{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T16:03:10Z","timestamp":1780070590434,"version":"3.54.0"},"reference-count":46,"publisher":"The Angle Orthodontist (EH Angle Education & Research Foundation)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,11]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objective:\u2002<\/jats:title>\n To elucidate the mesiodistal inclination of the unerupted mandibular second premolar (MnP2) in cases of mandibular incisor (MnIc) agenesis and unilateral MnP2 agenesis.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:\u2002<\/jats:title>\n \n Twenty-two cases of unilateral MnP2 agenesis (MnP2 agenesis group) and a control group (control group A) of 22 cases without permanent tooth agenesis excluding third molars were selected. Thirty-six cases of MnIc agenesis (MnIc agenesis group) and another control group (control group B) of 36 subjects were also selected. Mesiodistal inclination of the unerupted MnP2 on the panoramic X-rays was measured according to the distal angle and premolar-molar angle using the methods of Shalish et al. and Baccetti et al., respectively. Differences in mean values of the angular measurements between agenesis groups and corresponding controls were investigated (unpaired\n t<\/jats:italic>\n -test).\n <\/jats:p>\n <\/jats:sec>\n \n Results:\u2002<\/jats:title>\n \n In the MnP2 agenesis group, the mean distal angle decreased 12.3\u00b0 and the mean premolar-molar angle increased 13.3\u00b0 for the MnP2 compared with control group A (both\n P<\/jats:italic>\n < .001). In the MnIc agenesis group, no significant differences in the means of those angles for the MnP2 were found when compared with control group B.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:\u2002<\/jats:title>\n In Japanese orthodontic patients, there is a relationship between unilateral MnP2 agenesis and the mesiodistal angulation of the unerupted MnP2. However, no significant relationship was observed between MnIc agenesis (which relationship is often seen in Asian populations) and the position of the unerupted MnP2. These results suggest that different genetic factors are involved in MnP2 agenesis and MnIc agenesis.<\/jats:p>\n <\/jats:sec>","DOI":"10.2319\/081914-583.1","type":"journal-article","created":{"date-parts":[[2015,3,10]],"date-time":"2015-03-10T17:18:55Z","timestamp":1426007935000},"page":"949-954","source":"Crossref","is-referenced-by-count":3,"title":["Mesiodistal inclination of the unerupted second premolar in the mandible of Japanese orthodontic patients with incisor agenesis"],"prefix":"10.2319","volume":"85","author":[{"given":"Kenichi","family":"Kure","sequence":"first","affiliation":[{"name":"Assistant Professor, Department of Orthodontics, School of Life Dentistry at Tokyo, Nippon Dental University, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhito","family":"Arai","sequence":"additional","affiliation":[{"name":"Professor and Chair, Department of Orthodontics, School of Life Dentistry at Tokyo, Nippon Dental University, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1164","reference":[{"key":"r1","series-title":"Angle Orthod","first-page":"1015","article-title":"Dental Anomaly Patterns (DAP). A new way to look at malocclusion","volume":"79","author":"Peck\n S.","year":"2009","unstructured":"Peck\n S. \n \n Dental Anomaly Patterns (DAP). A new way to look at malocclusion. Angle Orthod. 2009;79:1015\u20131016."},{"key":"r2","series-title":"Am J Orthod Dentofacial Orthop","first-page":"53","article-title":"Malposition of unerupted mandibular second premolar associated with agenesis of its antimere","volume":"121","author":"Shalish\n M,","year":"2002","unstructured":"Shalish\n M, \n \n Peck\n S, \n \n Wasserstein\n A, \n \n Peck\n L. \n \n Malposition of unerupted mandibular second premolar associated with agenesis of its antimere. Am J Orthod Dentofacial Orthop. 2002;121:53\u201356."},{"key":"r3","series-title":"Angle Orthod","first-page":"436","article-title":"Increased occurrence of dental anomalies associated with second-premolar agenesis","volume":"79","author":"Garib\n DG,","year":"2009","unstructured":"Garib\n DG, \n \n Peck\n S, \n \n Gomes\n SC. \n \n Increased occurrence of dental anomalies associated with second-premolar agenesis. Angle Orthod. 2009;79:436\u2013441."},{"key":"r4","series-title":"Angle Orthod","first-page":"24","article-title":"Dental anomaly pattern (DAP): agenesis of mandibular second premolar, distal angulation of its antimere and delayed tooth formation","volume":"84","author":"Navarro\n J,","year":"2014","unstructured":"Navarro\n J, \n \n Cavaller\n M, \n \n Luque\n E, \n \n Tobella\n ML, \n \n Rivera\n A. \n \n Dental anomaly pattern (DAP): agenesis of mandibular second premolar, distal angulation of its antimere and delayed tooth formation. 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Orthod Craniofac Res. 2010;13:191\u2013196."},{"key":"r16","series-title":"Angle Orthod","first-page":"11","article-title":"Extreme distal migration of the mandibular second bicuspid. a variant of eruption","volume":"52","author":"Matteson\n SR,","year":"1982","unstructured":"Matteson\n SR, \n \n Kantor\n ML, \n \n Proffit\n WR. \n \n Extreme distal migration of the mandibular second bicuspid. a variant of eruption. Angle Orthod. 1982;52:11\u201318."},{"key":"r17","series-title":"Angle Orthod","first-page":"796","article-title":"Malposition of unerupted mandibular second premolar in children with palatally displaced canines","volume":"79","author":"Shalish\n M,","year":"2009","unstructured":"Shalish\n M, \n \n Chaushu\n S, \n \n Wasserstein\n A. \n \n Malposition of unerupted mandibular second premolar in children with palatally displaced canines. 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