{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:03:58Z","timestamp":1791090238169,"version":"4.1.0"},"reference-count":38,"publisher":"The Angle Orthodontist (EH Angle Education & Research Foundation)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,5]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objective:<\/jats:title>\n \n To test the hypothesis that mutations in the parathyroid hormone 1 receptor (\n PTH1R<\/jats:italic>\n ) include effects in both primary and permanent teeth.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n DNA was extracted from saliva samples of 29 patients (8 familial and 21 sporadic) who presented with clinical evidence of infraoccluded teeth, and their unaffected relatives (N = 22). Sequencing followed by mutational analysis of the coding regions of\n PTH1R<\/jats:italic>\n gene was completed for all individuals (N = 29).\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Eight of 29 cases revealed a heterozygous pathogenic variant in the\n PTH1R<\/jats:italic>\n gene; five of eight variants represented distinct mutations based on comparison with the dbSNP, HGMD, and ESP databases. One mutation (c.1765 T>C p.Trp89Arg) was found to segregate within a family (n = 3).\n In silico<\/jats:italic>\n analyses for all variants revealed a putative pathogenic effect. A genotype-phenotype correlation was reported as defined by a functional mutation in\n PTH1R<\/jats:italic>\n and corresponding effects on one or more posterior teeth only; unilateral or bilateral involvement, infraoccluded primary teeth.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n \n Novel mutations were reported in the\n PTH1R<\/jats:italic>\n gene that included PFE-affected primary molars, thus providing the basis for using a genetic diagnostic tool for early diagnosis leading to proper management.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.2319\/062717-430.1","type":"journal-article","created":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T08:57:32Z","timestamp":1517216252000},"page":"275-282","source":"Crossref","is-referenced-by-count":36,"title":["Primary failure of eruption: Clinical and genetic findings in the mixed dentition"],"prefix":"10.2319","volume":"88","author":[{"given":"Cristina","family":"Grippaudo","sequence":"first","affiliation":[{"name":"Associate Professor, Department of Orthodontics, School of Dentistry, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concetta","family":"Cafiero","sequence":"additional","affiliation":[{"name":"Private Practice, Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"D'Apolito","sequence":"additional","affiliation":[{"name":"PhD Student, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Ricci","sequence":"additional","affiliation":[{"name":"PhD Student, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia A.","family":"Frazier-Bowers","sequence":"additional","affiliation":[{"name":"Associate Professor, Department of Orthodontics, School of Dentistry, University of North Carolina, Chapel Hill, NC."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1164","reference":[{"key":"i0003-3219-88-3-275-b01","series-title":"Oral Histology, Development, Structure and Function","author":"Ten Cate \n AR.","year":"1989","unstructured":"Ten Cate \n AR. \n \n \n Oral Histology, Development, Structure and Function. St Louis: Mosby; 1989."},{"key":"i0003-3219-88-3-275-b02","series-title":"J Oral Path","first-page":"189","article-title":"Tooth eruption: evidence for the central role of the dental follicle","volume":"9","author":"Cahill \n DR,","year":"1983","unstructured":"Cahill \n DR, \n \n \n Marks \n SC. \n \n \n Tooth eruption: evidence for the central role of the dental follicle. J Oral Path. 1983;9:189\u2013200."