{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:43:53Z","timestamp":1792197833557,"version":"4.4.0"},"reference-count":38,"publisher":"The Angle Orthodontist (EH Angle Education & Research Foundation)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess the acceleratory effect of locally administered injectable platelet-rich fibrin (i-PRF) on overall treatment duration (OTD) and root resorption.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Patients with anterior crowding requiring extraction of all four first premolars were randomized into i-PRF and control groups, both treated with fixed appliances. The i-PRF group received submucosal injection of i-PRF distal to all canines on the buccal and palatal sides, and canine retraction was performed using sectional mechanics. A second i-PRF injection was administered in the anterior interradicular region, followed by alignment up to 0.018 \u00d7 0.025\u2033 stainless steel and space closure with NiTi closed coil springs (150 g). Control patients underwent the same protocol without i-PRF injections. Treatment duration was calculated; root resorption was assessed using cone-beam computed tomography, and volumetric analysis was accomplished using MIMICS software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All 30 enrolled patients (17 females, 13 males; mean age 16.6 \u00b1 2.7 years) completed the study, with 15 patients in each group. The mean OTD was 338.6 \u00b1 37.8 days for the i-PRF group and 374.3 \u00b1 49.3 days for the control group (\n                      <jats:italic>P<\/jats:italic>\n                      = .107). The percentage root volume loss for the central incisor was 3% and 4% in the intervention and control groups (\n                      <jats:italic>P<\/jats:italic>\n                      = .122), respectively, and 5% and 6% for the lateral incisor in the intervention and control groups (\n                      <jats:italic>P<\/jats:italic>\n                      = .767). Both the treatment duration and root volume loss in both groups were statistically and clinically nonsignificant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The use of i-PRF did not significantly reduce OTD or affect root resorption compared with the control group.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2319\/042325-316.1","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:51:50Z","timestamp":1770771110000},"page":"271-277","source":"Crossref","is-referenced-by-count":2,"title":["Does administration of injectable platelet-rich fibrin impact the overall treatment duration in orthodontic extraction cases? A randomized controlled trial"],"prefix":"10.2319","volume":"96","author":[{"given":"Kapil M.","family":"Sonar","sequence":"first","affiliation":[{"name":"Senior Resident, Division of Orthodontics and Dentofacial Deformities, Centre for Dental Education and Research, All India Institute of Medical Sciences, New Delhi, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupa J.","family":"Nimbai","sequence":"additional","affiliation":[{"name":"Resident, Division of Orthodontics and Dentofacial Deformities, Centre for Dental Education and Research, All India Institute of Medical Sciences, New Delhi, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saraa L.","family":"Angel","sequence":"additional","affiliation":[{"name":"Senior Resident, Division of Orthodontics and Dentofacial Deformities, Centre for Dental Education and Research, All India Institute of Medical Sciences, New Delhi, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vilas D.","family":"Samrit","sequence":"additional","affiliation":[{"name":"Additional Professor, Division of Orthodontics and Dentofacial Deformities, Centre for Dental Education and Research, All India Institute of Medical Sciences, New Delhi, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajiv","family":"Balachandran","sequence":"additional","affiliation":[{"name":"Assistant