{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T16:02:52Z","timestamp":1780070572240,"version":"3.54.0"},"reference-count":52,"publisher":"The Angle Orthodontist (EH Angle Education & Research Foundation)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,7]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objective:<\/jats:title>\n To investigate the characteristics of the dental phenotype in patients with cleidocranial dysplasia (CCD) using longitudinal data.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n Twelve unrelated Korean CCD patients were observed using a longitudinal series of radiographs and clinical photographs. Statistical analysis was performed on the dental phenotypic data.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Although dysplasia of the clavicles, open fontanelle, and wormian bone were observed in all 12 patients, delayed fusion of the mandibular symphysis was found in four patients. One patient did not have a supernumerary tooth (ST). However, 62 STs were found in 11 patients (mean, 5.6 per patient; range of ST emergence, 5 years 6 months\u201314 years 8 months; developing position, occlusal to the permanent incisors, canines, and premolars and distal and apical to the permanent molars). The mandibular premolar region was the most frequent area of ST development (50.0%,\n P<\/jats:italic>\n < .001). All 12 patients showed impacted permanent teeth (IPT), including one patient without ST (mean, 17.8 per patient). Impaction occurred most frequently in the mandibular premolar region and least frequently in the maxillary molar region (93.8% vs 39.6%,\n P<\/jats:italic>\n < .01). The ratio of spontaneous eruption of IPT after removal of retained deciduous teeth and\/or ST was highest for the maxillary and mandibular incisors (all 54.6%) and lowest for the mandibular canines and premolars (26.7% and 28.9%, respectively); however, the difference was not significant.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n The emergence time and development position of ST and the root development of IPT should be considered to determine the timing for the removal of ST and forced eruption of IPT.<\/jats:p>\n <\/jats:sec>","DOI":"10.2319\/092617-647.1","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T10:39:06Z","timestamp":1523961546000},"page":"416-424","source":"Crossref","is-referenced-by-count":9,"title":["Characterization of dental phenotype in patients with cleidocranial dysplasia using longitudinal data"],"prefix":"10.2319","volume":"88","author":[{"given":"Sang-Woon","family":"Ha","sequence":"first","affiliation":[{"name":"PhD student, Department of Orthodontics, School of Dentistry, Seoul National University, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Jin","family":"Jung","sequence":"additional","affiliation":[{"name":"PhD student, Department of Orthodontics, School of Dentistry, Seoul National University, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Sol","family":"Bae","sequence":"additional","affiliation":[{"name":"Postdoctoral student, Department of Molecular Genetics, School of Dentistry, Seoul National University, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Mo","family":"Ryoo","sequence":"additional","affiliation":[{"name":"Professor, Department of Molecular Genetics, School of Dentistry; and Dental Research Institute, BK21 Program, Seoul National University, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Il-Sik","family":"Cho","sequence":"additional","affiliation":[{"name":"Private practice, Pohang, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Hak","family":"Baek","sequence":"additional","affiliation":[{"name":"Professor, Department of Orthodontics, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1164","reference":[{"key":"i0003-3219-88-4-416-b01","series-title":"Cell","first-page":"773","article-title":"Mutations Involving the transcription factor CBFA1 cause cleidocranial dysplasia","volume":"89","author":"Mundlos \n S.","year":"1997","unstructured":"Mundlos \n S.