{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T03:42:23Z","timestamp":1782186143738,"version":"3.54.5"},"reference-count":42,"publisher":"The Angle Orthodontist (EH Angle Education & Research Foundation)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objectives<\/jats:title>\n To investigate whether the inhibition of 12\/15-lipoxygenase (12\/15-LOX), one of the core enzymes of the arachidonic acid cascade, suppresses orthodontically induced root resorption (OIRR), and examine the involvement of the hyaline degeneration of periodontal ligament cells and odontoclast differentiation.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n The left maxillary first molars of 10-week-old male Wistar rats were moved mesially for 14 days using a closed-coil spring (25 cN) inserted between the first molar and incisor. The rats were intraperitoneally administered with a 12\/15-LOX specific inhibitor (ML-351; 0.05 mmol\/kg) daily in the experimental group or vehicle (dimethyl sulfoxide) in the control group. Tooth movement was measured using microcomputed tomography on day 14. The appearance of OIRR, hyaline degeneration, osteoclasts, and odontoclasts was evaluated via histological analysis. Immunohistochemical staining for receptor-activated NF-kB ligand (RANKL) and osteoprotegerin was performed.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n OIRR observed on day 14 in the control group was strongly suppressed by ML-351 treatment. Hyaline degeneration observed on the compression side on day 3 and the appearance of osteoclasts and odontoclasts on days 3 and 14 were significantly suppressed by ML-351. RANKL expression on day 3 was significantly suppressed by ML-351. These key processes in OIRR were substantially suppressed by ML-351 treatment.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Inhibition of 12\/15-LOX reduced OIRR by suppressing hyaline degeneration and subsequent odontoclast differentiation.<\/jats:p>\n <\/jats:sec>","DOI":"10.2319\/103123-730.1","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T20:00:29Z","timestamp":1714507229000},"page":"566-573","source":"Crossref","is-referenced-by-count":2,"title":["Inhibition of 12\/15-lipoxygenase reduces orthodontically induced root resorption in rats"],"prefix":"10.2319","volume":"94","author":[{"given":"Yukako","family":"Nashiro-Oyakawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Hotokezaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Hotokezaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Moriishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariko","family":"Funaki-Dohi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Iuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mizuki","family":"Ohama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Morita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriaki","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1164","reference":[{"key":"i1945-7103-94-5-566-b01","series-title":"Am J Orthod","first-page":"462","article-title":"Root resorption associated with orthodontic tooth movement: a systematic review","volume":"137","author":"Weltman","year":"2010","unstructured":"Weltman\n B,\n \n \n Vig\n KW,\n \n \n Fields\n HW,\n \n \n Shanker\n S,\n \n \n Kaizar\n EE.\n \n \n Root resorption associated with orthodontic tooth movement: a systematic review. Am J Orthod. 2010;137:462\u2013476."},{"issue":"4","key":"i1945-7103-94-5-566-b02","series-title":"Eur J Orthod","first-page":"346","article-title":"Effects of systemic medication on root resorption associated with orthodontic tooth movement: a systematic review of animal studies","volume":"41","author":"Makrygiannakis","year":"2019","unstructured":"Makrygiannakis\n MA,\n \n \n Kaklamanos\n EG,\n \n \n Athanasiou\n AE.