{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T11:26:25Z","timestamp":1780485985539,"version":"3.54.1"},"reference-count":34,"publisher":"The Angle Orthodontist (EH Angle Education & Research Foundation)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,5]]},"abstract":"Abstract<\/jats:title>\n \n Objective:<\/jats:title>\n To test the null hypothesis that no differences exist in craniofacial morphology between patients with familial Mediterranean fever (FMF) and the healthy population.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n Standardized lateral cephalograms of 32 FMF patients (mean age, 11.50 \u00b1 2.72\u00a0years) and 32 healthy controls (mean age, 11.86 \u00b1 2.19\u00a0years) were obtained. Cranial and dentofacial parameters were measured using a cephalometric analysis program (Nemoceph Imaging Cephalometric and Tracing Software S.L., Spain). All statistical analyses were conducted using SPSS version 17.0.0 (SPSS Inc., Chicago, Ill). Descriptive statistics were calculated for all measurements, and the independent\n t<\/jats:italic>\n -test was used to evaluate intergroup differences.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The ANB angle was significantly greater in the FMF group (\n P<\/jats:italic>\n < .05). Differences in SNA and SNB angles were insignificant. Anterior (\n P<\/jats:italic>\n < .001) and posterior (\n P<\/jats:italic>\n < .05) face heights were significantly shorter in the FMF group. Mandibular body length (\n P<\/jats:italic>\n < .001) and condylion to gnathion (\n P<\/jats:italic>\n < .05) measurements were significantly shorter in the FMF group. The upper lip was more protrusive in the FMF group (\n P<\/jats:italic>\n < .05). U1\u2013NA (mm;\n P<\/jats:italic>\n < .001) and L1\u2013NB (mm;\n P<\/jats:italic>\n < .05) measurements were significantly shorter in the FMF group.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n The hypothesis is rejected. Significant differences exist between the craniofacial morphology of patients with FMF and the healthy population.<\/jats:p>\n <\/jats:sec>","DOI":"10.2319\/060811-375.1","type":"journal-article","created":{"date-parts":[[2011,11,30]],"date-time":"2011-11-30T15:28:05Z","timestamp":1322666885000},"page":"552-555","source":"Crossref","is-referenced-by-count":3,"title":["Cephalometric evaluation of children with familial Mediterranean fever"],"prefix":"10.2319","volume":"82","author":[{"given":"Ahmet Yalcin","family":"Gungor","sequence":"first","affiliation":[{"name":"Assistant Professor, Department of Orthodontics, Faculty of Dentistry, University of Akdeniz, Antalya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vefik","family":"Arica","sequence":"additional","affiliation":[{"name":"Assistant Professor, Department of Paediatrics, Faculty of Medicine, University of Mustafa Kemal, Hatay, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozge","family":"Gungor","sequence":"additional","affiliation":[{"name":"Assistant Professor, Department of Pediatric Dentistry, Faculty of Dentistry, University of Akdeniz, Antalya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Tutanc","sequence":"additional","affiliation":[{"name":"Assistant Professor, Department of Paediatrics, Faculty of Medicine, University of Mustafa Kemal, Hatay, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1164","reference":[{"issue":"5","key":"i0003-3219-82-3-552-b01","series-title":"Br J Haematol","first-page":"467","article-title":"Advances in the understanding of familial Mediterranean fever and possibilities for targeted therapy.","volume":"146","author":"Chae, J. J.","year":"2009","unstructured":"Chae, J. J., I.Aksentijevich, and D. L.Kastner. Advances in the understanding of familial Mediterranean fever and possibilities for targeted therapy.Br J Haematol2009. 146 (5):467\u2013478."