{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T05:21:25Z","timestamp":1780377685891,"version":"3.54.1"},"reference-count":15,"publisher":"The Angle Orthodontist (EH Angle Education & Research Foundation)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n        <jats:p>\n          <jats:bold>Objectives:<\/jats:bold> To test the hypothesis that experimentally created physiologically nonbalanced occlusion will not affect the thickness of the temporomandibular joint (TMJ) discs in rats.<\/jats:p>\n        <jats:p>\n          <jats:bold>Material and Methods:<\/jats:bold> Twenty-four 8-week-old Sprague-Dawley rats were equally divided into a control group that was left untreated and an experimental group where a nonbalanced occlusion was created. Elastic rubber bands, 1 mm in diameter, were inserted and 1 week later were replaced by plastic material between the first and the second molars of the left maxillary and the right mandibular dentitions to move the first molars about 0.8 mm mesially. This created and maintained a physiologically nonbalanced occlusion. The animals were euthanized 8 weeks later, and the TMJ disc thickness was measured on histologically prepared slices using an electronic meter. Two-way univariate analysis of variance was used to compare the groups (\u03b1 level = .05).<\/jats:p>\n        <jats:p>\n          <jats:bold>Results:<\/jats:bold> The intermediate zone was thicker in the experimental group than in the control group (<jats:italic>P<\/jats:italic> = .003), but no differences were found between groups regarding the anterior and posterior bands. There were no significant sex-related effects on this observation.<\/jats:p>\n        <jats:p>\n          <jats:bold>Conclusion:<\/jats:bold> The hypothesis is rejected. The results indicate that the intermediate zone of rat TMJ disc has the ability to adapt to the alteration of the space between condyle and fossa caused by occlusion changes. Further studies on larger groups that are followed for longer times are needed.<\/jats:p>","DOI":"10.2319\/091907-450.1","type":"journal-article","created":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T18:01:47Z","timestamp":1217613707000},"page":"51-53","source":"Crossref","is-referenced-by-count":22,"title":["Experimentally Created Nonbalanced Occlusion Effects on the Thickness of the Temporomandibular Joint Disc in Rats"],"prefix":"10.2319","volume":"79","author":[{"given":"Lei","family":"Sun","sequence":"first","affiliation":[{"name":"a\u2009Graduate (PhD) student, Department of Oral Anatomy and Physiology, the Stomatological College, Fourth Military Medical University, Xi-an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiqing","family":"Wang","sequence":"additional","affiliation":[{"name":"b\u2009Professor, Department of Oral Anatomy and Physiology, the Stomatological College, Fourth Miltary Medical University, Xi-an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"He","sequence":"additional","affiliation":[{"name":"c\u2009Associate Professor, Department of Oral Anatomy and Physiology, the Stomatological College, Fourth Military Medical University, Xi-an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Liu","sequence":"additional","affiliation":[{"name":"d\u2009Graduate (MS) student, Department of Oral Anatomy and Physiology, the Stomatological College, Fourth Military Medical University, Xi-an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Chen","sequence":"additional","affiliation":[{"name":"e\u2009Graduate (MS) student, Department of Oral Anatomy and Physiology, the Stomatological College, Fourth Military Medical University, Xi-an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven E.","family":"Widmalm","sequence":"additional","affiliation":[{"name":"f\u2009Associate Professor, Department of Biological and Materials Sciences, Division of Prosthodontics, University of Michigan, Ann Arbor, Mich"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1164","reference":[{"key":"i0003-3219-079-01-0051-b1","series-title":"Br Dent J","first-page":"125","article-title":"The structure and function of the mandibular joint.","volume":"96","author":"Rees, L. A.","year":"1954","unstructured":"Rees, L. A.