{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T15:05:11Z","timestamp":1780067111425,"version":"3.54.0"},"reference-count":54,"publisher":"The Angle Orthodontist (EH Angle Education & Research Foundation)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To compare the effects of injectable platelet-rich fibrin (I-PRF) and low-level laser therapy (LLLT) on the rate and pattern of orthodontic tooth movement, including canine angulation and rotation during en-masse retraction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      A single-center, single-blind, split-mouth randomized controlled trial was conducted in 33 female patients with Class I bimaxillary protrusion. Patients were assigned into three clusters: I-PRF vs control, LLLT vs control, and I-PRF vs LLLT. After premolar extraction and initial alignment, en-masse retraction was initiated using 150g force nickel-titanium coil springs. I-PRF (0.5 mL\/site) was administered at T0 and T1 (2 weeks). LLLT (650 nm, 8 J\/cm\n                      <jats:sup>2<\/jats:sup>\n                      , 100 mW Ga-Al-Ar diode laser) was applied at T0, T2 (4 weeks), and T3 (8 weeks). Control sites received no intervention. Digital study models were obtained at T1 (2 weeks), T2 (4 weeks), T3 (8 weeks), and T4 (12 weeks) to measure space closure and canine rotation. canine angulation was assessed on orthopantomograms at T0 and T4. Data were analyzed using mixed-design analysis of variance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both I-PRF and LLLT significantly enhanced space closure compared to control (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .001). LLLT showed the greatest retraction (3.02 \u00b1 0.24 mm), followed by I-PRF (2.82 \u00b1 0.27 mm) and control (1.99 \u00b1 0.42 mm). Group differences were large (\u03b7\n                      <jats:sup>2<\/jats:sup>\n                      p = 0.62), and time \u00d7 group interactions were moderate. Anchorage loss was higher in both intervention groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Both adjuncts accelerated en-masse retraction effectively, with LLLT demonstrating a modest but sustained clinical advantage over I-PRF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2319\/050225-348.1","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:51:53Z","timestamp":1770771113000},"page":"278-286","source":"Crossref","is-referenced-by-count":0,"title":["A three-arm parallel split-mouth randomized controlled trial comparing injectable platelet-rich fibrin and low-level laser therapy on the rate of orthodontic tooth movement and canine angulation during en-masse retraction"],"prefix":"10.2319","volume":"96","author":[{"given":"Shibitha","family":"Balakrishnan","sequence":"first","affiliation":[{"name":"Senior Lecturer, Department of Orthodontics, Malabar Dental College and Research Centre, Edappal, Malappuram, Kerala, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divya","family":"Ravuru","sequence":"additional","affiliation":[{"name":"Senior Lecturer, Department of Orthodontics, Oxford Dental College, Bangalore, Karnataka, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gowri Sankar","family":"Singaraju","sequence":"additional","affiliation":[{"name":"Professor, Department of Orthodontics, Narayana Dental College, Nellore, Andhra Pradesh, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek Reddy","family":"Ganugapanta","sequence":"additional","affiliation":[{"name":"Professor, Department of Orthodontics, Narayana Dental College, Nellore, Andhra Pradesh, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnson","family":"Perala","sequence":"additional","affiliation":[{"name":"Senior Lecturer, Department of Orthodontics, Narayana Dental College, Nellore, Andhra Pradesh, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasad","family":"Mandava","sequence":"additional","affiliation":[{"name":"Professor and Head, Department of Orthodontics, Narayana Dental College, Nellore, Andhra Pradesh, India."