{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T05:20:32Z","timestamp":1789536032318,"version":"build-2803163510"},"reference-count":64,"publisher":"The Angle Orthodontist (EH Angle Education & Research Foundation)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To provide a semi-quantitative assessment of the effect of different analgesics (celecoxib, ketorolac, and paracetamol) on tooth movement and bone resorption using immunohistochemical staining of matrix metalloproteinase-13 (MMP-13).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Forty white male rats (12-weeks old; body weight: 230\u2013250\u00a0g) were divided into four groups (10 rats each) and were given the treatment once a day for 2 consecutive months. Group A (control group) rats were given the reverse osmosis water; group B rats were given 10\u00a0mg\/kg celecoxib; group C rats were given 3\u00a0mg\/kg ketorolac; and group D rats were given 150\u00a0mg\/kg paracetamol. A precalibrated closed Sentalloy coil spring was placed inside each rat mouth to deliver a constant force of 50\u00a0cN. The magnitude of tooth movement was measured intraorally. After 2\u00a0months, the rats were sacrificed, and the sections were mounted on L-polylysine\u2013coated glass slides. Slides from each specimen were stained with hematoxylin and eosin, and others were stained with MMP-13. Data were analyzed with the one-way analysis of variance (ANOVA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Celecoxib, ketorolac, and paracetamol groups showed tooth movement of 1.81 \u00b1 0.43\u00a0mm, 1.13 \u00b1 0.28\u00a0mm, and 1.08 \u00b1 0.27\u00a0mm, respectively. The mean number of MMP-13\u2013positive osteoclasts was highest in celecoxib-treated group followed by the control group and was decreased in the ketorolac and paracetamol groups. Comparing all groups to the control revealed significant differences (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Administration of celecoxib did not reduce bone resorption or interfere with tooth movement in rats compared to other analgesics tested (ketorolac and paracetamol).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2319\/110911-691.1","type":"journal-article","created":{"date-parts":[[2012,2,27]],"date-time":"2012-02-27T08:33:00Z","timestamp":1330331580000},"page":"820-826","source":"Crossref","is-referenced-by-count":20,"title":["The use of different analgesics in orthodontic tooth movements"],"prefix":"10.2319","volume":"82","author":[{"given":"Shaza M.","family":"Hammad","sequence":"first","affiliation":[{"name":"Associate Professor of Orthodontics, Faculty of Dentistry, Mansoura University, Mansoura, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousry M.","family":"El-Hawary","sequence":"additional","affiliation":[{"name":"Associate Professor, Department of Oral Biology, Faculty of Dentistry, Mansoura University, Mansoura, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira K.","family":"El-Hawary","sequence":"additional","affiliation":[{"name":"Associate Professor, Department of Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1164","reference":[{"key":"i0003-3219-82-5-820-b01","series-title":"Reabsor\u00e7\u00f5es Dent\u00e1rias Nas Especialidades Cl\u00ednicas. 2nd ed","first-page":"353","author":"Consolaro, A.","year":"2005","unstructured":"Consolaro, A.\n          \n          Reabsor\u00e7\u00f5es Dent\u00e1rias Nas Especialidades Cl\u00ednicas. 2nd ed. Maring\u00e1, BrazilDental Press. 2005. 353\u2013400."},{"key":"i0003-3219-82-5-820-b02","series-title":"Dental Press Endod","first-page":"14","article-title":"Orthodontic treatment does not cause pulpal necrosis.","volume":"1","author":"Consolaro, A.","year":"2011","unstructured":"Consolaro, A.\n          \n          Orthodontic treatment does not cause pulpal necrosis.\n          Dental Press Endod\n          2011. 1:14\u201320."