{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T16:05:14Z","timestamp":1780070714089,"version":"3.54.0"},"reference-count":32,"publisher":"The Angle Orthodontist (EH Angle Education & Research Foundation)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec id=\"st1\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To evaluate the effect of a Herbst appliance on ventilation of the pharyngeal airway (PA) using computational fluid dynamics (CFD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"st2\">\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Twenty-one Class II patients (10 boys; mean age, 11.7 years) who required Herbst therapy with edgewise treatment underwent cone-beam computed tomography (CBCT) before and after treatment. Nineteen Class I control patients (8 boys; mean age, 11.9 years) received edgewise treatment alone. The pressure and velocity of the PA were compared between the groups using CFD based on three-dimensional CBCT images of the PA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"st3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The change in oropharyngeal airway velocity in the Herbst group (1.95 m\/s) was significantly larger than that in the control group (0.67 m\/s). Similarly, the decrease in laryngopharyngeal airway velocity in the Herbst group (1.37 m\/s) was significantly larger than that in the control group (0.57 m\/s).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"st4\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The Herbst appliance improves ventilation of the oropharyngeal and laryngopharyngeal airways. These results may provide a useful assessment of obstructive sleep apnea treatment during growth.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2319\/080616-603.1","type":"journal-article","created":{"date-parts":[[2017,1,25]],"date-time":"2017-01-25T10:13:22Z","timestamp":1485339202000},"page":"397-403","source":"Crossref","is-referenced-by-count":18,"title":["Herbst appliance effects on pharyngeal airway ventilation evaluated using computational fluid dynamics"],"prefix":"10.2319","volume":"87","author":[{"given":"Tomonori","family":"Iwasaki","sequence":"first","affiliation":[{"name":"Assistant Professor, Field of Developmental Medicine, Health Research Course, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Sato","sequence":"additional","affiliation":[{"name":"Lecturer, Field of Developmental Medicine, Health Research Course, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hokuto","family":"Suga","sequence":"additional","affiliation":[{"name":"Research Associate, Field of Developmental Medicine, Health Research Course, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayaka","family":"Minami","sequence":"additional","affiliation":[{"name":"Clinical Fellow, Field of Developmental Medicine, Health Research Course, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuushi","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Clinical Fellow, Field of Developmental Medicine, Health Research Course, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiko","family":"Takemoto","sequence":"additional","affiliation":[{"name":"Research Associate, Field of Developmental Medicine, Health Research Course, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emi","family":"Inada","sequence":"additional","affiliation":[{"name":"Research Associate, Field of Developmental Medicine, Health Research Course, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Issei","family":"Saitoh","sequence":"additional","affiliation":[{"name":"Assistant Professor, Division of Pediatric Dentistry, Department of Oral Health Science, Course of Oral Life Science, Graduate School of Medical and Dental Sciences, Niigata University, Nigata, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eriko","family":"Kakuno","sequence":"additional","affiliation":[{"name":"Private Practice, Himeji, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuzo","family":"Kanomi","sequence":"additional","affiliation":[{"name":"Private Practice, Himeji, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youichi","family":"Yamasaki","sequence":"additional","affiliation":[{"name":"Professor and Chairman, Field of Developmental Medicine, Health Research Course, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1164","reference":[{"key":"i0003-3219-87-3-397-b01","series-title":"Eur Respir J","first-page":"79","article-title":"Magnetic resonance imaging of the pharynx in OSA patients and healthy subjects","volume":"17","author":"Ciscar \n              MA,","year":"2001","unstructured":"Ciscar \n              MA, \n            \n            \n              Juan \n              G, \n            \n            \n              Martinez \n              V, \n            \n            et al. \n          Magnetic resonance imaging of the pharynx in OSA patients and healthy subjects. Eur Respir J. 2001;17:79\u201386."