\n \n \n Effects of systemic medication on root resorption associated with orthodontic tooth movement: a systematic review of animal studies. Eur J Orthod. 2019;41(4):346\u2013359."},{"key":"i1945-7103-94-5-566-b03","series-title":"Nordisk Tandl\u00e4kare Tidskrift","first-page":"236","article-title":"Einige Beitr\u00e4age zur Theorie der Zahnregulierung","volume":"5","author":"Sandstedt","year":"1904","unstructured":"Sandstedt\n C.\n \n \n Einige Beitr\u00e4age zur Theorie der Zahnregulierung. Nordisk Tandl\u00e4kare Tidskrift. 1904;5:236\u2013256."},{"key":"i1945-7103-94-5-566-b04","series-title":"Eur J Orthod","first-page":"249","article-title":"Root resorption beneath the main hyalinized zone","volume":"16","author":"Brudvik","year":"1994","unstructured":"Brudvik\n P,\n \n \n Rygh\n P.\n \n \n Root resorption beneath the main hyalinized zone. Eur J Orthod. 1994;16:249\u2013263."},{"key":"i1945-7103-94-5-566-b05","series-title":"Eur J Orthod","first-page":"249","article-title":"The initial phase of orthodontic root resorption incident to local compression of the periodontal ligament","volume":"15","author":"Brudvik","year":"1993","unstructured":"Brudvik\n P,\n \n \n Rygh\n P.\n \n \n The initial phase of orthodontic root resorption incident to local compression of the periodontal ligament. Eur J Orthod. 1993;15:249\u2013263."},{"key":"i1945-7103-94-5-566-b06","series-title":"Angle Orthod","first-page":"547","article-title":"Lithium reduces orthodontically induced root resorption by suppressing cell death, hyalinization, and odontoclast formation in rats","volume":"92","author":"Ueda-Ichinose","year":"2022","unstructured":"Ueda-Ichinose\n Y,\n \n \n Hotokezaka\n H,\n \n \n Miyazaki\n T,\n \n et al.\n Lithium reduces orthodontically induced root resorption by suppressing cell death, hyalinization, and odontoclast formation in rats. Angle Orthod. 2022;92:547\u2013554."},{"key":"i1945-7103-94-5-566-b07","series-title":"J Biol Chem","first-page":"6050","article-title":"Positional specificity of a reticulocyte lipoxygenase. Conversion of arachidonic acid to 15-S-hydroperoxy-eicosatetraenoic acid","volume":"257","author":"Bryant","year":"1982","unstructured":"Bryant\n RW,\n \n \n Bailey\n JM,\n \n \n Schewe\n T,\n \n \n Rapoport\n SM.\n \n \n Positional specificity of a reticulocyte lipoxygenase. Conversion of arachidonic acid to 15-S-hydroperoxy-eicosatetraenoic acid. J Biol Chem. 1982;257:6050\u20136055."},{"key":"i1945-7103-94-5-566-b08","series-title":"Prog Lipid Res","first-page":"28","article-title":"Emerging role of 12\/15-Lipoxygenase (ALOX15) in human pathologies","volume":"73","author":"Singh","year":"2019","unstructured":"Singh\n NK,\n \n \n Rao\n GN.\n \n \n Emerging role of 12\/15-Lipoxygenase (ALOX15) in human pathologies. Prog Lipid Res. 2019;73:28\u201345."},{"key":"i1945-7103-94-5-566-b09","series-title":"Adv Med Sci","first-page":"141","article-title":"The role of 12\/15-lipoxygenase in production of selected eicosanoids in allergic airway inflammation","volume":"61","author":"Sacharzewska","year":"2016","unstructured":"Sacharzewska\n E,\n \n \n Bielecki\n P,\n \n \n Bernatowicz\n P,\n \n \n Niklinski\n J,\n \n \n Kowal\n BO,\n \n \n Kowal\n K.\n \n \n The role of 12\/15-lipoxygenase in production of selected eicosanoids in allergic airway inflammation. Adv Med Sci. 2016;61:141\u2013146."},{"key":"i1945-7103-94-5-566-b10","series-title":"Angle Orthod","first-page":"103","article-title":"Root resorption and immune system factors in the Japanese","volume":"76","author":"Nishioka","year":"2006","unstructured":"Nishioka\n M,\n \n \n Ioi\n H,\n \n \n Nakata\n S,\n \n \n Nakasima\n A,\n \n \n Counts\n A.\n \n \n Root resorption and immune system factors in the Japanese. Angle Orthod. 2006;76:103\u2013108."