{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T23:18:24Z","timestamp":1784675904879,"version":"3.55.0"},"reference-count":46,"publisher":"The Angle Orthodontist (EH Angle Education & Research Foundation)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec id=\"st1\">\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To evaluate alveolar bone support around cleft-adjacent maxillary central incisors (U1) in patients with unilateral cleft lip, alveolus and palate (UCLAP) in the late mixed dentition and to investigate the correlation between the alveolar bone thickness (ABT) and tooth inclination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"st2\">\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      Cone beam computed tomography scans of 45 subjects with UCLAP (29 boys, 16 girls; mean age = 10.74 \u00b1 1.08 years) were assessed. The distance between the cementoenamel junction (CEJ) and alveolar bone crest (AC), and the ABTs at 3 mm, 6 mm, and the apex were measured on the labial, lingual and distal surfaces of U1. The cleft and normal sides were compared using a paired\n                      <jats:italic>t<\/jats:italic>\n                      -test and Pearson's \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      test. Pearson's correlation was used to explore the association between the ABT and tooth inclination of cleft-adjacent U1 in the labiolingual and mesiodistal dimensions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"st3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The CEJ-AC distances were significantly greater in cleft-adjacent U1 (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .01), with more bone height reduction observed labially and distally (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .001). The labial, lingual, and apico-distal ABTs were decreased on the cleft side (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .01). A positive correlation was found between the apico-labial ABT and the labiolingual inclination (\n                      <jats:italic>r<\/jats:italic>\n                      = 0.568,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"st4\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Patients with UCLAP have reduced alveolar bone support around the cleft-adjacent U1, and the apico-labial ABT tends to decrease with increasing lingual tooth inclination; however, the correlation was weak.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2319\/071517-472.1","type":"journal-article","created":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T14:02:06Z","timestamp":1517407326000},"page":"299-305","source":"Crossref","is-referenced-by-count":9,"title":["Evaluation of alveolar bone support around incisors in patients with unilateral cleft lip, alveolus, and palate in late mixed dentition using cone beam computed tomography"],"prefix":"10.2319","volume":"88","author":[{"given":"Yingdan","family":"Pan","sequence":"first","affiliation":[{"name":"Orthodontist, Department of Stomatology, Xiamen Branch, Zhongshan Hospital, Fudan University, Xiamen, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunting","family":"Zeng","sequence":"additional","affiliation":[{"name":"Orthodontist, Department of Orthodontics, Medical Center of Stomatology, The Second Xiangya Hospital, Central South University, Changsha, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Graduate student, Department of Orthodontics, Medical Center of Stomatology, The Second Xiangya Hospital, Central South University, Changsha, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqin","family":"Liu","sequence":"additional","affiliation":[{"name":"Graduate student, Department of Orthodontics, Medical Center of Stomatology, The Second Xiangya Hospital, Central South University, Changsha, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Jing","sequence":"additional","affiliation":[{"name":"Graduate student, Department of Orthodontics, Medical Center of Stomatology, The Second Xiangya Hospital, Central South University, Changsha, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwei","family":"Xiao","sequence":"additional","affiliation":[{"name":"Associate Professor, Department of Orthodontics, Medical Center of Stomatology, The Second Xiangya Hospital, Central South University, Changsha, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1164","reference":[{"key":"i0003-3219-88-3-299-b01","series-title":"Med Oral Patol Oral Cir Bucal","first-page":"e531","article-title":"Alveolar graft in the cleft lip and palate patient: review of 104 cases","volume":"19","author":"Luque-Martin \n              E,","year":"2014","unstructured":"Luque-Martin \n              E, \n            \n            \n              Tobella-Camps \n              ML, \n            \n            \n              Rivera-Baro \n              A. \n            \n          \n          Alveolar graft in the cleft lip and palate patient: review of 104 cases. Med Oral Patol Oral Cir Bucal. 2014;19:e531\u2013e537."