},{"key":"i0003-3219-87-3-397-b02","series-title":"Am J Orthod Dentofacial Orthop","first-page":"e135","article-title":"Evaluation of upper airway obstruction in Class II children with fluid-mechanical simulation","volume":"139","author":"Iwasaki \n              T,","year":"2011","unstructured":"Iwasaki \n              T, \n            \n            \n              Saitoh \n              I, \n            \n            \n              Takemoto \n              Y, \n            \n            et al. \n          Evaluation of upper airway obstruction in Class II children with fluid-mechanical simulation. Am J Orthod Dentofacial Orthop. 2011;139:e135\u2013e145."},{"key":"i0003-3219-87-3-397-b03","series-title":"Am J Orthod Dentofacial Orthop","first-page":"776","article-title":"Three-dimensional cone-beam computed tomography analysis of enlargement of the pharyngeal airway by the Herbst appliance","volume":"146","author":"Iwasaki \n              T,","year":"2014","unstructured":"Iwasaki \n              T, \n            \n            \n              Takemoto \n              Y, \n            \n            \n              Inada \n              E, \n            \n            et al. \n          Three-dimensional cone-beam computed tomography analysis of enlargement of the pharyngeal airway by the Herbst appliance. Am J Orthod Dentofacial Orthop. 2014;146:776\u2013785."},{"key":"i0003-3219-87-3-397-b04","series-title":"Thorax","first-page":"972","article-title":"Mandibular advancement oral appliance therapy for obstructive sleep apnoea: effect on awake calibre of the velopharynx","volume":"54","author":"Ryan \n              CF,","year":"1999","unstructured":"Ryan \n              CF, \n            \n            \n              Love \n              LL, \n            \n            \n              Peat \n              D, \n            \n            \n              Fleetham \n              JA, \n            \n            \n              Lowe \n              AA. \n            \n          \n          Mandibular advancement oral appliance therapy for obstructive sleep apnoea: effect on awake calibre of the velopharynx. Thorax. 1999;54:972\u2013977."},{"key":"i0003-3219-87-3-397-b05","series-title":"Angle Orthod","first-page":"15","article-title":"Obstructive sleep apnea patients with the oral appliance experience pharyngeal size and shape changes in three dimensions","volume":"75","author":"Kyung \n              SH,","year":"2005","unstructured":"Kyung \n              SH, \n            \n            \n              Park \n              YC, \n            \n            \n              Pae \n              EK. \n            \n          \n          Obstructive sleep apnea patients with the oral appliance experience pharyngeal size and shape changes in three dimensions. Angle Orthod. 2005;75:15\u201322."},{"key":"i0003-3219-87-3-397-b06","series-title":"Am J Orthod Dentofacial Orthop","first-page":"582","article-title":"Treatment effects of the edgewise Herbst appliance: a cephalometric and tomographic investigation","volume":"130","author":"VanLaecken \n              R,","year":"2006","unstructured":"VanLaecken \n              R, \n            \n            \n              Martin \n              CA, \n            \n            \n              Dischinger \n              T, \n            \n            \n              Razmus \n              T, \n            \n            \n              Ngan \n              P. \n            \n          \n          Treatment effects of the edgewise Herbst appliance: a cephalometric and tomographic investigation. Am J Orthod Dentofacial Orthop. 2006;130:582\u2013593."},{"key":"i0003-3219-87-3-397-b07","series-title":"Am J Orthod Dentofacial Orthop","first-page":"19","article-title":"Late adult skeletofacial growth after adolescent Herbst therapy: a 32-year longitudinal follow-up study","volume":"147","author":"Pancherz \n              H,","year":"2015","unstructured":"Pancherz \n              H, \n            \n            \n              Bjerklin \n              K, \n            \n            \n              Hashemi \n              K. \n            \n          \n          Late adult skeletofacial growth after adolescent Herbst therapy: a 32-year longitudinal follow-up study. Am J Orthod Dentofacial Orthop. 