Professor, Division of Orthodontics and Dentofacial Deformities, Centre for Dental Education and Research, All India Institute of Medical Sciences, New Delhi, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikender S.","family":"Yadav","sequence":"additional","affiliation":[{"name":"Additional Professor, Division of Periodontics, Centre for Dental Education and Research, All India Institute of Medical Sciences, New Delhi, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabhat Kumar","family":"Chaudhari","sequence":"additional","affiliation":[{"name":"Additional Professor, Division of Orthodontics and Dentofacial Deformities, Centre for Dental Education and Research, All India Institute of Medical Sciences, New Delhi, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritu","family":"Duggal","sequence":"additional","affiliation":[{"name":"Professor and Head, Division of Orthodontics and Dentofacial Deformities, Centre for Dental Education and Research, All India Institute of Medical Sciences, New Delhi, India."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1164","reference":[{"key":"i1945-7103-96-3-271-b01","series-title":"Eur J Trauma Emerg Surg","first-page":"87","article-title":"Reduction of relative centrifugation force within injectable platelet-rich-fibrin (PRF) concentrates advances patients\u2019 own inflammatory cells, platelets and growth factors: the first introduction to the low speed centrifugation concept","volume":"44","author":"Choukroun","year":"2018","unstructured":"Choukroun J,\nGhanaati S. Reduction of relative centrifugation force within injectable platelet-rich-fibrin (PRF) concentrates advances patients\u2019 own inflammatory cells, platelets and growth factors: the first introduction to the low speed centrifugation concept. Eur J Trauma Emerg Surg. 2018;44:87\u201395."},{"key":"i1945-7103-96-3-271-b02","series-title":"Clin Oral Investig","first-page":"1309","article-title":"Injectable platelet rich fibrin: cell content, morphological, and protein characterization","volume":"23","author":"Varela","year":"2019","unstructured":"Varela HA,\nSouza JCM,\nNascimento RM, et al. Injectable platelet rich fibrin: cell content, morphological, and protein characterization. Clin Oral Investig. 2019;23:1309\u20131318."},{"key":"i1945-7103-96-3-271-b03","series-title":"Clin Oral Investig","first-page":"2353","article-title":"Comparative release of growth factors from PRP, PRF, and advanced-PRF","volume":"20","author":"Kobayashi","year":"2016","unstructured":"Kobayashi E,\nFl\u00fcckiger L,\nFujioka-Kobayashi M, et al. Comparative release of growth factors from PRP, PRF, and advanced-PRF. Clin Oral Investig. 2016;20:2353\u20132360."},{"key":"i1945-7103-96-3-271-b04","series-title":"Angle Orthod","first-page":"285","article-title":"Effect of injectable platelet-rich fibrin (i-PRF) on the rate of tooth movement","volume":"91","author":"Erdur","year":"2021","unstructured":"Erdur EA,\nKarakasli K,\nOncu E,\nOzturk B,\nHakk\u0131 S. Effect of injectable platelet-rich fibrin (i-PRF) on the rate of tooth movement. Angle Orthod. 2021;91:285\u2013292."},{"key":"i1945-7103-96-3-271-b05","series-title":"Angle Orthod","first-page":"213","article-title":"The effect of platelet-rich fibrin (PRF) on maxillary incisor retraction rate","volume":"91","author":"Karakasli","year":"2021","unstructured":"Karakasli K,\nErdur EA. The effect of platelet-rich fibrin (PRF) on maxillary incisor retraction rate. Angle Orthod. 2021;91:213\u2013219."},{"key":"i1945-7103-96-3-271-b06","series-title":"J Orofac Orthop","first-page":"268","article-title":"Effect of injectable platelet-rich fibrin (i-PRF) in accelerating orthodontic tooth movement: a randomized split-mouth-controlled trial","volume":"82","author":"Zeitounlouian","year":"2021","unstructured":"Zeitounlouian TS,\nZeno KG,\nBrad BA,\nHaddad RA. Effect of injectable platelet-rich fibrin (i-PRF) in accelerating orthodontic tooth movement: a randomized split-mouth-controlled trial. J Orofac Orthop. 