},{"key":"i0003-3219-88-3-299-b02","series-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod","first-page":"e16","article-title":"Craniofacial morphology characteristics of operated unilateral complete cleft lip and palate patients in mixed dentition","volume":"112","author":"Liu \n              R,","year":"2011","unstructured":"Liu \n              R, \n            \n            \n              Lu \n              D, \n            \n            \n              Wamalwa \n              P, \n            \n            \n              Li \n              C, \n            \n            \n              Hu \n              H, \n            \n            \n              Zou \n              S. \n            \n          \n          Craniofacial morphology characteristics of operated unilateral complete cleft lip and palate patients in mixed dentition. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011;112:e16\u2013e25."},{"key":"i0003-3219-88-3-299-b03","series-title":"Sci Rep","first-page":"23597","article-title":"Difference in the surgical outcome of unilateral cleft lip and palate patients with and without pre-alveolar bone graft orthodontic treatment","volume":"6","author":"Chang \n              C-S,","year":"2016","unstructured":"Chang \n              C-S, \n            \n            \n              Wallace \n              CG, \n            \n            \n              Hsiao \n              Y-C, \n            \n            et al. \n          Difference in the surgical outcome of unilateral cleft lip and palate patients with and without pre-alveolar bone graft orthodontic treatment. Sci Rep. 2016;6:23597."},{"key":"i0003-3219-88-3-299-b04","series-title":"Cleft Palate Craniofac J","first-page":"73","article-title":"Periodontal status and oral hygiene in two populations of cleft patients","volume":"44","author":"Stec \n              M,","year":"2007","unstructured":"Stec \n              M, \n            \n            \n              Szczepanska \n              J, \n            \n            \n              Pypec \n              J, \n            \n            \n              Hirschfelder \n              U. \n            \n          \n          Periodontal status and oral hygiene in two populations of cleft patients. Cleft Palate Craniofac J. 2007;44:73\u201378."},{"key":"i0003-3219-88-3-299-b05","series-title":"Int J Paediatr Dent","first-page":"455","article-title":"Periodontal and microbiological parameters in children and adolescents with cleft lip and\/or palate","volume":"19","author":"Perdikogianni \n              H,","year":"2009","unstructured":"Perdikogianni \n              H, \n            \n            \n              Papaioannou \n              W, \n            \n            \n              Nakou \n              M, \n            \n            \n              Oulis \n              C, \n            \n            \n              Papagiannoulis \n              L. \n            \n          \n          Periodontal and microbiological parameters in children and adolescents with cleft lip and\/or palate. Int J Paediatr Dent. 2009;19:455\u2013467."},{"key":"i0003-3219-88-3-299-b06","series-title":"Cleft Palate Craniofac J","first-page":"357","article-title":"Periodontal status of teeth adjacent to nongrafted unilateral alveolar clefts","volume":"29","author":"Teja \n              Z,","year":"1992","unstructured":"Teja \n              Z, \n            \n            \n              Persson \n              R, \n            \n            \n              Omnell \n              ML. \n            \n          \n          Periodontal status of teeth adjacent to nongrafted unilateral alveolar clefts. Cleft Palate Craniofac J. 1992;29:357\u2013362."},{"key":"i0003-3219-88-3-299-b07","series-title":"Int J Periodontics Restorative Dent","first-page":"e344","article-title":"Periodontal indices and status in 34 growing patients with unilateral cleft lip and palate: a split-mouth study","volume":"37","author":"Plakwicz \n              P,","year":"2017","unstructured":"Plakwicz \n              P, \n            \n            \n              Wyrebek \n              B, \n            \n            \n              Gorska \n              R, \n            \n            \n              Cudzilo \n              D. \n            \n          \n          Periodontal indices and status in 34 growing patients with unilateral cleft lip and palate: a split-mouth study. Int J Periodontics Restorative Dent. 2017;37:e344\u2013e353."},{"key":"i0003-3219-88-3-299-b08","series-title":"J Clin Periodontol","first-page":"49","article-title":"A split-mouth study on periodontal and microbial parameters in children with complete unilateral cleft lip and palate","volume":"30","author":"Quirynen \n              M,","year":"2003","unstructured":"Quirynen \n              M, \n            \n            \n              Dewinter \n              G, \n            \n            \n              Avontroodt \n              P, \n            \n            \n              Heidbuchel \n              K, \n            \n            \n              Verdonck \n              A, \n            \n            \n              Carels \n              C. \n            \n          \n          A split-mouth study on periodontal and microbial parameters in children with complete unilateral cleft lip and palate. J Clin Periodontol. 2003;30:49\u201356."