{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T12:43:40Z","timestamp":1793191420035,"version":"4.5.0"},"reference-count":48,"publisher":"The Angle Orthodontist (EH Angle Education & Research Foundation)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec id=\"st1\">\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To analyze differences in upper cervical spine and craniofacial morphology, including posterior cranial fossa and growth prediction signs, between Danish and South Korean pre-orthodontic skeletal Class II children and to analyze associations between upper cervical spine morphology and craniofacial characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"st2\">\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>One hundred forty-six skeletal Class II children\u201493 Danes (54 boys and 39 girls, mean age 12.2 years) and 53 Koreans (27 boys and 26 girls, mean age 10.8 years)\u2014were included. Upper spine morphology, Atlas dimensions, and craniofacial morphology, including posterior cranial fossa and growth prediction signs, were assessed on lateral cephalograms. Differences and associations were analyzed by multiple linear and logistic regression analyses adjusted for age and gender.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"st3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Significant differences between the ethnic groups were found in the sagittal and vertical craniofacial dimensions (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .001), mandibular shape (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .01), dental relationship (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .01), posterior cranial fossa (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .05), and growth prediction signs (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .001). No significant differences were found in upper spine morphology and Atlas dimensions between the groups. Upper spine morphology\/dimensions were significantly associated with the cranial base angle (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .01), sagittal craniofacial dimensions (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .001), posterior cranial fossa (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .001), and growth prediction signs (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"st4\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Upper spine morphology\/dimensions may be valuable as predictive factors in treatment planning for growing Class II children.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2319\/083017-584.1","type":"journal-article","created":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T13:04:23Z","timestamp":1516107863000},"page":"283-291","source":"Crossref","is-referenced-by-count":25,"title":["Ethnic differences in craniofacial and upper spine morphology in children with skeletal Class II malocclusion"],"prefix":"10.2319","volume":"88","author":[{"given":"Eunhye","family":"Oh","sequence":"first","affiliation":[{"name":"PhD student, Section of Orthodontics, Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sug-Joon","family":"Ahn","sequence":"additional","affiliation":[{"name":"Professor, Department of Orthodontics, School of Dentistry, Seoul National University, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liselotte","family":"Sonnesen","sequence":"additional","affiliation":[{"name":"Associate Professor and Director of Postgraduate Program, Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1164","reference":[{"key":"i0003-3219-88-3-283-b01","series-title":"Am J Orthod Dentofacial Orthop","first-page":"431","article-title":"Craniofacial structure of Japanese and European-American adults with normal occlusions and well-balanced faces","volume":"110","author":"Miyajima \n              K,","year":"1996","unstructured":"Miyajima \n              K, \n            \n            \n              McNamara \n              JA\n              Jr, \n            \n            \n              Kimura \n              T, \n            \n            \n              Murata \n              S, \n            \n            \n              Iizuka \n              T. \n            \n          \n          Craniofacial structure of Japanese and European-American adults with normal occlusions and well-balanced faces. Am J Orthod Dentofacial Orthop. 1996;110:431\u2013438."},{"key":"i0003-3219-88-3-283-b02","series-title":"Am J Orthod Dentofacial Orthop","first-page":"54","article-title":"A cephalometric study of Korean adults","volume":"96","author":"Park \n              IC,","year":"1989","unstructured":"Park \n              IC, \n            \n            \n              Bowman \n              D, \n            \n            \n              Klapper \n              L. \n            \n          \n          A cephalometric study of Korean adults. 