2015;147:19\u201328."},{"key":"i0003-3219-87-3-397-b08","series-title":"Eur J Orthod","first-page":"607","article-title":"Sleep nasendoscopy: a diagnostic tool for predicting treatment success with mandibular advancement splints in obstructive sleep apnoea","volume":"27","author":"Johal \n              A,","year":"2005","unstructured":"Johal \n              A, \n            \n            \n              Battagel \n              JM, \n            \n            \n              Kotecha \n              BT. \n            \n          \n          Sleep nasendoscopy: a diagnostic tool for predicting treatment success with mandibular advancement splints in obstructive sleep apnoea. Eur J Orthod. 2005;27:607\u2013614."},{"issue":"2","key":"i0003-3219-87-3-397-b09","series-title":"Angle Orthod","first-page":"222","article-title":"Class II correction improves nocturnal breathing in adolescents","volume":"81","author":"Schutz \n              TC,","year":"2011","unstructured":"Schutz \n              TC, \n            \n            \n              Dominguez \n              GC, \n            \n            \n              Hallinan \n              MP, \n            \n            \n              Cunha \n              TC, \n            \n            \n              Tufik \n              S. \n            \n          \n          Class II correction improves nocturnal breathing in adolescents. Angle Orthod. 2011;81(2):222\u2013228."},{"key":"i0003-3219-87-3-397-b10","series-title":"Int J Oral Maxillofac Surg","first-page":"579","article-title":"The effect of head posture on the pharyngeal airway space (PAS)","volume":"31","author":"Muto \n              T,","year":"2002","unstructured":"Muto \n              T, \n            \n            \n              Takeda \n              S, \n            \n            \n              Kanazawa \n              M, \n            \n            \n              Yamazaki \n              A, \n            \n            \n              Fujiwara \n              Y, \n            \n            \n              Mizoguchi \n              I. \n            \n          \n          The effect of head posture on the pharyngeal airway space (PAS). Int J Oral Maxillofac Surg. 2002;31:579\u2013583."},{"key":"i0003-3219-87-3-397-b11","series-title":"Am J Orthod Dentofacial Orthop","first-page":"318.e1","article-title":"Oropharyngeal airway in children with Class III malocclusion evaluated by cone-beam computed tomography","volume":"136","author":"Iwasaki \n              T,","year":"2009","unstructured":"Iwasaki \n              T, \n            \n            \n              Hayasaki \n              H, \n            \n            \n              Takemoto \n              Y, \n            \n            \n              Kanomi \n              R, \n            \n            \n              Yamasaki \n              Y. \n            \n          \n          Oropharyngeal airway in children with Class III malocclusion evaluated by cone-beam computed tomography. Am J Orthod Dentofacial Orthop. 2009;136:318.e1\u2013e9; discussion 318\u2013319."},{"key":"i0003-3219-87-3-397-b12","series-title":"Stastistical Methods for Medical and Biological Students","author":"Dahlberg \n              G.","year":"1940","unstructured":"Dahlberg \n              G. \n            \n          \n          Stastistical Methods for Medical and Biological Students. New York: Interscience Publications;1940."},{"key":"i0003-3219-87-3-397-b13","series-title":"J Craniomaxillofac Surg","first-page":"1650","article-title":"Different therapeutic mechanisms of rigid and semi-rigid mandibular repositioning devices in obstructive sleep apnea syndrome","volume":"42","author":"Suga \n              H,","year":"2014","unstructured":"Suga \n              H, \n            \n            \n              Mishima \n              K, \n            \n            \n              Nakano \n              H, \n            \n            et al. \n          Different therapeutic mechanisms of rigid and semi-rigid mandibular repositioning devices in obstructive sleep apnea syndrome. J Craniomaxillofac Surg. 2014;42:1650\u20131654."