},{"key":"i1945-7103-94-5-566-b11","series-title":"Eur J Neurosci","first-page":"2049","article-title":"12-Lipoxygenase plays a key role in cell death caused by glutathione depletion and arachidonic acid in rat oligodendrocytes","volume":"20","author":"Wang","year":"2004","unstructured":"Wang\n H,\n \n \n Li\n J,\n \n \n Follett\n PL,\n \n et al.\n 12-Lipoxygenase plays a key role in cell death caused by glutathione depletion and arachidonic acid in rat oligodendrocytes. Eur J Neurosci. 2004;20:2049\u20132058."},{"key":"i1945-7103-94-5-566-b12","series-title":"J Neurosci Res","first-page":"904","article-title":"Novel lipoxygenase inhibitors as neuroprotective reagents","volume":"86","author":"van Leyen","year":"2008","unstructured":"van Leyen\n K,\n \n \n Arai\n K,\n \n \n Jin\n G,\n \n et al.\n Novel lipoxygenase inhibitors as neuroprotective reagents. J Neurosci Res. 2008;86:904\u2013909."},{"key":"i1945-7103-94-5-566-b13","series-title":"CNS Neurol Disord Drug Targets","first-page":"191","article-title":"Lipoxygenase: an emerging target for stroke therapy","volume":"12","author":"van Leyen","year":"2013","unstructured":"van Leyen\n K.\n \n \n Lipoxygenase: an emerging target for stroke therapy. CNS Neurol Disord Drug Targets. 2013;12:191\u2013199."},{"key":"i1945-7103-94-5-566-b14","series-title":"J Med Chem","first-page":"4035","article-title":"Potent and selective inhibitors of human reticulocyte 12\/15-lipoxygenase as anti-stroke therapies","volume":"57","author":"Rai","year":"2014","unstructured":"Rai\n G,\n \n \n Joshi\n N,\n \n \n Jung\n JE,\n \n et al.\n Potent and selective inhibitors of human reticulocyte 12\/15-lipoxygenase as anti-stroke therapies. J Med Chem. 2014;57:4035\u20134048."},{"key":"i1945-7103-94-5-566-b15","series-title":"Nature","first-page":"392","article-title":"A function for lipoxygenase in programmed organelle degradation","volume":"395","author":"van Leyen","year":"1998","unstructured":"van Leyen\n K,\n \n \n Duvoisin\n RM,\n \n \n Engelhardt\n H,\n \n \n Wiedmann\n M.\n \n \n A function for lipoxygenase in programmed organelle degradation. Nature. 1998;395:392\u2013395."},{"key":"i1945-7103-94-5-566-b16","series-title":"Science","first-page":"229","article-title":"Regulation of bone mass in mice by the lipoxygenase gene Alox15","volume":"303","author":"Klein","year":"2004","unstructured":"Klein\n RF,\n \n \n Allard\n J,\n \n \n Avnur\n Z,\n \n et al.\n Regulation of bone mass in mice by the lipoxygenase gene Alox15. Science. 2004;303:229\u2013232."},{"key":"i1945-7103-94-5-566-b17","series-title":"J Bone Miner Metab","first-page":"226","article-title":"Association of a single nucleotide polymorphism in the lipoxygenase ALOX15 5'-flanking region (-5229G\/A) with bone mineral density","volume":"23","author":"Urano","year":"2005","unstructured":"Urano\n T,\n \n \n Shiraki\n M,\n \n \n Fujita\n M,\n \n et al.\n Association of a single nucleotide polymorphism in the lipoxygenase ALOX15 5'-flanking region (-5229G\/A) with bone mineral density. J Bone Miner Metab. 2005;23:226\u2013230."},{"key":"i1945-7103-94-5-566-b18","series-title":"Autoimmunity","first-page":"383","article-title":"The 12\/15-lipoxygenase pathway promotes osteoclast development and differentiation","volume":"42","author":"Kr\u00f6nke","year":"2009","unstructured":"Kr\u00f6nke\n G,\n \n \n Uderhardt\n S,\n \n \n Katzenbeisser\n J,\n \n \n Schett\n G.\n \n \n The 12\/15-lipoxygenase pathway promotes osteoclast development and differentiation. Autoimmunity. 2009;42:383\u2013385."},{"key":"i1945-7103-94-5-566-b19","series-title":"Angle Orthod","first-page":"715","article-title":"Effects of steroidal and nonsteroidal drugs on tooth movement and root resorption in the rat molar","volume":"79","author":"Gonzales","year":"2009","unstructured":"Gonzales\n C,\n \n \n Hotokezaka\n H,\n \n \n Matsuo\n K,\n \n et al.\n Effects of steroidal and nonsteroidal drugs on tooth movement and root resorption in the rat molar. Angle Orthod. 