{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:52:58Z","timestamp":1787025178093,"version":"build-2736575974"},"reference-count":18,"publisher":"The Angle Orthodontist (EH Angle Education & Research Foundation)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The multiple endocrine neoplasia (MEN) syndromes are a relatively uncommon group of genetic disorders characterized by the development of tumors in various endocrine organs. MEN type 2B is of particular interest to the dental profession because of its oral manifestations, which are often some of the earliest clinically detectable signs of the disorder. Early identification of this syndrome is critical because affected patients often develop a characteristic malignancy, medullary carcinoma of the thyroid, at a very early age. We describe a 17-year-old male whose initial diagnosis of MEN-2B was triggered by his orthodontist's request for an oral and maxillofacial pathology consultation to evaluate the patient's oral abnormalities.<\/jats:p>","DOI":"10.2319\/042009-222.1","type":"journal-article","created":{"date-parts":[[2010,1,5]],"date-time":"2010-01-05T10:19:40Z","timestamp":1262686780000},"page":"585-590","source":"Crossref","is-referenced-by-count":15,"title":["Multiple Endocrine Neoplasia-2B Presenting with Orthodontic Relapse"],"prefix":"10.2319","volume":"80","author":[{"given":"Brent","family":"Accurso","sequence":"first","affiliation":[{"name":"Resident in Oral and Maxillofacial Pathology, College of Dentistry, The Ohio State University, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Mercado","sequence":"additional","affiliation":[{"name":"Clinical Assistant Professor, Orthodontics, College of Dentistry, The Ohio State University, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl M.","family":"Allen","sequence":"additional","affiliation":[{"name":"Professor and Director, Oral and Maxillofacial Pathology, College of Dentistry, The Ohio State University, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1164","reference":[{"key":"i0003-3219-80-3-585-b01","series-title":"Cecil Medicine","article-title":"Polyglandular disorders.","author":"Kronenberg, H. 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Syndrome of multiple mucosal neurofibromas, pheochromocytoma and medullary thyroid carcinoma\u2014report of a case.Int J Oral Surg1978. 7:126\u2013131."},{"key":"i0003-3219-80-3-585-b17","series-title":"Ann Surg Oncol","first-page":"293","article-title":"Failure to recognize multiple endocrine neoplasia 2b: more common than we think?","volume":"15","author":"Wray, C. J.","year":"2008","unstructured":"Wray, C. J., T. A.Rich, S. G.Waguespack, J. E.Lee, N. D.Perrier, and D. B.Evans. Failure to recognize multiple endocrine neoplasia 2b: more common than we think?Ann Surg Oncol2008. 15:293\u2013301."},{"key":"i0003-3219-80-3-585-b18","series-title":"Surgery","first-page":"1044","article-title":"Premonitory symptoms preceding metastatic medullary thyroid cancer in MEN 2B: an exploratory analysis.","volume":"144","author":"Brauckhoff, M.","year":"2008","unstructured":"Brauckhoff, M., A.Machens, S.Hess, K.Lorenz, O.Gimm, K.Brauckhoff, C.Sekulla, and H.Dralle. Premonitory symptoms preceding metastatic medullary thyroid cancer in MEN 2B: an exploratory analysis.Surgery2008. 144:1044\u20131053."}],"container-title":["The Angle Orthodontist"],"original-title":[],"link":[{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/view\/journals\/angl\/80\/3\/article-p585.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/downloadpdf\/journals\/angl\/80\/3\/article-p585.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/downloadpdf\/journals\/angl\/80\/3\/article-p585.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T20:51:33Z","timestamp":1747342293000},"score":1,"resource":{"primary":{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/view\/journals\/angl\/80\/3\/article-p585.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5]]},"references-count":18,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.2319\/042009-222.1","relation":{},"ISSN":["0003-3219","1945-7103"],"issn-type":[{"value":"0003-3219","type":"print"},{"value":"1945-7103","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5]]}}}