},{"key":"i0003-3219-87-3-397-b14","series-title":"J Biomech","first-page":"3708","article-title":"Functional imaging using computational fluid dynamics to predict treatment success of mandibular advancement devices in sleep-disordered breathing","volume":"40","author":"De Backer \n              JW,","year":"2007","unstructured":"De Backer \n              JW, \n            \n            \n              Vanderveken \n              OM, \n            \n            \n              Vos \n              WG, \n            \n            et al. \n          Functional imaging using computational fluid dynamics to predict treatment success of mandibular advancement devices in sleep-disordered breathing. J Biomech. 2007;40:3708\u20133714."},{"key":"i0003-3219-87-3-397-b15","series-title":"J Biomech","first-page":"142","article-title":"Computational fluid dynamics for the assessment of upper airway response to oral appliance treatment in obstructive sleep apnea","volume":"46","author":"Zhao \n              M,","year":"2013","unstructured":"Zhao \n              M, \n            \n            \n              Barber \n              T, \n            \n            \n              Cistulli \n              P, \n            \n            \n              Sutherland \n              K, \n            \n            \n              Rosengarten \n              G. \n            \n          \n          Computational fluid dynamics for the assessment of upper airway response to oral appliance treatment in obstructive sleep apnea. J Biomech. 2013;46:142\u2013150."},{"key":"i0003-3219-87-3-397-b16","series-title":"Am J Respir Crit Care Med","first-page":"123","article-title":"Randomized controlled study of an oral jaw-positioning appliance for the treatment of obstructive sleep apnea in children with malocclusion","volume":"165","author":"Villa \n              MP,","year":"2002","unstructured":"Villa \n              MP, \n            \n            \n              Bernkopf \n              E, \n            \n            \n              Pagani \n              J, \n            \n            \n              Broia \n              V, \n            \n            \n              Montesano \n              M, \n            \n            \n              Ronchetti \n              R. \n            \n          \n          Randomized controlled study of an oral jaw-positioning appliance for the treatment of obstructive sleep apnea in children with malocclusion. Am J Respir Crit Care Med. 2002;165:123\u2013127."},{"key":"i0003-3219-87-3-397-b01","series-title":"Eur Respir J","first-page":"79","article-title":"Magnetic resonance imaging of the pharynx in OSA patients and healthy subjects","volume":"17","author":"Ciscar \n              MA,","year":"2001","unstructured":"Ciscar \n              MA, \n            \n            \n              Juan \n              G, \n            \n            \n              Martinez \n              V, \n            \n            et al. \n          Magnetic resonance imaging of the pharynx in OSA patients and healthy subjects. Eur Respir J. 2001;17:79\u201386."},{"key":"i0003-3219-87-3-397-b02","series-title":"Am J Orthod Dentofacial Orthop","first-page":"e135","article-title":"Evaluation of upper airway obstruction in Class II children with fluid-mechanical simulation","volume":"139","author":"Iwasaki \n              T,","year":"2011","unstructured":"Iwasaki \n              T, \n            \n            \n              Saitoh \n              I, \n            \n            \n              Takemoto \n              Y, \n            \n            et al. \n          Evaluation of upper airway obstruction in Class II children with fluid-mechanical simulation. Am J Orthod Dentofacial Orthop. 2011;139:e135\u2013e145."},{"key":"i0003-3219-87-3-397-b03","series-title":"Am J Orthod Dentofacial Orthop","first-page":"776","article-title":"Three-dimensional cone-beam computed tomography analysis of enlargement of the pharyngeal airway by the Herbst appliance","volume":"146","author":"Iwasaki \n              T,","year":"2014","unstructured":"Iwasaki \n              T, \n            \n            \n              Takemoto \n              Y, \n            \n            \n              Inada \n              E, \n            \n            et al. \n          Three-dimensional cone-beam computed tomography analysis of enlargement of the pharyngeal airway by the Herbst appliance. Am J Orthod Dentofacial Orthop. 2014;146:776\u2013785."},{"key":"i0003-3219-87-3-397-b04","series-title":"Thorax","first-page":"972","article-title":"Mandibular advancement oral appliance therapy for obstructive sleep apnoea: effect on awake calibre of the velopharynx","volume":"54","author":"Ryan \n              CF,","year":"1999","unstructured":"Ryan \n              CF, \n            \n            \n              Love \n              LL, \n            \n            \n              Peat \n              D, \n            \n            \n              Fleetham \n              JA, \n            \n            \n              Lowe \n              AA. \n            \n          \n          Mandibular advancement oral appliance therapy for obstructive sleep apnoea: effect on awake calibre of the velopharynx. Thorax. 