},{"key":"i0003-3219-82-5-820-b03","series-title":"Am J Orthod Dentofacial Orthop","first-page":"231","article-title":"Experimental study of the effect of prostaglandin administration on tooth movement\u2014with particular emphasis on the relationship to the method of PGE1 administration.","volume":"98","author":"Lee, W. C.","year":"1990","unstructured":"Lee, W. C.\n          \n          Experimental study of the effect of prostaglandin administration on tooth movement\u2014with particular emphasis on the relationship to the method of PGE1 administration.\n          Am J Orthod Dentofacial Orthop\n          1990. 98:231\u2013241."},{"key":"i0003-3219-82-5-820-b04","series-title":"Clin Pharmacol Ther","first-page":"9","article-title":"New insights into the mechanism of action of acetaminophen: its clinical pharmacologic characteristics reflect its inhibition of the two prostaglandin H2 synthases.","volume":"79","author":"Aronoff, D. M.","year":"2006","unstructured":"Aronoff, D. M., J. A.Oates, and O.Boutaud. New insights into the mechanism of action of acetaminophen: its clinical pharmacologic characteristics reflect its inhibition of the two prostaglandin H2 synthases.Clin Pharmacol Ther2006. 79:9\u201319."},{"key":"i0003-3219-82-5-820-b05","series-title":"J Orofac Orthop","first-page":"331","article-title":"Pain and discomfort experienced after placement of a conventional or a superelastic NiTi aligning archwire. A randomized clinical trial.","volume":"59","author":"Fernandes, L. M.","year":"1998","unstructured":"Fernandes, L. M., B.Ogaard, and L.Skoglund. Pain and discomfort experienced after placement of a conventional or a superelastic NiTi aligning archwire. A randomized clinical trial.J Orofac Orthop1998. 59:331\u2013339."},{"key":"i0003-3219-82-5-820-b06","series-title":"Nat Rev Drug Discov","first-page":"75","article-title":"COX isoforms in the cardiovascular system: understanding the activities of non-steroidal anti-inflammatory drugs.","volume":"5","author":"Mitchell, J. A.","year":"2006","unstructured":"Mitchell, J. A. and T. D.Warner. COX isoforms in the cardiovascular system: understanding the activities of non-steroidal anti-inflammatory drugs.Nat Rev Drug Discov2006. 5:75\u201386."},{"key":"i0003-3219-82-5-820-b07","series-title":"Angle Orthod","first-page":"1169","article-title":"Effect of celecoxib on emotional stress and pain-related behaviors evoked by experimental tooth movement in the rat.","volume":"79","author":"Shibazaki, T.","year":"2009","unstructured":"Shibazaki, T., J. H.Yozgatian, J. L.Zeredo, C.Gonzales, H.Hotokezaka, Y.Koga, and N.Yoshida. Effect of celecoxib on emotional stress and pain-related behaviors evoked by experimental tooth movement in the rat.Angle Orthod2009. 79:1169\u20131174."},{"key":"i0003-3219-82-5-820-b08","series-title":"Basic and Clinical Pharmacology. 9th ed","article-title":"Nonsteroidal anti-inflammatory drugs, disease-modifying antirheumatic drugs, nonopioid analgesics and drugs used in gout.","author":"Wagner, W.","year":"2004","unstructured":"Wagner, W., P.Khanna, and D. E.Furst. Nonsteroidal anti-inflammatory drugs, disease-modifying antirheumatic drugs, nonopioid analgesics and drugs used in gout.InKatzung, B. G.ed.Basic and Clinical Pharmacology. 9th ed. New York, NYMcGraw-Hill. 2004. 586"},{"key":"i0003-3219-82-5-820-b09","series-title":"CNS Drug Rev","first-page":"250","article-title":"Paracetamol: new vistas of an old drug.","volume":"12","author":"Bertolini, A.","year":"2006","unstructured":"Bertolini, A., A.Ferrari, A.Ottani, S.Guerzoni, R.Tacchi, and S.Leone. Paracetamol: new vistas of an old drug.CNS Drug Rev2006. 12:250\u2013275."},{"key":"i0003-3219-82-5-820-b10","series-title":"FASEB J","first-page":"383","article-title":"Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man.","volume":"22","author":"Hinz, B.","year":"2008","unstructured":"Hinz, B., O.Cheremina, and K.Brune. Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man.FASEB J2008. 22:383\u2013390."