},{"key":"i0003-3219-88-3-299-b09","series-title":"Angle Orthod","first-page":"1003","article-title":"Assessment of the alveolar bone support of patients with unilateral cleft lip and palate: a cone-beam computed tomography study","volume":"85","author":"Ercan \n              E,","year":"2015","unstructured":"Ercan \n              E, \n            \n            \n              Celikoglu \n              M, \n            \n            \n              Buyuk \n              SK, \n            \n            \n              Sekerci \n              AE. \n            \n          \n          Assessment of the alveolar bone support of patients with unilateral cleft lip and palate: a cone-beam computed tomography study. 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Cleft Palate Craniofac J. 2012;49:208\u2013214."},{"key":"i0003-3219-88-3-299-b11","series-title":"Am J Orthod Dentofacial Orthop","first-page":"749","article-title":"Periodontal effects of rapid maxillary expansion with tooth-tissue-borne and tooth-borne expanders: a computed tomography evaluation","volume":"129","author":"Garib \n              DG,","year":"2006","unstructured":"Garib \n              DG, \n            \n            \n              Henriques \n              JF, \n            \n            \n              Janson \n              G, \n            \n            \n              de Freitas \n              MR, \n            \n            \n              Fernandes \n              AY. \n            \n          \n          Periodontal effects of rapid maxillary expansion with tooth-tissue-borne and tooth-borne expanders: a computed tomography evaluation. 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Clin Oral Investig. 2012;16:285\u2013294."},{"issue":"suppl","key":"i0003-3219-88-3-299-b15","series-title":"Am J Orthod Dentofacial Orthop","first-page":"S130","article-title":"Considerations in the use of cone-beam computed tomography for buccal bone measurements","volume":"137","author":"Molen \n              AD.","year":"2010","unstructured":"Molen \n              AD. \n            \n          \n          Considerations in the use of cone-beam computed tomography for buccal bone measurements. Am J Orthod Dentofacial Orthop. 2010;137(suppl):S130\u2013S135."},{"key":"i0003-3219-88-3-299-b16","series-title":"Am J Orthod Dentofacial Orthop","first-page":"e117","article-title":"Effect of bone thickness on alveolar bone-height measurements from cone-beam computed tomography images","volume":"139","author":"Sun \n              Z,","year":"2011","unstructured":"Sun \n              Z, \n            \n            \n              Smith \n              T, \n            \n            \n              Kortam \n              S, \n            \n            \n              Kim \n              DG, \n            \n            \n              Tee \n              BC, \n            \n            \n              Fields \n              H. \n            \n          \n          Effect of bone thickness on alveolar bone-height measurements from cone-beam computed tomography images. Am J Orthod Dentofacial Orthop. 2011;139:e117\u2013e127."},{"key":"i0003-3219-88-3-299-b17","series-title":"Cleft Palate Craniofac J","first-page":"161","article-title":"Are teeth close to the cleft more susceptible to periodontal disease?","volume":"46","author":"de Almeida \n              AL,","year":"2009","unstructured":"de Almeida \n              AL, \n            \n            \n              Gonzalez \n              MK, \n            \n            \n              Greghi \n              SL, \n            \n            \n              Conti \n              PC, \n            \n            \n              Pegoraro \n              LF. \n            \n          \n          Are teeth close to the cleft more susceptible to periodontal disease?\n          Cleft Palate Craniofac J. 2009;46:161\u2013165."},{"key":"i0003-3219-88-3-299-b18","series-title":"Angle Orthod","doi-asserted-by":"publisher","DOI":"10.2319\/031317\u2013031189.031311","article-title":"Evaluation of maxillary central incisors on the noncleft and cleft sides in patients with unilateral cleft lip and palate\u2014part 2: relationship between root resorption, horizontal tooth movement, and quantity of grafted autogenous bone","author":"Maeda-Iino \n              A,","year":"2017","unstructured":"Maeda-Iino \n              A, \n            \n            \n              Furukawa \n              M, \n            \n            \n              Kwon \n              S, \n            \n            et al. \n          Evaluation of maxillary central incisors on the noncleft and cleft sides in patients with unilateral cleft lip and palate\u2014part 2: relationship between root resorption, horizontal tooth movement, and quantity of grafted autogenous bone. Angle Orthod. 2017;Epub ahead of print: doi: 10.2319\/031317\u2013031189.031311."},{"key":"i0003-3219-88-3-299-b19","series-title":"Cleft Palate J","first-page":"290","article-title":"Facial growth in children with isolated cleft palate","volume":"6","author":"Shibasaki \n              Y,","year":"1969","unstructured":"Shibasaki \n              Y, \n            \n            \n              Ross \n              RB. \n            \n          \n          Facial growth in children with isolated cleft palate. 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Med Oral Patol Oral Cir Bucal. 2014;19:e531\u2013e537."