},{"key":"i0003-3219-88-3-275-b03","series-title":"Anat Rec","first-page":"67","article-title":"Eruption pathway formation in the presence of experimental tooth impaction in puppies","volume":"164","author":"Cahill \n DR.","year":"1969","unstructured":"Cahill \n DR. \n \n \n Eruption pathway formation in the presence of experimental tooth impaction in puppies. Anat Rec. 1969;164:67\u201377."},{"issue":"4","key":"i0003-3219-88-3-275-b04","series-title":"Crit Rev Oral Biol Med","first-page":"323","article-title":"Frazier Bowers S, D'Souza RN. Cellular, molecular, and genetic determinants of tooth eruption","volume":"13","author":"Wise \n GE,","year":"2002","unstructured":"Wise \n GE, \n \n \n Frazier Bowers S, D'Souza RN. Cellular, molecular, and genetic determinants of tooth eruption. Crit Rev Oral Biol Med. 2002;13(4):323\u2013334."},{"key":"i0003-3219-88-3-275-b05","series-title":"Semin Orthod","first-page":"180","article-title":"The etiology of eruption disorders\u2014further evidence of a \u201cgenetic paradigm.\u201d","volume":"16-3","author":"Frazier Bowers \n S,","year":"2010","unstructured":"Frazier Bowers \n S, \n \n \n Puranik \n CP, \n \n \n Nahaney \n MC. \n \n \n The etiology of eruption disorders\u2014further evidence of a \u201cgenetic paradigm.\u201d\n Semin Orthod. 2010;16-3:180\u2013185."},{"key":"i0003-3219-88-3-275-b06","series-title":"Am J Orthod","first-page":"173","article-title":"Primary failure of eruption: a possible cause of posterior open bite","volume":"80","author":"Proffit \n WR,","year":"1981","unstructured":"Proffit \n WR, \n \n \n Vig \n KW. \n \n \n Primary failure of eruption: a possible cause of posterior open bite. Am J Orthod. 1981;80:173\u2013190."},{"issue":"3","key":"i0003-3219-88-3-275-b07","series-title":"J Orofac Orthop","first-page":"226","article-title":"Differential diagnosis of primary failure of eruption (PFE) with and without evidence of pathogenic mutations in the PTHR1 gene","volume":"75","author":"Pilz \n P,","year":"2014","unstructured":"Pilz \n P, \n \n \n Meyer-Marcotty \n P, \n \n \n Eigenthaler \n M, \n \n \n Roth \n H, \n \n \n Weber \n BH, \n \n \n Stellzig-Eisenhauer \n A. \n \n \n Differential diagnosis of primary failure of eruption (PFE) with and without evidence of pathogenic mutations in the PTHR1 gene. J Orofac Orthop. 2014May;75(3):226\u2013239."},{"key":"i0003-3219-88-3-275-b08","series-title":"Am J Orthod Dentofacial Orthop","first-page":"194","article-title":"Establishing the diagnostic criteria for eruption disorders based on genetic and clinical data","volume":"144","author":"Rhoads \n SG,","year":"2013","unstructured":"Rhoads \n SG, \n \n \n Hendricks \n HM, \n \n \n Frazier-Bowers \n S. \n \n \n Establishing the diagnostic criteria for eruption disorders based on genetic and clinical data. Am J Orthod Dentofacial Orthop. 2013;144:194\u2013202."},{"issue":"2","key":"i0003-3219-88-3-275-b09","series-title":"Clin Oral Invest","first-page":"377","article-title":"Expanding the spectrum of PTH1R mutations in patients with primary failure of tooth eruption","volume":"18","author":"Roth \n H,","year":"2013","unstructured":"Roth \n H, \n \n \n Fritsche \n LG, \n \n \n Meier \n C, \n \n \n Pilz \n P. \n \n \n Expanding the spectrum of PTH1R mutations in patients with primary failure of tooth eruption. Clin Oral Invest. 2013;18(2):377\u2013384."