},{"issue":"4","key":"i0003-3219-82-3-552-b02","series-title":"Tohoku J Exp Med","first-page":"321","article-title":"Increased serum osteoprotegerin levels associated with decreased bone mineral density in familial Mediterranean fever.","volume":"217","author":"Yuksel, S.","year":"2009","unstructured":"Yuksel, S., H.Samli, M.Colbay, et al. Increased serum osteoprotegerin levels associated with decreased bone mineral density in familial Mediterranean fever.Tohoku J Exp Med2009. 217 (4):321\u2013327."},{"issue":"2","key":"i0003-3219-82-3-552-b03","series-title":"Am J Med","first-page":"227","article-title":"Familial Mediterranean fever: a survey of 470 cases and review of the literature.","volume":"43","author":"Sohar, E.","year":"1967","unstructured":"Sohar, E., J.Gafni, M.Pras, and H.Heller. Familial Mediterranean fever: a survey of 470 cases and review of the literature.Am J Med1967. 43 (2):227\u2013253."},{"issue":"9","key":"i0003-3219-82-3-552-b04","series-title":"Pediatr Nephrol","first-page":"853","article-title":"Familial Mediterranean fever.","volume":"18","author":"Bakkaloglu, A.","year":"2003","unstructured":"Bakkaloglu, A.\n \n Familial Mediterranean fever.\n Pediatr Nephrol\n 2003. 18 (9):853\u2013859."},{"issue":"4","key":"i0003-3219-82-3-552-b05","series-title":"Cell","first-page":"797","article-title":"Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever.","volume":"90","year":"1997","unstructured":"International FMF Consortium\n \n Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever.\n Cell\n 1997. 90 (4):797\u2013807."},{"issue":"1","key":"i0003-3219-82-3-552-b06","series-title":"Medicine (Baltimore)","first-page":"1","article-title":"Familial Mediterranean fever (FMF) in Turkey: results of a nationwide multicenter study.","volume":"84","author":"Tunca, M.","year":"2005","unstructured":"Tunca, M., S.Akar, F.Onen, et al. Familial Mediterranean fever (FMF) in Turkey: results of a nationwide multicenter study.Medicine (Baltimore)2005. 84 (1):1\u201311."},{"issue":"3","key":"i0003-3219-82-3-552-b07","series-title":"Clin Rheumatol","first-page":"230","article-title":"Bone mineral density in children with familial Mediterranean fever.","volume":"23","author":"Duzova, A.","year":"2004","unstructured":"Duzova, A., F.Ozaltin, A.Ozon, et al. Bone mineral density in children with familial Mediterranean fever.Clin Rheumatol2004. 23 (3):230\u2013234."},{"issue":"6","key":"i0003-3219-82-3-552-b08","series-title":"Ort Traumatol Rehab","first-page":"54","article-title":"Bone mineral metabolism in children with juvenile idiopathic arthritis: preliminary report.","volume":"1","author":"Gorska, A.","year":"2008","unstructured":"Gorska, A., M.Urban, M.Bartnicka, B.Zelazowska-Rutkowska, and J.Wysocka. Bone mineral metabolism in children with juvenile idiopathic arthritis: preliminary report.Ort Traumatol Rehab2008. 1 (6):54\u201362."},{"issue":"8","key":"i0003-3219-82-3-552-b09","series-title":"J Rheumatol","first-page":"1749","article-title":"Cartilage oligomeric matrix protein in patients with Juvenile Idiopathic arthritis relation to growth and disease activity.","volume":"36","author":"Bjonhart, B.","year":"2009","unstructured":"Bjonhart, B., A.Juul, Z.Nielsen, M.Zak, P.Svenningsen, and K.M\u00fcller. Cartilage oligomeric matrix protein in patients with Juvenile Idiopathic arthritis relation to growth and disease activity.J Rheumatol2009. 36 (8):1749\u20131754."},{"issue":"3","key":"i0003-3219-82-3-552-b10","series-title":"Arthritis Rheum","first-page":"433","article-title":"A two year prospective controlled study of bone mass and bone turnover in children with early juvenile idiopathic arthritis.","volume":"52","author":"Lien, G.","year":"2005","unstructured":"Lien, G., A. M.Selvaag, B.Flato, et al. A two year prospective controlled study of bone mass and bone turnover in children with early juvenile idiopathic arthritis.Arthritis Rheum2005. 