\n \n \n Otto \n F.\n \n \n Mundlos \n C.\n \n et al. \n Mutations Involving the transcription factor CBFA1 cause cleidocranial dysplasia. Cell. 1997;89:773\u2013779."},{"key":"i0003-3219-88-4-416-b02","series-title":"J Cell Biochem","first-page":"1152","article-title":"A novel RUNX2 mutation in exon 8, G462X, in a patient with cleidocranial dysplasia","volume":"119","author":"Jung \n YJ.","year":"2017","unstructured":"Jung \n YJ.\n \n \n Bae \n HS.\n \n \n Ryoo \n HM.\n \n \n Baek \n SH.\n \n \n A novel RUNX2 mutation in exon 8, G462X, in a patient with cleidocranial dysplasia. J Cell Biochem. 2017;119:1152\u20131162."},{"key":"i0003-3219-88-4-416-b03","series-title":"Cell","first-page":"765","article-title":"Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development","volume":"89","author":"Otto \n F.","year":"1997","unstructured":"Otto \n F.\n \n \n Thornell \n AP.\n \n \n Crompton \n T.\n \n et al. \n Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell. 1997;89:765\u2013771."},{"key":"i0003-3219-88-4-416-b04","series-title":"J Med Genet","first-page":"177","article-title":"Cleidocranial dysplasia: clinical and molecular genetics","volume":"36","author":"Mundlos \n S.","year":"1999","unstructured":"Mundlos \n S.\n \n \n Cleidocranial dysplasia: clinical and molecular genetics. J Med Genet. 1999;36:177\u2013182."},{"key":"i0003-3219-88-4-416-b05","series-title":"Oral Dis","first-page":"55","article-title":"RUNX2 mutations in cleidocranial dysplasia patients","volume":"16","author":"Ryoo \n HM.","year":"2010","unstructured":"Ryoo \n HM.\n \n \n Kang \n HY.\n \n \n Lee \n SK.\n \n \n Lee \n KE.\n \n \n Kim \n JW.\n \n \n RUNX2 mutations in cleidocranial dysplasia patients. Oral Dis. 2010;16:55\u201360."},{"key":"i0003-3219-88-4-416-b06","series-title":"Clin Genet","first-page":"393","article-title":"Cleidocranial dysplasia and RUNX2-clinical phenotype\u2013genotype correlation","volume":"90","author":"Jaruga \n A.","year":"2016","unstructured":"Jaruga \n A.\n \n \n Hordyjewska \n E.\n \n \n Kandzierski \n G.\n \n \n Tylzanowski \n P.\n \n \n Cleidocranial dysplasia and RUNX2-clinical phenotype\u2013genotype correlation. Clin Genet. 2016;90:393\u2013402."},{"key":"i0003-3219-88-4-416-b07","series-title":"Am J Med Genet A","first-page":"78","article-title":"Cleidocranial dysplasia: molecular genetic analysis and phenotypic-based description of a Middle European patient group","volume":"139A","author":"Baumert \n U.","year":"2005","unstructured":"Baumert \n U.\n \n \n Golan \n I.\n \n \n Redlich \n M.\n \n \n Aknin \n JJ.\n \n \n Muessig \n D.\n \n \n Cleidocranial dysplasia: molecular genetic analysis and phenotypic-based description of a Middle European patient group. Am J Med Genet A. 2005;139A:78\u201385."},{"key":"i0003-3219-88-4-416-b08","series-title":"BMJ Case Rep","article-title":"Surgical management of multiple supernumerary teeth and an impacted maxillary permanent central incisor","volume":"2013","author":"Rallan \n M.","year":"2013","unstructured":"Rallan \n M.\n \n \n Rallan \n NS.\n \n \n Goswami \n M.\n \n \n Rawat \n K.