{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T16:10:52Z","timestamp":1780071052053,"version":"3.54.0"},"reference-count":40,"publisher":"The Angle Orthodontist (EH Angle Education & Research Foundation)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To present a patient treated with submerging autotransplantation (SA) of an immature premolar and subsequent orthodontic space closure (OSC) and to report a 10-year follow-up result.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case and Method:<\/jats:title>\n                    <jats:p>A 10-year-old boy had multiple missing premolars with an asymmetric pattern (maxillary right first and second premolars, teeth 14 and 15; maxillary left second premolar, tooth 25; and mandibular right second premolar, tooth 45). After considering several treatment options, tooth 35 with immature root development underwent SA into the missing site of tooth 15 at a depth 5\u00a0mm below the occlusal plane and was stabilized with sutures to create a symmetric missing condition of the premolars in the four quadrants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Three months after autotransplantation, spontaneous eruption of the transplanted tooth was observed. Nine months after autotransplantation, presence of the lamina dura of the transplanted tooth was confirmed with a periapical radiograph. Active orthodontic treatment was initiated to reduce lip protrusion by closing the missing spaces of teeth 14, 25, 35, and 45 and to correct dental midline deviation. After 33\u00a0months of active orthodontic treatment, Class I canine and molar relationships were obtained. During the 10-year follow-up, the pulp vitality of the transplanted tooth was maintained without any pathologic findings, including root resorption or pulp canal obliteration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In a patient with lip protrusion and multiple congenitally missing premolars with an asymmetric pattern, SA of one premolar from the normal quadrant into the quadrant missing two premolars with subsequent OSC of the missing sites of the other premolars can be an effective treatment modality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2319\/070813-498.1","type":"journal-article","created":{"date-parts":[[2013,9,25]],"date-time":"2013-09-25T12:17:56Z","timestamp":1380111476000},"page":"561-567","source":"Crossref","is-referenced-by-count":9,"title":["A patient with protrusion and multiple missing teeth treated with autotransplantation and space closure"],"prefix":"10.2319","volume":"84","author":[{"given":"Jeong-Min","family":"Ko","sequence":"first","affiliation":[{"name":"Graduate Student (PhD) and Resident, Department of Orthodontics, School of Dentistry, Seoul National University, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheol-Ho","family":"Paik","sequence":"additional","affiliation":[{"name":"Clinical Professor, Department of Orthodontics, School of Dentistry, Seoul National University; and Private practice, SAI Orthodontic Center, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Choi","sequence":"additional","affiliation":[{"name":"Private Practice, Department of Periodontics and Implantology, Nexden Dental Hospital, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Hak","family":"Baek","sequence":"additional","affiliation":[{"name":"Professor, Department of Orthodontics, School of Dentistry, Seoul National University, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1164","reference":[{"key":"i0003-3219-84-3-561-b01","series-title":"Community Dent Oral Epidemiol","first-page":"217","article-title":"A meta-analysis of the prevalence of dental agenesis of permanent teeth","volume":"32","author":"Polder\n              BJ,","year":"2004","unstructured":"Polder\n              BJ, \n            \n              Van't Hof\n              MA, \n            \n              Van der Linden\n              FP, \n            \n              Kuijpers-Jagtman\n              AM. \n          \n          A meta-analysis of the prevalence of dental agenesis of permanent teeth. Community Dent Oral Epidemiol. 2004;32:217\u2013226."},{"key":"i0003-3219-84-3-561-b02","series-title":"Oral Dis","first-page":"620","article-title":"The pattern and prevalence of hypodontia in Koreans","volume":"14","author":"Chung\n              CJ,","year":"2008","unstructured":"Chung\n              CJ, \n            \n              Han\n              JH, \n            \n              Kim\n              KH. \n          \n          The pattern and prevalence of hypodontia in Koreans. Oral Dis. 2008;14:620\u2013625."