},{"key":"i0003-3219-82-5-820-b11","series-title":"Angle Orthod","first-page":"231","article-title":"The effect of acetaminophen on tooth movement in rabbits.","volume":"67","author":"Roche, J. J.","year":"1997","unstructured":"Roche, J. J., G. J.Cisneros, and G.Acs. The effect of acetaminophen on tooth movement in rabbits.Angle Orthod1997. 67:231\u2013236."},{"key":"i0003-3219-82-5-820-b12","series-title":"Arch Oral Biol","first-page":"907","article-title":"In situ hybridization for matrix metalloproteinase-1 and cathepsin K in rat root-resorbing tissue induced by tooth movement.","volume":"44","author":"Domon, S.","year":"1999","unstructured":"Domon, S., H.Shimokawa, Y.Matsumoto, S.Yamaguchi, and K.Soma. In situ hybridization for matrix metalloproteinase-1 and cathepsin K in rat root-resorbing tissue induced by tooth movement.Arch Oral Biol1999. 44:907\u2013915."},{"key":"i0003-3219-82-5-820-b13","series-title":"J Dent Res","first-page":"646","article-title":"Expression of MMP-8 and MMP-13 genes in the periodontal ligament during tooth movement in rats.","volume":"82","author":"Takahashi, I.","year":"2003","unstructured":"Takahashi, I., M.Nishimura, K.Onodera, J. W.Bae, H.Mitani, M.Okazaki, Y.Sasano, and H.Mitani. Expression of MMP-8 and MMP-13 genes in the periodontal ligament during tooth movement in rats.J Dent Res2003. 82:646\u2013651."},{"key":"i0003-3219-82-5-820-b14","series-title":"Acta Histochem","first-page":"215","article-title":"MMP-13 (collagenase 3) immunolocalisation during initial orthodontic tooth movement in rats.","volume":"109","author":"Leonardi, R.","year":"2007","unstructured":"Leonardi, R., N. F.Talic, and C.Loreto. MMP-13 (collagenase 3) immunolocalisation during initial orthodontic tooth movement in rats.Acta Histochem2007. 109:215\u2013220."},{"key":"i0003-3219-82-5-820-b15","series-title":"Am J Orthod Dentofacial Orthop","first-page":"568.e11","article-title":"Levels of matrix metalloproteinases 1 and 2 in human gingival crevicular fluid during initial tooth movement.","volume":"130","author":"Cantarella, G.","year":"2006","unstructured":"Cantarella, G., R.Cantarella, M.Caltabiano, N.Risuglia, R.Bernardini, and R.Leonardi. Levels of matrix metalloproteinases 1 and 2 in human gingival crevicular fluid during initial tooth movement.Am J Orthod Dentofacial Orthop2006. 130:568.e11\u201316."},{"key":"i0003-3219-82-5-820-b16","series-title":"Angle Orthod","first-page":"486","article-title":"Growth hormone receptor and IGF-I receptor immunoreactivity during orthodontic tooth movement in the prednisolone-treated rat.","volume":"71","author":"Ong, C. K.","year":"2001","unstructured":"Ong, C. K., B. K.Joseph, M. J.Waters, and A. L.Symons. Growth hormone receptor and IGF-I receptor immunoreactivity during orthodontic tooth movement in the prednisolone-treated rat.Angle Orthod2001. 71:486\u2013493."},{"key":"i0003-3219-82-5-820-b17","series-title":"Angle Orthod","first-page":"502","article-title":"Force magnitude and duration effects on amount of tooth movement and root resorption in the rat molar.","volume":"78","author":"Gonzales, C.","year":"2008","unstructured":"Gonzales, C., H.Hotokezaka, M.Yoshimatsu, J. H.Yozgatian, M. A.Darendeliler, and N.Yoshida. Force magnitude and duration effects on amount of tooth movement and root resorption in the rat molar.Angle Orthod2008. 78:502\u2013509."},{"key":"i0003-3219-82-5-820-b18","series-title":"J Dent Res","first-page":"692","article-title":"MMP-3 response to compressive forces in vitro and in vivo.","volume":"87","author":"Chang, H. H.","year":"2008","unstructured":"Chang, H. H., C. B.Wu, Y. J.Chen, et al. MMP-3 response to compressive forces in vitro and in vivo.J Dent Res2008. 87:692\u2013696."},{"key":"i0003-3219-82-5-820-b19","series-title":"J Dent Res","first-page":"1037","article-title":"CCR5 down-regulates osteoclast function in orthodontic tooth movement.","volume":"88","author":"Andrade\n              Jr, I.","year":"2009","unstructured":"Andrade\n              Jr, I., S. R.Taddei, G. P.Garlet, T. P.Garlet, A. L.Teixeira, T. A.Silva, and M. M.Teixeira. CCR5 down-regulates osteoclast function in orthodontic tooth movement.J Dent Res2009. 