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Eur J Orthod. 2007;29:1\u20136."},{"key":"i0003-3219-88-3-283-b04","series-title":"Eur J Orthod","first-page":"464","article-title":"Cervical vertebral body fusions in patients with skeletal deep bite","volume":"29","author":"Sonnesen \n              L,","year":"2007","unstructured":"Sonnesen \n              L, \n            \n            \n              Kj\u00e6r \n              I. \n            \n          \n          Cervical vertebral body fusions in patients with skeletal deep bite. Eur J Orthod. 2007;29:464\u2013470."},{"key":"i0003-3219-88-3-283-b05","series-title":"Cleft Palate J","first-page":"206","article-title":"Cervical vertebral anomalies in cleft lip and palate","volume":"23","author":"Sandham \n              A.","year":"1986","unstructured":"Sandham \n              A. \n            \n          \n          Cervical vertebral anomalies in cleft lip and palate. Cleft Palate J. 1986;23:206\u2013214."},{"key":"i0003-3219-88-3-283-b06","series-title":"Eur J Orthod","first-page":"435","article-title":"Association between morphology of the first cervical vertebra, head posture, and craniofacial structures","volume":"13","author":"Huggare \n              J.","year":"1991","unstructured":"Huggare \n              J. \n            \n          \n          Association between morphology of the first cervical vertebra, head posture, and craniofacial structures. Eur J Orthod. 1991;13:435\u2013440."},{"key":"i0003-3219-88-3-283-b07","series-title":"Eur J Orthod","first-page":"10","article-title":"The first cervical vertebra as an indicator of mandibular growth","volume":"11","author":"Huggare \n              J.","year":"1989","unstructured":"Huggare \n              J. \n            \n          \n          The first cervical vertebra as an indicator of mandibular growth. Eur J Orthod. 1989;11:10\u201316."},{"key":"i0003-3219-88-3-283-b08","series-title":"Eur J Orthod","first-page":"140","article-title":"Orthodontics and foetal pathology: a personal view on craniofacial patterning","volume":"32","author":"Kj\u00e6r \n              I.","year":"2010","unstructured":"Kj\u00e6r \n              I. \n            \n          \n          Orthodontics and foetal pathology: a personal view on craniofacial patterning. Eur J Orthod. 2010;32:140\u2013147."},{"key":"i0003-3219-88-3-283-b09","series-title":"Am J Orthod","first-page":"585","article-title":"Prediction of mandibular growth rotation","volume":"55","author":"Bj\u00f6rk \n              A.","year":"1969","unstructured":"Bj\u00f6rk \n              A. \n            \n          \n          Prediction of mandibular growth rotation. 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Skeletal maturation of the hand in relation to maximum pubertal growth in body height","volume":"75","author":"Helm \n              S,","year":"1971","unstructured":"Helm \n              S, \n            \n          \n          Siersb\u00e6k Nielsen S, Skieller V, Bj\u00f6rk A. Skeletal maturation of the hand in relation to maximum pubertal growth in body height. Danish Dent J. 1971;75:1223\u20131234."},{"key":"i0003-3219-88-3-283-b13","series-title":"Am J Phys Anthropol","first-page":"417","article-title":"Head posture and craniofacial morphology","volume":"44","author":"Solow \n              B,","year":"1976","unstructured":"Solow \n              B, \n            \n            \n              Tallgren \n              A. \n            \n          \n          Head posture and craniofacial morphology. Am J Phys Anthropol. 1976;44:417\u2013435."},{"key":"i0003-3219-88-3-283-b14","series-title":"Orthod Craniofac Res","first-page":"162","article-title":"How does occipitalization influence the dimensions of the cranium?","volume":"13","author":"Caspersen \n              LM,","year":"2010","unstructured":"Caspersen \n              LM, \n            \n            \n              Kj\u00e6r \n              I, \n            \n            \n              Sonnesen \n              L. \n            \n          \n          How does occipitalization influence the dimensions of the cranium?\n          Orthod Craniofac Res. 2010;13:162\u2013168."},{"key":"i0003-3219-88-3-283-b15","series-title":"Statistical Methods for Medical and Biological Students","first-page":"122","author":"Dahlberg \n              G.","year":"1940","unstructured":"Dahlberg \n              G. \n            \n          \n          Statistical Methods for Medical and Biological Students. New York, NY: Interscience;1940:122\u2013132."