52 (3):433\u2013440."},{"issue":"1","key":"i0003-3219-82-3-552-b11","series-title":"Horm Res","first-page":"13","article-title":"Natural history of growth and body composition in juvenile idiopathic arthritis.","volume":"72","author":"Bechtold, S.","year":"2009","unstructured":"Bechtold, S. and J.Roth. Natural history of growth and body composition in juvenile idiopathic arthritis.Horm Res2009. 72 (1):13\u201319."},{"issue":"6","key":"i0003-3219-82-3-552-b12","series-title":"J Pediatr","first-page":"910","article-title":"Vitamin D metabolism and bone mineralization in children with juvenile rhematoid arthritis.","volume":"124","author":"Hilman, L.","year":"1994","unstructured":"Hilman, L., J. T.Cassidy, L.Johnson, D.Lee, and S. H.Allen. Vitamin D metabolism and bone mineralization in children with juvenile rhematoid arthritis.J Pediatr1994. 124 (6):910\u2013916."},{"issue":"3","key":"i0003-3219-82-3-552-b13","series-title":"Clin Rheumatol","first-page":"230","article-title":"Bone mineral density in children with familial Mediterranean fever.","volume":"23","author":"Duzova, A.","year":"2004","unstructured":"Duzova, A., F.Ozaltin, A.Ozon, et al. Bone mineral density in children with familial Mediterranean fever.Clin Rheumatol2004. 23 (3):230\u2013234."},{"issue":"9","key":"i0003-3219-82-3-552-b14","series-title":"Clin Rheumatol","first-page":"1171","article-title":"Decreased bone mineral density in adult familial Mediterranean fever patients: a pilot study.","volume":"27","author":"Suyani, E.","year":"2008","unstructured":"Suyani, E., M. A.Ozturk, S. M.Deger, M. D.Demirag, B.Goker, and S.Haznedaroglu. Decreased bone mineral density in adult familial Mediterranean fever patients: a pilot study.Clin Rheumatol2008. 27 (9):1171\u20131175."},{"issue":"3","key":"i0003-3219-82-3-552-b15","series-title":"Rheumatol Int","first-page":"305","article-title":"Bone mineral density in patients with familial Mediterranean fever.","volume":"30","author":"Yildirim, K.","year":"2010","unstructured":"Yildirim, K., S.Karatay, R.Cetinkaya, et al. Bone mineral density in patients with familial Mediterranean fever.Rheumatol Int2010. 30 (3):305\u2013308."},{"issue":"5","key":"i0003-3219-82-3-552-b16","series-title":"Acta Odontol Scand","first-page":"591","article-title":"Natural head position in standing subjects.","volume":"29","author":"Solow, B.","year":"1971","unstructured":"Solow, B. and A.Tallgren. Natural head position in standing subjects.Acta Odontol Scand1971. 29 (5):591\u2013607."},{"issue":"4","key":"i0003-3219-82-3-552-b17","series-title":"J Pediatr","first-page":"657","article-title":"25-Hydroxy vitamin D therapy in children with active juvenile idiopathic arthritis: short term effects on serum osteocalsin levels and bone mineral density.","volume":"119","author":"Reed, A.","year":"1991","unstructured":"Reed, A., M.Haugen, and L. M.Pachman. 25-Hydroxy vitamin D therapy in children with active juvenile idiopathic arthritis: short term effects on serum osteocalsin levels and bone mineral density.J Pediatr1991. 119 (4):657\u2013660."},{"issue":"5","key":"i0003-3219-82-3-552-b01","series-title":"Br J Haematol","first-page":"467","article-title":"Advances in the understanding of familial Mediterranean fever and possibilities for targeted therapy.","volume":"146","author":"Chae, J. J.","year":"2009","unstructured":"Chae, J. J., I.Aksentijevich, and D. L.Kastner. Advances in the understanding of familial Mediterranean fever and possibilities for targeted therapy.Br J Haematol2009. 146 (5):467\u2013478."