},{"key":"i0003-3219-84-3-561-b03","series-title":"Am J Orthod Dentofacial Orthop","first-page":"29","article-title":"A survey of hypodontia in Japanese orthodontic patients","volume":"129","author":"Endo\n              T,","year":"2006","unstructured":"Endo\n              T, \n            \n              Ozoe\n              R, \n            \n              Kubota\n              M, \n            \n              Akiyama\n              M, \n            \n              Shimooka\n              S. \n          \n          A survey of hypodontia in Japanese orthodontic patients. Am J Orthod Dentofacial Orthop. 2006;129:29\u201335."},{"key":"i0003-3219-84-3-561-b04","series-title":"Eur J Orthod","first-page":"279","article-title":"The effect of osseointegrated implants on the dento-alveolar development. A clinical and radiographic study in growing pigs","volume":"13","author":"\u00d6dman\n              J,","year":"1991","unstructured":"\u00d6dman\n              J, \n            \n              Gr\u00f6ndahl\n              K, \n            \n              Lekholm\n              U, \n            \n              Thilander\n              B. \n          \n          The effect of osseointegrated implants on the dento-alveolar development. A clinical and radiographic study in growing pigs. Eur J Orthod. 1991;13:279\u2013286."},{"key":"i0003-3219-84-3-561-b05","series-title":"Eur J Orthod","first-page":"84","article-title":"Osseointegrated implants in adolescents. An alternative in replacing missing teeth","volume":"16","author":"Thilander\n              B,","year":"1994","unstructured":"Thilander\n              B, \n            \n              \u00d6dman\n              J, \n            \n              Gr\u00f6ndahl\n              K, \n            \n              Friberg\n              B. \n          \n          Osseointegrated implants in adolescents. An alternative in replacing missing teeth? Eur J Orthod. 1994;16:84\u201395."},{"key":"i0003-3219-84-3-561-b06","series-title":"Int J Periodontics Restorative Dent","first-page":"13","article-title":"New bone formation at the site of autotransplanted developing mandibular canines: a patient report","volume":"33","author":"Plakwicz\n              P,","year":"2013","unstructured":"Plakwicz\n              P, \n            \n              Wojtaszek\n              J, \n            \n              Zadurska\n              M. \n          \n          New bone formation at the site of autotransplanted developing mandibular canines: a patient report. Int J Periodontics Restorative Dent. 2013;33:13\u201320."},{"key":"i0003-3219-84-3-561-b07","series-title":"Am J Orthod Dentofacial Orthop","first-page":"641","article-title":"Multiple congenitally missing teeth treated with autotransplantation and orthodontics","volume":"141","author":"Park\n              JH,","year":"2012","unstructured":"Park\n              JH, \n            \n              Tai\n              K, \n            \n              Yuasa\n              K, \n            \n              Hayashi\n              D. \n          \n          Multiple congenitally missing teeth treated with autotransplantation and orthodontics. Am J Orthod Dentofacial Orthop. 2012;141:641\u2013651."},{"key":"i0003-3219-84-3-561-b08","series-title":"J Clin Pediatr Dent","first-page":"329","article-title":"The autotransplantation and orthodontic treatment of multiple congenitally missing and impacted teeth","volume":"36","author":"Park\n              SY,","year":"2012","unstructured":"Park\n              SY, \n            \n              Choi\n              SC, \n            \n              Choi\n              BJ, \n            \n              Kim\n              SJ, \n            \n              Park\n              JH. \n          \n          The autotransplantation and orthodontic treatment of multiple congenitally missing and impacted teeth. J Clin Pediatr Dent. 2012;36:329\u2013334."},{"key":"i0003-3219-84-3-561-b09","series-title":"Eur J Orthod","first-page":"14","article-title":"A long-term study of 370 autotransplanted premolars. Part II. 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Eur J Orthod. 1990;12:14\u201324."