{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:51:46Z","timestamp":1787025106526,"version":"build-2736575974"},"reference-count":64,"publisher":"The Angle Orthodontist (EH Angle Education & Research Foundation)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the change in tooth root volume using cone-beam computed tomography (CBCT) in a group of patients treated concurrently with clear aligners and an adjunctive photobiomodulation (PBM) device.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This retrospective cohort pilot study included the records of 32 consecutively treated clear aligner patients (23 female, 9 male) from the private practice of one orthodontist. The PBM group (n = 16) used the device once per day for 5 minutes per arch and was compared with a matched control group (n = 16). A semiautomated segmentation technique was used to obtain tooth volume of anterior teeth from CBCT imaging prior to (T0) and during or immediately following (T1) orthodontic treatment with clear aligners. The change in root volume between time points was assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There was no statistically significant difference between the pre- and posttreatment root volumes of maxillary and mandibular anterior teeth, regardless of which intervention group the patient belonged to (\n                      <jats:italic>P<\/jats:italic>\n                      &gt; .05). There was also no difference in the mean percentage change in root volume between clear aligner patients in this study who were treated with the PBM device compared with a matched control group (\n                      <jats:italic>P<\/jats:italic>\n                      &gt; .05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Clear aligner patients in this study who changed their aligners every 3 to 5 days and used adjunctive photobiomodulation therapy did not experience clinically relevant orthodontically induced external root resorption. Due to the small sample size and measurement error in the root segmentation process, the results should be interpreted with caution.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2319\/081823-567.1","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T19:05:05Z","timestamp":1709060705000},"page":"294-302","source":"Crossref","is-referenced-by-count":9,"title":["An evaluation of root resorption associated with the use of photobiomodulation during orthodontic treatment with clear aligners: a retrospective cohort pilot study"],"prefix":"10.2319","volume":"94","author":[{"given":"Antonio","family":"Rossi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Lagrav\u00e8re-Vich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giseon","family":"Heo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul W.","family":"Major","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarek","family":"El-Bialy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1164","reference":[{"issue":"4","key":"r1","series-title":"Am J Orthod Dentofacial Orthop","first-page":"462","article-title":"Root resorption associated with orthodontic tooth movement: a systematic review","volume":"137","author":"Weltman\n              B","year":"2010","unstructured":"Weltman\n              B\n            , VigKWL, FieldsHW, ShankerS, KaizarEE.\n          Root resorption associated with orthodontic tooth movement: a systematic review.\nAm J Orthod Dentofacial Orthop.\n2010;\n137(4):462\u2013476."},{"issue":"4","key":"r2","series-title":"Dental Traumatol.","first-page":"175","article-title":"Root resorption\u2014diagnosis, classification and treatment choices based on stimulation factors","volume":"19","author":"Fuss\n              Z","year":"2003","unstructured":"Fuss\n              Z\n            , TsesisI, LinS.\n          Root resorption\u2014diagnosis, classification and treatment choices based on stimulation factors.\nDental Traumatol.2003;\n19(4):175\u2013182."},{"issue":"2","key":"r3","series-title":"Semin Orthod","first-page":"128","article-title":"Root resorption caused by orthodontic treatment: an evidence-based review of literature","volume":"5","author":"Killiany\n              DM.","year":"1999","unstructured":"Killiany\n              DM.\n            \n          \n          Root resorption caused by orthodontic treatment: an evidence-based review of literature.\nSemin Orthod.\n1999;\n5(2):128\u2013133."},{"issue":"1","key":"r4","series-title":"Am J Orthod Dentofacial Orthop.","first-page":"35","article-title":"Patient characteristics and treatment variables associated with apical root resorption during orthodontic treatment","volume":"99","author":"Linge\n              L","year":"1991","unstructured":"Linge\n              L\n            , LingeBO.