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1164","reference":[{"issue":"2","key":"i1945-7103-96-3-278-b01","series-title":"Angle Orthod","first-page":"213","article-title":"The effect of platelet-rich fibrin (PRF) on maxillary incisor retraction rate","volume":"91","author":"Karakasli","year":"2021","unstructured":"Karakasli K,\nErdur EA. The effect of platelet-rich fibrin (PRF) on maxillary incisor retraction rate. Angle Orthod. 2021;91(2):213\u2013219."},{"issue":"1","key":"i1945-7103-96-3-278-b02","series-title":"Am J Orthod Dentofacial Orthop","first-page":"29","article-title":"Assessment of the effects of local platelet-rich fibrin injection and piezocision on orthodontic tooth movement during canine distalization","volume":"160","author":"\u00c7a\u011fl\u0131 Karc\u0131","year":"2021","unstructured":"\u00c7a\u011fl\u0131 Karc\u0131 \u0130,\nBaka ZM. Assessment of the effects of local platelet-rich fibrin injection and piezocision on orthodontic tooth movement during canine distalization. Am J Orthod Dentofacial Orthop. 2021;160(1):29\u201340."},{"issue":"6","key":"i1945-7103-96-3-278-b03","series-title":"J Appl Oral Sci","first-page":"522","article-title":"Efficiency of class I and class II malocclusion treatment with four premolar extractions","volume":"22","author":"Janson","year":"2014","unstructured":"Janson G,\nNakamura A,\nBarros SE,\nBombonatti R,\nChiqueto K. Efficiency of class I and class II malocclusion treatment with four premolar extractions. J Appl Oral Sci. 2014;22(6):522\u2013527."},{"issue":"1","key":"i1945-7103-96-3-278-b04","series-title":"J Orthod","first-page":"31","article-title":"A randomized clinical trial to compare three methods of orthodontic space closure","volume":"29","author":"Dixon","year":"2002","unstructured":"Dixon V,\nRead MJF,\nO\u2019Brien KD,\nWorthington HV,\nMandall NA. A randomized clinical trial to compare three methods of orthodontic space closure. J Orthod. 2002; 29(1):31\u201336."},{"issue":"5","key":"i1945-7103-96-3-278-b05","series-title":"Am J Orthod Dentofacial Orthop","first-page":"735","article-title":"Evaluation of injectable platelet-rich fibrin effect on the rate of canine retraction and alkaline phosphatase levels: an in-vivo study","volume":"162","author":"Gupta","year":"2022","unstructured":"Gupta P,\nBhagyalakshmi A,\nAvinash BS,\nPrashant A,\nRaghunath N. Evaluation of injectable platelet-rich fibrin effect on the rate of canine retraction and alkaline phosphatase levels: an in-vivo study. Am J Orthod Dentofacial Orthop. 2022;162(5):735\u2013743."},{"issue":"2","key":"i1945-7103-96-3-278-b06","series-title":"Semin Orthod","first-page":"172","article-title":"Accelerated orthodontics (AO): The past, present and the future","volume":"30","author":"Gandedkar","year":"2024","unstructured":"Gandedkar NH,\nDalci O,\nDarendeliler MA. Accelerated orthodontics (AO): The past, present and the future. Semin Orthod. 2024;30(2):172\u2013182."},{"issue":"3","key":"i1945-7103-96-3-278-b07","series-title":"APOS Trends Orthod","first-page":"202","article-title":"Platelet-rich derivatives for accelerating the rate of orthodontic tooth movement - a systematic review and meta-analysis","volume":"12","author":"Katyal","year":"2022","unstructured":"Katyal D,\nGeorge AM,\nJain RK,\nBalasubramaniam A,\nSrirengalakshmi M,\nVaid NR. Platelet-rich derivatives for accelerating the rate of orthodontic tooth movement - a systematic review and meta-analysis. APOS Trends Orthod. 2022;12(3):202\u2013213."},{"issue":"1","key":"i1945-7103-96-3-278-b08","series-title":"Platelets","first-page":"48","article-title":"Effects of an injectable platelet-rich fibrin on osteoblast behavior and bone tissue formation in comparison to platelet-rich plasma","volume":"29","author":"Wang","year":"2018","unstructured":"Wang X,\nZhang Y,\nChoukroun J,\nGhanaati S,\nMiron RJ. Effects of an injectable platelet-rich fibrin on osteoblast behavior and bone tissue formation in comparison to platelet-rich plasma. Platelets. 