{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:20:19Z","timestamp":1792678819619,"version":"4.5.0"},"reference-count":33,"publisher":"The Angle Orthodontist (EH Angle Education & Research Foundation)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n        <jats:p>\n          <jats:bold>Objective:<\/jats:bold> To examine the effect of anti-c-Fms antibody on odontoclastogenesis and root resorption in an orthodontic tooth movement mouse model.<\/jats:p>\n        <jats:p>\n          <jats:bold>Materials and Methods:<\/jats:bold> We used orthodontic tooth movement in which an Ni-Ti coil spring was inserted between the upper incisors and the upper first molar. Root resorption occurred in this model. Anti-c-Fms antibody was injected daily into a local site for 12 days during mechanical loading. Odontoclastogenesis and root resorption were assessed by histology and scanning electron microscopy.<\/jats:p>\n        <jats:p>\n          <jats:bold>Results:<\/jats:bold> The anti-c-Fms antibody significantly inhibited odontoclastogenesis and root resorption during orthodontic tooth movement.<\/jats:p>\n        <jats:p>\n          <jats:bold>Conclusion:<\/jats:bold> M-CSF and\/or its receptor is a potential therapeutic target in mechanical stress\u2013 induced odontoclastogenesis, and injection of an anti-c-Fms antibody might be useful for inhibition of mechanical stress\u2013induced root resorption during orthodontic tooth movement.<\/jats:p>","DOI":"10.2319\/080708-412.1","type":"journal-article","created":{"date-parts":[[2009,4,15]],"date-time":"2009-04-15T18:46:00Z","timestamp":1239821160000},"page":"835-841","source":"Crossref","is-referenced-by-count":20,"title":["An M-CSF Receptor c-Fms Antibody Inhibits Mechanical Stress\u2013Induced Root Resorption during Orthodontic Tooth Movement in Mice"],"prefix":"10.2319","volume":"79","author":[{"given":"Hideki","family":"Kitaura","sequence":"first","affiliation":[{"name":"a\u2009Assistant Professor, Divisions of Orthodontic and Dentofacial Orthopedics, Department of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Fujimura","sequence":"additional","affiliation":[{"name":"b\u2009Post doc, Department of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masako","family":"Yoshimatsu","sequence":"additional","affiliation":[{"name":"c\u2009Assistant Professor, Department of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiko","family":"Eguchi","sequence":"additional","affiliation":[{"name":"d\u2009Graduate PhD student, Department of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruka","family":"Kohara","sequence":"additional","affiliation":[{"name":"d\u2009Graduate PhD student, Department of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Insan","family":"Jang","sequence":"additional","affiliation":[{"name":"d\u2009Graduate PhD student, Department of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Morita","sequence":"additional","affiliation":[{"name":"d\u2009Graduate PhD student, Department of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriaki","family":"Yoshida","sequence":"additional","affiliation":[{"name":"e\u2009Professor, Department of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1164","reference":[{"key":"i0003-3219-079-05-0835-b1","series-title":"J Clin Invest","first-page":"3418","article-title":"M-CSF mediates TNF-induced inflammatory osteolysis.","volume":"115","author":"Kitaura, H.","year":"2005","unstructured":"Kitaura, H., P.Zhou, H. 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