2021;82:268\u2013277."},{"key":"i1945-7103-96-3-271-b07","series-title":"Am J Orthod Dentofacial Orthop","first-page":"735","article-title":"Evaluation of injectable platelet-rich fibrin effect on the rate of canine retraction and alkaline phosphatase levels: an in-vivo study","volume":"162","author":"Gupta","year":"2022","unstructured":"Gupta P,\nBhagyalakshmi A,\nAvinash BS,\nPrashant A,\nRaghunath N. Evaluation of injectable platelet-rich fibrin effect on the rate of canine retraction and alkaline phosphatase levels: an in-vivo study. Am J Orthod Dentofacial Orthop. 2022;162:735\u2013743."},{"key":"i1945-7103-96-3-271-b08","series-title":"Am J Orthod Dentofacial Orthop","first-page":"e28","article-title":"Effect of platelet-rich plasma on the rate of orthodontic tooth movement","volume":"162","author":"Chandak","year":"2022","unstructured":"Chandak S,\nPatil AS. Effect of platelet-rich plasma on the rate of orthodontic tooth movement. Am J Orthod Dentofacial Orthop. 2022;162:e28\u2013e34."},{"key":"i1945-7103-96-3-271-b09","series-title":"Eur J Orthod","first-page":"cjad056","article-title":"Evaluation of the effectiveness of the platelet-rich plasma compared to the injectable platelet-rich fibrin on the rate of maxillary canine retraction: a three-arm randomized controlled trial","volume":"46","author":"Ammar","year":"2024","unstructured":"Ammar AM,\nAl-Sabbagh R,\nHajeer MY. Evaluation of the effectiveness of the platelet-rich plasma compared to the injectable platelet-rich fibrin on the rate of maxillary canine retraction: a three-arm randomized controlled trial. Eur J Orthod. 2024;46:cjad056."},{"key":"i1945-7103-96-3-271-b10","series-title":"APOS Trends Orthod","first-page":"1","article-title":"Platelet-rich derivatives for accelerating the rate of orthodontic tooth movement-a systematic review and meta-analysis","volume":"21","author":"Katyal","year":"2022","unstructured":"Katyal D,\nGeorge AM,\nJain RK,\nBalasubramaniam A,\nSrirengalakshmi M,\nVaid NR. Platelet-rich derivatives for accelerating the rate of orthodontic tooth movement-a systematic review and meta-analysis. APOS Trends Orthod. 2022;21:1\u201312."},{"key":"i1945-7103-96-3-271-b11","series-title":"J World Fed Orthod","first-page":"229","article-title":"Evaluating the efficacy of platelet-rich plasma on orthodontic tooth movement rate: a systematic review and meta-analysis","volume":"13","author":"Jaiswal","year":"2024","unstructured":"Jaiswal A,\nAngel LS,\nSennimalai K, et al. Evaluating the efficacy of platelet-rich plasma on orthodontic tooth movement rate: a systematic review and meta-analysis. J World Fed Orthod. 2024;13:229\u2013239."},{"key":"i1945-7103-96-3-271-b12","series-title":"Clin Oral Investig","first-page":"2619","article-title":"Injectable platelet rich fibrin (i-PRF): opportunities in regenerative dentistry","volume":"21","author":"Miron","year":"2017","unstructured":"Miron RJ,\nFujioka-Kobayashi M,\nHernandez M, et al. Injectable platelet rich fibrin (i-PRF): opportunities in regenerative dentistry? Clin Oral Investig. 2017;21:2619\u20132627."},{"key":"i1945-7103-96-3-271-b13","series-title":"J Orofac Orthop","first-page":"181","article-title":"Root resorption due to orthodontic treatment using self-ligating and conventional brackets","volume":"79","author":"Aras","year":"2018","unstructured":"Aras I,\nUnal I,\nHuniler G,\nAras A. Root resorption due to orthodontic treatment using self-ligating and conventional brackets. J Orofac Orthop. 2018;79:181\u2013190."},{"key":"i1945-7103-96-3-271-b14","series-title":"Orthod Craniofac Res","first-page":"206","article-title":"Accuracy of volumetric measurement of teeth in vivo based on cone beam computer tomography","volume":"14","author":"Wang","year":"2011","unstructured":"Wang Y,\nHe S,\nYu L,\nLi J,\nChen S. Accuracy of volumetric measurement of teeth in vivo based on cone beam computer tomography. Orthod Craniofac Res. 2011;14:206\u2013212."