1999;54:972\u2013977."},{"key":"i0003-3219-87-3-397-b05","series-title":"Angle Orthod","first-page":"15","article-title":"Obstructive sleep apnea patients with the oral appliance experience pharyngeal size and shape changes in three dimensions","volume":"75","author":"Kyung \n              SH,","year":"2005","unstructured":"Kyung \n              SH, \n            \n            \n              Park \n              YC, \n            \n            \n              Pae \n              EK. \n            \n          \n          Obstructive sleep apnea patients with the oral appliance experience pharyngeal size and shape changes in three dimensions. Angle Orthod. 2005;75:15\u201322."},{"key":"i0003-3219-87-3-397-b06","series-title":"Am J Orthod Dentofacial Orthop","first-page":"582","article-title":"Treatment effects of the edgewise Herbst appliance: a cephalometric and tomographic investigation","volume":"130","author":"VanLaecken \n              R,","year":"2006","unstructured":"VanLaecken \n              R, \n            \n            \n              Martin \n              CA, \n            \n            \n              Dischinger \n              T, \n            \n            \n              Razmus \n              T, \n            \n            \n              Ngan \n              P. \n            \n          \n          Treatment effects of the edgewise Herbst appliance: a cephalometric and tomographic investigation. Am J Orthod Dentofacial Orthop. 2006;130:582\u2013593."},{"key":"i0003-3219-87-3-397-b07","series-title":"Am J Orthod Dentofacial Orthop","first-page":"19","article-title":"Late adult skeletofacial growth after adolescent Herbst therapy: a 32-year longitudinal follow-up study","volume":"147","author":"Pancherz \n              H,","year":"2015","unstructured":"Pancherz \n              H, \n            \n            \n              Bjerklin \n              K, \n            \n            \n              Hashemi \n              K. \n            \n          \n          Late adult skeletofacial growth after adolescent Herbst therapy: a 32-year longitudinal follow-up study. Am J Orthod Dentofacial Orthop. 2015;147:19\u201328."},{"key":"i0003-3219-87-3-397-b08","series-title":"Eur J Orthod","first-page":"607","article-title":"Sleep nasendoscopy: a diagnostic tool for predicting treatment success with mandibular advancement splints in obstructive sleep apnoea","volume":"27","author":"Johal \n              A,","year":"2005","unstructured":"Johal \n              A, \n            \n            \n              Battagel \n              JM, \n            \n            \n              Kotecha \n              BT. \n            \n          \n          Sleep nasendoscopy: a diagnostic tool for predicting treatment success with mandibular advancement splints in obstructive sleep apnoea. Eur J Orthod. 2005;27:607\u2013614."},{"issue":"2","key":"i0003-3219-87-3-397-b09","series-title":"Angle Orthod","first-page":"222","article-title":"Class II correction improves nocturnal breathing in adolescents","volume":"81","author":"Schutz \n              TC,","year":"2011","unstructured":"Schutz \n              TC, \n            \n            \n              Dominguez \n              GC, \n            \n            \n              Hallinan \n              MP, \n            \n            \n              Cunha \n              TC, \n            \n            \n              Tufik \n              S. \n            \n          \n          Class II correction improves nocturnal breathing in adolescents. Angle Orthod. 2011;81(2):222\u2013228."},{"key":"i0003-3219-87-3-397-b10","series-title":"Int J Oral Maxillofac Surg","first-page":"579","article-title":"The effect of head posture on the pharyngeal airway space (PAS)","volume":"31","author":"Muto \n              T,","year":"2002","unstructured":"Muto \n              T, \n            \n            \n              Takeda \n              S, \n            \n            \n              Kanazawa \n              M, \n            \n            \n              Yamazaki \n              A, \n            \n            \n              Fujiwara \n              Y, \n            \n            \n              Mizoguchi \n              I. \n            \n          \n          The effect of head posture on the pharyngeal airway space (PAS). Int J Oral Maxillofac Surg. 2002;31:579\u2013583."