},{"key":"i0003-3219-84-3-561-b10","series-title":"Am J Orthod Dentofacial Orthop","first-page":"592","article-title":"Autotransplantation of premolars to replace maxillary incisors: a comparison with natural incisors","volume":"118","author":"Czochrowska\n              EM,","year":"2000","unstructured":"Czochrowska\n              EM, \n            \n              Stenvik\n              A, \n            \n              Album\n              B, \n            \n              Zachrisson\n              BU. \n          \n          Autotransplantation of premolars to replace maxillary incisors: a comparison with natural incisors. Am J Orthod Dentofacial Orthop. 2000;118:592\u2013600."},{"key":"i0003-3219-84-3-561-b11","series-title":"Int J Oral Surg","first-page":"200","article-title":"Autotransplantation of human premolars. A clinical and radiographic study of 100 teeth","volume":"14","author":"Kristerson\n              L.","year":"1985","unstructured":"Kristerson\n              L. \n          \n          Autotransplantation of human premolars. A clinical and radiographic study of 100 teeth. Int J Oral Surg. 1985;14:200\u2013213."},{"key":"i0003-3219-84-3-561-b12","series-title":"Eur J Orthod","first-page":"38","article-title":"A long-term study of 370 autotransplanted premolars. Part IV. Root development subsequent to transplantation","volume":"12","author":"Andreasen\n              JO,","year":"1990","unstructured":"Andreasen\n              JO, \n            \n              Paulsen\n              HU, \n            \n              Yu\n              Z, \n            \n              Bayer\n              T. \n          \n          A long-term study of 370 autotransplanted premolars. Part IV. Root development subsequent to transplantation. Eur J Orthod. 1990;12:38\u201350."},{"key":"i0003-3219-84-3-561-b13","series-title":"Int Endod J","first-page":"119","article-title":"Resorption of autotransplanted human teeth: a retrospective study of 291 transplantations over a period of 25\u00a0years","volume":"18","author":"Schwartz\n              O,","year":"1985","unstructured":"Schwartz\n              O, \n            \n              Bergmann\n              P, \n            \n              Klausen\n              B. \n          \n          Resorption of autotransplanted human teeth: a retrospective study of 291 transplantations over a period of 25\u00a0years. Int Endod J. 1985;18:119\u2013131."},{"key":"i0003-3219-84-3-561-b14","series-title":"Eur J Orthod","first-page":"25","article-title":"A long-term study of 370 autotransplanted premolars. Part III. 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Eur J Orthod. 1990;12:25\u201337."},{"key":"i0003-3219-84-3-561-b15","series-title":"Dent Traumatol","first-page":"114","article-title":"Clinical application of computer-aided rapid prototyping for tooth transplantation","volume":"17","author":"Lee\n              SJ,","year":"2001","unstructured":"Lee\n              SJ, \n            \n              Jung\n              IY, \n            \n              Lee\n              CY, \n            \n              Choi\n              SY, \n            \n              Kum\n              KY. \n          \n          Clinical application of computer-aided rapid prototyping for tooth transplantation. Dent Traumatol. 2001;17:114\u2013119."},{"key":"i0003-3219-84-3-561-b16","series-title":"Int J Oral Maxillofac Surg","first-page":"1016","article-title":"Use of a replica graft tooth for evaluation before autotransplantation of a tooth. A CAD\/CAM model produced using dental-cone-beam computed tomography","volume":"39","author":"Honda\n              M,","year":"2010","unstructured":"Honda\n              M, \n            \n              Uehara\n              H, \n            \n              Uehara\n              T, \n            et al. \n          Use of a replica graft tooth for evaluation before autotransplantation of a tooth. A CAD\/CAM model produced using dental-cone-beam computed tomography. Int J Oral Maxillofac Surg. 2010;39:1016\u20131019."},{"key":"i0003-3219-84-3-561-b17","series-title":"Dent Traumatol","first-page":"322","article-title":"Autotransplantation of immature third molars: influence of different splinting methods and fixation periods","volume":"18","author":"Bauss\n              O,","year":"2002","unstructured":"Bauss\n              O, \n            \n              Schilke\n              R, \n            \n              Fenske\n              C, \n            \n              Engelke\n              W, \n            \n              Kiliaridis\n              S. \n          \n          Autotransplantation of immature third molars: influence of different splinting methods and fixation periods. Dent Traumatol. 