},{"key":"i0003-3219-88-3-283-b16","series-title":"Am J Orthod","first-page":"382","article-title":"The analysis of errors in orthodontic measurements","volume":"83","author":"Houston \n              WJB.","year":"1983","unstructured":"Houston \n              WJB. \n            \n          \n          The analysis of errors in orthodontic measurements. Am J Orthod. 1983;83:382\u2013390."},{"key":"i0003-3219-88-3-283-b17","series-title":"Educ Psych Meas","first-page":"37","article-title":"A coefficient of agreement for nominal scales","volume":"23","author":"Cohen \n              J.","year":"1960","unstructured":"Cohen \n              J. \n            \n          \n          A coefficient of agreement for nominal scales. Educ Psych Meas. 1960;23:37\u201346."},{"key":"i0003-3219-88-3-283-b18","series-title":"Eur J Orthod","first-page":"194","article-title":"Diagnostic reliability of the third finger middle phalanx maturation (MPM) method in the identification of the mandibular growth peak","volume":"39","author":"Perinette \n              G,","year":"2017","unstructured":"Perinette \n              G, \n            \n            \n              Sbardella \n              V, \n            \n            \n              Contardo \n              L. \n            \n          \n          Diagnostic reliability of the third finger middle phalanx maturation (MPM) method in the identification of the mandibular growth peak. Eur J Orthod. 2017;39:194\u2013201."},{"key":"i0003-3219-88-3-283-b19","series-title":"Angle Orthod","first-page":"506","article-title":"Association between Bjork's structural signs of mandibular growth rotation and skeletofacial morphology","volume":"75","author":"Bremen \n              JV,","year":"2005","unstructured":"Bremen \n              JV, \n            \n            \n              Pancherz \n              H. \n            \n          \n          Association between Bjork's structural signs of mandibular growth rotation and skeletofacial morphology. Angle Orthod. 2005;75:506\u2013509."},{"key":"i0003-3219-88-3-283-b20","series-title":"Eur J Orthod","first-page":"555","article-title":"The use of Bjork's indications of growth for evaluation of extremes of skeletal morphology","volume":"38","author":"Davidovitch \n              M,","year":"2016","unstructured":"Davidovitch \n              M, \n            \n            \n              Eleftheriadi \n              I, \n            \n            \n              Kostaki \n              A, \n            \n            \n              Shpack \n              N. \n            \n          \n          The use of Bjork's indications of growth for evaluation of extremes of skeletal morphology. Eur J Orthod. 2016;38:555\u2013562."},{"key":"i0003-3219-88-3-283-b21","series-title":"Eur J Orthod","first-page":"226","article-title":"Cervical vertebrae anomalies in subjects with Class II malocclusion assessed by lateral cephalogram and cone beam computed tomography","volume":"34","author":"Bebnowski \n              D,","year":"2012","unstructured":"Bebnowski \n              D, \n            \n            \n              H\u00e4nggi \n              MP, \n            \n            \n              Markic \n              G, \n            \n            \n              Roos \n              M, \n            \n            \n              Peltom\u00e4ki \n              T. \n            \n          \n          Cervical vertebrae anomalies in subjects with Class II malocclusion assessed by lateral cephalogram and cone beam computed tomography. Eur J Orthod. 2012;34:226\u2013231."},{"key":"i0003-3219-88-3-283-b22","series-title":"Dentomaxillofac Radiol","first-page":"20130060","article-title":"Cervical vertebral column morphology in patients with obstructive sleep apnoea assessed using lateral cephalograms and cone beam CT. A comparative study","volume":"42","author":"Sonnesen \n              L,","year":"2013","unstructured":"Sonnesen \n              L, \n            \n            \n              Jensen \n              KE, \n            \n            \n              Petersson \n              AR, \n            \n            \n              Petri \n              N, \n            \n            \n              Berg \n              S, \n            \n            \n              Svanholt \n              P. \n            \n          \n          Cervical vertebral column morphology in patients with obstructive sleep apnoea assessed using lateral cephalograms and cone beam CT. A comparative study. Dentomaxillofac Radiol. 2013;42:20130060."},{"key":"i0003-3219-88-3-283-b23","series-title":"Eur J Orthod","first-page":"217","article-title":"Upper spine morphology in hypophosphatemic rickets and healthy controls: a radiographic study","volume":"36","author":"Gj\u00f8rup \n              H,","year":"2014","unstructured":"Gj\u00f8rup \n              H, \n            \n            \n              Sonnesen \n              L, \n            \n            \n              Beck-Nielsen \n              S, \n            \n            \n              Haubek \n              D. \n            \n          \n          Upper spine morphology in hypophosphatemic rickets and healthy controls: a radiographic study. Eur J Orthod. 