88:1037\u20131041."},{"key":"i0003-3219-82-5-820-b20","series-title":"J Dent Res","first-page":"902","article-title":"Early responses of periodontal ligament cells to mechanical stimulus in vivo.","volume":"84","author":"Kawarizadeh, A.","year":"2005","unstructured":"Kawarizadeh, A., C.Bourauel, W.G\u00f6tz, and A.J\u00e4ger. Early responses of periodontal ligament cells to mechanical stimulus in vivo.J Dent Res2005. 84:902\u2013906."},{"key":"i0003-3219-82-5-820-b21","series-title":"Eur J Orthod","first-page":"529","article-title":"Matrix metalloproteinases and tissue inhibitors of metalloproteinases in gingival crevicular fluid during orthodontic tooth movement.","volume":"31","author":"Bildt, M. M.","year":"2009","unstructured":"Bildt, M. M., M.Bloemen, A. M.Kuijpers-Jagtman, and J. W.Von den Hoff. Matrix metalloproteinases and tissue inhibitors of metalloproteinases in gingival crevicular fluid during orthodontic tooth movement.Eur J Orthod2009. 31:529\u2013535."},{"key":"i0003-3219-82-5-820-b22","series-title":"Angle Orthod","first-page":"715","article-title":"Effects of steroidal and nonsteroidal drugs on tooth movement and root resorption in the rat molar.","volume":"79","author":"Gonzales, C.","year":"2009","unstructured":"Gonzales, C., H.Hotokezaka, K.Matsuo, T.Shibazaki, J. H.Yozgatian, and M. A.Darendeliler. Effects of steroidal and nonsteroidal drugs on tooth movement and root resorption in the rat molar.Angle Orthod2009. 79:715\u2013726."},{"key":"i0003-3219-82-5-820-b23","series-title":"J Calif Dent Assoc","first-page":"951","article-title":"Celebrex offers a small protection from root resorption associated with orthodontic movement.","volume":"33","author":"Jerome, J.","year":"2005","unstructured":"Jerome, J., T.Brunson, G.Takeoka, C.Foster, H. B.Moon, E.Graged, and M.Zeichner-David. Celebrex offers a small protection from root resorption associated with orthodontic movement.J Calif Dent Assoc2005. 33:951\u2013959."},{"key":"i0003-3219-82-5-820-b24","series-title":"Eur J Orthod","first-page":"596","article-title":"Orthodontic tooth movement after different coxib therapies.","volume":"29","author":"De Carlos, F.","year":"2007","unstructured":"De Carlos, F., J.Cobo, C.Perillan, M. A.Garcia, J.Arguelles, M.Vijande, and M.Costales. Orthodontic tooth movement after different coxib therapies.Eur J Orthod2007. 29:596\u2013599."},{"key":"i0003-3219-82-5-820-b25","series-title":"Eur J Orthod","first-page":"175","article-title":"Prostaglandins and tooth movement.","volume":"6","author":"Sandy, J. R.","year":"1984","unstructured":"Sandy, J. R. and M.Harris. Prostaglandins and tooth movement.Eur J Orthod1984. 6:175\u2013182."},{"key":"i0003-3219-82-5-820-b26","series-title":"BMC Cancer","first-page":"181","article-title":"Inhibition of cyclooxygenase-2 decreases breast cancer cell motility, invasion and matrix metalloproteinase expression.","volume":"6","author":"Larkins, T. L.","year":"2006","unstructured":"Larkins, T. L., M.Nowell, S.Singh, and G. L.Sanford. Inhibition of cyclooxygenase-2 decreases breast cancer cell motility, invasion and matrix metalloproteinase expression.BMC Cancer2006. 6:181\u2013187. ."},{"key":"i0003-3219-82-5-820-b27","series-title":"Brain Res Bull","first-page":"396","article-title":"Effects of short term acetaminophen and celecoxib treatment on orthodontic tooth movement and neuronal activation in rat.","volume":"79","author":"Stabile, A. C.","year":"2009","unstructured":"Stabile, A. C., M. B.Stuani, C. R.Leite-Panissi, and M. J.Rocha. Effects of short term acetaminophen and celecoxib treatment on orthodontic tooth movement and neuronal activation in rat.Brain Res Bull2009. 79:396\u2013401."