},{"key":"i0003-3219-87-3-397-b11","series-title":"Am J Orthod Dentofacial Orthop","first-page":"318.e1","article-title":"Oropharyngeal airway in children with Class III malocclusion evaluated by cone-beam computed tomography","volume":"136","author":"Iwasaki \n              T,","year":"2009","unstructured":"Iwasaki \n              T, \n            \n            \n              Hayasaki \n              H, \n            \n            \n              Takemoto \n              Y, \n            \n            \n              Kanomi \n              R, \n            \n            \n              Yamasaki \n              Y. \n            \n          \n          Oropharyngeal airway in children with Class III malocclusion evaluated by cone-beam computed tomography. Am J Orthod Dentofacial Orthop. 2009;136:318.e1\u2013e9; discussion 318\u2013319."},{"key":"i0003-3219-87-3-397-b12","series-title":"Stastistical Methods for Medical and Biological Students","author":"Dahlberg \n              G.","year":"1940","unstructured":"Dahlberg \n              G. \n            \n          \n          Stastistical Methods for Medical and Biological Students. New York: Interscience Publications;1940."},{"key":"i0003-3219-87-3-397-b13","series-title":"J Craniomaxillofac Surg","first-page":"1650","article-title":"Different therapeutic mechanisms of rigid and semi-rigid mandibular repositioning devices in obstructive sleep apnea syndrome","volume":"42","author":"Suga \n              H,","year":"2014","unstructured":"Suga \n              H, \n            \n            \n              Mishima \n              K, \n            \n            \n              Nakano \n              H, \n            \n            et al. \n          Different therapeutic mechanisms of rigid and semi-rigid mandibular repositioning devices in obstructive sleep apnea syndrome. J Craniomaxillofac Surg. 2014;42:1650\u20131654."},{"key":"i0003-3219-87-3-397-b14","series-title":"J Biomech","first-page":"3708","article-title":"Functional imaging using computational fluid dynamics to predict treatment success of mandibular advancement devices in sleep-disordered breathing","volume":"40","author":"De Backer \n              JW,","year":"2007","unstructured":"De Backer \n              JW, \n            \n            \n              Vanderveken \n              OM, \n            \n            \n              Vos \n              WG, \n            \n            et al. \n          Functional imaging using computational fluid dynamics to predict treatment success of mandibular advancement devices in sleep-disordered breathing. J Biomech. 2007;40:3708\u20133714."},{"key":"i0003-3219-87-3-397-b15","series-title":"J Biomech","first-page":"142","article-title":"Computational fluid dynamics for the assessment of upper airway response to oral appliance treatment in obstructive sleep apnea","volume":"46","author":"Zhao \n              M,","year":"2013","unstructured":"Zhao \n              M, \n            \n            \n              Barber \n              T, \n            \n            \n              Cistulli \n              P, \n            \n            \n              Sutherland \n              K, \n            \n            \n              Rosengarten \n              G. \n            \n          \n          Computational fluid dynamics for the assessment of upper airway response to oral appliance treatment in obstructive sleep apnea. J Biomech. 2013;46:142\u2013150."},{"key":"i0003-3219-87-3-397-b16","series-title":"Am J Respir Crit Care Med","first-page":"123","article-title":"Randomized controlled study of an oral jaw-positioning appliance for the treatment of obstructive sleep apnea in children with malocclusion","volume":"165","author":"Villa \n              MP,","year":"2002","unstructured":"Villa \n              MP, \n            \n            \n              Bernkopf \n              E, \n            \n            \n              Pagani \n              J, \n            \n            \n              Broia \n              V, \n            \n            \n              Montesano \n              M, \n            \n            \n              Ronchetti \n              R. \n            \n          \n          Randomized controlled study of an oral jaw-positioning appliance for the treatment of obstructive sleep apnea in children with malocclusion. 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