{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T12:02:41Z","timestamp":1788177761161,"version":"build-2803163510"},"reference-count":50,"publisher":"The Angle Orthodontist (EH Angle Education & Research Foundation)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,14]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objectives<\/jats:title>\n To examine the relationship between mandibular volume and craniofacial morphology in patients with cleft lip and palate using cone beam computed tomography (CBCT) and to compare these findings with control (noncleft) patients undergoing CBCT for other purposes during the deciduous dentition period.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n Eighty-four patients were categorized into the unilateral cleft lip and alveolus (UCLA) group (n = 25; mean age, 4.60 \u00b1 0.40 years), unilateral cleft lip and palate (UCLP) group (n = 23; mean age, 4.52 \u00b1 0.39 years), bilateral cleft lip and palate (BCLP) group (n = 22; mean age, 4.54 \u00b1 0.37 years), and control group without cleft (n = 14; mean age, 5.19 \u00b1 0.52 years). Mandibular volume and craniofacial cephalometric measurements were obtained using CBCT. All measurements were assessed by analysis of covariance (ANCOVA) using Bonferroni post hoc pairwise comparison tests.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n ANCOVA revealed no statistically significant differences in mandibular volume among the groups. SNA\u00b0 and ANB\u00b0 were significantly larger in the UCLA and BCLP groups than in the control group. SN-MP\u00b0 was smallest in the UCLA group. Co-A in the UCLP group was shorter than in the UCLA and BCLP groups. Go-Gn was shortest in the UCLP and BCLP groups compared with the control group.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Three-dimensional evaluation of craniofacial morphology using CBCT can provide valuable information on malocclusion and other dentoskeletal problems among patients with CLP.<\/jats:p>\n <\/jats:sec>","DOI":"10.2319\/112618-831.1","type":"journal-article","created":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T12:37:50Z","timestamp":1565354270000},"page":"85-91","source":"Crossref","is-referenced-by-count":11,"title":["Three-dimensional Evaluation of Mandibular Volume in Patients with Cleft Lip and Palate During the Deciduous Dentition Period"],"prefix":"10.2319","volume":"90","author":[{"given":"Abhishekhi","family":"Shrestha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsutaro","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Adel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayu","family":"Furuhata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Hikita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takatoshi","family":"Nakawaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koutaro","family":"Maki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1164","reference":[{"key":"i0003-3219-90-1-85-b01","series-title":"Hum Mol Genet","first-page":"1853","article-title":"The many faces and factors of orofacial clefts","volume":"8","author":"Schutte","year":"1999","unstructured":"Schutte\n BC,\n \n \n Murray\n JC.\n \n \n The many faces and factors of orofacial clefts.\n\t\t\t\t\tHum Mol Genet.\n\t\t\t\t\t1999;\n\t\t\t\t\t8:\n\t\t\t\t\t1853\u2013\n\t\t\t\t\t1859."},{"key":"i0003-3219-90-1-85-b02","series-title":"Nat Rev Genet","first-page":"167","article-title":"Cleft lip and palate: understanding genetic and environmental influences","volume":"12","author":"Dixon","year":"2011","unstructured":"Dixon\n MJ,\n \n \n Marazita\n ML,\n \n \n Beaty\n TH,\n \n \n Murray\n JC.\n \n \n Cleft lip and palate: understanding genetic and environmental influences.\n\t\t\t\t\tNat Rev Genet.\n\t\t\t\t\t2011;\n\t\t\t\t\t12:\n\t\t\t\t\t167\u2013\n\t\t\t\t\t178."},{"key":"i0003-3219-90-1-85-b03","series-title":"Have we reached the turning point? 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Br J Oral Maxillofac Surg","first-page":"594","article-title":"Contemporary management of cleft lip and palate in the United Kingdom","volume":"53","author":"Colbert","year":"2015","unstructured":"Colbert\n SD,\n \n \n Green\n B,\n \n \n Brennan\n PA,\n \n \n Mercer\n N.\n \n \n Contemporary management of cleft lip and palate in the United Kingdom.\n\t\t\t\t\tHave we reached the turning point? Br J Oral Maxillofac Surg.\n\t\t\t\t\t2015;\n\t\t\t\t\t53:\n\t\t\t\t\t594\u2013\n\t\t\t\t\t598."},{"key":"i0003-3219-90-1-85-b04","series-title":"Cleft Palate Craniofac J","first-page":"511","article-title":"Nasal airway in breathing and speech","volume":"29","author":"Warren","year":"1992","unstructured":"Warren\n DW,\n \n \n Drake\n AF,\n \n \n Davis\n JU.\n \n \n Nasal airway in breathing and speech.\n\t\t\t\t\tCleft Palate Craniofac J.\n\t\t\t\t\t1992;\n\t\t\t\t\t29:\n\t\t\t\t\t511\u2013\n\t\t\t\t\t519."},{"key":"i0003-3219-90-1-85-b05","series-title":"J Oral Sci","first-page":"165","article-title":"Three-dimensional craniofacial morphology in unilateral cleft lip and palate","volume":"56","author":"Abuhijleh","year":"2014","unstructured":"Abuhijleh\n E,\n \n \n Aydemir\n H,\n \n \n Toygar-Memiko\u011flu\n U.\n \n \n Three-dimensional craniofacial morphology in unilateral cleft lip and palate.\n\t\t\t\t\tJ Oral 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Sekerci\n AE,\n \n \n Akin\n M.\n \n \n Evaluation of the mandibular volume and correlating variables in patients affected by unilateral and bilateral cleft lip and palate: a cone-beam computed tomography study.\n\t\t\t\t\tClin Oral Invest.\n\t\t\t\t\t2016;\n\t\t\t\t\t20:\n\t\t\t\t\t1741\u2013\n\t\t\t\t\t1746."},{"key":"i0003-3219-90-1-85-b08","series-title":"Saudi Dent J","first-page":"12","article-title":"CBCT imaging\u2014a boon to orthodontics","volume":"27","author":"Machado","year":"2015","unstructured":"Machado\n GL.\n \n \n CBCT imaging\u2014a boon to orthodontics.\n\t\t\t\t\tSaudi Dent J.\n\t\t\t\t\t2015;\n\t\t\t\t\t27:\n\t\t\t\t\t12\u2013\n\t\t\t\t\t21."},{"key":"i0003-3219-90-1-85-b09","series-title":"Dentmaxillofac Radiol","first-page":"20140282","article-title":"CBCT in orthodontics: assessment of treatment outcomes and indications for its use","volume":"44","author":"Kapila","year":"2015","unstructured":"Kapila\n SD,\n \n \n Nervina\n JM.\n \n \n CBCT in orthodontics: 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