2014;36:217\u2013225."},{"key":"i0003-3219-88-3-283-b24","series-title":"Sven Tandlak Tidskr","first-page":"124","article-title":"The face in profile","volume":"40","author":"Bj\u00f6rk \n              A.","year":"1947","unstructured":"Bj\u00f6rk \n              A. \n            \n          \n          The face in profile. Sven Tandlak Tidskr. 1947;40:124\u2013168."},{"key":"i0003-3219-88-3-283-b01","series-title":"Am J Orthod Dentofacial Orthop","first-page":"431","article-title":"Craniofacial structure of Japanese and European-American adults with normal occlusions and well-balanced faces","volume":"110","author":"Miyajima \n              K,","year":"1996","unstructured":"Miyajima \n              K, \n            \n            \n              McNamara \n              JA\n              Jr, \n            \n            \n              Kimura \n              T, \n            \n            \n              Murata \n              S, \n            \n            \n              Iizuka \n              T. \n            \n          \n          Craniofacial structure of Japanese and European-American adults with normal occlusions and well-balanced faces. Am J Orthod Dentofacial Orthop. 1996;110:431\u2013438."},{"key":"i0003-3219-88-3-283-b02","series-title":"Am J Orthod Dentofacial Orthop","first-page":"54","article-title":"A cephalometric study of Korean adults","volume":"96","author":"Park \n              IC,","year":"1989","unstructured":"Park \n              IC, \n            \n            \n              Bowman \n              D, \n            \n            \n              Klapper \n              L. \n            \n          \n          A cephalometric study of Korean adults. 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Eur J Orthod. 2007;29:1\u20136."},{"key":"i0003-3219-88-3-283-b04","series-title":"Eur J Orthod","first-page":"464","article-title":"Cervical vertebral body fusions in patients with skeletal deep bite","volume":"29","author":"Sonnesen \n              L,","year":"2007","unstructured":"Sonnesen \n              L, \n            \n            \n              Kj\u00e6r \n              I. \n            \n          \n          Cervical vertebral body fusions in patients with skeletal deep bite. Eur J Orthod. 2007;29:464\u2013470."},{"key":"i0003-3219-88-3-283-b05","series-title":"Cleft Palate J","first-page":"206","article-title":"Cervical vertebral anomalies in cleft lip and palate","volume":"23","author":"Sandham \n              A.","year":"1986","unstructured":"Sandham \n              A. \n            \n          \n          Cervical vertebral anomalies in cleft lip and palate. 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Am J Orthod. 1969;55:585\u2013599."},{"key":"i0003-3219-88-3-283-b10","series-title":"Am J Orthod","first-page":"729","article-title":"Cephalometrics for you and me","volume":"39","author":"Steiner \n              CC.","year":"1953","unstructured":"Steiner \n              CC. \n            \n          \n          Cephalometrics for you and me. Am J Orthod. 1953;39:729\u2013755."},{"key":"i0003-3219-88-3-283-b11","series-title":"Am J Orthod","first-page":"330","article-title":"A foundation for cephalometric communication","volume":"46","author":"Ricketts \n              RM.","year":"1960","unstructured":"Ricketts \n              RM. \n            \n          \n          A foundation for cephalometric communication. Am J Orthod. 1960;46:330\u2013357."},{"key":"i0003-3219-88-3-283-b12","series-title":"Danish Dent J","first-page":"1223","article-title":"Siersb\u00e6k Nielsen S, Skieller V, Bj\u00f6rk A. 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Am J Phys Anthropol. 1976;44:417\u2013435."},{"key":"i0003-3219-88-3-283-b14","series-title":"Orthod Craniofac Res","first-page":"162","article-title":"How does occipitalization influence the dimensions of the cranium?","volume":"13","author":"Caspersen \n              LM,","year":"2010","unstructured":"Caspersen \n              LM, \n            \n            \n              Kj\u00e6r \n              I, \n            \n            \n              Sonnesen \n              L. \n            \n          \n          How does occipitalization influence the dimensions of the cranium?\n          Orthod Craniofac Res. 2010;13:162\u2013168."