},{"issue":"4","key":"i0003-3219-82-3-552-b02","series-title":"Tohoku J Exp Med","first-page":"321","article-title":"Increased serum osteoprotegerin levels associated with decreased bone mineral density in familial Mediterranean fever.","volume":"217","author":"Yuksel, S.","year":"2009","unstructured":"Yuksel, S., H.Samli, M.Colbay, et al. Increased serum osteoprotegerin levels associated with decreased bone mineral density in familial Mediterranean fever.Tohoku J Exp Med2009. 217 (4):321\u2013327."},{"issue":"2","key":"i0003-3219-82-3-552-b03","series-title":"Am J Med","first-page":"227","article-title":"Familial Mediterranean fever: a survey of 470 cases and review of the literature.","volume":"43","author":"Sohar, E.","year":"1967","unstructured":"Sohar, E., J.Gafni, M.Pras, and H.Heller. Familial Mediterranean fever: a survey of 470 cases and review of the literature.Am J Med1967. 43 (2):227\u2013253."},{"issue":"9","key":"i0003-3219-82-3-552-b04","series-title":"Pediatr Nephrol","first-page":"853","article-title":"Familial Mediterranean fever.","volume":"18","author":"Bakkaloglu, A.","year":"2003","unstructured":"Bakkaloglu, A.\n \n Familial Mediterranean fever.\n Pediatr Nephrol\n 2003. 18 (9):853\u2013859."},{"issue":"4","key":"i0003-3219-82-3-552-b05","series-title":"Cell","first-page":"797","article-title":"Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever.","volume":"90","year":"1997","unstructured":"International FMF Consortium\n \n Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever.\n Cell\n 1997. 90 (4):797\u2013807."},{"issue":"1","key":"i0003-3219-82-3-552-b06","series-title":"Medicine (Baltimore)","first-page":"1","article-title":"Familial Mediterranean fever (FMF) in Turkey: results of a nationwide multicenter study.","volume":"84","author":"Tunca, M.","year":"2005","unstructured":"Tunca, M., S.Akar, F.Onen, et al. Familial Mediterranean fever (FMF) in Turkey: results of a nationwide multicenter study.Medicine (Baltimore)2005. 84 (1):1\u201311."},{"issue":"3","key":"i0003-3219-82-3-552-b07","series-title":"Clin Rheumatol","first-page":"230","article-title":"Bone mineral density in children with familial Mediterranean fever.","volume":"23","author":"Duzova, A.","year":"2004","unstructured":"Duzova, A., F.Ozaltin, A.Ozon, et al. Bone mineral density in children with familial Mediterranean fever.Clin Rheumatol2004. 23 (3):230\u2013234."},{"issue":"6","key":"i0003-3219-82-3-552-b08","series-title":"Ort Traumatol Rehab","first-page":"54","article-title":"Bone mineral metabolism in children with juvenile idiopathic arthritis: preliminary report.","volume":"1","author":"Gorska, A.","year":"2008","unstructured":"Gorska, A., M.Urban, M.Bartnicka, B.Zelazowska-Rutkowska, and J.Wysocka. Bone mineral metabolism in children with juvenile idiopathic arthritis: preliminary report.Ort Traumatol Rehab2008. 1 (6):54\u201362."},{"issue":"8","key":"i0003-3219-82-3-552-b09","series-title":"J Rheumatol","first-page":"1749","article-title":"Cartilage oligomeric matrix protein in patients with Juvenile Idiopathic arthritis relation to growth and disease activity.","volume":"36","author":"Bjonhart, B.","year":"2009","unstructured":"Bjonhart, B., A.Juul, Z.Nielsen, M.Zak, P.Svenningsen, and K.M\u00fcller. Cartilage oligomeric matrix protein in patients with Juvenile Idiopathic arthritis relation to growth and disease activity.J Rheumatol2009. 36 (8):1749\u20131754."},{"issue":"3","key":"i0003-3219-82-3-552-b10","series-title":"Arthritis Rheum","first-page":"433","article-title":"A two year prospective controlled study of bone mass and bone turnover in children with early juvenile idiopathic arthritis.","volume":"52","author":"Lien, G.","year":"2005","unstructured":"Lien, G., A. M.Selvaag, B.Flato, et al. A two year prospective controlled study of bone mass and bone turnover in children with early juvenile idiopathic arthritis.Arthritis Rheum2005. 52 (3):433\u2013440."