{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T04:12:13Z","timestamp":1747368733870,"version":"3.40.5"},"reference-count":17,"publisher":"The Angle Orthodontist (EH Angle Education & Research Foundation)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n        <jats:sec>\n          <jats:title>Objective:<\/jats:title>\n          <jats:p>To compare craniofacial differences between twins discordant for surgically repaired unilateral cleft lip and palate (CLP) during the developmental ages and to test the effect of zygosity on the shape and size of the craniofacial skeleton of the same twins by means of thin plate spline (TPS) analysis.<\/jats:p>\n        <\/jats:sec>\n        <jats:sec>\n          <jats:title>Materials and Methods:<\/jats:title>\n          <jats:p>Lateral and posteroanterior (PA) cephalometric films from 19 sets of monozygotic (MZ) twins (15 male and 4 female) and 10 dizygotic (DZ) twins (7 male and 3 female) were analyzed. TPS analysis evaluated statistically significant differences in the craniofacial shape and size between affected and unaffected twins within MZ and DZ twin couples.<\/jats:p>\n        <\/jats:sec>\n        <jats:sec>\n          <jats:title>Results:<\/jats:title>\n          <jats:p>No statistically significant differences in craniofacial shape or size between CLP and non-CLP MZ or DZ twins were observed. The level of morphological similarity in CLP vs non-CLP MZ twins was statistically greater than in DZ twins.<\/jats:p>\n        <\/jats:sec>\n        <jats:sec>\n          <jats:title>Conclusions:<\/jats:title>\n          <jats:p>Morphometric analysis showed that surgically repaired CLP does not produce significant shape or size differences in the craniofacial features of MZ or DZ twins discordant for unilateral CLP.<\/jats:p>\n        <\/jats:sec>","DOI":"10.2319\/121710-725.1","type":"journal-article","created":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T16:55:49Z","timestamp":1301676949000},"page":"878-883","source":"Crossref","is-referenced-by-count":3,"title":["Morphometric analysis of craniofacial features in mono- and dizygotic twins discordant for unilateral cleft lip and palate"],"prefix":"10.2319","volume":"81","author":[{"given":"Alexis Y.","family":"Tessler","sequence":"first","affiliation":[{"name":"Private practice, Ann Arbor, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Franchi","sequence":"additional","affiliation":[{"name":"Assistant Professor, Department of Orthodontics, University of Florence, Florence, Italy; Thomas M. Graber Visiting Scholar, Department of Orthodontics and Pediatric Dentistry, School of Dentistry, The University of Michigan, Ann Arbor, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A.","family":"McNamara","sequence":"additional","affiliation":[{"name":"Thomas M. and Doris Graber Endowed Professor of Dentistry, Department of Orthodontics and Pediatric Dentistry, School of Dentistry; Professor of Cell and Developmental Biology, School of Medicine; Research Professor, Center for Human Growth and Development, The University of Michigan, Ann Arbor, Michigan; Private Practice of Orthodontics, Ann Arbor, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiziano","family":"Baccetti","sequence":"additional","affiliation":[{"name":"Assistant Professor, Department of Orthodontics, University of Florence, Florence, Italy; Thomas M. Graber Visiting Scholar, Department of Orthodontics and Pediatric Dentistry, School of Dentistry, The University of Michigan, Ann Arbor, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1164","reference":[{"key":"i0003-3219-81-5-878-b01","series-title":"Int J Oral Maxillofac Surg","first-page":"1146","article-title":"An analysis of quality of life in 130 families having small children with cleft lip\/palate using the impact on family scale.","volume":"36","author":"Kramer, F. J.","year":"2007","unstructured":"Kramer, F. J., C.Baethge, B.Sinikovic, and H.Schliephake. An analysis of quality of life in 130 families having small children with cleft lip\/palate using the impact on family scale.Int J Oral Maxillofac Surg2007. 