\n          Patient characteristics and treatment variables associated with apical root resorption during orthodontic treatment.\nAm J Orthod Dentofacial Orthop.1991;\n99(1):35\u201343."},{"issue":"5","key":"r5","series-title":"Am J Orthod Dentofacial Orthop","first-page":"610","article-title":"Association of orthodontic force system and root resorption: a systematic review","volume":"147","author":"Roscoe\n              MG","year":"2015","unstructured":"Roscoe\n              MG\n            , MeiraJBC, CattaneoPM.\n          Association of orthodontic force system and root resorption: a systematic review.\nAm J Orthod Dentofacial Orthop.\n2015;\n147(5):610\u2013626."},{"key":"r6","series-title":"Aust Dent J","first-page":"63","article-title":"Accelerated orthodontic treatment\u2014what\u2019s the evidence","volume":"62","author":"Miles\n              P.","year":"2017","unstructured":"Miles\n              P.\n            \n          \n          Accelerated orthodontic treatment\u2014what\u2019s the evidence? Aust Dent J.\n2017;\n62:63\u201370."},{"issue":"2","key":"r7","series-title":"Photomed Laser Surg.","first-page":"121","article-title":"Clinical and Experimental Applications of NIR-LED photobiomodulation","volume":"24","author":"Desmet\n              KD","year":"2006","unstructured":"Desmet\n              KD\n            , PazDA, CorryJJ, . Clinical and Experimental Applications of NIR-LED photobiomodulation.\nPhotomed Laser Surg.2006;\n24(2):121\u2013128."},{"key":"r8","series-title":"PBM\u2014Clinical and scientific dossier","year":"2019","unstructured":"PBM\u2014Clinical and scientific dossier.\n2019. https:\/\/www.orthopulse.com\/wp-content\/uploads\/2023\/05\/230503_TD-IFU-EN_Orthopulse_V1.7US_01.pdf"},{"issue":"6","key":"r9","series-title":"Proc Natl Acad Sci U S A.","first-page":"3439","article-title":"Therapeutic photobiomodulation for methanol-induced retinal toxicity","volume":"100","author":"Eells\n              JT","year":"2003","unstructured":"Eells\n              JT\n            , HenryMM, SummerfeltP, . Therapeutic photobiomodulation for methanol-induced retinal toxicity.\nProc Natl Acad Sci U S A.2003;\n100(6):3439\u20133944."},{"issue":"1","key":"r10","series-title":"J Mol Cell Cardiol","first-page":"4","article-title":"Near infrared light protects cardiomyocytes from hypoxia and reoxygenation injury by a nitric oxide dependent mechanism","volume":"46","author":"Zhang\n              R","year":"2009","unstructured":"Zhang\n              R\n            , MioY, PrattPF, . Near infrared light protects cardiomyocytes from hypoxia and reoxygenation injury by a nitric oxide dependent mechanism.\nJ Mol Cell Cardiol.\n2009;\n46(1):4\u201314."},{"issue":"2","key":"r11","series-title":"Photomed Laser Surg","first-page":"72","article-title":"Low-level laser effects on simulated orthodontic tension side periodontal ligament cells","volume":"31","author":"Huang\n              T-H","year":"2013","unstructured":"Huang\n              T-H\n            , LiuS-L, ChenC-L, ShieM-Y, KaoC-T.\n          Low-level laser effects on simulated orthodontic tension side periodontal ligament cells.\nPhotomed Laser Surg.\n2013;\n31(2):72\u201377."},{"issue":"1","key":"r12","series-title":"Am J Orthod Dentofacial Orthop","first-page":"77","article-title":"Quantification of external root resorption by low- vs high-resolution cone-beam computed tomography and periapical radiography: a volumetric and linear analysis","volume":"143","author":"Ponder\n              SN","year":"2013","unstructured":"Ponder\n              SN\n            , BenavidesE, KapilaS, HatchNE.\n          Quantification of external root resorption by low- vs high-resolution cone-beam computed tomography and periapical radiography: a volumetric and linear analysis.\nAm J Orthod Dentofacial Orthop.\n2013;\n143(1):77\u201391."},{"issue":"4","key":"r13","series-title":"Am J Orthod Dentofacial Orthop","first-page":"S100","article-title":"Accuracy and reliability of tooth and root lengths measured on cone-beam computed tomographs","volume":"137","author":"Sherrard\n              JF","year":"2010","unstructured":"Sherrard\n              JF\n            , RossouwPE, BensonBW, CarrilloR, BuschangPH.\n          Accuracy and reliability of tooth and root lengths measured on cone-beam computed tomographs.\nAm J Orthod Dentofacial Orthop.\n2010;\n137(4):S100\u2013S108."},{"issue":"3","key":"r14","series-title":"Angle Orthod","first-page":"466","article-title":"Cone beam computed tomography for assessment of root length and marginal bone level during orthodontic treatment","volume":"80","author":"Lund\n              H","year":"2010","unstructured":"Lund\n              H\n            , Gr\u00f6ndahlK, Gr\u00f6ndahlH-G.