},{"issue":"1","key":"i0003-3219-82-3-552-b11","series-title":"Horm Res","first-page":"13","article-title":"Natural history of growth and body composition in juvenile idiopathic arthritis.","volume":"72","author":"Bechtold, S.","year":"2009","unstructured":"Bechtold, S. and J.Roth. Natural history of growth and body composition in juvenile idiopathic arthritis.Horm Res2009. 72 (1):13\u201319."},{"issue":"6","key":"i0003-3219-82-3-552-b12","series-title":"J Pediatr","first-page":"910","article-title":"Vitamin D metabolism and bone mineralization in children with juvenile rhematoid arthritis.","volume":"124","author":"Hilman, L.","year":"1994","unstructured":"Hilman, L., J. T.Cassidy, L.Johnson, D.Lee, and S. H.Allen. Vitamin D metabolism and bone mineralization in children with juvenile rhematoid arthritis.J Pediatr1994. 124 (6):910\u2013916."},{"issue":"3","key":"i0003-3219-82-3-552-b13","series-title":"Clin Rheumatol","first-page":"230","article-title":"Bone mineral density in children with familial Mediterranean fever.","volume":"23","author":"Duzova, A.","year":"2004","unstructured":"Duzova, A., F.Ozaltin, A.Ozon, et al. Bone mineral density in children with familial Mediterranean fever.Clin Rheumatol2004. 23 (3):230\u2013234."},{"issue":"9","key":"i0003-3219-82-3-552-b14","series-title":"Clin Rheumatol","first-page":"1171","article-title":"Decreased bone mineral density in adult familial Mediterranean fever patients: a pilot study.","volume":"27","author":"Suyani, E.","year":"2008","unstructured":"Suyani, E., M. A.Ozturk, S. M.Deger, M. D.Demirag, B.Goker, and S.Haznedaroglu. Decreased bone mineral density in adult familial Mediterranean fever patients: a pilot study.Clin Rheumatol2008. 27 (9):1171\u20131175."},{"issue":"3","key":"i0003-3219-82-3-552-b15","series-title":"Rheumatol Int","first-page":"305","article-title":"Bone mineral density in patients with familial Mediterranean fever.","volume":"30","author":"Yildirim, K.","year":"2010","unstructured":"Yildirim, K., S.Karatay, R.Cetinkaya, et al. Bone mineral density in patients with familial Mediterranean fever.Rheumatol Int2010. 30 (3):305\u2013308."},{"issue":"5","key":"i0003-3219-82-3-552-b16","series-title":"Acta Odontol Scand","first-page":"591","article-title":"Natural head position in standing subjects.","volume":"29","author":"Solow, B.","year":"1971","unstructured":"Solow, B. and A.Tallgren. Natural head position in standing subjects.Acta Odontol Scand1971. 29 (5):591\u2013607."},{"issue":"4","key":"i0003-3219-82-3-552-b17","series-title":"J Pediatr","first-page":"657","article-title":"25-Hydroxy vitamin D therapy in children with active juvenile idiopathic arthritis: short term effects on serum osteocalsin levels and bone mineral density.","volume":"119","author":"Reed, A.","year":"1991","unstructured":"Reed, A., M.Haugen, and L. M.Pachman. 25-Hydroxy vitamin D therapy in children with active juvenile idiopathic arthritis: short term effects on serum osteocalsin levels and bone mineral density.J Pediatr1991. 119 (4):657\u2013660."}],"container-title":["The Angle Orthodontist"],"original-title":[],"link":[{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/view\/journals\/angl\/82\/3\/article-p552.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/downloadpdf\/journals\/angl\/82\/3\/article-p552.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/downloadpdf\/journals\/angl\/82\/3\/article-p552.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T16:04:28Z","timestamp":1780070668000},"score":1,"resource":{"primary":{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/view\/journals\/angl\/82\/3\/article-p552.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":34,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.2319\/060811-375.1","relation":{},"ISSN":["0003-3219","1945-7103"],"issn-type":[{"value":"0003-3219","type":"print"},{"value":"1945-7103","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5]]}}}