2018;29(1):48\u201355."},{"issue":"3","key":"i1945-7103-96-3-278-b09","series-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod","first-page":"e37\u201344","article-title":"Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution","volume":"101","author":"Dohan","year":"2006","unstructured":"Dohan DM,\nChoukroun J,\nDiss A, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101(3):e37\u201344."},{"issue":"1","key":"i1945-7103-96-3-278-b10","series-title":"Immun Ageing","first-page":"23","article-title":"Platelet-rich plasma (PRP) in dental and oral surgery: from the wound healing to bone regeneration","volume":"10","author":"Albanese","year":"2013","unstructured":"Albanese A,\nLicata ME,\nPolizzi B,\nCampisi G. Platelet-rich plasma (PRP) in dental and oral surgery: from the wound healing to bone regeneration. Immun Ageing. 2013;10(1):23."},{"issue":"1","key":"i1945-7103-96-3-278-b11","series-title":"BMC Oral Health","first-page":"92","article-title":"Three-dimensional evaluation of the effects of injectable platelet rich fibrin (i-PRF) on alveolar bone and root length during orthodontic treatment: a randomized split mouth trial","volume":"21","author":"Zeitounlouian","year":"2021","unstructured":"Zeitounlouian TS,\nZeno KG,\nBrad BA,\nHaddad RA. Three-dimensional evaluation of the effects of injectable platelet rich fibrin (i-PRF) on alveolar bone and root length during orthodontic treatment: a randomized split mouth trial. BMC Oral Health. 2021;21(1):92."},{"issue":"3","key":"i1945-7103-96-3-278-b12","series-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod","first-page":"e56\u201360","article-title":"Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part IV: clinical effects on tissue healing","volume":"101","author":"Choukroun","year":"2006","unstructured":"Choukroun J,\nDiss A,\nSimonpieri A, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part IV: clinical effects on tissue healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101(3):e56\u201360."},{"issue":"1","key":"i1945-7103-96-3-278-b13","series-title":"Am J Orthod Dentofacial Orthop","first-page":"87","article-title":"Effects of low-level laser therapy and mechanical vibration on orthodontic pain caused by initial archwire","volume":"156","author":"Celebi","year":"2019","unstructured":"Celebi F,\nTurk T,\nBicakci AA. Effects of low-level laser therapy and mechanical vibration on orthodontic pain caused by initial archwire. Am J Orthod Dentofacial Orthop. 2019;156(1):87\u201393."},{"key":"i1945-7103-96-3-278-b14","series-title":"Pain Res Manag","first-page":"6271835","article-title":"Laser-assisted orthodontic tooth movement in Saudi population: a prospective clinical intervention of low-level laser therapy in the 1st week of pain perception in four treatment modalities","volume":"2019","author":"Alam","year":"2019","unstructured":"Alam MK. Laser-assisted orthodontic tooth movement in Saudi population: a prospective clinical intervention of low-level laser therapy in the 1st week of pain perception in four treatment modalities. Pain Res Manag. 2019;2019:6271835."},{"issue":"3","key":"i1945-7103-96-3-278-b15","series-title":"Orthod Craniofac Res","first-page":"143","article-title":"Low-energy laser stimulates tooth movement velocity via expression of RANK and RANKL","volume":"11","author":"Fujita","year":"2008","unstructured":"Fujita S,\nYamaguchi M,\nUtsunomiya T,\nYamamoto H,\nKasai K. Low-energy laser stimulates tooth movement velocity via expression of RANK and RANKL. Orthod Craniofac Res. 2008;11(3):143\u2013155."