Oral Biol. 2012;57:519\u2013524."},{"key":"i0003-3219-86-2-187-r19","series-title":"J Clin Periodontol","first-page":"507","article-title":"Effect of periodontal treatment on IL-1beta, IL-1ra, and IL-10 levels in gingival crevicular fluid in patients with aggressive periodontitis","volume":"35","author":"Toker\n H,","year":"2008","unstructured":"Toker\n H, \n \n Poyraz\n O, \n \n Eren\n K.\n \n \n Effect of periodontal treatment on IL-1beta, IL-1ra, and IL-10 levels in gingival crevicular fluid in patients with aggressive periodontitis. J Clin Periodontol. 2008;35:507\u2013513."},{"key":"i0003-3219-86-2-187-r20","series-title":"Orthod Craniofac Res","first-page":"129","article-title":"IL-1 gene polymorphisms, secretion in gingival crevicular fluid, and speed of human orthodontic tooth movement","volume":"12","author":"Iwasaki\n LR,","year":"2009","unstructured":"Iwasaki\n LR, \n \n Chandler\n JR, \n \n Marx\n DB, \n \n Pandey\n JP, \n \n Nickel\n JC.\n \n \n IL-1 gene polymorphisms, secretion in gingival crevicular fluid, and speed of human orthodontic tooth movement. Orthod Craniofac Res. 2009;12:129\u2013140."},{"key":"i0003-3219-86-2-187-r21","series-title":"Am J Orthod Dentofacial Orthop","first-page":"36","article-title":"Comparison between electrochemical ELISA and spectrophotometric ELISA for the detection of dentine sialophosphoprotein for root resorption","volume":"145","author":"Sha\n H,","year":"2014","unstructured":"Sha\n H, \n \n Bai\n Y, \n \n Li\n S, \n \n Wang\n X, \n \n Yin\n Y.\n \n \n Comparison between electrochemical ELISA and spectrophotometric ELISA for the detection of dentine sialophosphoprotein for root resorption. Am J Orthod Dentofacial Orthop. 2014;145:36\u201340."},{"key":"i0003-3219-86-2-187-r22","series-title":"J Periodontal Res","first-page":"98","article-title":"Repeatability of gingival crevicular fluid collection and quantification, as determined through its alkaline phosphatase activity: implications for diagnostic use","volume":"48","author":"Perinetti\n G,","year":"2013","unstructured":"Perinetti\n G, \n \n Di Leonardo\n B, \n \n Di Lenarda\n R, \n \n Contardo\n L.\n \n \n Repeatability of gingival crevicular fluid collection and quantification, as determined through its alkaline phosphatase activity: implications for diagnostic use. J Periodontal Res. 2013;48:98\u2013104."},{"key":"i0003-3219-86-2-187-r1","series-title":"Taking Advantage of Emerging Technologies in Clinical Practice","first-page":"223","article-title":"Oral fluid-based diagnostics and applications in orthodontics","author":"Rody\n WJ\n Jr,","year":"2012","unstructured":"Rody\n WJ\n Jr, \n \n Iwasaki\n LR, \n \n Krokhin\n O.\n \n \n Oral fluid-based diagnostics and applications in orthodontics. In: McNamaraJ, ed. Taking Advantage of Emerging Technologies in Clinical Practice. Ann Arbor, MI: University of Michigan; 2012:223\u2013261."},{"key":"i0003-3219-86-2-187-r2","series-title":"Electrophoresis","first-page":"4261","article-title":"Protein microchips in biomedicine and biomarker discovery","volume":"28","author":"Spisak\n S,","year":"2007","unstructured":"Spisak\n S, \n \n Tulassay\n Z, \n \n Molnar\n B, \n \n Guttman\n A.\n \n \n Protein microchips in biomedicine and biomarker discovery. Electrophoresis. 2007;28:4261\u20134273."},{"key":"i0003-3219-86-2-187-r3","series-title":"Cytokine Growth Factor Rev","first-page":"323","article-title":"The balance between IL-1 and IL-1Ra in disease","volume":"13","author":"Arend\n WP.","year":"2002","unstructured":"Arend\n WP.\n \n \n The balance between IL-1 and IL-1Ra in disease. Cytokine Growth Factor Rev. 2002;13:323\u2013340."},{"key":"i0003-3219-86-2-187-r4","series-title":"J Clin Periodontol","first-page":"239","article-title":"The RANKL-OPG system in clinical periodontology","volume":"39","author":"Belibasakis\n GN,","year":"2012","unstructured":"Belibasakis\n GN, \n \n Bostanci\n N.\n \n \n The RANKL-OPG system in clinical periodontology. J Clin Periodontol. 2012;39:239\u2013248."},{"key":"i0003-3219-86-2-187-r5","series-title":"Angle Orthod","first-page":"120","article-title":"Differences in the gingival crevicular fluid composition between adults and adolescents undergoing orthodontic treatment","volume":"84","author":"Rody\n WJ\n Jr,","year":"2014","unstructured":"Rody\n WJ\n Jr, \n \n Wijegunasinghe\n M, \n \n Wiltshire\n WA, \n \n Dufault\n B.