},{"key":"i0003-3219-82-5-820-b28","series-title":"Am J Orthod Dentofacial Orthop","first-page":"16","article-title":"Medication effects on the rate of orthodontic tooth movement: a systematic literature review.","volume":"135","author":"Bartzela, T.","year":"2009","unstructured":"Bartzela, T., J. C.T\u00fcrp, E.Motschall, and J. C.Maltha. Medication effects on the rate of orthodontic tooth movement: a systematic literature review.Am J Orthod Dentofacial Orthop2009. 135:16\u201326."},{"key":"i0003-3219-82-5-820-b29","series-title":"Dental Press J Orthod","first-page":"16","article-title":"Sources of controversies over analgesics prescribed after activation of orthodontic appliances acetylsalicylic acid or acetaminophen?","volume":"15","author":"Consolaro, A.","year":"2010","unstructured":"Consolaro, A., V.Maldonado, M.J\u00fanior, and M.Consolaro. Sources of controversies over analgesics prescribed after activation of orthodontic appliances acetylsalicylic acid or acetaminophen?Dental Press J Orthod2010. 15:16\u201324."},{"key":"i0003-3219-82-5-820-b30","series-title":"Ann Pharmacother","first-page":"113","article-title":"NSAID impairment of orthodontic tooth movement.","volume":"35","author":"Walker, J. B.","year":"2001","unstructured":"Walker, J. B. and S. M.Buring. NSAID impairment of orthodontic tooth movement.Ann Pharmacother2001. 35:113\u2013115."},{"key":"i0003-3219-82-5-820-b31","series-title":"J Dent Res","first-page":"877","article-title":"The role of cyclic AMP, calcium, and prostaglandins in the induction of osteoclastic bone resorption associated with experimental tooth movement.","volume":"62","author":"Yamasaki, K.","year":"1983","unstructured":"Yamasaki, K.\n          \n          The role of cyclic AMP, calcium, and prostaglandins in the induction of osteoclastic bone resorption associated with experimental tooth movement.\n          J Dent Res\n          1983. 62:877\u2013881."},{"key":"i0003-3219-82-5-820-b32","series-title":"Angle Orthod","first-page":"299","article-title":"A bone resorptive agent extracted from orthodontically-treated tissues of the rat.","volume":"56","author":"King, G. J.","year":"1986","unstructured":"King, G. J. and J.Collier. 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Maring\u00e1, BrazilDental Press. 2005. 353\u2013400."},{"key":"i0003-3219-82-5-820-b02","series-title":"Dental Press Endod","first-page":"14","article-title":"Orthodontic treatment does not cause pulpal necrosis.","volume":"1","author":"Consolaro, A.","year":"2011","unstructured":"Consolaro, A.\n          \n          Orthodontic treatment does not cause pulpal necrosis.\n          Dental Press Endod\n          2011. 1:14\u201320."},{"key":"i0003-3219-82-5-820-b03","series-title":"Am J Orthod Dentofacial Orthop","first-page":"231","article-title":"Experimental study of the effect of prostaglandin administration on tooth movement\u2014with particular emphasis on the relationship to the method of PGE1 administration.","volume":"98","author":"Lee, W. C.","year":"1990","unstructured":"Lee, W. C.\n          \n          Experimental study of the effect of prostaglandin administration on tooth movement\u2014with particular emphasis on the relationship to the method of PGE1 administration.\n          Am J Orthod Dentofacial Orthop\n          1990. 98:231\u2013241."},{"key":"i0003-3219-82-5-820-b04","series-title":"Clin Pharmacol Ther","first-page":"9","article-title":"New insights into the mechanism of action of acetaminophen: its clinical pharmacologic characteristics reflect its inhibition of the two prostaglandin H2 synthases.","volume":"79","author":"Aronoff, D. M.","year":"2006","unstructured":"Aronoff, D. M., J. A.Oates, and O.Boutaud. New insights into the mechanism of action of acetaminophen: its clinical pharmacologic characteristics reflect its inhibition of the two prostaglandin H2 synthases.Clin Pharmacol Ther2006. 79:9\u201319."