2009;79:715\u2013726."},{"key":"i1945-7103-94-5-566-b20","series-title":"BMC Oral Health","first-page":"290","article-title":"Mechanical force regulates root resorption in rats through RANKL and OPG","volume":"22","author":"Zhou","year":"2022","unstructured":"Zhou\n J,\n \n \n Guo\n L,\n \n \n Yang\n Y,\n \n \n Liu\n Y,\n \n \n Zhang\n C.\n \n \n Mechanical force regulates root resorption in rats through RANKL and OPG. BMC Oral Health. 2022;22:290."},{"key":"i1945-7103-94-5-566-b21","series-title":"J Dent Res","first-page":"920","article-title":"Local OPG gene transfer to periodontal tissue inhibits orthodontic tooth movement","volume":"83","author":"Kanzaki","year":"2004","unstructured":"Kanzaki\n H,\n \n \n Chiba\n M,\n \n \n Takahashi\n I,\n \n et al.\n Local OPG gene transfer to periodontal tissue inhibits orthodontic tooth movement. J Dent Res. 2004;83:920-925."},{"key":"i1945-7103-94-5-566-b01","series-title":"Am J Orthod","first-page":"462","article-title":"Root resorption associated with orthodontic tooth movement: a systematic review","volume":"137","author":"Weltman","year":"2010","unstructured":"Weltman\n B,\n \n \n Vig\n KW,\n \n \n Fields\n HW,\n \n \n Shanker\n S,\n \n \n Kaizar\n EE.\n \n \n Root resorption associated with orthodontic tooth movement: a systematic review. Am J Orthod. 2010;137:462\u2013476."},{"issue":"4","key":"i1945-7103-94-5-566-b02","series-title":"Eur J Orthod","first-page":"346","article-title":"Effects of systemic medication on root resorption associated with orthodontic tooth movement: a systematic review of animal studies","volume":"41","author":"Makrygiannakis","year":"2019","unstructured":"Makrygiannakis\n MA,\n \n \n Kaklamanos\n EG,\n \n \n Athanasiou\n AE.\n \n \n Effects of systemic medication on root resorption associated with orthodontic tooth movement: a systematic review of animal studies. Eur J Orthod. 2019;41(4):346\u2013359."},{"key":"i1945-7103-94-5-566-b03","series-title":"Nordisk Tandl\u00e4kare Tidskrift","first-page":"236","article-title":"Einige Beitr\u00e4age zur Theorie der Zahnregulierung","volume":"5","author":"Sandstedt","year":"1904","unstructured":"Sandstedt\n C.\n \n \n Einige Beitr\u00e4age zur Theorie der Zahnregulierung. Nordisk Tandl\u00e4kare Tidskrift. 1904;5:236\u2013256."},{"key":"i1945-7103-94-5-566-b04","series-title":"Eur J Orthod","first-page":"249","article-title":"Root resorption beneath the main hyalinized zone","volume":"16","author":"Brudvik","year":"1994","unstructured":"Brudvik\n P,\n \n \n Rygh\n P.\n \n \n Root resorption beneath the main hyalinized zone. Eur J Orthod. 1994;16:249\u2013263."},{"key":"i1945-7103-94-5-566-b05","series-title":"Eur J Orthod","first-page":"249","article-title":"The initial phase of orthodontic root resorption incident to local compression of the periodontal ligament","volume":"15","author":"Brudvik","year":"1993","unstructured":"Brudvik\n P,\n \n \n Rygh\n P.\n \n \n The initial phase of orthodontic root resorption incident to local compression of the periodontal ligament. Eur J Orthod. 1993;15:249\u2013263."},{"key":"i1945-7103-94-5-566-b06","series-title":"Angle Orthod","first-page":"547","article-title":"Lithium reduces orthodontically induced root resorption by suppressing cell death, hyalinization, and odontoclast formation in rats","volume":"92","author":"Ueda-Ichinose","year":"2022","unstructured":"Ueda-Ichinose\n Y,\n \n \n Hotokezaka\n H,\n \n \n Miyazaki\n T,\n \n et al.\n Lithium reduces orthodontically induced root resorption by suppressing cell death, hyalinization, and odontoclast formation in rats. Angle Orthod. 2022;92:547\u2013554."