\n \n \n Differences in the gingival crevicular fluid composition between adults and adolescents undergoing orthodontic treatment. Angle Orthod. 2014;84:120\u2013126."},{"key":"i0003-3219-86-2-187-r6","series-title":"J Dent Res","first-page":"166","article-title":"Differential expression of RANKL and osteoprotegerin in gingival crevicular fluid of patients with periodontitis","volume":"83","author":"Mogi\n M,","year":"2004","unstructured":"Mogi\n M, \n \n Otogoto\n J, \n \n Ota\n N, \n \n Togari\n A.\n \n \n Differential expression of RANKL and osteoprotegerin in gingival crevicular fluid of patients with periodontitis. J Dent Res. 2004;83:166\u2013169."},{"key":"i0003-3219-86-2-187-r7","series-title":"Adv Clin Chem","first-page":"199","article-title":"Matrix metalloproteinases in biologic samples","volume":"65","author":"Jones\n GT.","year":"2014","unstructured":"Jones\n GT.\n \n \n Matrix metalloproteinases in biologic samples. Adv Clin Chem. 2014;65:199\u2013219."},{"key":"i0003-3219-86-2-187-r8","series-title":"Arch Oral Biol","first-page":"203","article-title":"Biological markers for evaluation of root resorption","volume":"52","author":"Balducci\n L,","year":"2007","unstructured":"Balducci\n L, \n \n Ramachandran\n A, \n \n Hao\n J, \n \n Narayanan\n K, \n \n Evans\n C, \n \n George\n A.\n \n \n Biological markers for evaluation of root resorption. Arch Oral Biol. 2007;52:203\u2013208."},{"key":"i0003-3219-86-2-187-r9","series-title":"Eur J Orthod","first-page":"25","article-title":"Dentine phosphoproteins in gingival crevicular fluid during root resorption","volume":"26","author":"Mah\n J,","year":"2004","unstructured":"Mah\n J, \n \n Prasad\n N.\n \n \n Dentine phosphoproteins in gingival crevicular fluid during root resorption. Eur J Orthod. 2004;26:25\u201330."},{"key":"i0003-3219-86-2-187-r10","series-title":"Eur J Orthod","first-page":"307","article-title":"Identification of dentine sialoprotein in gingival crevicular fluid during physiological root resorption and orthodontic tooth movement","volume":"30","author":"Kereshanan\n S,","year":"2008","unstructured":"Kereshanan\n S, \n \n Stephenson\n P, \n \n Waddington\n R.\n \n \n Identification of dentine sialoprotein in gingival crevicular fluid during physiological root resorption and orthodontic tooth movement. Eur J Orthod. 2008;30:307\u2013314."},{"key":"i0003-3219-86-2-187-r11","series-title":"Am J Orthod Dentofacial Orthop","first-page":"787","article-title":"Mass spectrometry analysis of gingival crevicular fluid in the presence of external root resorption","volume":"145","author":"Rody\n WJ\n Jr,","year":"2014","unstructured":"Rody\n WJ\n Jr, \n \n Holliday\n LS, \n \n McHugh\n KP, \n \n Wallet\n SM, \n \n Spicer\n V, \n \n Krokhin\n O.\n \n \n Mass spectrometry analysis of gingival crevicular fluid in the presence of external root resorption. Am J Orthod Dentofacial Orthop. 2014;145:787\u2013798."},{"key":"i0003-3219-86-2-187-r12","series-title":"Med Hypotheses","first-page":"1222","article-title":"Trigger osteoclast formation and activation: molecular treatment strategy of delayed tooth eruption","volume":"69","author":"Hua\n F,","year":"2007","unstructured":"Hua\n F, \n \n Zhang\n L, \n \n Chen\n Z.\n \n \n Trigger osteoclast formation and activation: molecular treatment strategy of delayed tooth eruption. Med Hypotheses. 2007;69:1222\u20131224."},{"key":"i0003-3219-86-2-187-r13","series-title":"Crit Rev Oral Biol Med","first-page":"323","article-title":"Cellular, molecular, and genetic determinants of tooth eruption","volume":"13","author":"Wise\n GE,","year":"2002","unstructured":"Wise\n GE, \n \n Frazier-Bowers\n S, \n \n D'Souza\n RN.\n \n \n Cellular, molecular, and genetic determinants of tooth eruption. Crit Rev Oral Biol Med. 2002;13:323\u2013334."},{"key":"i0003-3219-86-2-187-r14","series-title":"Arch Oral Biol","first-page":"961","article-title":"Implications for tooth eruption of the effect of interleukin-1alpha on nuclear factor-kappaB gene expression in the rat dental follicle","volume":"44","author":"Que\n BG,","year":"1999","unstructured":"Que\n BG, \n \n Lumpkin\n SJ, \n \n Wise\n GE.