},{"key":"i1945-7103-96-3-271-b15","series-title":"Angle Orthod","first-page":"480","article-title":"Apical root resorption during orthodontic treatment. A prospective study using cone beam CT","volume":"82","author":"Lund","year":"2012","unstructured":"Lund H,\nGr\u00f6ndahl K,\nHansen K,\nGr\u00f6ndahl HG. Apical root resorption during orthodontic treatment. A prospective study using cone beam CT. Angle Orthod. 2012;82:480\u2013487."},{"key":"i1945-7103-96-3-271-b16","series-title":"Am J Orthod Dentofacial Orthop","first-page":"348","article-title":"Root resorptions associated with canine retraction treatment","volume":"152","author":"Jiang","year":"2017","unstructured":"Jiang F,\nChen J,\nKula K,\nGu H,\nDu Y,\nEckert G. Root resorptions associated with canine retraction treatment. Am J Orthod Dentofacial Orthop. 2017;152:348\u2013354."},{"key":"i1945-7103-96-3-271-b17","series-title":"Prog Orthod","first-page":"1","article-title":"Prevalence and severity of apical root resorption during orthodontic treatment with clear aligners and fixed appliances: a cone beam computed tomography study","volume":"21","author":"Li","year":"2020","unstructured":"Li Y,\nDeng S,\nMei L, et al. Prevalence and severity of apical root resorption during orthodontic treatment with clear aligners and fixed appliances: a cone beam computed tomography study. Prog Orthod. 2020;21:1\u20138."},{"key":"i1945-7103-96-3-271-b18","series-title":"BMC Oral Health","first-page":"92","article-title":"Three-dimensional evaluation of the effects of injectable platelet rich fibrin (i-PRF) on alveolar bone and root length during orthodontic treatment: a randomized split mouth trial","volume":"21","author":"Zeitounlouian","year":"2021","unstructured":"Zeitounlouian TS,\nZeno KG,\nBrad BA,\nHaddad RA. Three-dimensional evaluation of the effects of injectable platelet rich fibrin (i-PRF) on alveolar bone and root length during orthodontic treatment: a randomized split mouth trial. BMC Oral Health. 2021;21:92."},{"key":"i1945-7103-96-3-271-b19","series-title":"Am J Orthod Dentofacial Orthop","first-page":"20","article-title":"Duration of tooth alignment with fixed appliances: a systematic review and meta-analysis","volume":"161","author":"Wazwaz","year":"2022","unstructured":"Wazwaz F,\nSeehra J,\nCarpenter GH,\nIreland AJ,\nPapageorgiou SN,\nCobourne MT. Duration of tooth alignment with fixed appliances: a systematic review and meta-analysis. Am J Orthod Dentofacial Orthop. 2022;161:20\u201336."},{"key":"i1945-7103-96-3-271-b01","series-title":"Eur J Trauma Emerg Surg","first-page":"87","article-title":"Reduction of relative centrifugation force within injectable platelet-rich-fibrin (PRF) concentrates advances patients\u2019 own inflammatory cells, platelets and growth factors: the first introduction to the low speed centrifugation concept","volume":"44","author":"Choukroun","year":"2018","unstructured":"Choukroun J,\nGhanaati S. Reduction of relative centrifugation force within injectable platelet-rich-fibrin (PRF) concentrates advances patients\u2019 own inflammatory cells, platelets and growth factors: the first introduction to the low speed centrifugation concept. Eur J Trauma Emerg Surg. 2018;44:87\u201395."},{"key":"i1945-7103-96-3-271-b02","series-title":"Clin Oral Investig","first-page":"1309","article-title":"Injectable platelet rich fibrin: cell content, morphological, and protein characterization","volume":"23","author":"Varela","year":"2019","unstructured":"Varela HA,\nSouza JCM,\nNascimento RM, et al. Injectable platelet rich fibrin: cell content, morphological, and protein characterization. Clin Oral Investig. 2019;23:1309\u20131318."},{"key":"i1945-7103-96-3-271-b03","series-title":"Clin Oral Investig","first-page":"2353","article-title":"Comparative release of growth factors from PRP, PRF, and advanced-PRF","volume":"20","author":"Kobayashi","year":"2016","unstructured":"Kobayashi E,\nFl\u00fcckiger L,\nFujioka-Kobayashi M, et al. Comparative release of growth factors from PRP, PRF, and advanced-PRF. Clin Oral Investig. 