\n \n \n Surgical management of multiple supernumerary teeth and an impacted maxillary permanent central incisor. BMJ Case Rep. 2013;2013:pii: bcr2013009995."},{"key":"i0003-3219-88-4-416-b09","series-title":"J Craniofac Genet Dev Biol","first-page":"212","article-title":"Histological observations of teeth and peridental tissues in cleidocranial dysplasia imply increased activity of odontogenic epithelium and abnormal bone remodeling","volume":"15","author":"Lukinmaa \n PL.","year":"1995","unstructured":"Lukinmaa \n PL.\n \n \n Jensen \n BL.\n \n \n Thesleff \n I.\n \n \n Andreasen \n JO.\n \n \n Kreiborg \n S.\n \n \n Histological observations of teeth and peridental tissues in cleidocranial dysplasia imply increased activity of odontogenic epithelium and abnormal bone remodeling. J Craniofac Genet Dev Biol. 1995;15:212\u2013221."},{"key":"i0003-3219-88-4-416-b10","series-title":"J Orofac Orthop","first-page":"495","article-title":"The role of periodontal ligament cells in delayed tooth eruption in patients with cleidocranial dysostosis","volume":"70","author":"Lossd\u00f6rfer \n S.","year":"2009","unstructured":"Lossd\u00f6rfer \n S.\n \n \n Abou Jamra \n B.\n \n \n Rath-Deschner \n B.\n \n et al. \n The role of periodontal ligament cells in delayed tooth eruption in patients with cleidocranial dysostosis. J Orofac Orthop. 2009;70:495\u2013510."},{"key":"i0003-3219-88-4-416-b11","series-title":"Pediatr Dent","first-page":"101","article-title":"Dental development and molar root length in children with cleidocranial dysplasia","volume":"17","author":"Seow \n WK.","year":"1995","unstructured":"Seow \n WK.\n \n \n Hertzberg \n J.\n \n \n Dental development and molar root length in children with cleidocranial dysplasia. Pediatr Dent. 1995;17:101\u2013105."},{"key":"i0003-3219-88-4-416-b12","series-title":"ASDC J Dent Child","first-page":"325","article-title":"Delayed dental maturation in cleidocranial dysplasia","volume":"65","author":"Shaikh \n R.","year":"1998","unstructured":"Shaikh \n R.\n \n \n Shusterman \n S.\n \n \n Delayed dental maturation in cleidocranial dysplasia. ASDC J Dent Child. 1998;65:325\u2013329, 355."},{"key":"i0003-3219-88-4-416-b13","series-title":"Orthod Craniofac Res","first-page":"222","article-title":"Diversity of supernumerary tooth formation in siblings with cleidocranial dysplasia having identical mutation in RUNX2: possible involvement of non-genetic or epigenetic regulation","volume":"10","author":"Suda \n N.","year":"2007","unstructured":"Suda \n N.\n \n \n Hamada \n T.\n \n \n Hattori \n M.\n \n et al. \n Diversity of supernumerary tooth formation in siblings with cleidocranial dysplasia having identical mutation in RUNX2: possible involvement of non-genetic or epigenetic regulation. Orthod Craniofac Res. 2007;10:222\u2013225."},{"key":"i0003-3219-88-4-416-b14","series-title":"Orthod Craniofac Res","first-page":"197","article-title":"Correlation between genotype and supernumerary tooth formation in cleidocranial dysplasia","volume":"13","author":"Suda \n N.","year":"2010","unstructured":"Suda \n N.\n \n \n Hattori \n M.\n \n \n Kosaki \n K.\n \n et al. \n Correlation between genotype and supernumerary tooth formation in cleidocranial dysplasia. Orthod Craniofac Res. 2010;13:197\u2013202."},{"key":"i0003-3219-88-4-416-b15","series-title":"Genet Mol Res","first-page":"4567","article-title":"RUNX2 mutations in cleidocranial dysplasia","volume":"12","author":"Lee \n KE.","year":"2013","unstructured":"Lee \n KE.\n \n \n Seymen \n F.\n \n \n Ko \n J.\n \n et al. \n RUNX2 mutations in cleidocranial dysplasia. Genet Mol Res. 2013;12:4567\u20134574."