\n          Cone beam computed tomography for assessment of root length and marginal bone level during orthodontic treatment.\nAngle Orthod.\n2010;\n80(3):466\u2013473."},{"issue":"4","key":"r15","series-title":"Orthod Craniofac Res","first-page":"206","article-title":"Accuracy of volumetric measurement of teeth in vivo based on cone beam computer tomography","volume":"14","author":"Wang\n              Y","year":"2011","unstructured":"Wang\n              Y\n            , HeS, YuL, LiJ, ChenS.\n          Accuracy of volumetric measurement of teeth in vivo based on cone beam computer tomography.\nOrthod Craniofac Res.\n2011;\n14(4):206\u2013212."},{"issue":"1","key":"r16","series-title":"Angle Orthod","first-page":"160","article-title":"The validity of in vivo tooth volume determinations from cone-beam computed tomography","volume":"80","author":"Liu\n              Y","year":"2009","unstructured":"Liu\n              Y\n            , OlszewskiR, AlexandroniES, EncisoR, XuT, MahJK.\n          The validity of in vivo tooth volume determinations from cone-beam computed tomography.\nAngle Orthod.\n2009;\n80(1):160\u2013166."},{"issue":"6","key":"r17","series-title":"Angle Orthod","first-page":"710","article-title":"Volumetric evaluation of root resorption on the upper incisors using cone beam computed tomography after 1 year of orthodontic treatment in adult patients with marginal bone loss","volume":"88","author":"Puttaravuttiporn\n              P","year":"2018","unstructured":"Puttaravuttiporn\n              P\n            , WongsuwanlertM, CharoemratroteC, LeethanakulC.\n          Volumetric evaluation of root resorption on the upper incisors using cone beam computed tomography after 1 year of orthodontic treatment in adult patients with marginal bone loss.\nAngle Orthod.\n2018;\n88(6):710\u2013718."},{"issue":"2","key":"r18","series-title":"Am J Orthod Dentofacial Orthop","first-page":"218","article-title":"Physical properties of root cementum: part 10. Comparison of the effects of invisible removable thermoplastic appliances with light and heavy orthodontic forces on premolar cementum. A microcomputed-tomography study","volume":"133","author":"Barbagallo\n              LJ","year":"2008","unstructured":"Barbagallo\n              LJ\n            , JonesAS, PetoczP, DarendelilerMA.\n          Physical properties of root cementum: part 10. Comparison of the effects of invisible removable thermoplastic appliances with light and heavy orthodontic forces on premolar cementum. A microcomputed-tomography study.\nAm J Orthod Dentofacial Orthop.\n2008;\n133(2):218\u2013227."},{"key":"r19","series-title":"J Orthod Sci","first-page":"11","article-title":"Evaluation of root length following treatment with clear aligners and two different fixed orthodontic appliances: a pilot study","volume":"7","author":"Eissa\n              O","year":"2018","unstructured":"Eissa\n              O\n            , CarlyleT, El-BialyT.\n          Evaluation of root length following treatment with clear aligners and two different fixed orthodontic appliances: a pilot study.\nJ Orthod Sci.\n2018;\n7:11."},{"issue":"1","key":"r20","series-title":"Prog Orthod.","first-page":"1","article-title":"Prevalence and severity of apical root resorption during orthodontic treatment with clear aligners and fixed appliances: a cone beam computed tomography study","volume":"21","author":"Li\n              Y","year":"2020","unstructured":"Li\n              Y\n            , DengS, MeiL, . Prevalence and severity of apical root resorption during orthodontic treatment with clear aligners and fixed appliances: a cone beam computed tomography study.\nProg Orthod.2020;\n21(1):1."},{"key":"r21","series-title":"Clin Cosmet Investig Dent","first-page":"1","article-title":"The effect of photobiomodulation on root resorption during orthodontic treatment","volume":"6","author":"Nimeri\n              G","year":"2014","unstructured":"Nimeri\n              G\n            , KauCH, CoronaR, ShellyJ.\n          The effect of photobiomodulation on root resorption during orthodontic treatment.\nClin Cosmet Investig Dent.\n2014;\n6:1\u20138."},{"issue":"3","key":"r22","series-title":"Eur J Orthod","first-page":"326","article-title":"The effect of biologic factors and adjunctive therapies on orthodontically induced inflammatory root resorption: a systematic review and meta-analysis","volume":"40","author":"Haugland\n              L","year":"2018","unstructured":"Haugland\n              L\n            , KristensenKD, LieSA, Vandevska-RadunovicV.\n          The effect of biologic factors and adjunctive therapies on orthodontically induced inflammatory root resorption: a systematic review and meta-analysis.