2016;20:2353\u20132360."},{"key":"i1945-7103-96-3-271-b04","series-title":"Angle Orthod","first-page":"285","article-title":"Effect of injectable platelet-rich fibrin (i-PRF) on the rate of tooth movement","volume":"91","author":"Erdur","year":"2021","unstructured":"Erdur EA,\nKarakasli K,\nOncu E,\nOzturk B,\nHakk\u0131 S. Effect of injectable platelet-rich fibrin (i-PRF) on the rate of tooth movement. Angle Orthod. 2021;91:285\u2013292."},{"key":"i1945-7103-96-3-271-b05","series-title":"Angle Orthod","first-page":"213","article-title":"The effect of platelet-rich fibrin (PRF) on maxillary incisor retraction rate","volume":"91","author":"Karakasli","year":"2021","unstructured":"Karakasli K,\nErdur EA. The effect of platelet-rich fibrin (PRF) on maxillary incisor retraction rate. Angle Orthod. 2021;91:213\u2013219."},{"key":"i1945-7103-96-3-271-b06","series-title":"J Orofac Orthop","first-page":"268","article-title":"Effect of injectable platelet-rich fibrin (i-PRF) in accelerating orthodontic tooth movement: a randomized split-mouth-controlled trial","volume":"82","author":"Zeitounlouian","year":"2021","unstructured":"Zeitounlouian TS,\nZeno KG,\nBrad BA,\nHaddad RA. Effect of injectable platelet-rich fibrin (i-PRF) in accelerating orthodontic tooth movement: a randomized split-mouth-controlled trial. J Orofac Orthop. 2021;82:268\u2013277."},{"key":"i1945-7103-96-3-271-b07","series-title":"Am J Orthod Dentofacial Orthop","first-page":"735","article-title":"Evaluation of injectable platelet-rich fibrin effect on the rate of canine retraction and alkaline phosphatase levels: an in-vivo study","volume":"162","author":"Gupta","year":"2022","unstructured":"Gupta P,\nBhagyalakshmi A,\nAvinash BS,\nPrashant A,\nRaghunath N. Evaluation of injectable platelet-rich fibrin effect on the rate of canine retraction and alkaline phosphatase levels: an in-vivo study. Am J Orthod Dentofacial Orthop. 2022;162:735\u2013743."},{"key":"i1945-7103-96-3-271-b08","series-title":"Am J Orthod Dentofacial Orthop","first-page":"e28","article-title":"Effect of platelet-rich plasma on the rate of orthodontic tooth movement","volume":"162","author":"Chandak","year":"2022","unstructured":"Chandak S,\nPatil AS. Effect of platelet-rich plasma on the rate of orthodontic tooth movement. Am J Orthod Dentofacial Orthop. 2022;162:e28\u2013e34."},{"key":"i1945-7103-96-3-271-b09","series-title":"Eur J Orthod","first-page":"cjad056","article-title":"Evaluation of the effectiveness of the platelet-rich plasma compared to the injectable platelet-rich fibrin on the rate of maxillary canine retraction: a three-arm randomized controlled trial","volume":"46","author":"Ammar","year":"2024","unstructured":"Ammar AM,\nAl-Sabbagh R,\nHajeer MY. Evaluation of the effectiveness of the platelet-rich plasma compared to the injectable platelet-rich fibrin on the rate of maxillary canine retraction: a three-arm randomized controlled trial. Eur J Orthod. 2024;46:cjad056."},{"key":"i1945-7103-96-3-271-b10","series-title":"APOS Trends Orthod","first-page":"1","article-title":"Platelet-rich derivatives for accelerating the rate of orthodontic tooth movement-a systematic review and meta-analysis","volume":"21","author":"Katyal","year":"2022","unstructured":"Katyal D,\nGeorge AM,\nJain RK,\nBalasubramaniam A,\nSrirengalakshmi M,\nVaid NR. Platelet-rich derivatives for accelerating the rate of orthodontic tooth movement-a systematic review and meta-analysis. APOS Trends Orthod. 2022;21:1\u201312."},{"key":"i1945-7103-96-3-271-b11","series-title":"J World Fed Orthod","first-page":"229","article-title":"Evaluating the efficacy of platelet-rich plasma on orthodontic tooth movement rate: a systematic review and meta-analysis","volume":"13","author":"Jaiswal","year":"2024","unstructured":"Jaiswal A,\nAngel LS,\nSennimalai K, et al. Evaluating the efficacy of platelet-rich plasma on orthodontic tooth movement rate: a systematic review and meta-analysis. J World Fed Orthod. 