\n \n \n Implications for tooth eruption of the effect of interleukin-1alpha on nuclear factor-kappaB gene expression in the rat dental follicle. Arch Oral Biol. 1999;44:961\u2013967."},{"key":"i0003-3219-86-2-187-r15","series-title":"Dev Dyn","first-page":"346","article-title":"Tooth eruption molecules enhance MCP-1 gene expression in the dental follicle of the rat","volume":"212","author":"Que\n BG,","year":"1998","unstructured":"Que\n BG, \n \n Wise\n GE.\n \n \n Tooth eruption molecules enhance MCP-1 gene expression in the dental follicle of the rat. Dev Dyn. 1998;212:346\u2013351."},{"key":"i0003-3219-86-2-187-r16","series-title":"Annu Rev Immunol","first-page":"27","article-title":"Interleukin-1 receptor antagonist: role in biology","volume":"16","author":"Arend\n WP,","year":"1998","unstructured":"Arend\n WP, \n \n Malyak\n M, \n \n Guthridge\n CJ, \n \n Gabay\n C.\n \n \n Interleukin-1 receptor antagonist: role in biology. Annu Rev Immunol. 1998;16:27\u201355."},{"key":"i0003-3219-86-2-187-r17","series-title":"Am J Orthod Dentofacial Orthop","first-page":"483","article-title":"Tooth movement and cytokines in gingival crevicular fluid and whole blood in growing and adult subjects","volume":"128","author":"Iwasaki\n LR,","year":"2005","unstructured":"Iwasaki\n LR, \n \n Crouch\n LD, \n \n Tutor\n A, \n et al\n . Tooth movement and cytokines in gingival crevicular fluid and whole blood in growing and adult subjects. Am J Orthod Dentofacial Orthop. 2005;128:483\u2013491."},{"key":"i0003-3219-86-2-187-r18","series-title":"Arch Oral Biol","first-page":"519","article-title":"The effect of IL-1 receptor antagonist on orthodontic tooth movement in mice","volume":"57","author":"Salla\n JT,","year":"2012","unstructured":"Salla\n JT, \n \n Taddei\n SR, \n \n Queiroz-Junior\n CM, \n \n Andrade Junior\n I, \n \n Teixeira\n MM, \n \n Silva\n TA.\n \n \n The effect of IL-1 receptor antagonist on orthodontic tooth movement in mice. Arch Oral Biol. 2012;57:519\u2013524."},{"key":"i0003-3219-86-2-187-r19","series-title":"J Clin Periodontol","first-page":"507","article-title":"Effect of periodontal treatment on IL-1beta, IL-1ra, and IL-10 levels in gingival crevicular fluid in patients with aggressive periodontitis","volume":"35","author":"Toker\n H,","year":"2008","unstructured":"Toker\n H, \n \n Poyraz\n O, \n \n Eren\n K.\n \n \n Effect of periodontal treatment on IL-1beta, IL-1ra, and IL-10 levels in gingival crevicular fluid in patients with aggressive periodontitis. J Clin Periodontol. 2008;35:507\u2013513."},{"key":"i0003-3219-86-2-187-r20","series-title":"Orthod Craniofac Res","first-page":"129","article-title":"IL-1 gene polymorphisms, secretion in gingival crevicular fluid, and speed of human orthodontic tooth movement","volume":"12","author":"Iwasaki\n LR,","year":"2009","unstructured":"Iwasaki\n LR, \n \n Chandler\n JR, \n \n Marx\n DB, \n \n Pandey\n JP, \n \n Nickel\n JC.\n \n \n IL-1 gene polymorphisms, secretion in gingival crevicular fluid, and speed of human orthodontic tooth movement. Orthod Craniofac Res. 2009;12:129\u2013140."},{"key":"i0003-3219-86-2-187-r21","series-title":"Am J Orthod Dentofacial Orthop","first-page":"36","article-title":"Comparison between electrochemical ELISA and spectrophotometric ELISA for the detection of dentine sialophosphoprotein for root resorption","volume":"145","author":"Sha\n H,","year":"2014","unstructured":"Sha\n H, \n \n Bai\n Y, \n \n Li\n S, \n \n Wang\n X, \n \n Yin\n Y.\n \n \n Comparison between electrochemical ELISA and spectrophotometric ELISA for the detection of dentine sialophosphoprotein for root resorption. Am J Orthod Dentofacial Orthop. 2014;145:36\u201340."},{"key":"i0003-3219-86-2-187-r22","series-title":"J Periodontal Res","first-page":"98","article-title":"Repeatability of gingival crevicular fluid collection and quantification, as determined through its alkaline phosphatase activity: implications for diagnostic use","volume":"48","author":"Perinetti\n G,","year":"2013","unstructured":"Perinetti\n G, \n \n Di Leonardo\n B, \n \n Di Lenarda\n R, \n \n Contardo\n L.\n \n \n Repeatability of gingival crevicular fluid collection and quantification, as determined through its alkaline phosphatase activity: implications for diagnostic use. 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