{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T17:02:47Z","timestamp":1792342967441,"version":"4.4.0"},"reference-count":70,"publisher":"The Angle Orthodontist (EH Angle Education & Research Foundation)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec id=\"st1\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To evaluate the efficiency of injectable platelet-rich fibrin (i-PRF) in accelerating canine tooth movement and to examine levels of the matrix metalloproteinase-8 (MMP-8\n                      <jats:bold>)<\/jats:bold>\n                      , interleukin-1\u03b2 (IL-1\u03b2), receptor activator of nuclear factor kappa-light-chain-enhancer of activated B cells ligand (RANKL), and osteoprotegerin (OPG) in the gingival crevicular fluid during orthodontic treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"st2\">\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Twenty patients (mean age = 21.4 \u00b1 2.9 years) with Class II Division 1 malocclusion were included in a split-mouth study. The treatment plan for all patients was extraction of maxillary first premolars followed by canine distalization with closed-coil springs using 150 g of force on each side. The study group received i-PRF two times, with a 2-week interval, on one side of the maxilla. The contralateral side served as the control and did not receive i-PRF. Maxillary canine tooth movement was measured at five time points (T1\u2013T5) on each side. Also, the activity of inflammatory cytokines was evaluated at three time points in the gingival crevicular fluid samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"st3\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There was a significant difference in canine tooth movement between the two groups (\n                      <jats:italic>P &lt;<\/jats:italic>\n                      .001). i-PRF significantly increased the rate of tooth movement, and stimulation in the levels of inflammatory cytokines supported this result (\n                      <jats:italic>P &lt;<\/jats:italic>\n                      .001). The levels of cytokines changed in both groups between T1 and T2. The IL-1\u03b2, MMP8, and RANKL values were significantly increased in the study group compared with the control group, while the OPG values were significantly decreased.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"st4\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>i-PRF-facilitated orthodontics is an effective and safe treatment modality to accelerate tooth movement, and this method can help shorten orthodontic treatment duration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2319\/060320-508.1","type":"journal-article","created":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T12:40:05Z","timestamp":1610973605000},"page":"285-292","source":"Crossref","is-referenced-by-count":44,"title":["Effect of injectable platelet-rich fibrin (i-PRF) on the rate of tooth movement:"],"prefix":"10.2319","volume":"91","author":[{"given":"Emire Aybuke","family":"Erdur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuter","family":"Karakasl\u0131","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elif","family":"Oncu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahad\u0131r","family":"Ozturk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sema","family":"Hakk\u0131","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1164","reference":[{"key":"i0003-3219-91-3-285-b01","series-title":"Am J Orthod Dentofacial Orthop","first-page":"230","article-title":"Factors influencing treatment time in orthodontic patients","volume":"129","author":"Skidmore","year":"2006","unstructured":"Skidmore\n              KJ,\n            \n            \n              Brook\n           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Kandalam\n              U,\n            \n            \n              Zhang\n              Y,\n            \n            \n              Choukroun\n              J\n            .\n\t\t\t\t\t\n          Optimized platelet rich fibrin with the low speed concept: growth factor release, biocompatibility and cellular response.\n\t\t\t\t\tJ Periodontol.\n\t\t\t\t\t2017;\n\t\t\t\t\t88;112\u2013\n\t\t\t\t\t121."},{"key":"i0003-3219-91-3-285-b31","series-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod","first-page":"48","article-title":"Platelet-rich plasma and platelet-rich fibrin in human cell culture","volume":"108","author":"Gassling","year":"2009","unstructured":"Gassling\n              VL,\n            \n            \n              A\u00e7il\n              Y,\n            \n            \n              Springer\n              IN,\n            \n            \n              Hubert\n              N,\n            \n            \n              Wiltfang\n              J\n            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from PRP, PRF, and advanced-PRF.\n\t\t\t\t\tClin Oral Invest.\n\t\t\t\t\t2016;\n\t\t\t\t\t20:\n\t\t\t\t\t2353\u2013\n\t\t\t\t\t2360."},{"key":"i0003-3219-91-3-285-b33","series-title":"J Oral Maxillofac Surg","first-page":"1176","article-title":"Investigation of platelet-rich plasma in rabbit cranial defects: a pilot study","volume":"60","author":"Aghaloo","year":"2002","unstructured":"Aghaloo\n              TL,\n            \n            \n              Moy\n              PK,\n            \n            \n              Freymiller\n              EG.\n            \n          \n          Investigation of platelet-rich plasma in rabbit cranial defects: a pilot study.\n\t\t\t\t\tJ Oral Maxillofac Surg2002;\n\t\t\t\t\t60:\n\t\t\t\t\t1176\u2013\n\t\t\t\t\t81."},{"key":"i0003-3219-91-3-285-b34","series-title":"J Dent Res","first-page":"887","article-title":"Dual regulation of osteoclast differentiation by PDL cells through RANKL stimulation and OPG 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Haruyama\n              N,\n            \n            \n              Nishimura\n              M,\n            \n            \n              Mitani\n              H\n            .\n\t\t\t\t\t\n          Local OPG gene transfer to periodontal tissue inhibits orthodontic tooth movement.\n\t\t\t\t\tJ Dent Res.\n\t\t\t\t\t2004;\n\t\t\t\t\t83:\n\t\t\t\t\t920\u2013\n\t\t\t\t\t925."},{"key":"i0003-3219-91-3-285-b01","series-title":"Am J Orthod Dentofacial Orthop","first-page":"230","article-title":"Factors influencing treatment time in orthodontic patients","volume":"129","author":"Skidmore","year":"2006","unstructured":"Skidmore\n              KJ,\n            \n            \n              Brook\n              KJ,\n            \n            \n              Thomson\n              WM,\n            \n            \n              Harding\n              WJ\n            .\n\t\t\t\t\t\n          Factors influencing treatment time in orthodontic patients.\n\t\t\t\t\tAm J Orthod Dentofacial 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