36:1146\u20131152."},{"key":"i0003-3219-81-5-878-b02","series-title":"Cleft Palate J","first-page":"7","article-title":"A preliminary study of facial growth and morphology in unoperated male unilateral cleft lip and palate subjects over 13\u00a0years of age.","volume":"27","author":"Mars, M.","year":"1990","unstructured":"Mars, M. and W. J.Houston. A preliminary study of facial growth and morphology in unoperated male unilateral cleft lip and palate subjects over 13\u00a0years of age.Cleft Palate J1990. 27:7\u201310."},{"key":"i0003-3219-81-5-878-b03","series-title":"Cleft Palate J","first-page":"37","article-title":"The clinical implications of facial growth in cleft lip and palate.","volume":"7","author":"Ross, R. B.","year":"1970","unstructured":"Ross, R. B.\n          \n          The clinical implications of facial growth in cleft lip and palate.\n          Cleft Palate J\n          1970. 7:37\u201347."},{"key":"i0003-3219-81-5-878-b04","series-title":"Cleft Palate Craniofac J","first-page":"594","article-title":"Long-term effects of palate repair on craniofacial morphology in patients with unilateral cleft lip and palate.","volume":"42","author":"Liao, Y. F.","year":"2005","unstructured":"Liao, Y. F. and M.Mars. Long-term effects of palate repair on craniofacial morphology in patients with unilateral cleft lip and palate.Cleft Palate Craniofac J2005. 42:594\u2013600."},{"issue":"suppl 1","key":"i0003-3219-81-5-878-b05","series-title":"Arch Oral Biol","first-page":"S45","article-title":"Genetic and environmental influences on human dental variation: a critical evaluation of studies involving twins.","volume":"54","author":"Townsend, G.","year":"2009","unstructured":"Townsend, G., T.Hughes, M.Luciano, M.Bockmann, and A.Brook. Genetic and environmental influences on human dental variation: a critical evaluation of studies involving twins.Arch Oral Biol2009. 54 (suppl 1):S45\u2013S51."},{"key":"i0003-3219-81-5-878-b06","series-title":"Cleft Palate J","first-page":"379","article-title":"Twins with clefts: a descriptive statistical analysis of selected variables.","volume":"8","author":"Hay, S.","year":"1971","unstructured":"Hay, S. and D. A.Wehrung. Twins with clefts: a descriptive statistical analysis of selected variables.Cleft Palate J1971. 8:379\u2013386."},{"key":"i0003-3219-81-5-878-b07","series-title":"J Can Dent Assoc","first-page":"149","article-title":"Craniofacial morphology in six pairs of monozygotic twins discordant for cleft lip and palate.","volume":"31","author":"Ross, R. B.","year":"1965","unstructured":"Ross, R. B. and T. B.Coupe. Craniofacial morphology in six pairs of monozygotic twins discordant for cleft lip and palate.J Can Dent Assoc1965. 31:149\u2013157."},{"key":"i0003-3219-81-5-878-b08","series-title":"Cleft Palate J","first-page":"116","article-title":"Craniofacial morphology in twins discordant for cleft lip and\/or palate.","volume":"17","author":"Cronin, D. G.","year":"1980","unstructured":"Cronin, D. G. and W. S.Hunter. Craniofacial morphology in twins discordant for cleft lip and\/or palate.Cleft Palate J1980. 17:116\u2013126."},{"key":"i0003-3219-81-5-878-b09","series-title":"J Craniofac Genet Dev Biol","first-page":"235","article-title":"Review: the Michigan cleft twin study.","volume":"1","author":"Hunter, W. S.","year":"1981","unstructured":"Hunter, W. S.\n          \n          Review: the Michigan cleft twin study.\n          J Craniofac Genet Dev Biol\n          1981. 1:235\u2013242."},{"key":"i0003-3219-81-5-878-b10","series-title":"Angle Orthod","first-page":"135","article-title":"Analyses of craniofacial and dental morphology in monozygotic twins discordant for cleft lip and unilateral cleft lip and palate.","volume":"63","author":"Trotman, C. A.","year":"1993","unstructured":"Trotman, C. A., A. R.Collett, J. A.McNamaraJr, and S. R.Cohen. Analyses of craniofacial and dental morphology in monozygotic twins discordant for cleft lip and unilateral cleft lip and palate.Angle Orthod1993. 63:135\u2013139."