{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:54:51Z","timestamp":1762458891093,"version":"3.40.5"},"reference-count":28,"publisher":"The Angle Orthodontist (EH Angle Education & Research Foundation)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n        <jats:sec>\n          <jats:title>Objective:<\/jats:title>\n          <jats:p>To examine whether intermittent posterior condylar displacement causes changes in cancellous bone in the mandibular condyle during the growth period.<\/jats:p>\n        <\/jats:sec>\n        <jats:sec>\n          <jats:title>Materials and Methods:<\/jats:title>\n          <jats:p>Sixteen 5-week-old male Wistar rats were divided into experimental and control groups. In the experimental group, an appliance was attached to the maxillary incisors to induce posterior displacement of the condyles in the occluded condition. Untreated rats served as the control group. Animals were sacrificed at 14\u00a0days, and the condyles were removed to analyze the three-dimensional cancellous bone structure by microcomputed tomography (micro-CT). Serial sagittal paraffin sections of the condyles were used for hematoxylin and eosin staining to investigate histomorphological changes and for tartrate-resistant acid phosphatase (TRAP) staining to identify osteoclastic cells.<\/jats:p>\n        <\/jats:sec>\n        <jats:sec>\n          <jats:title>Results:<\/jats:title>\n          <jats:p>Micro-CT analysis showed that in the experimental group, the bone volume fraction and the degree of anisotropy were significantly decreased compared with those in the control group in the anterior region of the condyle. Moreover, the number of TRAP-positive cells was significantly greater in the same region in the experimental group than in the control group.<\/jats:p>\n        <\/jats:sec>\n        <jats:sec>\n          <jats:title>Conclusion:<\/jats:title>\n          <jats:p>Intermittent posterior displacement of the mandible can cause region-specific changes in the profile and microarchitecture of the condylar cancellous bone.<\/jats:p>\n        <\/jats:sec>","DOI":"10.2319\/122810-749.1","type":"journal-article","created":{"date-parts":[[2011,6,9]],"date-time":"2011-06-09T21:09:50Z","timestamp":1307653790000},"page":"975-982","source":"Crossref","is-referenced-by-count":16,"title":["Intermittent posterior displacement of the rat mandible in the growth period affects the condylar cancellous bone"],"prefix":"10.2319","volume":"81","author":[{"given":"Yukiko","family":"Kuroda","sequence":"first","affiliation":[{"name":"Graduate student, Orthodontic Science, Department of Orofacial Development and Function, Division of Oral Health Science, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikuo","family":"Yonemitsu","sequence":"additional","affiliation":[{"name":"Assistant Professor, Department of Oral and Maxillofacial Surgery, Yokohama City University Medical Center, Yokohama, Japan; Part-time Lecturer, Orthodontic Science, Department of Orofacial Development and Function, Division of Oral Health Science, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Hosomichi","sequence":"additional","affiliation":[{"name":"Assistant Professor, Orthodontic Science, Department of Orofacial Development and Function, Division of Oral Health Science, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan; Postdoctoral Fellow for Research Abroad, Japan Society for the Promotion of Science, Visiting Scholar, Department of Orthodontics and Pediatric Dentistry, University of Michigan, Ann Arbor, Mich, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ippei","family":"Watari","sequence":"additional","affiliation":[{"name":"Assistant Professor, Orthodontic Science, Department of Orofacial Development and Function, Division of Oral Health Science, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maki","family":"Takei","sequence":"additional","affiliation":[{"name":"Research Assistant, Orthodontic Science, Department of Orofacial Development and Function, Division of Oral Health Science, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Ishida","sequence":"additional","affiliation":[{"name":"Research Assistant, Orthodontic Science, Department of Orofacial Development and Function, Division of Oral Health Science, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Ono","sequence":"additional","affiliation":[{"name":"Professor, Orthodontic Science, Department of Orofacial Development and Function, Division of Oral Health Science, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1164","reference":[{"key":"i0003-3219-81-6-975-b01","series-title":"Acta Anat","first-page":"218","article-title":"New aspects of the histology of the mandibular condyle in the rat.","volume":"126","author":"Kantomaa, T.","year":"1986","unstructured":"Kantomaa, T.