},{"key":"i0003-3219-82-5-820-b05","series-title":"J Orofac Orthop","first-page":"331","article-title":"Pain and discomfort experienced after placement of a conventional or a superelastic NiTi aligning archwire. A randomized clinical trial.","volume":"59","author":"Fernandes, L. M.","year":"1998","unstructured":"Fernandes, L. M., B.Ogaard, and L.Skoglund. Pain and discomfort experienced after placement of a conventional or a superelastic NiTi aligning archwire. A randomized clinical trial.J Orofac Orthop1998. 59:331\u2013339."},{"key":"i0003-3219-82-5-820-b06","series-title":"Nat Rev Drug Discov","first-page":"75","article-title":"COX isoforms in the cardiovascular system: understanding the activities of non-steroidal anti-inflammatory drugs.","volume":"5","author":"Mitchell, J. A.","year":"2006","unstructured":"Mitchell, J. A. and T. D.Warner. COX isoforms in the cardiovascular system: understanding the activities of non-steroidal anti-inflammatory drugs.Nat Rev Drug Discov2006. 5:75\u201386."},{"key":"i0003-3219-82-5-820-b07","series-title":"Angle Orthod","first-page":"1169","article-title":"Effect of celecoxib on emotional stress and pain-related behaviors evoked by experimental tooth movement in the rat.","volume":"79","author":"Shibazaki, T.","year":"2009","unstructured":"Shibazaki, T., J. H.Yozgatian, J. L.Zeredo, C.Gonzales, H.Hotokezaka, Y.Koga, and N.Yoshida. 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Paracetamol: new vistas of an old drug.CNS Drug Rev2006. 12:250\u2013275."},{"key":"i0003-3219-82-5-820-b10","series-title":"FASEB J","first-page":"383","article-title":"Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man.","volume":"22","author":"Hinz, B.","year":"2008","unstructured":"Hinz, B., O.Cheremina, and K.Brune. Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man.FASEB J2008. 22:383\u2013390."},{"key":"i0003-3219-82-5-820-b11","series-title":"Angle Orthod","first-page":"231","article-title":"The effect of acetaminophen on tooth movement in rabbits.","volume":"67","author":"Roche, J. J.","year":"1997","unstructured":"Roche, J. J., G. J.Cisneros, and G.Acs. The effect of acetaminophen on tooth movement in rabbits.Angle Orthod1997. 67:231\u2013236."},{"key":"i0003-3219-82-5-820-b12","series-title":"Arch Oral Biol","first-page":"907","article-title":"In situ hybridization for matrix metalloproteinase-1 and cathepsin K in rat root-resorbing tissue induced by tooth movement.","volume":"44","author":"Domon, S.","year":"1999","unstructured":"Domon, S., H.Shimokawa, Y.Matsumoto, S.Yamaguchi, and K.Soma. In situ hybridization for matrix metalloproteinase-1 and cathepsin K in rat root-resorbing tissue induced by tooth movement.Arch Oral Biol1999. 44:907\u2013915."},{"key":"i0003-3219-82-5-820-b13","series-title":"J Dent Res","first-page":"646","article-title":"Expression of MMP-8 and MMP-13 genes in the periodontal ligament during tooth movement in rats.","volume":"82","author":"Takahashi, I.","year":"2003","unstructured":"Takahashi, I., M.Nishimura, K.Onodera, J. W.Bae, H.Mitani, M.Okazaki, Y.Sasano, and H.Mitani. Expression of MMP-8 and MMP-13 genes in the periodontal ligament during tooth movement in rats.J Dent Res2003. 82:646\u2013651."},{"key":"i0003-3219-82-5-820-b14","series-title":"Acta Histochem","first-page":"215","article-title":"MMP-13 (collagenase 3) immunolocalisation during initial orthodontic tooth movement in rats.","volume":"109","author":"Leonardi, R.","year":"2007","unstructured":"Leonardi, R., N. F.Talic, and C.Loreto. MMP-13 (collagenase 3) immunolocalisation during initial orthodontic tooth movement in rats.Acta Histochem2007. 109:215\u2013220."},{"key":"i0003-3219-82-5-820-b15","series-title":"Am J Orthod Dentofacial Orthop","first-page":"568.e11","article-title":"Levels of matrix metalloproteinases 1 and 2 in human gingival crevicular fluid during initial tooth movement.","volume":"130","author":"Cantarella, G.","year":"2006","unstructured":"Cantarella, G., R.Cantarella, M.Caltabiano, N.Risuglia, R.Bernardini, and R.Leonardi. 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