},{"key":"i0003-3219-81-5-878-b11","series-title":"Cleft Palate Craniofac J","first-page":"403","article-title":"Deformations of the midfacial complex in twins with orofacial clefts.","volume":"40","author":"Singh, G. D.","year":"2003","unstructured":"Singh, G. D., E.Kutcipal, and J. A.McNamaraJr. Deformations of the midfacial complex in twins with orofacial clefts.Cleft Palate Craniofac J2003. 40:403\u2013408."},{"key":"i0003-3219-81-5-878-b12","series-title":"Twin Res Hum Genet","first-page":"362","article-title":"Verification of self-report of zygosity determined via DNA testing in a subset of the NAS-NRC twin registry 40\u00a0years later.","volume":"8","author":"Reed, T.","year":"2005","unstructured":"Reed, T., B. L.Plassman, C. M.Tanner, D. M.Dick, S. A.Rinehart, and W. C.Nichols. Verification of self-report of zygosity determined via DNA testing in a subset of the NAS-NRC twin registry 40\u00a0years later.Twin Res Hum Genet2005. 8:362\u2013367."},{"key":"i0003-3219-81-5-878-b13","series-title":"Morphometric Tools for Landmark Data\u2014Geometry and Biology","author":"Bookstein, F. L.","year":"1991","unstructured":"Bookstein, F. L.\n          \n          Morphometric Tools for Landmark Data\u2014Geometry and Biology. Cambridge, UKThe Press Syndicate of the University of Cambridge. 1991."},{"key":"i0003-3219-81-5-878-b14","series-title":"Plast Reconstr Surg","first-page":"687","article-title":"Maxillofacial growth in children with unilateral cleft lip and palate following secondary alveolar bone grafting: an interim evaluation.","volume":"115","author":"Chang, H. P.","year":"2005","unstructured":"Chang, H. P., M. C.Chuang, Y. H.Yang, et al. Maxillofacial growth in children with unilateral cleft lip and palate following secondary alveolar bone grafting: an interim evaluation.Plast Reconstr Surg2005. 115:687\u2013695."},{"key":"i0003-3219-81-5-878-b15","series-title":"Eur J Orthod","first-page":"375","article-title":"Parental craniofacial morphology in orofacial clefting.","volume":"26","author":"McIntyre, G. T.","year":"2004","unstructured":"McIntyre, G. T. and P. A.Mossey. Parental craniofacial morphology in orofacial clefting.Eur J Orthod2004. 26:375\u2013384."},{"key":"i0003-3219-81-5-878-b16","series-title":"Syst Zool","first-page":"40","article-title":"Extensions of the Procrustes method for the optimal superimposition of landmarks.","volume":"39","author":"Rohlf, J. S.","year":"1990","unstructured":"Rohlf, J. S. and D.Slice. Extensions of the Procrustes method for the optimal superimposition of landmarks.Syst Zool1990. 39:40\u201359."},{"key":"i0003-3219-81-5-878-b17","series-title":"Aust Dent J","first-page":"95","article-title":"Epigenetic influences may explain dental differences in monozygotic twin pairs.","volume":"50","author":"Townsend, G. C.","year":"2005","unstructured":"Townsend, G. C., L.Richards, T.Hughes, S.Pinkerton, and W.Schwerdt. Epigenetic influences may explain dental differences in monozygotic twin pairs.Aust Dent J2005. 50:95\u2013100."}],"container-title":["The Angle Orthodontist"],"original-title":[],"link":[{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/view\/journals\/angl\/81\/5\/article-p878.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/angle-orthodontist\/article-pdf\/81\/5\/878\/1393289\/121710-725_1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/downloadpdf\/journals\/angl\/81\/5\/article-p878.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/downloadpdf\/journals\/angl\/81\/5\/article-p878.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:55:44Z","timestamp":1747356944000},"score":1,"resource":{"primary":{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/view\/journals\/angl\/81\/5\/article-p878.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9]]},"references-count":17,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.2319\/121710-725.1","relation":{},"ISSN":["0003-3219","1945-7103"],"issn-type":[{"type":"print","value":"0003-3219"},{"type":"electronic","value":"1945-7103"}],"subject":[],"published":{"date-parts":[[2011,9]]}}}