2024;13:229\u2013239."},{"key":"i1945-7103-96-3-271-b12","series-title":"Clin Oral Investig","first-page":"2619","article-title":"Injectable platelet rich fibrin (i-PRF): opportunities in regenerative dentistry","volume":"21","author":"Miron","year":"2017","unstructured":"Miron RJ,\nFujioka-Kobayashi M,\nHernandez M, et al. Injectable platelet rich fibrin (i-PRF): opportunities in regenerative dentistry? Clin Oral Investig. 2017;21:2619\u20132627."},{"key":"i1945-7103-96-3-271-b13","series-title":"J Orofac Orthop","first-page":"181","article-title":"Root resorption due to orthodontic treatment using self-ligating and conventional brackets","volume":"79","author":"Aras","year":"2018","unstructured":"Aras I,\nUnal I,\nHuniler G,\nAras A. Root resorption due to orthodontic treatment using self-ligating and conventional brackets. J Orofac Orthop. 2018;79:181\u2013190."},{"key":"i1945-7103-96-3-271-b14","series-title":"Orthod Craniofac Res","first-page":"206","article-title":"Accuracy of volumetric measurement of teeth in vivo based on cone beam computer tomography","volume":"14","author":"Wang","year":"2011","unstructured":"Wang Y,\nHe S,\nYu L,\nLi J,\nChen S. Accuracy of volumetric measurement of teeth in vivo based on cone beam computer tomography. Orthod Craniofac Res. 2011;14:206\u2013212."},{"key":"i1945-7103-96-3-271-b15","series-title":"Angle Orthod","first-page":"480","article-title":"Apical root resorption during orthodontic treatment. A prospective study using cone beam CT","volume":"82","author":"Lund","year":"2012","unstructured":"Lund H,\nGr\u00f6ndahl K,\nHansen K,\nGr\u00f6ndahl HG. Apical root resorption during orthodontic treatment. A prospective study using cone beam CT. Angle Orthod. 2012;82:480\u2013487."},{"key":"i1945-7103-96-3-271-b16","series-title":"Am J Orthod Dentofacial Orthop","first-page":"348","article-title":"Root resorptions associated with canine retraction treatment","volume":"152","author":"Jiang","year":"2017","unstructured":"Jiang F,\nChen J,\nKula K,\nGu H,\nDu Y,\nEckert G. Root resorptions associated with canine retraction treatment. Am J Orthod Dentofacial Orthop. 2017;152:348\u2013354."},{"key":"i1945-7103-96-3-271-b17","series-title":"Prog Orthod","first-page":"1","article-title":"Prevalence and severity of apical root resorption during orthodontic treatment with clear aligners and fixed appliances: a cone beam computed tomography study","volume":"21","author":"Li","year":"2020","unstructured":"Li Y,\nDeng S,\nMei L, et al. Prevalence and severity of apical root resorption during orthodontic treatment with clear aligners and fixed appliances: a cone beam computed tomography study. Prog Orthod. 2020;21:1\u20138."},{"key":"i1945-7103-96-3-271-b18","series-title":"BMC Oral Health","first-page":"92","article-title":"Three-dimensional evaluation of the effects of injectable platelet rich fibrin (i-PRF) on alveolar bone and root length during orthodontic treatment: a randomized split mouth trial","volume":"21","author":"Zeitounlouian","year":"2021","unstructured":"Zeitounlouian TS,\nZeno KG,\nBrad BA,\nHaddad RA. Three-dimensional evaluation of the effects of injectable platelet rich fibrin (i-PRF) on alveolar bone and root length during orthodontic treatment: a randomized split mouth trial. BMC Oral Health. 2021;21:92."},{"key":"i1945-7103-96-3-271-b19","series-title":"Am J Orthod Dentofacial Orthop","first-page":"20","article-title":"Duration of tooth alignment with fixed appliances: a systematic review and meta-analysis","volume":"161","author":"Wazwaz","year":"2022","unstructured":"Wazwaz F,\nSeehra J,\nCarpenter GH,\nIreland AJ,\nPapageorgiou SN,\nCobourne MT. Duration of tooth alignment with fixed appliances: a systematic review and meta-analysis. 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