},{"key":"i1945-7103-94-5-566-b07","series-title":"J Biol Chem","first-page":"6050","article-title":"Positional specificity of a reticulocyte lipoxygenase. Conversion of arachidonic acid to 15-S-hydroperoxy-eicosatetraenoic acid","volume":"257","author":"Bryant","year":"1982","unstructured":"Bryant\n RW,\n \n \n Bailey\n JM,\n \n \n Schewe\n T,\n \n \n Rapoport\n SM.\n \n \n Positional specificity of a reticulocyte lipoxygenase. Conversion of arachidonic acid to 15-S-hydroperoxy-eicosatetraenoic acid. J Biol Chem. 1982;257:6050\u20136055."},{"key":"i1945-7103-94-5-566-b08","series-title":"Prog Lipid Res","first-page":"28","article-title":"Emerging role of 12\/15-Lipoxygenase (ALOX15) in human pathologies","volume":"73","author":"Singh","year":"2019","unstructured":"Singh\n NK,\n \n \n Rao\n GN.\n \n \n Emerging role of 12\/15-Lipoxygenase (ALOX15) in human pathologies. Prog Lipid Res. 2019;73:28\u201345."},{"key":"i1945-7103-94-5-566-b09","series-title":"Adv Med Sci","first-page":"141","article-title":"The role of 12\/15-lipoxygenase in production of selected eicosanoids in allergic airway inflammation","volume":"61","author":"Sacharzewska","year":"2016","unstructured":"Sacharzewska\n E,\n \n \n Bielecki\n P,\n \n \n Bernatowicz\n P,\n \n \n Niklinski\n J,\n \n \n Kowal\n BO,\n \n \n Kowal\n K.\n \n \n The role of 12\/15-lipoxygenase in production of selected eicosanoids in allergic airway inflammation. Adv Med Sci. 2016;61:141\u2013146."},{"key":"i1945-7103-94-5-566-b10","series-title":"Angle Orthod","first-page":"103","article-title":"Root resorption and immune system factors in the Japanese","volume":"76","author":"Nishioka","year":"2006","unstructured":"Nishioka\n M,\n \n \n Ioi\n H,\n \n \n Nakata\n S,\n \n \n Nakasima\n A,\n \n \n Counts\n A.\n \n \n Root resorption and immune system factors in the Japanese. Angle Orthod. 2006;76:103\u2013108."},{"key":"i1945-7103-94-5-566-b11","series-title":"Eur J Neurosci","first-page":"2049","article-title":"12-Lipoxygenase plays a key role in cell death caused by glutathione depletion and arachidonic acid in rat oligodendrocytes","volume":"20","author":"Wang","year":"2004","unstructured":"Wang\n H,\n \n \n Li\n J,\n \n \n Follett\n PL,\n \n et al.\n 12-Lipoxygenase plays a key role in cell death caused by glutathione depletion and arachidonic acid in rat oligodendrocytes. Eur J Neurosci. 2004;20:2049\u20132058."},{"key":"i1945-7103-94-5-566-b12","series-title":"J Neurosci Res","first-page":"904","article-title":"Novel lipoxygenase inhibitors as neuroprotective reagents","volume":"86","author":"van Leyen","year":"2008","unstructured":"van Leyen\n K,\n \n \n Arai\n K,\n \n \n Jin\n G,\n \n et al.\n Novel lipoxygenase inhibitors as neuroprotective reagents. J Neurosci Res. 2008;86:904\u2013909."},{"key":"i1945-7103-94-5-566-b13","series-title":"CNS Neurol Disord Drug Targets","first-page":"191","article-title":"Lipoxygenase: an emerging target for stroke therapy","volume":"12","author":"van Leyen","year":"2013","unstructured":"van Leyen\n K.\n \n \n Lipoxygenase: an emerging target for stroke therapy. CNS Neurol Disord Drug Targets. 2013;12:191\u2013199."},{"key":"i1945-7103-94-5-566-b14","series-title":"J Med Chem","first-page":"4035","article-title":"Potent and selective inhibitors of human reticulocyte 12\/15-lipoxygenase as anti-stroke therapies","volume":"57","author":"Rai","year":"2014","unstructured":"Rai\n G,\n \n \n Joshi\n N,\n \n \n Jung\n JE,\n \n et al.\n Potent and selective inhibitors of human reticulocyte 12\/15-lipoxygenase as anti-stroke therapies. J Med Chem. 2014;57:4035\u20134048."},{"key":"i1945-7103-94-5-566-b15","series-title":"Nature","first-page":"392","article-title":"A function for lipoxygenase in programmed organelle degradation","volume":"395","author":"van Leyen","year":"1998","unstructured":"van Leyen\n K,\n \n \n Duvoisin\n RM,\n \n \n Engelhardt\n H,\n \n \n Wiedmann\n M.\n \n \n A function for lipoxygenase in programmed organelle degradation. Nature. 