},{"issue":"4","key":"i1945-7103-96-3-278-b16","series-title":"Am J Orthod Dentofacial Orthop","first-page":"535","article-title":"Low-level laser therapy increases interleukin-1\u03b2 in gingival crevicular fluid and enhances the rate of orthodontic tooth movement","volume":"154","author":"Varella","year":"2018","unstructured":"Varella AM,\nRevankar AV,\nPatil AK. Low-level laser therapy increases interleukin-1\u03b2 in gingival crevicular fluid and enhances the rate of orthodontic tooth movement. Am J Orthod Dentofacial Orthop. 2018;154(4):535\u2013544.e5."},{"issue":"1","key":"i1945-7103-96-3-278-b17","series-title":"Am J Orthod Dentofacial Orthop","first-page":"146","article-title":"Sample-size calculation for repeated-measures and longitudinal studies","volume":"147","author":"Guo","year":"2015","unstructured":"Guo Y,\nPandis N. Sample-size calculation for repeated-measures and longitudinal studies. Am J Orthod Dentofacial Orthop. 2015;147(1):146\u2013149."},{"issue":"6","key":"i1945-7103-96-3-278-b18","series-title":"Am J Orthod Dentofacial Orthop","first-page":"818","article-title":"Sample calculation for split-mouth designs","volume":"141","author":"Pandis","year":"2012","unstructured":"Pandis N. Sample calculation for split-mouth designs. Am J Orthod Dentofacial Orthop. 2012;141(6):818\u2013819."},{"issue":"5","key":"i1945-7103-96-3-278-b19","series-title":"Am J Orthod","first-page":"554","article-title":"The Irregularity Index: a quantitative score of mandibular anterior alignment","volume":"68","author":"Little","year":"1975","unstructured":"Little RM. The Irregularity Index: a quantitative score of mandibular anterior alignment. Am J Orthod. 1975;68(5):554\u2013563."},{"issue":"3","key":"i1945-7103-96-3-278-b20","series-title":"Angle Orthod","first-page":"285","article-title":"Effect of injectable platelet-rich fibrin (i-PRF) on the rate of tooth movement","volume":"91","author":"Erdur","year":"2021","unstructured":"Erdur EA,\nKarakasl\u0131 K,\nOncu E,\nOzturk B,\nHakk\u0131 S. Effect of injectable platelet-rich fibrin (i-PRF) on the rate of tooth movement. Angle Orthod. 2021;91(3):285\u2013292."},{"issue":"4","key":"i1945-7103-96-3-278-b21","series-title":"J Orofac Orthop","first-page":"268","article-title":"Effect of injectable platelet-rich fibrin (i-PRF) in accelerating orthodontic tooth movement: a randomized split-mouth-controlled trial","volume":"82","author":"Zeitounlouian","year":"2021","unstructured":"Zeitounlouian TS,\nZeno KG,\nBrad BA,\nHaddad RA. Effect of injectable platelet-rich fibrin (i-PRF) in accelerating orthodontic tooth movement: a randomized split-mouth-controlled trial. J Orofac Orthop. 2021;82(4):268\u2013277."},{"issue":"6","key":"i1945-7103-96-3-278-b22","series-title":"Eur J Orthod","first-page":"783","article-title":"Split-mouth designs in orthodontics: an overview with applications to orthodontic clinical trials","volume":"35","author":"Pandis","year":"2013","unstructured":"Pandis N,\nWalsh T,\nPolychronopoulou A,\nKatsaros C,\nEliades T. Split-mouth designs in orthodontics: an overview with applications to orthodontic clinical trials. Eur J Orthod. 2013;35(6):783\u2013789."},{"issue":"1","key":"i1945-7103-96-3-278-b23","series-title":"BMC Oral Health","first-page":"324","article-title":"Clinical research: low-level laser therapy in accelerating orthodontic tooth movement","volume":"21","author":"Zheng","year":"2021","unstructured":"Zheng J,\nYang K. Clinical research: low-level laser therapy in accelerating orthodontic tooth movement. BMC Oral Health. 2021;21(1):324."},{"issue":"2","key":"i1945-7103-96-3-278-b24","series-title":"J Orofac Orthop","first-page":"110","article-title":"Low-level laser therapy, piezocision, or their combination vs. conventional treatment for orthodontic tooth movement: a hierarchical 6-arm split-mouth randomized clinical trial","volume":"85","author":"Moradinejad","year":"2024","unstructured":"Moradinejad M,\nChaharmahali R,\nShamohammadi M,\nMir M,\nRakhshan V. Low-level laser therapy, piezocision, or their combination vs. conventional treatment for orthodontic tooth movement: a hierarchical 6-arm split-mouth randomized clinical trial. J Orofac Orthop. 