{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T15:06:56Z","timestamp":1780067216071,"version":"3.54.0"},"reference-count":106,"publisher":"The Angle Orthodontist (EH Angle Education & Research Foundation)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To analyze, appraise, and synthesize papers in which authors have compared the effects of chemotherapeutic toothpaste (CTP) and regular toothpaste (RTP) on plaque scores (PSs), gingival scores (GSs), and bleeding scores (BSs) in orthodontic patients wearing fixed appliances (FAs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>PubMed-MEDLINE, Cochrane-CENTRAL, and Embase databases were searched with predefined search terms until April 2024 for controlled or randomized controlled clinical trials aligning with the aim. In the eligible papers, risk of bias was evaluated, data of interest were extracted, and a descriptive analysis was performed. If possible, meta-analyses and subanalyses on specific factors were conducted. The quality of evidence and strength of the recommendation were rated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In our search and selection, we obtained five papers describing eight comparisons. Potential risk of bias was assessed as some concerns to high, and heterogeneity was considered substantial. Descriptive analysis revealed no significant difference in PS and BS, with an improvement in GS favoring CTP. Meta-analyses of the end scores showed CTP significantly reduced PS (standardized mean difference [SMD] = \u22120.26; 95% confidence interval [CI] = \u22120.52, \u22120.01;\n                      <jats:italic>P<\/jats:italic>\n                      = .04). However, no significant effects were observed on GS and BS. These findings were supported by the subanalyses on CTP with chlorhexidine (CHX; PS: mean difference [MD] = \u22125.12; 95% CI = \u221210.08, \u22120.15;\n                      <jats:italic>P<\/jats:italic>\n                      = .04). The quality of evidence was graded as very low, and strength of the recommendation was judged as very weak.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>For orthodontic patients with FAs, very weak certainty exists in recommending CTP (eg, with CHX) over RTP for use with toothbrushing. CTP may have a very small effect on PS and a small effect on GS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2319\/071824-573.1","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T23:24:21Z","timestamp":1744932261000},"page":"550-562","source":"Crossref","is-referenced-by-count":0,"title":["Effects of chemotherapeutic vs regular toothpastes on dental plaque and gingival inflammation in orthodontic patients with fixed appliances: a systematic review and meta-analysis"],"prefix":"10.2319","volume":"95","author":[{"given":"Yinli","family":"Liu","sequence":"first","affiliation":[{"name":"PhD candidate, DDS, Department of Orthodontics, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cees","family":"Valkenburg","sequence":"additional","affiliation":[{"name":"Lecturer, PhD, DDS, Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald Edwin Gaston","family":"Jonkman","sequence":"additional","affiliation":[{"name":"Associate professor, PhD, DDS, Department of Orthodontics, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagmar Else","family":"Slot","sequence":"additional","affiliation":[{"name":"Professor, PhD, RDH, Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1164","reference":[{"issue":"2","key":"i1945-7103-95-5-550-b01","series-title":"J Periodontal Res","first-page":"225","article-title":"Epidemiology of gingivitis in schoolchildren in Bucharest, Romania: a cross-sectional study","volume":"52","author":"Funieru","year":"2017","unstructured":"Funieru C,\nKlinger A,\nBaicus C, et al. Epidemiology of gingivitis in schoolchildren in Bucharest, Romania: a cross-sectional study. J Periodontal Res. 2017;52(2):225\u2013232."},{"issue":"5","key":"i1945-7103-95-5-550-b02","series-title":"J Appl Oral Sci","first-page":"524","article-title":"Prevalence, severity, and risk indicators of gingival inflammation in a multi-center study on South American adults: a cross sectional study","volume":"24","author":"Carvajal","year":"2016","unstructured":"Carvajal P,\nGomez M,\nGomes S, et al. Prevalence, severity, and risk indicators of gingival inflammation in a multi-center study on South American adults: a cross sectional study. J Appl Oral Sci. 2016;24(5):524\u2013534."},{"issue":"1","key":"i1945-7103-95-5-550-b03","series-title":"Dent Clin North Am","first-page":"69","article-title":"Evidence-based update on diagnosis and management of gingivitis and periodontitis","volume":"63","author":"Kumar","year":"2019","unstructured":"Kumar S. 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A systematic review. J Clin Periodontol. 2016;43(12):1050\u20131058."},{"issue":"1","key":"i1945-7103-95-5-550-b12","series-title":"Cochrane Database Syst Rev","first-page":"CD002278","article-title":"Fluoride toothpastes for preventing dental caries in children and adolescents","volume":"2003","author":"Marinho","year":"2003","unstructured":"Marinho VC,\nHiggins JP,\nSheiham A, et al. Fluoride toothpastes for preventing dental caries in children and adolescents. Cochrane Database Syst Rev. 2003;2003(1):CD002278."},{"issue":"12","key":"i1945-7103-95-5-550-b13","series-title":"J Clin Periodontol","first-page":"1059","article-title":"Efficacy of adjunctive anti-plaque chemical agents: a systematic review and network meta-analyses of the Turesky modification of the Quigley and Hein plaque index","volume":"43","author":"Escribano","year":"2016","unstructured":"Escribano M,\nFiguero E,\nMartin C, et al. 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Periodontol 2000. 2019;79(1):221\u2013232."},{"issue":"5","key":"i1945-7103-95-5-550-b17","series-title":"Eur J Orthod","first-page":"465","article-title":"Clinical and microbiological effects of the use of a cetylpyridinium chloride dentifrice and mouth rinse in orthodontic patients: a 3-month randomized clinical trial","volume":"40","author":"Herrera","year":"2018","unstructured":"Herrera D,\nEscudero N,\nPerez L, et al. Clinical and microbiological effects of the use of a cetylpyridinium chloride dentifrice and mouth rinse in orthodontic patients: a 3-month randomized clinical trial. 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