},{"key":"i0003-3219-88-3-275-b10","series-title":"Am J Hum Genet","first-page":"781","article-title":"et al. PTH1R loss-of-function mutations in familial, nonsyndromic primary failure of tooth eruption","volume":"83","author":"Decker \n E,","year":"2008","unstructured":"Decker \n E, \n \n \n Stellzing-Eisenhauer \n A, \n \n \n Fiebig \n BS, \n \n \n et al. PTH1R loss-of-function mutations in familial, nonsyndromic primary failure of tooth eruption. Am J Hum Genet. 2008;83:781\u2013786."},{"issue":"2","key":"i0003-3219-88-3-275-b11","series-title":"J Dent Res","first-page":"134","article-title":"Novel mutations in PTH1R associated with primary failure of eruption and ostheoarthritis","volume":"93","year":"2014","unstructured":"Frazier Bowers S, Hendricks HM, Wight JL, Long K, Dibble CF, Bencharit S. Novel mutations in PTH1R associated with primary failure of eruption and ostheoarthritis. J Dent Res. 2014; 93(2):134\u2013139."},{"key":"i0003-3219-88-3-275-b12","series-title":"Cell Signal","first-page":"1254","article-title":"and PTHrP signaling in osteoblasts","volume":"21","author":"Datta \n NS,","year":"2009","unstructured":"Datta \n NS, \n \n \n Abou-Samra \n AB. PTH\n \n \n and PTHrP signaling in osteoblasts. Cell Signal. 2009; 21:1254."},{"key":"i0003-3219-88-3-275-b13","series-title":"N Eng J Med","first-page":"177","article-title":"The physiology of parathyroid hormone-related protein","volume":"342","author":"Strewler \n GJ.","year":"2000","unstructured":"Strewler \n GJ. \n \n \n The physiology of parathyroid hormone-related protein. N Eng J Med. 2000;342:177\u2013185."},{"key":"i0003-3219-88-3-275-b14","series-title":"Am J Physiol Renal Physiol","first-page":"F882","article-title":"PTH increases FGF23 gene expression and mediates the high FGF23 levels of experimental kidney failure: a bone parathyroid feedback loop","volume":"299","author":"Lavi-Moshayoff \n V,","year":"2010","unstructured":"Lavi-Moshayoff \n V, \n \n \n Wasserman \n G, \n \n \n Meier \n T, \n \n \n Silver \n J, \n \n \n Naveh-Many \n T. \n \n \n PTH increases FGF23 gene expression and mediates the high FGF23 levels of experimental kidney failure: a bone parathyroid feedback loop. Am J Physiol Renal Physiol. 2010;299:F882\u2013F889."},{"key":"i0003-3219-88-3-275-b15","series-title":"J Dent Res","first-page":"414","article-title":"Mechanisms of tooth eruption and orthodontic tooth movement","volume":"87","author":"Wise \n GE,","year":"2008","unstructured":"Wise \n GE, \n \n \n King \n GJ. \n \n \n Mechanisms of tooth eruption and orthodontic tooth movement. J Dent Res. 2008;87:414\u2013434."},{"key":"i0003-3219-88-3-275-b16","series-title":"Am J Orthod Dentofacial Orthop","first-page":"578e1","article-title":"Primary Failure of eruption: further characterization of a rare eruption disorder","volume":"131","year":"2007","unstructured":"Frazier Bowers S, Koeheler K, Ackerman J, Proffit W. Primary Failure of eruption: further characterization of a rare eruption disorder. Am J Orthod Dentofacial Orthop. 2007;131:578e1\u2013578e11."},{"key":"i0003-3219-88-3-275-b17","series-title":"J Bone Miner Res","first-page":"1655","article-title":"Exon resequensing combined with linkage analysis identifies novel PTH1R variants in primary failure of tooth eruption in Japanese","volume":"26","author":"Yamaguchi \n T,","year":"2011","unstructured":"Yamaguchi \n T, \n \n \n Hosomichi \n K, \n \n \n Narita \n A, \n \n \n Shirota \n T\n \n et al. \n Exon resequensing combined with linkage analysis identifies novel PTH1R variants in primary failure of tooth eruption in Japanese. J Bone Miner Res. 2011;26:1655\u20131661."