2024;85(2):110\u2013122."},{"issue":"4","key":"i1945-7103-96-3-278-b25","series-title":"Am J Orthod Dentofacial Orthop","first-page":"444","article-title":"The effects of a clinically feasible application of low-level laser therapy on the rate of orthodontic tooth movement: A triple-blind, split-mouth, randomized controlled trial","volume":"157","author":"Mistry","year":"2020","unstructured":"Mistry D,\nDalci O,\nPapageorgiou SN,\nDarendeliler MA,\nPapadopoulou AK. The effects of a clinically feasible application of low-level laser therapy on the rate of orthodontic tooth movement: A triple-blind, split-mouth, randomized controlled trial. Am J Orthod Dentofacial Orthop. 2020;157(4):444\u2013453."},{"issue":"3","key":"i1945-7103-96-3-278-b26","series-title":"Angle Orthod","first-page":"354","article-title":"Effect of platelet-rich plasma on the rate of orthodontic tooth movement","volume":"90","author":"El-Timamy","year":"2020","unstructured":"El-Timamy A,\nEl Sharaby F,\nEid F,\nEl Dakroury A,\nMostafa Y,\nShaker O. Effect of platelet-rich plasma on the rate of orthodontic tooth movement. Angle Orthod. 2020;90(3):354\u2013361."},{"issue":"1","key":"i1945-7103-96-3-278-b27","series-title":"Angle Orthod","first-page":"73","article-title":"Effects of submucosally administered platelet-rich plasma on the rate of tooth movement","volume":"92","author":"Angel","year":"2022","unstructured":"Angel SL,\nSamrit VD,\nKharbanda OP, et al. Effects of submucosally administered platelet-rich plasma on the rate of tooth movement. Angle Orthod. 2022;92(1):73\u201379."},{"issue":"2","key":"i1945-7103-96-3-278-b01","series-title":"Angle Orthod","first-page":"213","article-title":"The effect of platelet-rich fibrin (PRF) on maxillary incisor retraction rate","volume":"91","author":"Karakasli","year":"2021","unstructured":"Karakasli K,\nErdur EA. The effect of platelet-rich fibrin (PRF) on maxillary incisor retraction rate. Angle Orthod. 2021;91(2):213\u2013219."},{"issue":"1","key":"i1945-7103-96-3-278-b02","series-title":"Am J Orthod Dentofacial Orthop","first-page":"29","article-title":"Assessment of the effects of local platelet-rich fibrin injection and piezocision on orthodontic tooth movement during canine distalization","volume":"160","author":"\u00c7a\u011fl\u0131 Karc\u0131","year":"2021","unstructured":"\u00c7a\u011fl\u0131 Karc\u0131 \u0130,\nBaka ZM. Assessment of the effects of local platelet-rich fibrin injection and piezocision on orthodontic tooth movement during canine distalization. Am J Orthod Dentofacial Orthop. 2021;160(1):29\u201340."},{"issue":"6","key":"i1945-7103-96-3-278-b03","series-title":"J Appl Oral Sci","first-page":"522","article-title":"Efficiency of class I and class II malocclusion treatment with four premolar extractions","volume":"22","author":"Janson","year":"2014","unstructured":"Janson G,\nNakamura A,\nBarros SE,\nBombonatti R,\nChiqueto K. Efficiency of class I and class II malocclusion treatment with four premolar extractions. J Appl Oral Sci. 2014;22(6):522\u2013527."},{"issue":"1","key":"i1945-7103-96-3-278-b04","series-title":"J Orthod","first-page":"31","article-title":"A randomized clinical trial to compare three methods of orthodontic space closure","volume":"29","author":"Dixon","year":"2002","unstructured":"Dixon V,\nRead MJF,\nO\u2019Brien KD,\nWorthington HV,\nMandall NA. A randomized clinical trial to compare three methods of orthodontic space closure. J Orthod. 2002; 29(1):31\u201336."},{"issue":"5","key":"i1945-7103-96-3-278-b05","series-title":"Am J Orthod Dentofacial Orthop","first-page":"735","article-title":"Evaluation of injectable platelet-rich fibrin effect on the rate of canine retraction and alkaline phosphatase levels: an in-vivo study","volume":"162","author":"Gupta","year":"2022","unstructured":"Gupta P,\nBhagyalakshmi A,\nAvinash BS,\nPrashant A,\nRaghunath N. Evaluation of injectable platelet-rich fibrin effect on the rate of canine retraction and alkaline phosphatase levels: an in-vivo study. Am J Orthod Dentofacial Orthop. 