},{"key":"i0003-3219-88-4-416-b16","series-title":"Am J Med Genet","first-page":"69","article-title":"Somatic development in cleidocranial dysplasia","volume":"35","author":"Jensen \n BL.","year":"1990","unstructured":"Jensen \n BL.\n \n \n Somatic development in cleidocranial dysplasia. Am J Med Genet. 1990;35:69\u201374."},{"key":"i0003-3219-88-4-416-b17","series-title":"J Oral Pathol Med","first-page":"89","article-title":"Development of the dentition in cleidocranial dysplasia","volume":"19","author":"Jensen \n BL.","year":"1990","unstructured":"Jensen \n BL.\n \n \n Kreiborg \n S.\n \n \n Development of the dentition in cleidocranial dysplasia. J Oral Pathol Med. 1990;19:89\u201393."},{"key":"i0003-3219-88-4-416-b18","series-title":"Int J Paediatr Dent","first-page":"254","article-title":"A prospective cohort study on emergence of permanent teeth and caries experience in Korean children","volume":"21","author":"Kim \n C.","year":"2011","unstructured":"Kim \n C.\n \n \n Hong \n Y.\n \n \n Han \n DH.\n \n et al. \n A prospective cohort study on emergence of permanent teeth and caries experience in Korean children. Int J Paediatr Dent. 2011;21:254\u2013260."},{"key":"i0003-3219-88-4-416-b19","series-title":"Forensic Sci Int","first-page":"125","article-title":"Age estimation of Korean children based on dental maturity","volume":"178","author":"Lee \n SE.","year":"2008","unstructured":"Lee \n SE.\n \n \n Lee \n SH.\n \n \n Lee \n JY.\n \n \n Park \n HK.\n \n \n Kim \n YK.\n \n \n Age estimation of Korean children based on dental maturity. Forensic Sci Int. 2008;178:125\u2013131."},{"key":"i0003-3219-88-4-416-b20","series-title":"Am J Hum Genet","first-page":"724","article-title":"Functional analysis of RUNX2 mutations in Japanese patients with cleidocranial dysplasia demonstrates novel genotype-phenotype correlations","volume":"71","author":"Yoshida \n T.","year":"2002","unstructured":"Yoshida \n T.\n \n \n Kanegane \n H.\n \n \n Osato \n M.\n \n et al. \n Functional analysis of RUNX2 mutations in Japanese patients with cleidocranial dysplasia demonstrates novel genotype-phenotype correlations. Am J Hum Genet. 2002;71:724\u2013738."},{"key":"i0003-3219-88-4-416-b21","series-title":"Dentomaxillofac Radiol","first-page":"347","article-title":"Dentomaxillofacial variability of cleidocranial dysplasia: clinicoradiological presentation and systematic review","volume":"32","author":"Golan \n I.","year":"2003","unstructured":"Golan \n I.\n \n \n Baumert \n U.\n \n \n Hrala \n BP.\n \n \n M\u00fcssig \n D.\n \n \n Dentomaxillofacial variability of cleidocranial dysplasia: clinicoradiological presentation and systematic review. Dentomaxillofac Radiol. 2003;32:347\u2013354."},{"key":"i0003-3219-88-4-416-b22","series-title":"Korean J Orthod","first-page":"248","article-title":"Orthodontic and surgical management of cleidocranial dysplasia","volume":"43","author":"Park \n TK.","year":"2013","unstructured":"Park \n TK.\n \n \n Vargervik \n K.\n \n \n Oberoi \n S.\n \n \n Orthodontic and surgical management of cleidocranial dysplasia. Korean J Orthod. 2013;43:248\u2013260."},{"key":"i0003-3219-88-4-416-b23","series-title":"Dentomaxillofac Radiol","first-page":"89","article-title":"Cleidocranial dysplasia: radiological appearances on dental panoramic radiography","volume":"28","author":"McNamara \n CM.","year":"1999","unstructured":"McNamara \n CM.\n \n \n O'Riordan \n BC.\n \n \n Blake \n M.\n \n \n Sandy \n JR.\n \n \n Cleidocranial dysplasia: radiological appearances on dental panoramic radiography. Dentomaxillofac Radiol. 