},{"key":"i0003-3219-88-3-275-b18","series-title":"Am J Orthod Dentofacial Orthop","first-page":"160","article-title":"Primary failure of eruption and PTH1R: the importance of a genetic diagnosis for orthodontic treatment planning","volume":"137","year":"2010","unstructured":"Frazier Bowers S, Simmons D, Wright T, Proffitt WR, Ackerman JL. Primary failure of eruption and PTH1R: the importance of a genetic diagnosis for orthodontic treatment planning. Am J Orthod Dentofacial Orthop. 2010;137:160\u2013161."},{"issue":"3","key":"i0003-3219-88-3-275-b19","series-title":"Orthod Fr","first-page":"241","article-title":"Primary failure of eruption (PFE). Clinical and molecular genetics analysis","volume":"84","author":"Stellzig-Eisenhauer \n A,","year":"2013","unstructured":"Stellzig-Eisenhauer \n A, \n \n \n Decker \n E, \n \n \n Meyer-Marcotty \n P, \n \n et al. \n Primary failure of eruption (PFE). Clinical and molecular genetics analysis. Orthod Fr. 2013Sep;84(3):241\u2013250."},{"key":"i0003-3219-88-3-275-b01","series-title":"Oral Histology, Development, Structure and Function","author":"Ten Cate \n AR.","year":"1989","unstructured":"Ten Cate \n AR. \n \n \n Oral Histology, Development, Structure and Function. St Louis: Mosby; 1989."},{"key":"i0003-3219-88-3-275-b02","series-title":"J Oral Path","first-page":"189","article-title":"Tooth eruption: evidence for the central role of the dental follicle","volume":"9","author":"Cahill \n DR,","year":"1983","unstructured":"Cahill \n DR, \n \n \n Marks \n SC. \n \n \n Tooth eruption: evidence for the central role of the dental follicle. J Oral Path. 1983;9:189\u2013200."},{"key":"i0003-3219-88-3-275-b03","series-title":"Anat Rec","first-page":"67","article-title":"Eruption pathway formation in the presence of experimental tooth impaction in puppies","volume":"164","author":"Cahill \n DR.","year":"1969","unstructured":"Cahill \n DR. \n \n \n Eruption pathway formation in the presence of experimental tooth impaction in puppies. Anat Rec. 1969;164:67\u201377."},{"issue":"4","key":"i0003-3219-88-3-275-b04","series-title":"Crit Rev Oral Biol Med","first-page":"323","article-title":"Frazier Bowers S, D'Souza RN. Cellular, molecular, and genetic determinants of tooth eruption","volume":"13","author":"Wise \n GE,","year":"2002","unstructured":"Wise \n GE, \n \n \n Frazier Bowers S, D'Souza RN. Cellular, molecular, and genetic determinants of tooth eruption. Crit Rev Oral Biol Med. 2002;13(4):323\u2013334."},{"key":"i0003-3219-88-3-275-b05","series-title":"Semin Orthod","first-page":"180","article-title":"The etiology of eruption disorders\u2014further evidence of a \u201cgenetic paradigm.\u201d","volume":"16-3","author":"Frazier Bowers \n S,","year":"2010","unstructured":"Frazier Bowers \n S, \n \n \n Puranik \n CP, \n \n \n Nahaney \n MC. \n \n \n The etiology of eruption disorders\u2014further evidence of a \u201cgenetic paradigm.\u201d\n Semin Orthod. 2010;16-3:180\u2013185."},{"key":"i0003-3219-88-3-275-b06","series-title":"Am J Orthod","first-page":"173","article-title":"Primary failure of eruption: a possible cause of posterior open bite","volume":"80","author":"Proffit \n WR,","year":"1981","unstructured":"Proffit \n WR, \n \n \n Vig \n KW. \n \n \n Primary failure of eruption: a possible cause of posterior open bite. Am J Orthod. 1981;80:173\u2013190."