2022;162(5):735\u2013743."},{"issue":"2","key":"i1945-7103-96-3-278-b06","series-title":"Semin Orthod","first-page":"172","article-title":"Accelerated orthodontics (AO): The past, present and the future","volume":"30","author":"Gandedkar","year":"2024","unstructured":"Gandedkar NH,\nDalci O,\nDarendeliler MA. Accelerated orthodontics (AO): The past, present and the future. Semin Orthod. 2024;30(2):172\u2013182."},{"issue":"3","key":"i1945-7103-96-3-278-b07","series-title":"APOS Trends Orthod","first-page":"202","article-title":"Platelet-rich derivatives for accelerating the rate of orthodontic tooth movement - a systematic review and meta-analysis","volume":"12","author":"Katyal","year":"2022","unstructured":"Katyal D,\nGeorge AM,\nJain RK,\nBalasubramaniam A,\nSrirengalakshmi M,\nVaid NR. Platelet-rich derivatives for accelerating the rate of orthodontic tooth movement - a systematic review and meta-analysis. APOS Trends Orthod. 2022;12(3):202\u2013213."},{"issue":"1","key":"i1945-7103-96-3-278-b08","series-title":"Platelets","first-page":"48","article-title":"Effects of an injectable platelet-rich fibrin on osteoblast behavior and bone tissue formation in comparison to platelet-rich plasma","volume":"29","author":"Wang","year":"2018","unstructured":"Wang X,\nZhang Y,\nChoukroun J,\nGhanaati S,\nMiron RJ. Effects of an injectable platelet-rich fibrin on osteoblast behavior and bone tissue formation in comparison to platelet-rich plasma. Platelets. 2018;29(1):48\u201355."},{"issue":"3","key":"i1945-7103-96-3-278-b09","series-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod","first-page":"e37\u201344","article-title":"Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution","volume":"101","author":"Dohan","year":"2006","unstructured":"Dohan DM,\nChoukroun J,\nDiss A, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101(3):e37\u201344."},{"issue":"1","key":"i1945-7103-96-3-278-b10","series-title":"Immun Ageing","first-page":"23","article-title":"Platelet-rich plasma (PRP) in dental and oral surgery: from the wound healing to bone regeneration","volume":"10","author":"Albanese","year":"2013","unstructured":"Albanese A,\nLicata ME,\nPolizzi B,\nCampisi G. Platelet-rich plasma (PRP) in dental and oral surgery: from the wound healing to bone regeneration. Immun Ageing. 2013;10(1):23."},{"issue":"1","key":"i1945-7103-96-3-278-b11","series-title":"BMC Oral Health","first-page":"92","article-title":"Three-dimensional evaluation of the effects of injectable platelet rich fibrin (i-PRF) on alveolar bone and root length during orthodontic treatment: a randomized split mouth trial","volume":"21","author":"Zeitounlouian","year":"2021","unstructured":"Zeitounlouian TS,\nZeno KG,\nBrad BA,\nHaddad RA. Three-dimensional evaluation of the effects of injectable platelet rich fibrin (i-PRF) on alveolar bone and root length during orthodontic treatment: a randomized split mouth trial. BMC Oral Health. 2021;21(1):92."},{"issue":"3","key":"i1945-7103-96-3-278-b12","series-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod","first-page":"e56\u201360","article-title":"Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part IV: clinical effects on tissue healing","volume":"101","author":"Choukroun","year":"2006","unstructured":"Choukroun J,\nDiss A,\nSimonpieri A, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part IV: clinical effects on tissue healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101(3):e56\u201360."},{"issue":"1","key":"i1945-7103-96-3-278-b13","series-title":"Am J Orthod Dentofacial Orthop","first-page":"87","article-title":"Effects of low-level laser therapy and mechanical vibration on orthodontic pain caused by initial archwire","volume":"156","author":"Celebi","year":"2019","unstructured":"Celebi F,\nTurk T,\nBicakci AA. Effects of low-level laser therapy and mechanical vibration on orthodontic pain caused by initial archwire. Am J Orthod Dentofacial Orthop. 