{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T11:29:34Z","timestamp":1780486174731,"version":"3.54.1"},"reference-count":58,"publisher":"The Angle Orthodontist (EH Angle Education & Research Foundation)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To assess the association of several dental malocclusion features with temporomandibular joint (TMJ) click sounds in a population of temporomandibular disorder (TMD) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Four hundred forty-two TMD patients (72% female; 32.2 \u00b1 5.7\u00a0years, range 25\u201344\u00a0years) were divided into a TMJ clicking and a no-TMJ clicking group, based on the Research Diagnostic Criteria for Temporomandibular Disorders (RDC\/TMD) assessment. Seven occlusal features were recorded for each patient: (1) posterior crossbite, (2) overbite, (3) open bite, (4) overjet, (5) mediotrusive and (6) laterotrusive interferences and (7) retruded contact position to maximum intercuspation (RCP-MI) slide length. A logistic regression model was created to estimate the association of occlusal features with TMJ clicking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The difference between the groups as for the prevalence of the various occlusal features was generally not statistically significant, with minor exceptions. Mediotrusive interferences (\n                      <jats:italic>P<\/jats:italic>\n                      \u200a=\u200a .015) and RCP-MI slide \u22652\u00a0mm (\n                      <jats:italic>P<\/jats:italic>\n                      \u200a=\u200a .001) were the two occlusal features that were associated with the probability of having TMJ clicking, even if the adjusted odds ratios for TMJ clicking were low for both variables (1.63 and 1.89, respectively). Moreover, the amount of variance in the prevalence of TMJ clicking that was predicted by the final model was as low as 4.5% (\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u200a=\u200a 0.045).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Findings from the present investigation suggested that in a population of TMD patients, the contribution of dental malocclusion features to predict TMJ click sounds is minimal with no clinical relevance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2319\/041613-295.1","type":"journal-article","created":{"date-parts":[[2013,8,19]],"date-time":"2013-08-19T10:16:21Z","timestamp":1376907381000},"page":"310-315","source":"Crossref","is-referenced-by-count":52,"title":["Dental malocclusion is not related to temporomandibular joint clicking: a logistic regression analysis in a patient population"],"prefix":"10.2319","volume":"84","author":[{"given":"Daniele","family":"Manfredini","sequence":"first","affiliation":[{"name":"Assistant Professor, Temporomandibular Disorders Clinic, Department of Maxillofacial Surgery, University of Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Perinetti","sequence":"additional","affiliation":[{"name":"Research Fellow, Department of Medical, Surgical and Health Sciences, School of Dentistry University of Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Guarda-Nardini","sequence":"additional","affiliation":[{"name":"Head, Temporomandibular Disorders Clinic, Department of Maxillofacial Surgery, University of Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1164","reference":[{"key":"i0003-3219-84-2-310-b01","series-title":"Oral Maxillofac Surg Clin North Am","first-page":"133","article-title":"The classification of orofacial pains","volume":"20","author":"Okeson\n              JP.","year":"2008","unstructured":"Okeson\n              JP. \n          \n          The classification of orofacial pains. 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J Dent Res. 1993;72:968\u2013979."},{"key":"i0003-3219-84-2-310-b08","series-title":"J Prosthet Dent","first-page":"66","article-title":"Quantification and validation of predictive values of occlusal variables in temporomandibular disorders using a multifactorial analysis","volume":"83","author":"Pullinger\n              AG,","year":"2000","unstructured":"Pullinger\n              AG, \n            \n              Seligman\n              DA. \n          \n          Quantification and validation of predictive values of occlusal variables in temporomandibular disorders using a multifactorial analysis. 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J Prosthet Dent. 2004;92:190\u2013195."},{"key":"i0003-3219-84-2-310-b10","series-title":"Cranio","first-page":"105","article-title":"Predictive value of combined clinically diagnosed bruxism and occlusal features for TMJ pain","volume":"28","author":"Manfredini\n              D.,","year":"2010","unstructured":"Manfredini\n              D., \n            \n              Peretta\n              R, \n            \n              Guarda-Nardini\n              L, \n            \n              Ferronato\n              G. \n          \n          Predictive value of combined clinically diagnosed bruxism and occlusal features for TMJ pain. Cranio. 