\nEur J Orthod.\n2018;\n40(3):326\u2013336."},{"issue":"S1","key":"r23","series-title":"Orthod Craniofac Res","first-page":"117","article-title":"Evaluation of three-dimensional root surface changes and resorption following rapid maxillary expansion: a cone beam computed tomography investigation","volume":"18","author":"Akyalcin\n              S","year":"2015","unstructured":"Akyalcin\n              S\n            , AlexanderSP, SilvaRM, EnglishJD.\n          Evaluation of three-dimensional root surface changes and resorption following rapid maxillary expansion: a cone beam computed tomography investigation.\nOrthod Craniofac Res.\n2015;\n18(S1):117\u2013126."},{"issue":"5","key":"r24","series-title":"Am J Orthod Dentofacial Orthop","first-page":"505","article-title":"Predicting and preventing root resorption: part I. Diagnostic factors","volume":"119","author":"Sameshima\n              GT","year":"2001","unstructured":"Sameshima\n              GT\n            , SinclairPM.\n          Predicting and preventing root resorption: part I. Diagnostic factors.\nAm J Orthod Dentofacial Orthop.\n2001;\n119(5):505\u2013510."},{"issue":"3","key":"r25","series-title":"Am J Orthod","first-page":"183","article-title":"The effect of extraction and orthodontic treatment on dentoalveolar support","volume":"84","author":"Kennedy\n              DB","year":"1983","unstructured":"Kennedy\n              DB\n            , JoondephDR, OsterbergSK, LittleRM.\n          The effect of extraction and orthodontic treatment on dentoalveolar support.\nAm J Orthod.\n1983;\n84(3):183\u2013190."},{"issue":"4","key":"r26","series-title":"Orthod Craniofacial Res.","first-page":"459","article-title":"Impact of intraoral non-pharmacological non-surgical adjunctive interventions on orthodontically induced inflammatory root resorption in humans: a systematic review","volume":"24","author":"Al-Dboush\n              Re","year":"2021","unstructured":"Al-Dboush\n              Re\n            , Flores-MirC, El-BialyT.\n          Impact of intraoral non-pharmacological non-surgical adjunctive interventions on orthodontically induced inflammatory root resorption in humans: a systematic review.\nOrthod Craniofacial Res.2021;\n24(4):459\u2013479."},{"issue":"8","key":"r27","series-title":"Dentomaxillofac Radiol","first-page":"649","article-title":"Effect of voxel size on the accuracy of 3D reconstructions with cone beam CT","volume":"41","author":"Maret\n              D","year":"2012","unstructured":"Maret\n              D\n            , TelmonN, PetersOA, . Effect of voxel size on the accuracy of 3D reconstructions with cone beam CT.\nDentomaxillofac Radiol.\n2012;\n41(8):649\u2013655."},{"issue":"3","key":"r28","series-title":"Am J Orthod Dentofacial Orthop","first-page":"320.e1","article-title":"Physical properties of root cementum: Part 13. Repair of root resorption 4 and 8 weeks after the application of continuous light and heavy forces for 4 weeks: A microcomputed-tomography study","volume":"136","author":"Cheng\n              LL","year":"2009","unstructured":"Cheng\n              LL\n            , T\u00fcrkT, Elekda\u011f-T\u00fcrkS, JonesAS, PetoczP, DarendelilerMA.\n          Physical properties of root cementum: Part 13. Repair of root resorption 4 and 8 weeks after the application of continuous light and heavy forces for 4 weeks: A microcomputed-tomography study.\nAm J Orthod Dentofacial Orthop.\n2009;\n136(3):320.e1\u2013320.e10."},{"issue":"7","key":"r29","series-title":"Adv Clin Exp Med","first-page":"1001","article-title":"Validation of a windowing protocol for accurate in vivo tooth segmentation using i-CAT cone beam computed tomography","volume":"27","author":"Rastegar\n              B","year":"2018","unstructured":"Rastegar\n              B\n            , ThumilaireB, OdriGA, . Validation of a windowing protocol for accurate in vivo tooth segmentation using i-CAT cone beam computed tomography.\nAdv Clin Exp Med.\n2018;\n27(7):1001\u20131008."},{"issue":"10","key":"r30","series-title":"Int Endod J","first-page":"959","article-title":"CBCT-based volume of simulated root resorption\u2014influence of FOV and voxel size","volume":"48","author":"Da Silveira\n              PF","year":"2015","unstructured":"Da Silveira\n              PF\n            , FontanaMP, OliveiraHW, . CBCT-based volume of simulated root resorption\u2014influence of FOV and voxel size.\nInt Endod J.\n2015;\n48(10):959\u2013965."},{"key":"r31","article-title":"Align Technology Introduces One-Week Aligner Wear For Invisalign(R) Teen And Full Products","author":"","year":"2016","unstructured":"Align Technology Introduces One-Week Aligner Wear For Invisalign(R) Teen And Full Products.