},{"issue":"3","key":"i0003-3219-88-3-275-b07","series-title":"J Orofac Orthop","first-page":"226","article-title":"Differential diagnosis of primary failure of eruption (PFE) with and without evidence of pathogenic mutations in the PTHR1 gene","volume":"75","author":"Pilz \n P,","year":"2014","unstructured":"Pilz \n P, \n \n \n Meyer-Marcotty \n P, \n \n \n Eigenthaler \n M, \n \n \n Roth \n H, \n \n \n Weber \n BH, \n \n \n Stellzig-Eisenhauer \n A. \n \n \n Differential diagnosis of primary failure of eruption (PFE) with and without evidence of pathogenic mutations in the PTHR1 gene. J Orofac Orthop. 2014May;75(3):226\u2013239."},{"key":"i0003-3219-88-3-275-b08","series-title":"Am J Orthod Dentofacial Orthop","first-page":"194","article-title":"Establishing the diagnostic criteria for eruption disorders based on genetic and clinical data","volume":"144","author":"Rhoads \n SG,","year":"2013","unstructured":"Rhoads \n SG, \n \n \n Hendricks \n HM, \n \n \n Frazier-Bowers \n S. \n \n \n Establishing the diagnostic criteria for eruption disorders based on genetic and clinical data. Am J Orthod Dentofacial Orthop. 2013;144:194\u2013202."},{"issue":"2","key":"i0003-3219-88-3-275-b09","series-title":"Clin Oral Invest","first-page":"377","article-title":"Expanding the spectrum of PTH1R mutations in patients with primary failure of tooth eruption","volume":"18","author":"Roth \n H,","year":"2013","unstructured":"Roth \n H, \n \n \n Fritsche \n LG, \n \n \n Meier \n C, \n \n \n Pilz \n P. \n \n \n Expanding the spectrum of PTH1R mutations in patients with primary failure of tooth eruption. Clin Oral Invest. 2013;18(2):377\u2013384."},{"key":"i0003-3219-88-3-275-b10","series-title":"Am J Hum Genet","first-page":"781","article-title":"et al. PTH1R loss-of-function mutations in familial, nonsyndromic primary failure of tooth eruption","volume":"83","author":"Decker \n E,","year":"2008","unstructured":"Decker \n E, \n \n \n Stellzing-Eisenhauer \n A, \n \n \n Fiebig \n BS, \n \n \n et al. PTH1R loss-of-function mutations in familial, nonsyndromic primary failure of tooth eruption. Am J Hum Genet. 2008;83:781\u2013786."},{"issue":"2","key":"i0003-3219-88-3-275-b11","series-title":"J Dent Res","first-page":"134","article-title":"Novel mutations in PTH1R associated with primary failure of eruption and ostheoarthritis","volume":"93","year":"2014","unstructured":"Frazier Bowers S, Hendricks HM, Wight JL, Long K, Dibble CF, Bencharit S. Novel mutations in PTH1R associated with primary failure of eruption and ostheoarthritis. J Dent Res. 2014; 93(2):134\u2013139."},{"key":"i0003-3219-88-3-275-b12","series-title":"Cell Signal","first-page":"1254","article-title":"and PTHrP signaling in osteoblasts","volume":"21","author":"Datta \n NS,","year":"2009","unstructured":"Datta \n NS, \n \n \n Abou-Samra \n AB. PTH\n \n \n and PTHrP signaling in osteoblasts. Cell Signal. 2009; 21:1254."},{"key":"i0003-3219-88-3-275-b13","series-title":"N Eng J Med","first-page":"177","article-title":"The physiology of parathyroid hormone-related protein","volume":"342","author":"Strewler \n GJ.","year":"2000","unstructured":"Strewler \n GJ. \n \n \n The physiology of parathyroid hormone-related protein. N Eng J Med. 2000;342:177\u2013185."},{"key":"i0003-3219-88-3-275-b14","series-title":"Am J Physiol Renal Physiol","first-page":"F882","article-title":"PTH increases FGF23 gene expression and mediates the high FGF23 levels of experimental kidney failure: a bone parathyroid feedback loop","volume":"299","author":"Lavi-Moshayoff \n V,","year":"2010","unstructured":"Lavi-Moshayoff \n V, \n \n \n Wasserman \n G, \n \n \n Meier \n T, \n \n \n Silver \n J, \n \n \n Naveh-Many \n T. \n \n \n PTH increases FGF23 gene expression and mediates the high FGF23 levels of experimental kidney failure: a bone parathyroid feedback loop. Am J Physiol Renal Physiol. 