2002;18:322\u2013328."},{"key":"i0003-3219-84-3-561-b18","series-title":"Int J Oral Surg","first-page":"239","article-title":"The effect of splinting upon periodontal and pulpal healing after autotransplantation of mature and immature permanent incisors in monkeys","volume":"12","author":"Kristerson\n              L,","year":"1983","unstructured":"Kristerson\n              L, \n            \n              Andreasen\n              JO. \n          \n          The effect of splinting upon periodontal and pulpal healing after autotransplantation of mature and immature permanent incisors in monkeys. Int J Oral Surg. 1983;12:239\u2013249."},{"key":"i0003-3219-84-3-561-b19","series-title":"Eur J Orthod","first-page":"45","article-title":"Eruption of premolars subsequent to autotransplantation. 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Community Dent Oral Epidemiol. 2004;32:217\u2013226."},{"key":"i0003-3219-84-3-561-b02","series-title":"Oral Dis","first-page":"620","article-title":"The pattern and prevalence of hypodontia in Koreans","volume":"14","author":"Chung\n              CJ,","year":"2008","unstructured":"Chung\n              CJ, \n            \n              Han\n              JH, \n            \n              Kim\n              KH. \n          \n          The pattern and prevalence of hypodontia in Koreans. Oral Dis. 2008;14:620\u2013625."},{"key":"i0003-3219-84-3-561-b03","series-title":"Am J Orthod Dentofacial Orthop","first-page":"29","article-title":"A survey of hypodontia in Japanese orthodontic patients","volume":"129","author":"Endo\n              T,","year":"2006","unstructured":"Endo\n              T, \n            \n              Ozoe\n              R, \n            \n              Kubota\n              M, \n            \n              Akiyama\n              M, \n            \n              Shimooka\n              S. \n          \n          A survey of hypodontia in Japanese orthodontic patients. Am J Orthod Dentofacial Orthop. 2006;129:29\u201335."},{"key":"i0003-3219-84-3-561-b04","series-title":"Eur J Orthod","first-page":"279","article-title":"The effect of osseointegrated implants on the dento-alveolar development. 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Am J Orthod Dentofacial Orthop. 2012;141:641\u2013651."},{"key":"i0003-3219-84-3-561-b08","series-title":"J Clin Pediatr Dent","first-page":"329","article-title":"The autotransplantation and orthodontic treatment of multiple congenitally missing and impacted teeth","volume":"36","author":"Park\n              SY,","year":"2012","unstructured":"Park\n              SY, \n            \n              Choi\n              SC, \n            \n              Choi\n              BJ, \n            \n              Kim\n              SJ, \n            \n              Park\n              JH. \n          \n          The autotransplantation and orthodontic treatment of multiple congenitally missing and impacted teeth. J Clin Pediatr Dent. 2012;36:329\u2013334."},{"key":"i0003-3219-84-3-561-b09","series-title":"Eur J Orthod","first-page":"14","article-title":"A long-term study of 370 autotransplanted premolars. Part II. 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Dent Traumatol. 2002;18:322\u2013328."},{"key":"i0003-3219-84-3-561-b18","series-title":"Int J Oral Surg","first-page":"239","article-title":"The effect of splinting upon periodontal and pulpal healing after autotransplantation of mature and immature permanent incisors in monkeys","volume":"12","author":"Kristerson\n              L,","year":"1983","unstructured":"Kristerson\n              L, \n            \n              Andreasen\n              JO. \n          \n          The effect of splinting upon periodontal and pulpal healing after autotransplantation of mature and immature permanent incisors in monkeys. Int J Oral Surg. 1983;12:239\u2013249."},{"key":"i0003-3219-84-3-561-b19","series-title":"Eur J Orthod","first-page":"45","article-title":"Eruption of premolars subsequent to autotransplantation. 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