\n2016. https:\/\/investor.aligntech.com\/news-releases\/news-release-details\/align-technology-introduces-one-week-aligner-wear-invisalignr#:~:text=At%20the%20treating%20doctor\u2019s%20discretion,by%20up%20to%2050%20percent*"},{"issue":"6","key":"r32","series-title":"Eur J Orthod.","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1093\/ejo\/cjac022","article-title":"Physical properties of root cementum: part 29. The effects of LED-mediated photobiomodulation on orthodontically induced root resorption and pain: a pilot split-mouth randomized controlled trial","volume":"44","author":"Sambevski\n              J","year":"2022","unstructured":"Sambevski\n              J\n            , PapadopoulouAK, FoleyM, . Physical properties of root cementum: part 29. The effects of LED-mediated photobiomodulation on orthodontically induced root resorption and pain: a pilot split-mouth randomized controlled trial.\nEur J Orthod.2022;\n44(6):650\u2013658. doi:10.1093\/ejo\/cjac022"},{"issue":"4","key":"r1","series-title":"Am J Orthod Dentofacial Orthop","first-page":"462","article-title":"Root resorption associated with orthodontic tooth movement: a systematic review","volume":"137","author":"Weltman\n              B","year":"2010","unstructured":"Weltman\n              B\n            , VigKWL, FieldsHW, ShankerS, KaizarEE.\n          Root resorption associated with orthodontic tooth movement: a systematic review.\nAm J Orthod Dentofacial Orthop.\n2010;\n137(4):462\u2013476."},{"issue":"4","key":"r2","series-title":"Dental Traumatol.","first-page":"175","article-title":"Root resorption\u2014diagnosis, classification and treatment choices based on stimulation factors","volume":"19","author":"Fuss\n              Z","year":"2003","unstructured":"Fuss\n              Z\n            , TsesisI, LinS.\n          Root resorption\u2014diagnosis, classification and treatment choices based on stimulation factors.\nDental Traumatol.2003;\n19(4):175\u2013182."},{"issue":"2","key":"r3","series-title":"Semin Orthod","first-page":"128","article-title":"Root resorption caused by orthodontic treatment: an evidence-based review of literature","volume":"5","author":"Killiany\n              DM.","year":"1999","unstructured":"Killiany\n              DM.\n            \n          \n          Root resorption caused by orthodontic treatment: an evidence-based review of literature.\nSemin Orthod.\n1999;\n5(2):128\u2013133."},{"issue":"1","key":"r4","series-title":"Am J Orthod Dentofacial Orthop.","first-page":"35","article-title":"Patient characteristics and treatment variables associated with apical root resorption during orthodontic treatment","volume":"99","author":"Linge\n              L","year":"1991","unstructured":"Linge\n              L\n            , LingeBO.\n          Patient characteristics and treatment variables associated with apical root resorption during orthodontic treatment.\nAm J Orthod Dentofacial Orthop.1991;\n99(1):35\u201343."},{"issue":"5","key":"r5","series-title":"Am J Orthod Dentofacial Orthop","first-page":"610","article-title":"Association of orthodontic force system and root resorption: a systematic review","volume":"147","author":"Roscoe\n              MG","year":"2015","unstructured":"Roscoe\n              MG\n            , MeiraJBC, CattaneoPM.\n          Association of orthodontic force system and root resorption: a systematic review.\nAm J Orthod Dentofacial Orthop.\n2015;\n147(5):610\u2013626."},{"key":"r6","series-title":"Aust Dent J","first-page":"63","article-title":"Accelerated orthodontic treatment\u2014what\u2019s the evidence","volume":"62","author":"Miles\n              P.","year":"2017","unstructured":"Miles\n              P.\n            \n          \n          Accelerated orthodontic treatment\u2014what\u2019s the evidence? Aust Dent J.\n2017;\n62:63\u201370."},{"issue":"2","key":"r7","series-title":"Photomed Laser Surg.","first-page":"121","article-title":"Clinical and Experimental Applications of NIR-LED photobiomodulation","volume":"24","author":"Desmet\n              KD","year":"2006","unstructured":"Desmet\n              KD\n            , PazDA, CorryJJ, . Clinical and Experimental Applications of NIR-LED photobiomodulation.\nPhotomed Laser Surg.2006;\n24(2):121\u2013128."},{"key":"r8","series-title":"PBM\u2014Clinical and scientific dossier","year":"2019","unstructured":"PBM\u2014Clinical and scientific dossier.\n2019. https:\/\/www.orthopulse.com\/wp-content\/uploads\/2023\/05\/230503_TD-IFU-EN_Orthopulse_V1.7US_01.pdf"},{"issue":"6","key":"r9","series-title":"Proc Natl Acad Sci U S A.","first-page":"3439","article-title":"Therapeutic photobiomodulation for methanol-induced retinal toxicity","volume":"100","author":"Eells\n              JT","year":"2003","unstructured":"Eells\n              JT\n            , HenryMM, SummerfeltP, . Therapeutic photobiomodulation for methanol-induced retinal toxicity.