2019;156(1):87\u201393."},{"key":"i1945-7103-96-3-278-b14","series-title":"Pain Res Manag","first-page":"6271835","article-title":"Laser-assisted orthodontic tooth movement in Saudi population: a prospective clinical intervention of low-level laser therapy in the 1st week of pain perception in four treatment modalities","volume":"2019","author":"Alam","year":"2019","unstructured":"Alam MK. Laser-assisted orthodontic tooth movement in Saudi population: a prospective clinical intervention of low-level laser therapy in the 1st week of pain perception in four treatment modalities. Pain Res Manag. 2019;2019:6271835."},{"issue":"3","key":"i1945-7103-96-3-278-b15","series-title":"Orthod Craniofac Res","first-page":"143","article-title":"Low-energy laser stimulates tooth movement velocity via expression of RANK and RANKL","volume":"11","author":"Fujita","year":"2008","unstructured":"Fujita S,\nYamaguchi M,\nUtsunomiya T,\nYamamoto H,\nKasai K. Low-energy laser stimulates tooth movement velocity via expression of RANK and RANKL. Orthod Craniofac Res. 2008;11(3):143\u2013155."},{"issue":"4","key":"i1945-7103-96-3-278-b16","series-title":"Am J Orthod Dentofacial Orthop","first-page":"535","article-title":"Low-level laser therapy increases interleukin-1\u03b2 in gingival crevicular fluid and enhances the rate of orthodontic tooth movement","volume":"154","author":"Varella","year":"2018","unstructured":"Varella AM,\nRevankar AV,\nPatil AK. Low-level laser therapy increases interleukin-1\u03b2 in gingival crevicular fluid and enhances the rate of orthodontic tooth movement. Am J Orthod Dentofacial Orthop. 2018;154(4):535\u2013544.e5."},{"issue":"1","key":"i1945-7103-96-3-278-b17","series-title":"Am J Orthod Dentofacial Orthop","first-page":"146","article-title":"Sample-size calculation for repeated-measures and longitudinal studies","volume":"147","author":"Guo","year":"2015","unstructured":"Guo Y,\nPandis N. Sample-size calculation for repeated-measures and longitudinal studies. Am J Orthod Dentofacial Orthop. 2015;147(1):146\u2013149."},{"issue":"6","key":"i1945-7103-96-3-278-b18","series-title":"Am J Orthod Dentofacial Orthop","first-page":"818","article-title":"Sample calculation for split-mouth designs","volume":"141","author":"Pandis","year":"2012","unstructured":"Pandis N. Sample calculation for split-mouth designs. Am J Orthod Dentofacial Orthop. 2012;141(6):818\u2013819."},{"issue":"5","key":"i1945-7103-96-3-278-b19","series-title":"Am J Orthod","first-page":"554","article-title":"The Irregularity Index: a quantitative score of mandibular anterior alignment","volume":"68","author":"Little","year":"1975","unstructured":"Little RM. The Irregularity Index: a quantitative score of mandibular anterior alignment. Am J Orthod. 1975;68(5):554\u2013563."},{"issue":"3","key":"i1945-7103-96-3-278-b20","series-title":"Angle Orthod","first-page":"285","article-title":"Effect of injectable platelet-rich fibrin (i-PRF) on the rate of tooth movement","volume":"91","author":"Erdur","year":"2021","unstructured":"Erdur EA,\nKarakasl\u0131 K,\nOncu E,\nOzturk B,\nHakk\u0131 S. Effect of injectable platelet-rich fibrin (i-PRF) on the rate of tooth movement. Angle Orthod. 2021;91(3):285\u2013292."},{"issue":"4","key":"i1945-7103-96-3-278-b21","series-title":"J Orofac Orthop","first-page":"268","article-title":"Effect of injectable platelet-rich fibrin (i-PRF) in accelerating orthodontic tooth movement: a randomized split-mouth-controlled trial","volume":"82","author":"Zeitounlouian","year":"2021","unstructured":"Zeitounlouian TS,\nZeno KG,\nBrad BA,\nHaddad RA. Effect of injectable platelet-rich fibrin (i-PRF) in accelerating orthodontic tooth movement: a randomized split-mouth-controlled trial. J Orofac Orthop. 2021;82(4):268\u2013277."