1999;28:89\u201397."},{"key":"i0003-3219-88-4-416-b24","series-title":"Int J Paediatr Dent","first-page":"225","article-title":"Facial and dental anomalies in cleidocranial dysplasia: a study of 17 cases","volume":"4","author":"Richardson \n A.","year":"1994","unstructured":"Richardson \n A.\n \n \n Deussen \n FF.\n \n \n Facial and dental anomalies in cleidocranial dysplasia: a study of 17 cases. Int J Paediatr Dent. 1994;4:225\u2013231."},{"key":"i0003-3219-88-4-416-b25","series-title":"Stomatologija","first-page":"103","article-title":"Impaction of the central maxillary incisor associated with supernumerary teeth: initial position and spontaneous eruption timing","volume":"8","author":"Smailiene \n D.","year":"2006","unstructured":"Smailiene \n D.\n \n \n Sidlauskas \n A.\n \n \n Bucinskiene \n J.\n \n \n Impaction of the central maxillary incisor associated with supernumerary teeth: initial position and spontaneous eruption timing. Stomatologija. 2006;8:103\u2013107."},{"key":"i0003-3219-88-4-416-b26","series-title":"Br Dent J","first-page":"243","article-title":"Dental treatment strategies in cleidocranial dysplasia","volume":"172","author":"Jensen \n BL.","year":"1992","unstructured":"Jensen \n BL.\n \n \n Kreiborg \n S.\n \n \n Dental treatment strategies in cleidocranial dysplasia. Br Dent J. 1992;172:243\u2013247."},{"key":"i0003-3219-88-4-416-b01","series-title":"Cell","first-page":"773","article-title":"Mutations Involving the transcription factor CBFA1 cause cleidocranial dysplasia","volume":"89","author":"Mundlos \n S.","year":"1997","unstructured":"Mundlos \n S.\n \n \n Otto \n F.\n \n \n Mundlos \n C.\n \n et al. \n Mutations Involving the transcription factor CBFA1 cause cleidocranial dysplasia. Cell. 1997;89:773\u2013779."},{"key":"i0003-3219-88-4-416-b02","series-title":"J Cell Biochem","first-page":"1152","article-title":"A novel RUNX2 mutation in exon 8, G462X, in a patient with cleidocranial dysplasia","volume":"119","author":"Jung \n YJ.","year":"2017","unstructured":"Jung \n YJ.\n \n \n Bae \n HS.\n \n \n Ryoo \n HM.\n \n \n Baek \n SH.\n \n \n A novel RUNX2 mutation in exon 8, G462X, in a patient with cleidocranial dysplasia. J Cell Biochem. 2017;119:1152\u20131162."},{"key":"i0003-3219-88-4-416-b03","series-title":"Cell","first-page":"765","article-title":"Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development","volume":"89","author":"Otto \n F.","year":"1997","unstructured":"Otto \n F.\n \n \n Thornell \n AP.\n \n \n Crompton \n T.\n \n et al. \n Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell. 1997;89:765\u2013771."},{"key":"i0003-3219-88-4-416-b04","series-title":"J Med Genet","first-page":"177","article-title":"Cleidocranial dysplasia: clinical and molecular genetics","volume":"36","author":"Mundlos \n S.","year":"1999","unstructured":"Mundlos \n S.\n \n \n Cleidocranial dysplasia: clinical and molecular genetics. J Med Genet. 1999;36:177\u2013182."},{"key":"i0003-3219-88-4-416-b05","series-title":"Oral Dis","first-page":"55","article-title":"RUNX2 mutations in cleidocranial dysplasia patients","volume":"16","author":"Ryoo \n HM.","year":"2010","unstructured":"Ryoo \n HM.\n \n \n Kang \n HY.\n \n \n Lee \n SK.\n \n \n Lee \n KE.\n \n \n Kim \n JW.\n \n \n RUNX2 mutations in cleidocranial dysplasia patients. Oral Dis. 2010;16:55\u201360."},{"key":"i0003-3219-88-4-416-b06","series-title":"Clin Genet","first-page":"393","article-title":"Cleidocranial dysplasia and RUNX2-clinical phenotype\u2013genotype correlation","volume":"90","author":"Jaruga \n A.","year":"2016","unstructured":"Jaruga \n A.