\nProc Natl Acad Sci U S A.2003;\n100(6):3439\u20133944."},{"issue":"1","key":"r10","series-title":"J Mol Cell Cardiol","first-page":"4","article-title":"Near infrared light protects cardiomyocytes from hypoxia and reoxygenation injury by a nitric oxide dependent mechanism","volume":"46","author":"Zhang\n              R","year":"2009","unstructured":"Zhang\n              R\n            , MioY, PrattPF, . Near infrared light protects cardiomyocytes from hypoxia and reoxygenation injury by a nitric oxide dependent mechanism.\nJ Mol Cell Cardiol.\n2009;\n46(1):4\u201314."},{"issue":"2","key":"r11","series-title":"Photomed Laser Surg","first-page":"72","article-title":"Low-level laser effects on simulated orthodontic tension side periodontal ligament cells","volume":"31","author":"Huang\n              T-H","year":"2013","unstructured":"Huang\n              T-H\n            , LiuS-L, ChenC-L, ShieM-Y, KaoC-T.\n          Low-level laser effects on simulated orthodontic tension side periodontal ligament cells.\nPhotomed Laser Surg.\n2013;\n31(2):72\u201377."},{"issue":"1","key":"r12","series-title":"Am J Orthod Dentofacial Orthop","first-page":"77","article-title":"Quantification of external root resorption by low- vs high-resolution cone-beam computed tomography and periapical radiography: a volumetric and linear analysis","volume":"143","author":"Ponder\n              SN","year":"2013","unstructured":"Ponder\n              SN\n            , BenavidesE, KapilaS, HatchNE.\n          Quantification of external root resorption by low- vs high-resolution cone-beam computed tomography and periapical radiography: a volumetric and linear analysis.\nAm J Orthod Dentofacial Orthop.\n2013;\n143(1):77\u201391."},{"issue":"4","key":"r13","series-title":"Am J Orthod Dentofacial Orthop","first-page":"S100","article-title":"Accuracy and reliability of tooth and root lengths measured on cone-beam computed tomographs","volume":"137","author":"Sherrard\n              JF","year":"2010","unstructured":"Sherrard\n              JF\n            , RossouwPE, BensonBW, CarrilloR, BuschangPH.\n          Accuracy and reliability of tooth and root lengths measured on cone-beam computed tomographs.\nAm J Orthod Dentofacial Orthop.\n2010;\n137(4):S100\u2013S108."},{"issue":"3","key":"r14","series-title":"Angle Orthod","first-page":"466","article-title":"Cone beam computed tomography for assessment of root length and marginal bone level during orthodontic treatment","volume":"80","author":"Lund\n              H","year":"2010","unstructured":"Lund\n              H\n            , Gr\u00f6ndahlK, Gr\u00f6ndahlH-G.\n          Cone beam computed tomography for assessment of root length and marginal bone level during orthodontic treatment.\nAngle Orthod.\n2010;\n80(3):466\u2013473."},{"issue":"4","key":"r15","series-title":"Orthod Craniofac Res","first-page":"206","article-title":"Accuracy of volumetric measurement of teeth in vivo based on cone beam computer tomography","volume":"14","author":"Wang\n              Y","year":"2011","unstructured":"Wang\n              Y\n            , HeS, YuL, LiJ, ChenS.\n          Accuracy of volumetric measurement of teeth in vivo based on cone beam computer tomography.\nOrthod Craniofac Res.\n2011;\n14(4):206\u2013212."},{"issue":"1","key":"r16","series-title":"Angle Orthod","first-page":"160","article-title":"The validity of in vivo tooth volume determinations from cone-beam computed tomography","volume":"80","author":"Liu\n              Y","year":"2009","unstructured":"Liu\n              Y\n            , OlszewskiR, AlexandroniES, EncisoR, XuT, MahJK.\n          The validity of in vivo tooth volume determinations from cone-beam computed tomography.\nAngle Orthod.\n2009;\n80(1):160\u2013166."},{"issue":"6","key":"r17","series-title":"Angle Orthod","first-page":"710","article-title":"Volumetric evaluation of root resorption on the upper incisors using cone beam computed tomography after 1 year of orthodontic treatment in adult patients with marginal bone loss","volume":"88","author":"Puttaravuttiporn\n              P","year":"2018","unstructured":"Puttaravuttiporn\n              P\n            , WongsuwanlertM, CharoemratroteC, LeethanakulC.\n          Volumetric evaluation of root resorption on the upper incisors using cone beam computed tomography after 1 year of orthodontic treatment in adult patients with marginal bone loss.\nAngle Orthod.\n2018;\n88(6):710\u2013718."