\n          \n          The structure and function of the mandibular joint.\n          Br Dent J\n          1954. 96:125\u2013133."},{"key":"i0003-3219-079-01-0051-b2","series-title":"Acta Odont Scand","first-page":"77","article-title":"Thickness of the soft tissue layers and the articular disk in the temporomandibular joint.","volume":"35","author":"Hansson, T.","year":"1977","unstructured":"Hansson, T., T.\u00d6berg, G. E.Carlsson, and S.Kopp. Thickness of the soft tissue layers and the articular disk in the temporomandibular joint.Acta Odont Scand1977. 35:77\u201383."},{"key":"i0003-3219-079-01-0051-b3","series-title":"J Prosthet Dent","first-page":"415","article-title":"Internal derangements of the temporomandibular joint: fact or fiction?","volume":"49","author":"Dolwick, M. F.","year":"1983","unstructured":"Dolwick, M. F., R. W.Katzberg, and C. A.Helms. Internal derangements of the temporomandibular joint: fact or fiction?J Prosthet Dent1983. 49:415\u2013418."},{"key":"i0003-3219-079-01-0051-b4","series-title":"Radiology","first-page":"67","article-title":"Defining the normal temporomandibular joint: closed-, partial open-, and open-mouth MR imaging of asymptomatic subjects.","volume":"177","author":"Drace, J. E.","year":"1990","unstructured":"Drace, J. E. and D. R.Enzmann. Defining the normal temporomandibular joint: closed-, partial open-, and open-mouth MR imaging of asymptomatic subjects.Radiology1990. 177:67\u201371."},{"key":"i0003-3219-079-01-0051-b5","series-title":"J Orofac Pain","first-page":"193","article-title":"Osteoarthritis of the temporomandibular joint organ and its relationship to disc displacement.","volume":"15","author":"Stegenga, B.","year":"2001","unstructured":"Stegenga, B.\n          \n          Osteoarthritis of the temporomandibular joint organ and its relationship to disc displacement.\n          J Orofac Pain\n          2001. 15:193\u2013205."},{"key":"i0003-3219-079-01-0051-b6","series-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod","first-page":"141","article-title":"Magnetic resonance evaluation of the disk before and after arthroscopic surgery for temporomandibular joint disorders.","volume":"96","author":"Ohnuki, T.","year":"2003","unstructured":"Ohnuki, T., M.Fukuda, M.Iino, and T.Takahashi. Magnetic resonance evaluation of the disk before and after arthroscopic surgery for temporomandibular joint disorders.Oral Surg Oral Med Oral Pathol Oral Radiol Endod2003. 96:141\u2013148."},{"key":"i0003-3219-079-01-0051-b7","series-title":"J Orofac Pain","first-page":"29","article-title":"The mediolateral temporomandibular joint disc position: an in vivo quantitative study.","volume":"16","author":"Chen, Y. J.","year":"2002","unstructured":"Chen, Y. J., L. M.Gallo, and S.Palla. The mediolateral temporomandibular joint disc position: an in vivo quantitative study.J Orofac Pain2002. 16:29\u201338."},{"key":"i0003-3219-079-01-0051-b8","series-title":"J Oral Maxillofac Surg","first-page":"860","article-title":"Magnetic resonance imaging evaluation of temporomandibular joint disc deformities in relation to type of disc displacement.","volume":"59","author":"Taskaya-Yilmaz, N.","year":"2001","unstructured":"Taskaya-Yilmaz, N. and M.Ogutcen-Toller. Magnetic resonance imaging evaluation of temporomandibular joint disc deformities in relation to type of disc displacement.J Oral Maxillofac Surg2001. 59:860\u2013865."},{"key":"i0003-3219-079-01-0051-b9","series-title":"Dentomaxillofac Radiol","first-page":"245","article-title":"MRI characteristics of anterior disc displacement with and without reduction.","volume":"33","author":"Sener, S.","year":"2004","unstructured":"Sener, S. and F.Akganlu. MRI characteristics of anterior disc displacement with and without reduction.Dentomaxillofac Radiol2004. 33:245\u2013252."