1998;395:392\u2013395."},{"key":"i1945-7103-94-5-566-b16","series-title":"Science","first-page":"229","article-title":"Regulation of bone mass in mice by the lipoxygenase gene Alox15","volume":"303","author":"Klein","year":"2004","unstructured":"Klein\n RF,\n \n \n Allard\n J,\n \n \n Avnur\n Z,\n \n et al.\n Regulation of bone mass in mice by the lipoxygenase gene Alox15. Science. 2004;303:229\u2013232."},{"key":"i1945-7103-94-5-566-b17","series-title":"J Bone Miner Metab","first-page":"226","article-title":"Association of a single nucleotide polymorphism in the lipoxygenase ALOX15 5'-flanking region (-5229G\/A) with bone mineral density","volume":"23","author":"Urano","year":"2005","unstructured":"Urano\n T,\n \n \n Shiraki\n M,\n \n \n Fujita\n M,\n \n et al.\n Association of a single nucleotide polymorphism in the lipoxygenase ALOX15 5'-flanking region (-5229G\/A) with bone mineral density. J Bone Miner Metab. 2005;23:226\u2013230."},{"key":"i1945-7103-94-5-566-b18","series-title":"Autoimmunity","first-page":"383","article-title":"The 12\/15-lipoxygenase pathway promotes osteoclast development and differentiation","volume":"42","author":"Kr\u00f6nke","year":"2009","unstructured":"Kr\u00f6nke\n G,\n \n \n Uderhardt\n S,\n \n \n Katzenbeisser\n J,\n \n \n Schett\n G.\n \n \n The 12\/15-lipoxygenase pathway promotes osteoclast development and differentiation. Autoimmunity. 2009;42:383\u2013385."},{"key":"i1945-7103-94-5-566-b19","series-title":"Angle Orthod","first-page":"715","article-title":"Effects of steroidal and nonsteroidal drugs on tooth movement and root resorption in the rat molar","volume":"79","author":"Gonzales","year":"2009","unstructured":"Gonzales\n C,\n \n \n Hotokezaka\n H,\n \n \n Matsuo\n K,\n \n et al.\n Effects of steroidal and nonsteroidal drugs on tooth movement and root resorption in the rat molar. Angle Orthod. 2009;79:715\u2013726."},{"key":"i1945-7103-94-5-566-b20","series-title":"BMC Oral Health","first-page":"290","article-title":"Mechanical force regulates root resorption in rats through RANKL and OPG","volume":"22","author":"Zhou","year":"2022","unstructured":"Zhou\n J,\n \n \n Guo\n L,\n \n \n Yang\n Y,\n \n \n Liu\n Y,\n \n \n Zhang\n C.\n \n \n Mechanical force regulates root resorption in rats through RANKL and OPG. BMC Oral Health. 2022;22:290."},{"key":"i1945-7103-94-5-566-b21","series-title":"J Dent Res","first-page":"920","article-title":"Local OPG gene transfer to periodontal tissue inhibits orthodontic tooth movement","volume":"83","author":"Kanzaki","year":"2004","unstructured":"Kanzaki\n H,\n \n \n Chiba\n M,\n \n \n Takahashi\n I,\n \n et al.\n Local OPG gene transfer to periodontal tissue inhibits orthodontic tooth movement. J Dent Res. 2004;83:920-925."}],"container-title":["The Angle Orthodontist"],"original-title":[],"link":[{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/view\/journals\/angl\/94\/5\/article-p566.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/meridian.allenpress.com\/angle-orthodontist\/article-pdf\/94\/5\/566\/3426674\/i1945-7103-94-5-566.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/downloadpdf\/journals\/angl\/94\/5\/article-p566.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/downloadpdf\/journals\/angl\/94\/5\/article-p566.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T14:19:36Z","timestamp":1780064376000},"score":1,"resource":{"primary":{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/view\/journals\/angl\/94\/5\/article-p566.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":42,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.2319\/103123-730.1","relation":{},"ISSN":["1945-7103","0003-3219"],"issn-type":[{"value":"1945-7103","type":"electronic"},{"value":"0003-3219","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]}}}