\n \n \n Hordyjewska \n E.\n \n \n Kandzierski \n G.\n \n \n Tylzanowski \n P.\n \n \n Cleidocranial dysplasia and RUNX2-clinical phenotype\u2013genotype correlation. Clin Genet. 2016;90:393\u2013402."},{"key":"i0003-3219-88-4-416-b07","series-title":"Am J Med Genet A","first-page":"78","article-title":"Cleidocranial dysplasia: molecular genetic analysis and phenotypic-based description of a Middle European patient group","volume":"139A","author":"Baumert \n U.","year":"2005","unstructured":"Baumert \n U.\n \n \n Golan \n I.\n \n \n Redlich \n M.\n \n \n Aknin \n JJ.\n \n \n Muessig \n D.\n \n \n Cleidocranial dysplasia: molecular genetic analysis and phenotypic-based description of a Middle European patient group. Am J Med Genet A. 2005;139A:78\u201385."},{"key":"i0003-3219-88-4-416-b08","series-title":"BMJ Case Rep","article-title":"Surgical management of multiple supernumerary teeth and an impacted maxillary permanent central incisor","volume":"2013","author":"Rallan \n M.","year":"2013","unstructured":"Rallan \n M.\n \n \n Rallan \n NS.\n \n \n Goswami \n M.\n \n \n Rawat \n K.\n \n \n Surgical management of multiple supernumerary teeth and an impacted maxillary permanent central incisor. BMJ Case Rep. 2013;2013:pii: bcr2013009995."},{"key":"i0003-3219-88-4-416-b09","series-title":"J Craniofac Genet Dev Biol","first-page":"212","article-title":"Histological observations of teeth and peridental tissues in cleidocranial dysplasia imply increased activity of odontogenic epithelium and abnormal bone remodeling","volume":"15","author":"Lukinmaa \n PL.","year":"1995","unstructured":"Lukinmaa \n PL.\n \n \n Jensen \n BL.\n \n \n Thesleff \n I.\n \n \n Andreasen \n JO.\n \n \n Kreiborg \n S.\n \n \n Histological observations of teeth and peridental tissues in cleidocranial dysplasia imply increased activity of odontogenic epithelium and abnormal bone remodeling. J Craniofac Genet Dev Biol. 1995;15:212\u2013221."},{"key":"i0003-3219-88-4-416-b10","series-title":"J Orofac Orthop","first-page":"495","article-title":"The role of periodontal ligament cells in delayed tooth eruption in patients with cleidocranial dysostosis","volume":"70","author":"Lossd\u00f6rfer \n S.","year":"2009","unstructured":"Lossd\u00f6rfer \n S.\n \n \n Abou Jamra \n B.\n \n \n Rath-Deschner \n B.\n \n et al. \n The role of periodontal ligament cells in delayed tooth eruption in patients with cleidocranial dysostosis. J Orofac Orthop. 2009;70:495\u2013510."},{"key":"i0003-3219-88-4-416-b11","series-title":"Pediatr Dent","first-page":"101","article-title":"Dental development and molar root length in children with cleidocranial dysplasia","volume":"17","author":"Seow \n WK.","year":"1995","unstructured":"Seow \n WK.\n \n \n Hertzberg \n J.\n \n \n Dental development and molar root length in children with cleidocranial dysplasia. Pediatr Dent. 1995;17:101\u2013105."},{"key":"i0003-3219-88-4-416-b12","series-title":"ASDC J Dent Child","first-page":"325","article-title":"Delayed dental maturation in cleidocranial dysplasia","volume":"65","author":"Shaikh \n R.","year":"1998","unstructured":"Shaikh \n R.\n \n \n Shusterman \n S.\n \n \n Delayed dental maturation in cleidocranial dysplasia. ASDC J Dent Child. 1998;65:325\u2013329, 355."},{"key":"i0003-3219-88-4-416-b13","series-title":"Orthod Craniofac Res","first-page":"222","article-title":"Diversity of supernumerary tooth formation in siblings with cleidocranial dysplasia having identical mutation in RUNX2: possible involvement of non-genetic or epigenetic regulation","volume":"10","author":"Suda \n N.","year":"2007","unstructured":"Suda \n N.