},{"issue":"6","key":"i1945-7103-96-3-278-b22","series-title":"Eur J Orthod","first-page":"783","article-title":"Split-mouth designs in orthodontics: an overview with applications to orthodontic clinical trials","volume":"35","author":"Pandis","year":"2013","unstructured":"Pandis N,\nWalsh T,\nPolychronopoulou A,\nKatsaros C,\nEliades T. Split-mouth designs in orthodontics: an overview with applications to orthodontic clinical trials. Eur J Orthod. 2013;35(6):783\u2013789."},{"issue":"1","key":"i1945-7103-96-3-278-b23","series-title":"BMC Oral Health","first-page":"324","article-title":"Clinical research: low-level laser therapy in accelerating orthodontic tooth movement","volume":"21","author":"Zheng","year":"2021","unstructured":"Zheng J,\nYang K. Clinical research: low-level laser therapy in accelerating orthodontic tooth movement. BMC Oral Health. 2021;21(1):324."},{"issue":"2","key":"i1945-7103-96-3-278-b24","series-title":"J Orofac Orthop","first-page":"110","article-title":"Low-level laser therapy, piezocision, or their combination vs. conventional treatment for orthodontic tooth movement: a hierarchical 6-arm split-mouth randomized clinical trial","volume":"85","author":"Moradinejad","year":"2024","unstructured":"Moradinejad M,\nChaharmahali R,\nShamohammadi M,\nMir M,\nRakhshan V. Low-level laser therapy, piezocision, or their combination vs. conventional treatment for orthodontic tooth movement: a hierarchical 6-arm split-mouth randomized clinical trial. J Orofac Orthop. 2024;85(2):110\u2013122."},{"issue":"4","key":"i1945-7103-96-3-278-b25","series-title":"Am J Orthod Dentofacial Orthop","first-page":"444","article-title":"The effects of a clinically feasible application of low-level laser therapy on the rate of orthodontic tooth movement: A triple-blind, split-mouth, randomized controlled trial","volume":"157","author":"Mistry","year":"2020","unstructured":"Mistry D,\nDalci O,\nPapageorgiou SN,\nDarendeliler MA,\nPapadopoulou AK. The effects of a clinically feasible application of low-level laser therapy on the rate of orthodontic tooth movement: A triple-blind, split-mouth, randomized controlled trial. Am J Orthod Dentofacial Orthop. 2020;157(4):444\u2013453."},{"issue":"3","key":"i1945-7103-96-3-278-b26","series-title":"Angle Orthod","first-page":"354","article-title":"Effect of platelet-rich plasma on the rate of orthodontic tooth movement","volume":"90","author":"El-Timamy","year":"2020","unstructured":"El-Timamy A,\nEl Sharaby F,\nEid F,\nEl Dakroury A,\nMostafa Y,\nShaker O. Effect of platelet-rich plasma on the rate of orthodontic tooth movement. Angle Orthod. 2020;90(3):354\u2013361."},{"issue":"1","key":"i1945-7103-96-3-278-b27","series-title":"Angle Orthod","first-page":"73","article-title":"Effects of submucosally administered platelet-rich plasma on the rate of tooth movement","volume":"92","author":"Angel","year":"2022","unstructured":"Angel SL,\nSamrit VD,\nKharbanda OP, et al. Effects of submucosally administered platelet-rich plasma on the rate of tooth movement. Angle Orthod. 2022;92(1):73\u201379."}],"container-title":["The Angle Orthodontist"],"original-title":[],"link":[{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/view\/journals\/angl\/96\/3\/article-p278.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/downloadpdf\/journals\/angl\/96\/3\/article-p278.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/downloadpdf\/journals\/angl\/96\/3\/article-p278.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T14:12:17Z","timestamp":1780063937000},"score":1,"resource":{"primary":{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/view\/journals\/angl\/96\/3\/article-p278.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":54,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.2319\/050225-348.1","relation":{},"ISSN":["1945-7103","0003-3219"],"issn-type":[{"value":"1945-7103","type":"electronic"},{"value":"0003-3219","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]}}}