},{"key":"i0003-3219-88-3-299-b02","series-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod","first-page":"e16","article-title":"Craniofacial morphology characteristics of operated unilateral complete cleft lip and palate patients in mixed dentition","volume":"112","author":"Liu \n              R,","year":"2011","unstructured":"Liu \n              R, \n            \n            \n              Lu \n              D, \n            \n            \n              Wamalwa \n              P, \n            \n            \n              Li \n              C, \n            \n            \n              Hu \n              H, \n            \n            \n              Zou \n              S. \n            \n          \n          Craniofacial morphology characteristics of operated unilateral complete cleft lip and palate patients in mixed dentition. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011;112:e16\u2013e25."},{"key":"i0003-3219-88-3-299-b03","series-title":"Sci Rep","first-page":"23597","article-title":"Difference in the surgical outcome of unilateral cleft lip and palate patients with and without pre-alveolar bone graft orthodontic treatment","volume":"6","author":"Chang \n              C-S,","year":"2016","unstructured":"Chang \n              C-S, \n            \n            \n              Wallace \n              CG, \n            \n            \n              Hsiao \n              Y-C, \n            \n            et al. \n          Difference in the surgical outcome of unilateral cleft lip and palate patients with and without pre-alveolar bone graft orthodontic treatment. 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Cleft Palate Craniofac J. 2007;44:73\u201378."},{"key":"i0003-3219-88-3-299-b05","series-title":"Int J Paediatr Dent","first-page":"455","article-title":"Periodontal and microbiological parameters in children and adolescents with cleft lip and\/or palate","volume":"19","author":"Perdikogianni \n              H,","year":"2009","unstructured":"Perdikogianni \n              H, \n            \n            \n              Papaioannou \n              W, \n            \n            \n              Nakou \n              M, \n            \n            \n              Oulis \n              C, \n            \n            \n              Papagiannoulis \n              L. \n            \n          \n          Periodontal and microbiological parameters in children and adolescents with cleft lip and\/or palate. Int J Paediatr Dent. 2009;19:455\u2013467."},{"key":"i0003-3219-88-3-299-b06","series-title":"Cleft Palate Craniofac J","first-page":"357","article-title":"Periodontal status of teeth adjacent to nongrafted unilateral alveolar clefts","volume":"29","author":"Teja \n              Z,","year":"1992","unstructured":"Teja \n              Z, \n            \n            \n              Persson \n              R, \n            \n            \n              Omnell \n              ML. \n            \n          \n          Periodontal status of teeth adjacent to nongrafted unilateral alveolar clefts. Cleft Palate Craniofac J. 1992;29:357\u2013362."},{"key":"i0003-3219-88-3-299-b07","series-title":"Int J Periodontics Restorative Dent","first-page":"e344","article-title":"Periodontal indices and status in 34 growing patients with unilateral cleft lip and palate: a split-mouth study","volume":"37","author":"Plakwicz \n              P,","year":"2017","unstructured":"Plakwicz \n              P, \n            \n            \n              Wyrebek \n              B, \n            \n            \n              Gorska \n              R, \n            \n            \n              Cudzilo \n              D. \n            \n          \n          Periodontal indices and status in 34 growing patients with unilateral cleft lip and palate: a split-mouth study. Int J Periodontics Restorative Dent. 2017;37:e344\u2013e353."},{"key":"i0003-3219-88-3-299-b08","series-title":"J Clin Periodontol","first-page":"49","article-title":"A split-mouth study on periodontal and microbial parameters in children with complete unilateral cleft lip and palate","volume":"30","author":"Quirynen \n              M,","year":"2003","unstructured":"Quirynen \n              M, \n            \n            \n              Dewinter \n              G, \n            \n            \n              Avontroodt \n              P, \n            \n            \n              Heidbuchel \n              K, \n            \n            \n              Verdonck \n              A, \n            \n            \n              Carels \n              C. \n            \n          \n          A split-mouth study on periodontal and microbial parameters in children with complete unilateral cleft lip and palate. 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Angle Orthod. 2015;85:1003\u20131008."},{"key":"i0003-3219-88-3-299-b10","series-title":"Cleft Palate Craniofac J","first-page":"208","article-title":"Alveolar bone morphology in patients with bilateral complete cleft lip and palate in the mixed dentition: cone beam computed tomography evaluation","volume":"49","author":"Garib \n              DG,","year":"2012","unstructured":"Garib \n              DG, \n            \n            \n              Yatabe \n              MS, \n            \n            \n              Ozawa \n              TO, \n            \n            \n              da Silva Filho \n              OG. \n            \n          \n          Alveolar bone morphology in patients with bilateral complete cleft lip and palate in the mixed dentition: cone beam computed tomography evaluation. 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