\n \n \n Hamada \n T.\n \n \n Hattori \n M.\n \n et al. \n Diversity of supernumerary tooth formation in siblings with cleidocranial dysplasia having identical mutation in RUNX2: possible involvement of non-genetic or epigenetic regulation. Orthod Craniofac Res. 2007;10:222\u2013225."},{"key":"i0003-3219-88-4-416-b14","series-title":"Orthod Craniofac Res","first-page":"197","article-title":"Correlation between genotype and supernumerary tooth formation in cleidocranial dysplasia","volume":"13","author":"Suda \n N.","year":"2010","unstructured":"Suda \n N.\n \n \n Hattori \n M.\n \n \n Kosaki \n K.\n \n et al. \n Correlation between genotype and supernumerary tooth formation in cleidocranial dysplasia. Orthod Craniofac Res. 2010;13:197\u2013202."},{"key":"i0003-3219-88-4-416-b15","series-title":"Genet Mol Res","first-page":"4567","article-title":"RUNX2 mutations in cleidocranial dysplasia","volume":"12","author":"Lee \n KE.","year":"2013","unstructured":"Lee \n KE.\n \n \n Seymen \n F.\n \n \n Ko \n J.\n \n et al. \n RUNX2 mutations in cleidocranial dysplasia. Genet Mol Res. 2013;12:4567\u20134574."},{"key":"i0003-3219-88-4-416-b16","series-title":"Am J Med Genet","first-page":"69","article-title":"Somatic development in cleidocranial dysplasia","volume":"35","author":"Jensen \n BL.","year":"1990","unstructured":"Jensen \n BL.\n \n \n Somatic development in cleidocranial dysplasia. Am J Med Genet. 1990;35:69\u201374."},{"key":"i0003-3219-88-4-416-b17","series-title":"J Oral Pathol Med","first-page":"89","article-title":"Development of the dentition in cleidocranial dysplasia","volume":"19","author":"Jensen \n BL.","year":"1990","unstructured":"Jensen \n BL.\n \n \n Kreiborg \n S.\n \n \n Development of the dentition in cleidocranial dysplasia. J Oral Pathol Med. 1990;19:89\u201393."},{"key":"i0003-3219-88-4-416-b18","series-title":"Int J Paediatr Dent","first-page":"254","article-title":"A prospective cohort study on emergence of permanent teeth and caries experience in Korean children","volume":"21","author":"Kim \n C.","year":"2011","unstructured":"Kim \n C.\n \n \n Hong \n Y.\n \n \n Han \n DH.\n \n et al. \n A prospective cohort study on emergence of permanent teeth and caries experience in Korean children. Int J Paediatr Dent. 2011;21:254\u2013260."},{"key":"i0003-3219-88-4-416-b19","series-title":"Forensic Sci Int","first-page":"125","article-title":"Age estimation of Korean children based on dental maturity","volume":"178","author":"Lee \n SE.","year":"2008","unstructured":"Lee \n SE.\n \n \n Lee \n SH.\n \n \n Lee \n JY.\n \n \n Park \n HK.\n \n \n Kim \n YK.\n \n \n Age estimation of Korean children based on dental maturity. Forensic Sci Int. 2008;178:125\u2013131."},{"key":"i0003-3219-88-4-416-b20","series-title":"Am J Hum Genet","first-page":"724","article-title":"Functional analysis of RUNX2 mutations in Japanese patients with cleidocranial dysplasia demonstrates novel genotype-phenotype correlations","volume":"71","author":"Yoshida \n T.","year":"2002","unstructured":"Yoshida \n T.\n \n \n Kanegane \n H.\n \n \n Osato \n M.\n \n et al. \n Functional analysis of RUNX2 mutations in Japanese patients with cleidocranial dysplasia demonstrates novel genotype-phenotype correlations. Am J Hum Genet. 2002;71:724\u2013738."},{"key":"i0003-3219-88-4-416-b21","series-title":"Dentomaxillofac Radiol","first-page":"347","article-title":"Dentomaxillofacial variability of cleidocranial dysplasia: clinicoradiological presentation and systematic review","volume":"32","author":"Golan \n I.","year":"2003","unstructured":"Golan \n I.