},{"issue":"2","key":"r18","series-title":"Am J Orthod Dentofacial Orthop","first-page":"218","article-title":"Physical properties of root cementum: part 10. Comparison of the effects of invisible removable thermoplastic appliances with light and heavy orthodontic forces on premolar cementum. A microcomputed-tomography study","volume":"133","author":"Barbagallo\n              LJ","year":"2008","unstructured":"Barbagallo\n              LJ\n            , JonesAS, PetoczP, DarendelilerMA.\n          Physical properties of root cementum: part 10. Comparison of the effects of invisible removable thermoplastic appliances with light and heavy orthodontic forces on premolar cementum. A microcomputed-tomography study.\nAm J Orthod Dentofacial Orthop.\n2008;\n133(2):218\u2013227."},{"key":"r19","series-title":"J Orthod Sci","first-page":"11","article-title":"Evaluation of root length following treatment with clear aligners and two different fixed orthodontic appliances: a pilot study","volume":"7","author":"Eissa\n              O","year":"2018","unstructured":"Eissa\n              O\n            , CarlyleT, El-BialyT.\n          Evaluation of root length following treatment with clear aligners and two different fixed orthodontic appliances: a pilot study.\nJ Orthod Sci.\n2018;\n7:11."},{"issue":"1","key":"r20","series-title":"Prog Orthod.","first-page":"1","article-title":"Prevalence and severity of apical root resorption during orthodontic treatment with clear aligners and fixed appliances: a cone beam computed tomography study","volume":"21","author":"Li\n              Y","year":"2020","unstructured":"Li\n              Y\n            , DengS, MeiL, . Prevalence and severity of apical root resorption during orthodontic treatment with clear aligners and fixed appliances: a cone beam computed tomography study.\nProg Orthod.2020;\n21(1):1."},{"key":"r21","series-title":"Clin Cosmet Investig Dent","first-page":"1","article-title":"The effect of photobiomodulation on root resorption during orthodontic treatment","volume":"6","author":"Nimeri\n              G","year":"2014","unstructured":"Nimeri\n              G\n            , KauCH, CoronaR, ShellyJ.\n          The effect of photobiomodulation on root resorption during orthodontic treatment.\nClin Cosmet Investig Dent.\n2014;\n6:1\u20138."},{"issue":"3","key":"r22","series-title":"Eur J Orthod","first-page":"326","article-title":"The effect of biologic factors and adjunctive therapies on orthodontically induced inflammatory root resorption: a systematic review and meta-analysis","volume":"40","author":"Haugland\n              L","year":"2018","unstructured":"Haugland\n              L\n            , KristensenKD, LieSA, Vandevska-RadunovicV.\n          The effect of biologic factors and adjunctive therapies on orthodontically induced inflammatory root resorption: a systematic review and meta-analysis.\nEur J Orthod.\n2018;\n40(3):326\u2013336."},{"issue":"S1","key":"r23","series-title":"Orthod Craniofac Res","first-page":"117","article-title":"Evaluation of three-dimensional root surface changes and resorption following rapid maxillary expansion: a cone beam computed tomography investigation","volume":"18","author":"Akyalcin\n              S","year":"2015","unstructured":"Akyalcin\n              S\n            , AlexanderSP, SilvaRM, EnglishJD.\n          Evaluation of three-dimensional root surface changes and resorption following rapid maxillary expansion: a cone beam computed tomography investigation.\nOrthod Craniofac Res.\n2015;\n18(S1):117\u2013126."},{"issue":"5","key":"r24","series-title":"Am J Orthod Dentofacial Orthop","first-page":"505","article-title":"Predicting and preventing root resorption: part I. Diagnostic factors","volume":"119","author":"Sameshima\n              GT","year":"2001","unstructured":"Sameshima\n              GT\n            , SinclairPM.\n          Predicting and preventing root resorption: part I. Diagnostic factors.\nAm J Orthod Dentofacial Orthop.\n2001;\n119(5):505\u2013510."},{"issue":"3","key":"r25","series-title":"Am J Orthod","first-page":"183","article-title":"The effect of extraction and orthodontic treatment on dentoalveolar support","volume":"84","author":"Kennedy\n              DB","year":"1983","unstructured":"Kennedy\n              DB\n            , JoondephDR, OsterbergSK, LittleRM.\n          The effect of extraction and orthodontic treatment on dentoalveolar support.\nAm J Orthod.\n1983;\n84(3):183\u2013190."},{"issue":"4","key":"r26","series-title":"Orthod Craniofacial Res.","first-page":"459","article-title":"Impact of intraoral non-pharmacological non-surgical adjunctive interventions on orthodontically induced inflammatory root resorption in humans: a systematic review","volume":"24","author":"Al-Dboush\n              Re","year":"2021","unstructured":"Al-Dboush\n              Re\n            , Flores-MirC, El-BialyT.