2010;28:105\u2013113."},{"key":"i0003-3219-84-2-310-b11","series-title":"J Dent Res","first-page":"518","article-title":"Occlusion and temporomandibular disorders (TMD): still unsolved questions","volume":"81","author":"Alanen\n              P.","year":"2002","unstructured":"Alanen\n              P. \n          \n          Occlusion and temporomandibular disorders (TMD): still unsolved questions? J Dent Res. 2002;81:518\u2013519."},{"key":"i0003-3219-84-2-310-b12","series-title":"Am J Orthod Dentofacial Orthop","first-page":"424","article-title":"TMD, bruxism, and occlusion","volume":"139","author":"Greven\n              M.","year":"2011","unstructured":"Greven\n              M. \n          \n          TMD, bruxism, and occlusion. 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Am J Orthod. 1984;86:419\u2013426."},{"key":"i0003-3219-84-2-310-b14","series-title":"Oral Health Prev Dent","first-page":"119","article-title":"The prevalence of malocclusal traits and their correlations in mixed dentition children: results from the Italian OHSAR Survey","volume":"6","author":"Perinetti\n              G.,","year":"2008","unstructured":"Perinetti\n              G., \n            \n              Cordella\n              C, \n            \n              Pellegrini\n              F, \n            \n              Esposito\n              P. \n          \n          The prevalence of malocclusal traits and their correlations in mixed dentition children: results from the Italian OHSAR Survey. Oral Health Prev Dent. 2008;6:119\u2013129."},{"key":"i0003-3219-84-2-310-b15","series-title":"Arthritis Rheum","first-page":"160","article-title":"The American College of Rheumatology criteria for the classification of fibromyalgia. Report of the Multicenter Criteria Committee","volume":"33","author":"Wolfe\n              F.,","year":"1990","unstructured":"Wolfe\n              F., \n            \n              Smythe\n              HA, \n            \n              Yunus\n              MB, \n            et al\n          . The American College of Rheumatology criteria for the classification of fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis Rheum. 1990;33:160\u2013172."},{"key":"i0003-3219-84-2-310-b16","series-title":"Arthritis Rheum","first-page":"315","article-title":"The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis","volume":"31","author":"Arnett\n              FC.,","year":"1988","unstructured":"Arnett\n              FC., \n            \n              Edworthy\n              SM, \n            \n              Bloch\n              DA, \n            et al\n          . The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988;31:315\u2013324."},{"key":"i0003-3219-84-2-310-b17","series-title":"J Craniomandib Disord","first-page":"301","article-title":"Research diagnostic criteria for temporomandibular disorders: review, criteria, examinations and specifications, critique","volume":"6","author":"Dworkin\n              S. F,","year":"1992","unstructured":"Dworkin\n              S. F, \n            \n              LeResche\n              L. \n          \n          Research diagnostic criteria for temporomandibular disorders: review, criteria, examinations and specifications, critique. J Craniomandib Disord. 1992;6:301\u2013355."},{"key":"i0003-3219-84-2-310-b18","series-title":"Clin Oral Investig","first-page":"749","article-title":"Correlation of RDC\/TMD axis I diagnoses and axis II pain-related disability. A multicenter study","volume":"15","author":"Manfredini\n              D.,","year":"2011","unstructured":"Manfredini\n              D., \n            \n              Ahlberg\n              J, \n            \n              Winocur\n              E, \n            \n              Guarda-Nardini\n              L, \n            \n              Lobbezoo\n              F. \n          \n          Correlation of RDC\/TMD axis I diagnoses and axis II pain-related disability. A multicenter study. Clin Oral Investig. 2011;15:749\u2013756."},{"key":"i0003-3219-84-2-310-b19","series-title":"J Orofac Pain","first-page":"163","article-title":"Occlusal factors are not related with self-reported bruxism","volume":"26","author":"Manfredini\n              D.,","year":"2012","unstructured":"Manfredini\n              D., \n            \n              Visscher\n              C, \n            \n              Guarda-Nardini\n              L, \n            \n              Lobbezoo\n              F. \n          \n          Occlusal factors are not related with self-reported bruxism. J Orofac Pain. 2012;26:163\u2013167."