2010;299:F882\u2013F889."},{"key":"i0003-3219-88-3-275-b15","series-title":"J Dent Res","first-page":"414","article-title":"Mechanisms of tooth eruption and orthodontic tooth movement","volume":"87","author":"Wise \n GE,","year":"2008","unstructured":"Wise \n GE, \n \n \n King \n GJ. \n \n \n Mechanisms of tooth eruption and orthodontic tooth movement. J Dent Res. 2008;87:414\u2013434."},{"key":"i0003-3219-88-3-275-b16","series-title":"Am J Orthod Dentofacial Orthop","first-page":"578e1","article-title":"Primary Failure of eruption: further characterization of a rare eruption disorder","volume":"131","year":"2007","unstructured":"Frazier Bowers S, Koeheler K, Ackerman J, Proffit W. Primary Failure of eruption: further characterization of a rare eruption disorder. Am J Orthod Dentofacial Orthop. 2007;131:578e1\u2013578e11."},{"key":"i0003-3219-88-3-275-b17","series-title":"J Bone Miner Res","first-page":"1655","article-title":"Exon resequensing combined with linkage analysis identifies novel PTH1R variants in primary failure of tooth eruption in Japanese","volume":"26","author":"Yamaguchi \n T,","year":"2011","unstructured":"Yamaguchi \n T, \n \n \n Hosomichi \n K, \n \n \n Narita \n A, \n \n \n Shirota \n T\n \n et al. \n Exon resequensing combined with linkage analysis identifies novel PTH1R variants in primary failure of tooth eruption in Japanese. J Bone Miner Res. 2011;26:1655\u20131661."},{"key":"i0003-3219-88-3-275-b18","series-title":"Am J Orthod Dentofacial Orthop","first-page":"160","article-title":"Primary failure of eruption and PTH1R: the importance of a genetic diagnosis for orthodontic treatment planning","volume":"137","year":"2010","unstructured":"Frazier Bowers S, Simmons D, Wright T, Proffitt WR, Ackerman JL. Primary failure of eruption and PTH1R: the importance of a genetic diagnosis for orthodontic treatment planning. Am J Orthod Dentofacial Orthop. 2010;137:160\u2013161."},{"issue":"3","key":"i0003-3219-88-3-275-b19","series-title":"Orthod Fr","first-page":"241","article-title":"Primary failure of eruption (PFE). Clinical and molecular genetics analysis","volume":"84","author":"Stellzig-Eisenhauer \n A,","year":"2013","unstructured":"Stellzig-Eisenhauer \n A, \n \n \n Decker \n E, \n \n \n Meyer-Marcotty \n P, \n \n et al. \n Primary failure of eruption (PFE). Clinical and molecular genetics analysis. Orthod Fr. 2013Sep;84(3):241\u2013250."}],"container-title":["The Angle Orthodontist"],"original-title":[],"link":[{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/view\/journals\/angl\/88\/3\/article-p275.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/angle-orthodontist\/article-pdf\/88\/3\/275\/1395270\/062717-430_1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/downloadpdf\/journals\/angl\/88\/3\/article-p275.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/downloadpdf\/journals\/angl\/88\/3\/article-p275.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T15:12:58Z","timestamp":1780067578000},"score":1,"resource":{"primary":{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/view\/journals\/angl\/88\/3\/article-p275.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":38,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.2319\/062717-430.1","relation":{},"ISSN":["0003-3219","1945-7103"],"issn-type":[{"value":"0003-3219","type":"print"},{"value":"1945-7103","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5]]}}}