\n          Impact of intraoral non-pharmacological non-surgical adjunctive interventions on orthodontically induced inflammatory root resorption in humans: a systematic review.\nOrthod Craniofacial Res.2021;\n24(4):459\u2013479."},{"issue":"8","key":"r27","series-title":"Dentomaxillofac Radiol","first-page":"649","article-title":"Effect of voxel size on the accuracy of 3D reconstructions with cone beam CT","volume":"41","author":"Maret\n              D","year":"2012","unstructured":"Maret\n              D\n            , TelmonN, PetersOA, . Effect of voxel size on the accuracy of 3D reconstructions with cone beam CT.\nDentomaxillofac Radiol.\n2012;\n41(8):649\u2013655."},{"issue":"3","key":"r28","series-title":"Am J Orthod Dentofacial Orthop","first-page":"320.e1","article-title":"Physical properties of root cementum: Part 13. Repair of root resorption 4 and 8 weeks after the application of continuous light and heavy forces for 4 weeks: A microcomputed-tomography study","volume":"136","author":"Cheng\n              LL","year":"2009","unstructured":"Cheng\n              LL\n            , T\u00fcrkT, Elekda\u011f-T\u00fcrkS, JonesAS, PetoczP, DarendelilerMA.\n          Physical properties of root cementum: Part 13. Repair of root resorption 4 and 8 weeks after the application of continuous light and heavy forces for 4 weeks: A microcomputed-tomography study.\nAm J Orthod Dentofacial Orthop.\n2009;\n136(3):320.e1\u2013320.e10."},{"issue":"7","key":"r29","series-title":"Adv Clin Exp Med","first-page":"1001","article-title":"Validation of a windowing protocol for accurate in vivo tooth segmentation using i-CAT cone beam computed tomography","volume":"27","author":"Rastegar\n              B","year":"2018","unstructured":"Rastegar\n              B\n            , ThumilaireB, OdriGA, . Validation of a windowing protocol for accurate in vivo tooth segmentation using i-CAT cone beam computed tomography.\nAdv Clin Exp Med.\n2018;\n27(7):1001\u20131008."},{"issue":"10","key":"r30","series-title":"Int Endod J","first-page":"959","article-title":"CBCT-based volume of simulated root resorption\u2014influence of FOV and voxel size","volume":"48","author":"Da Silveira\n              PF","year":"2015","unstructured":"Da Silveira\n              PF\n            , FontanaMP, OliveiraHW, . CBCT-based volume of simulated root resorption\u2014influence of FOV and voxel size.\nInt Endod J.\n2015;\n48(10):959\u2013965."},{"key":"r31","article-title":"Align Technology Introduces One-Week Aligner Wear For Invisalign(R) Teen And Full Products","author":"","year":"2016","unstructured":"Align Technology Introduces One-Week Aligner Wear For Invisalign(R) Teen And Full Products.\n2016. https:\/\/investor.aligntech.com\/news-releases\/news-release-details\/align-technology-introduces-one-week-aligner-wear-invisalignr#:~:text=At%20the%20treating%20doctor\u2019s%20discretion,by%20up%20to%2050%20percent*"},{"issue":"6","key":"r32","series-title":"Eur J Orthod.","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1093\/ejo\/cjac022","article-title":"Physical properties of root cementum: part 29. The effects of LED-mediated photobiomodulation on orthodontically induced root resorption and pain: a pilot split-mouth randomized controlled trial","volume":"44","author":"Sambevski\n              J","year":"2022","unstructured":"Sambevski\n              J\n            , PapadopoulouAK, FoleyM, . Physical properties of root cementum: part 29. The effects of LED-mediated photobiomodulation on orthodontically induced root resorption and pain: a pilot split-mouth randomized controlled trial.\nEur J Orthod.2022;\n44(6):650\u2013658. doi:10.1093\/ejo\/cjac022"}],"container-title":["The Angle Orthodontist"],"original-title":[],"link":[{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/view\/journals\/angl\/94\/3\/article-p294.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/meridian.allenpress.com\/angle-orthodontist\/article-pdf\/94\/3\/294\/3359362\/i1945-7103-94-3-294.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/downloadpdf\/journals\/angl\/94\/3\/article-p294.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/downloadpdf\/journals\/angl\/94\/3\/article-p294.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T14:21:12Z","timestamp":1780064472000},"score":1,"resource":{"primary":{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/view\/journals\/angl\/94\/3\/article-p294.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":64,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.2319\/081823-567.1","relation":{},"ISSN":["1945-7103","0003-3219"],"issn-type":[{"value":"1945-7103","type":"electronic"},{"value":"0003-3219","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]}}}