},{"key":"i0003-3219-88-3-283-b15","series-title":"Statistical Methods for Medical and Biological Students","first-page":"122","author":"Dahlberg \n              G.","year":"1940","unstructured":"Dahlberg \n              G. \n            \n          \n          Statistical Methods for Medical and Biological Students. New York, NY: Interscience;1940:122\u2013132."},{"key":"i0003-3219-88-3-283-b16","series-title":"Am J Orthod","first-page":"382","article-title":"The analysis of errors in orthodontic measurements","volume":"83","author":"Houston \n              WJB.","year":"1983","unstructured":"Houston \n              WJB. \n            \n          \n          The analysis of errors in orthodontic measurements. Am J Orthod. 1983;83:382\u2013390."},{"key":"i0003-3219-88-3-283-b17","series-title":"Educ Psych Meas","first-page":"37","article-title":"A coefficient of agreement for nominal scales","volume":"23","author":"Cohen \n              J.","year":"1960","unstructured":"Cohen \n              J. \n            \n          \n          A coefficient of agreement for nominal scales. Educ Psych Meas. 1960;23:37\u201346."},{"key":"i0003-3219-88-3-283-b18","series-title":"Eur J Orthod","first-page":"194","article-title":"Diagnostic reliability of the third finger middle phalanx maturation (MPM) method in the identification of the mandibular growth peak","volume":"39","author":"Perinette \n              G,","year":"2017","unstructured":"Perinette \n              G, \n            \n            \n              Sbardella \n              V, \n            \n            \n              Contardo \n              L. \n            \n          \n          Diagnostic reliability of the third finger middle phalanx maturation (MPM) method in the identification of the mandibular growth peak. Eur J Orthod. 2017;39:194\u2013201."},{"key":"i0003-3219-88-3-283-b19","series-title":"Angle Orthod","first-page":"506","article-title":"Association between Bjork's structural signs of mandibular growth rotation and skeletofacial morphology","volume":"75","author":"Bremen \n              JV,","year":"2005","unstructured":"Bremen \n              JV, \n            \n            \n              Pancherz \n              H. \n            \n          \n          Association between Bjork's structural signs of mandibular growth rotation and skeletofacial morphology. Angle Orthod. 2005;75:506\u2013509."},{"key":"i0003-3219-88-3-283-b20","series-title":"Eur J Orthod","first-page":"555","article-title":"The use of Bjork's indications of growth for evaluation of extremes of skeletal morphology","volume":"38","author":"Davidovitch \n              M,","year":"2016","unstructured":"Davidovitch \n              M, \n            \n            \n              Eleftheriadi \n              I, \n            \n            \n              Kostaki \n              A, \n            \n            \n              Shpack \n              N. \n            \n          \n          The use of Bjork's indications of growth for evaluation of extremes of skeletal morphology. Eur J Orthod. 2016;38:555\u2013562."},{"key":"i0003-3219-88-3-283-b21","series-title":"Eur J Orthod","first-page":"226","article-title":"Cervical vertebrae anomalies in subjects with Class II malocclusion assessed by lateral cephalogram and cone beam computed tomography","volume":"34","author":"Bebnowski \n              D,","year":"2012","unstructured":"Bebnowski \n              D, \n            \n            \n              H\u00e4nggi \n              MP, \n            \n            \n              Markic \n              G, \n            \n            \n              Roos \n              M, \n            \n            \n              Peltom\u00e4ki \n              T. \n            \n          \n          Cervical vertebrae anomalies in subjects with Class II malocclusion assessed by lateral cephalogram and cone beam computed tomography. Eur J Orthod. 2012;34:226\u2013231."},{"key":"i0003-3219-88-3-283-b22","series-title":"Dentomaxillofac Radiol","first-page":"20130060","article-title":"Cervical vertebral column morphology in patients with obstructive sleep apnoea assessed using lateral cephalograms and cone beam CT. A comparative study","volume":"42","author":"Sonnesen \n              L,","year":"2013","unstructured":"Sonnesen \n              L, \n            \n            \n              Jensen \n              KE, \n            \n            \n              Petersson \n              AR, \n            \n            \n              Petri \n              N, \n            \n            \n              Berg \n              S, \n            \n            \n              Svanholt \n              P. \n            \n          \n          Cervical vertebral column morphology in patients with obstructive sleep apnoea assessed using lateral cephalograms and cone beam CT. A comparative study. 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