\n \n \n Baumert \n U.\n \n \n Hrala \n BP.\n \n \n M\u00fcssig \n D.\n \n \n Dentomaxillofacial variability of cleidocranial dysplasia: clinicoradiological presentation and systematic review. Dentomaxillofac Radiol. 2003;32:347\u2013354."},{"key":"i0003-3219-88-4-416-b22","series-title":"Korean J Orthod","first-page":"248","article-title":"Orthodontic and surgical management of cleidocranial dysplasia","volume":"43","author":"Park \n TK.","year":"2013","unstructured":"Park \n TK.\n \n \n Vargervik \n K.\n \n \n Oberoi \n S.\n \n \n Orthodontic and surgical management of cleidocranial dysplasia. Korean J Orthod. 2013;43:248\u2013260."},{"key":"i0003-3219-88-4-416-b23","series-title":"Dentomaxillofac Radiol","first-page":"89","article-title":"Cleidocranial dysplasia: radiological appearances on dental panoramic radiography","volume":"28","author":"McNamara \n CM.","year":"1999","unstructured":"McNamara \n CM.\n \n \n O'Riordan \n BC.\n \n \n Blake \n M.\n \n \n Sandy \n JR.\n \n \n Cleidocranial dysplasia: radiological appearances on dental panoramic radiography. Dentomaxillofac Radiol. 1999;28:89\u201397."},{"key":"i0003-3219-88-4-416-b24","series-title":"Int J Paediatr Dent","first-page":"225","article-title":"Facial and dental anomalies in cleidocranial dysplasia: a study of 17 cases","volume":"4","author":"Richardson \n A.","year":"1994","unstructured":"Richardson \n A.\n \n \n Deussen \n FF.\n \n \n Facial and dental anomalies in cleidocranial dysplasia: a study of 17 cases. Int J Paediatr Dent. 1994;4:225\u2013231."},{"key":"i0003-3219-88-4-416-b25","series-title":"Stomatologija","first-page":"103","article-title":"Impaction of the central maxillary incisor associated with supernumerary teeth: initial position and spontaneous eruption timing","volume":"8","author":"Smailiene \n D.","year":"2006","unstructured":"Smailiene \n D.\n \n \n Sidlauskas \n A.\n \n \n Bucinskiene \n J.\n \n \n Impaction of the central maxillary incisor associated with supernumerary teeth: initial position and spontaneous eruption timing. Stomatologija. 2006;8:103\u2013107."},{"key":"i0003-3219-88-4-416-b26","series-title":"Br Dent J","first-page":"243","article-title":"Dental treatment strategies in cleidocranial dysplasia","volume":"172","author":"Jensen \n BL.","year":"1992","unstructured":"Jensen \n BL.\n \n \n Kreiborg \n S.\n \n \n Dental treatment strategies in cleidocranial dysplasia. Br Dent J. 1992;172:243\u2013247."}],"container-title":["The Angle Orthodontist"],"original-title":[],"link":[{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/view\/journals\/angl\/88\/4\/article-p416.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/angle-orthodontist\/article-pdf\/88\/4\/416\/1395962\/092617-647_1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/downloadpdf\/journals\/angl\/88\/4\/article-p416.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/downloadpdf\/journals\/angl\/88\/4\/article-p416.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T15:10:21Z","timestamp":1780067421000},"score":1,"resource":{"primary":{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/view\/journals\/angl\/88\/4\/article-p416.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":52,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.2319\/092617-647.1","relation":{},"ISSN":["0003-3219","1945-7103"],"issn-type":[{"value":"0003-3219","type":"print"},{"value":"1945-7103","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7]]}}}