},{"key":"i0003-3219-84-2-310-b20","series-title":"Biometrika","first-page":"691","article-title":"A note on a general definition of the coefficient of determination","volume":"78","author":"Nagelkerke\n              NJD.","year":"1991","unstructured":"Nagelkerke\n              NJD. \n          \n          A note on a general definition of the coefficient of determination. 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Angle Orthod. 2003;73:71\u201378."},{"key":"i0003-3219-84-2-310-b24","series-title":"Am J Orthod Dentofacial Orthop","first-page":"73","article-title":"Signs and symptoms of temporomandibular disorders (TMD) and craniofacial form","volume":"110","author":"Dibbets\n              JM,","year":"1996","unstructured":"Dibbets\n              JM, \n            \n              van der Weele\n              LT. \n          \n          Signs and symptoms of temporomandibular disorders (TMD) and craniofacial form. 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Am J Orthod. 1986;89:326\u2013330."},{"key":"i0003-3219-84-2-310-b26","series-title":"J Craniomandib Disord","first-page":"227","article-title":"Association of occlusal variables among refined TM patient diagnostic groups","volume":"3","author":"Seligman\n              DA,","year":"1989","unstructured":"Seligman\n              DA, \n            \n              Pullinger\n              AG. \n          \n          Association of occlusal variables among refined TM patient diagnostic groups. 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Philadelphia, Pa: Saunders; 1966."},{"key":"i0003-3219-84-2-310-b06","series-title":"J Oral Rehabil","first-page":"502","article-title":"The dental occlusion as a suspected cause for TMDs: epidemiological and etiological considerations","volume":"39","author":"T\u00fcrp\n              JC,","year":"2012","unstructured":"T\u00fcrp\n              JC, \n            \n              Schindler\n              HJ. \n          \n          The dental occlusion as a suspected cause for TMDs: epidemiological and etiological considerations. 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J Prosthet Dent. 2004;92:190\u2013195."},{"key":"i0003-3219-84-2-310-b10","series-title":"Cranio","first-page":"105","article-title":"Predictive value of combined clinically diagnosed bruxism and occlusal features for TMJ pain","volume":"28","author":"Manfredini\n              D.,","year":"2010","unstructured":"Manfredini\n              D., \n            \n              Peretta\n              R, \n            \n              Guarda-Nardini\n              L, \n            \n              Ferronato\n              G. \n          \n          Predictive value of combined clinically diagnosed bruxism and occlusal features for TMJ pain. Cranio. 2010;28:105\u2013113."},{"key":"i0003-3219-84-2-310-b11","series-title":"J Dent Res","first-page":"518","article-title":"Occlusion and temporomandibular disorders (TMD): still unsolved questions","volume":"81","author":"Alanen\n              P.","year":"2002","unstructured":"Alanen\n              P. \n          \n          Occlusion and temporomandibular disorders (TMD): still unsolved questions? J Dent Res. 2002;81:518\u2013519."},{"key":"i0003-3219-84-2-310-b12","series-title":"Am J Orthod Dentofacial Orthop","first-page":"424","article-title":"TMD, bruxism, and occlusion","volume":"139","author":"Greven\n              M.","year":"2011","unstructured":"Greven\n              M. \n          \n          TMD, bruxism, and occlusion. Am J Orthod Dentofacial Orthop. 2011;139:424."},{"key":"i0003-3219-84-2-310-b13","series-title":"Am J Orthod","first-page":"419","article-title":"An epidemiologic transition in dental occlusion in world populations","volume":"86","author":"Corruccini\n              RS.","year":"1984","unstructured":"Corruccini\n              RS. \n          \n          An epidemiologic transition in dental occlusion in world populations. Am J Orthod. 1984;86:419\u2013426."},{"key":"i0003-3219-84-2-310-b14","series-title":"Oral Health Prev Dent","first-page":"119","article-title":"The prevalence of malocclusal traits and their correlations in mixed dentition children: results from the Italian OHSAR Survey","volume":"6","author":"Perinetti\n              G.,","year":"2008","unstructured":"Perinetti\n              G., \n            \n              Cordella\n              C, \n            \n              Pellegrini\n              F, \n            \n              Esposito\n              P. \n          \n          The prevalence of malocclusal traits and their correlations in mixed dentition children: results from the Italian OHSAR Survey. Oral Health Prev Dent. 2008;6:119\u2013129."},{"key":"i0003-3219-84-2-310-b15","series-title":"Arthritis Rheum","first-page":"160","article-title":"The American College of Rheumatology criteria for the classification of fibromyalgia. 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