},{"key":"i0003-3219-079-01-0051-b10","series-title":"Dentomaxillofac Radiol","first-page":"352","article-title":"Magnetic resonance imaging of temporomandibular disorders: classification, prevalence and interpretation of disc displacement and deformation.","volume":"29","author":"Milano, V.","year":"2000","unstructured":"Milano, V., A.Desiate, R.Bellino, and T.Garofalo. Magnetic resonance imaging of temporomandibular disorders: classification, prevalence and interpretation of disc displacement and deformation.Dentomaxillofac Radiol2000. 29:352\u2013361."},{"key":"i0003-3219-079-01-0051-b11","series-title":"J Oral Maxillofac Surg","first-page":"339","article-title":"Prevalence of morphological changes in the surface of the temporomandibular joint disc associated with internal derangement.","volume":"56","author":"Kondoh, T.","year":"1998","unstructured":"Kondoh, T., P. L.Westesson, T.Takahashi, and K.Seto. Prevalence of morphological changes in the surface of the temporomandibular joint disc associated with internal derangement.J Oral Maxillofac Surg1998. 56:339\u2013343."},{"key":"i0003-3219-079-01-0051-b12","series-title":"J Oral Rehabil","first-page":"279","article-title":"The disc of the human temporomandibular joint: design, function and failure.","volume":"12","author":"Osborn, J. W.","year":"1985","unstructured":"Osborn, J. W.\n          \n          The disc of the human temporomandibular joint: design, function and failure.\n          J Oral Rehabil\n          1985. 12:279\u2013293."},{"key":"i0003-3219-079-01-0051-b13","series-title":"Br Dent J","first-page":"127","article-title":"The structure and function of the temporomandibular joint.","volume":"173","author":"McKay, G. S.","year":"1992","unstructured":"McKay, G. S. and R.Yemm. The structure and function of the temporomandibular joint.Br Dent J1992. 173:127\u2013132."},{"key":"i0003-3219-079-01-0051-b14","series-title":"Oral Med Oral Surg Oral Pathol","first-page":"635","article-title":"Histologic features of the temporomandibular joint disk and posterior disk attachment: comparison of symptom-free persons with normally positioned disks and patients with internal derangement.","volume":"67","author":"Kurita, K.","year":"1989","unstructured":"Kurita, K., P.Westesson, N. H.Sternby, L.Eriksson, L. E.Carlsson, H.Lundh, and N. G.Toremalm. Histologic features of the temporomandibular joint disk and posterior disk attachment: comparison of symptom-free persons with normally positioned disks and patients with internal derangement.Oral Med Oral Surg Oral Pathol1989. 67:635\u2013643."},{"key":"i0003-3219-079-01-0051-b15","series-title":"J Prosthet Dent","first-page":"303","article-title":"The load of the temporomandibular joint: physical calculations and analyses.","volume":"31","author":"Hekneby, M.","year":"1974","unstructured":"Hekneby, M.\n          \n          The load of the temporomandibular joint: physical calculations and analyses.\n          J Prosthet Dent\n          1974. 31:303\u2013312."}],"container-title":["The Angle Orthodontist"],"original-title":[],"link":[{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/view\/journals\/angl\/79\/1\/article-p51.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/angle-orthodontist\/article-pdf\/79\/1\/51\/1384829\/091907-450_1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/downloadpdf\/journals\/angl\/79\/1\/article-p51.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/downloadpdf\/journals\/angl\/79\/1\/article-p51.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:46:16Z","timestamp":1747356376000},"score":1,"resource":{"primary":{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/view\/journals\/angl\/79\/1\/article-p51.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1]]},"references-count":15,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.2319\/091907-450.1","relation":{},"ISSN":["0003-3219","1945-7103"],"issn-type":[{"value":"0003-3219","type":"print"},{"value":"1945-7103","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1]]}}}