\n          \n          New aspects of the histology of the mandibular condyle in the rat.\n          Acta Anat\n          1986. 126:218\u2013222."},{"key":"i0003-3219-81-6-975-b02","series-title":"Arch Oral Biol","first-page":"487","article-title":"The influence of masseter activity on rat mandibular growth.","volume":"52","author":"Yonemitsu, I.","year":"2007","unstructured":"Yonemitsu, I., T.Muramoto, and K.Soma. The influence of masseter activity on rat mandibular growth.Arch Oral Biol2007. 52:487\u2013493."},{"key":"i0003-3219-81-6-975-b03","series-title":"Arch Oral Biol","first-page":"1186","article-title":"Effect of masticatory muscle force on temporomandibular joint disc growth in rats.","volume":"52","author":"Sakurai, M.","year":"2007","unstructured":"Sakurai, M., I.Yonemitsu, T.Muramoto, and K.Soma. Effect of masticatory muscle force on temporomandibular joint disc growth in rats.Arch Oral Biol2007. 52:1186\u20131193."},{"key":"i0003-3219-81-6-975-b04","series-title":"Orthod Waves","first-page":"15","article-title":"Influence of liquid diet feeding on calcitonin gene-related peptide-like immunoreactive nerve fibers in rat temporomandibular joints during growth period.","volume":"67","author":"Takei, M.","year":"2008","unstructured":"Takei, M., I.Yonemitsu, I.Watari, T.Muramoto, and K.Soma. Influence of liquid diet feeding on calcitonin gene-related peptide-like immunoreactive nerve fibers in rat temporomandibular joints during growth period.Orthod Waves2008. 67:15\u201322."},{"key":"i0003-3219-81-6-975-b05","series-title":"Arch Oral Biol","first-page":"967","article-title":"Growth of the mandibular condylar cartilage of the rat in serum-free organ culture.","volume":"28","author":"Copray, J. C.","year":"1983","unstructured":"Copray, J. C., H. W.Jansen, and H. S.Duterloo. Growth of the mandibular condylar cartilage of the rat in serum-free organ culture.Arch Oral Biol1983. 28:967\u2013974."},{"key":"i0003-3219-81-6-975-b06","series-title":"Am J Orthod Dentofacial Orthop","first-page":"472","article-title":"Temporomandibular joint forces measured at the condyle of Macaca arctoides.","volume":"97","author":"Boyd, R. L.","year":"1990","unstructured":"Boyd, R. L., C. N.Gibbs, P. E.Mahan, A. F.Richmond, and J. L.Laskon. Temporomandibular joint forces measured at the condyle of Macaca arctoides.Am J Orthod Dentofacial Orthop1990. 97:472\u2013479."},{"key":"i0003-3219-81-6-975-b07","series-title":"Angle Orthod","first-page":"787","article-title":"Effect of a mandibular lateral shift on the condyle and mandibular bone in growing rats.","volume":"77","author":"Liu, C.","year":"2007","unstructured":"Liu, C., S.Kaneko, and K.Soma. Effect of a mandibular lateral shift on the condyle and mandibular bone in growing rats.Angle Orthod2007. 77:787\u2013793."},{"key":"i0003-3219-81-6-975-b08","series-title":"Angle Orthod","first-page":"591","article-title":"Functional lateral deviation of the mandible and its positional recovery on the rat condylar cartilage during the growth period.","volume":"76","author":"Sato, C.","year":"2006","unstructured":"Sato, C., T.Muramoto, and K.Soma. Functional lateral deviation of the mandible and its positional recovery on the rat condylar cartilage during the growth period.Angle Orthod2006. 76:591\u2013597."},{"key":"i0003-3219-81-6-975-b09","series-title":"Dental Occlusion and the Temporomandibular Joint","first-page":"27","article-title":"Disturbed biomechanics of the temporomandibular joint.","author":"Gerber, A.","year":"1990","unstructured":"Gerber, A. and G.Steinhardt. Disturbed biomechanics of the temporomandibular joint.In. Dental Occlusion and the Temporomandibular Joint. Chicago, IllQuintessence. 1990. 27\u201347."},{"key":"i0003-3219-81-6-975-b10","series-title":"J Craniomandib Pract","first-page":"333","article-title":"Orthodontic\/orthopedic treatment of craniomandibular pain dysfunction. Part 2: posterior condylar displacement.","volume":"2","author":"Owen\n              III, A. H.","year":"1984","unstructured":"Owen\n              III, A. H.\n          . Orthodontic\/orthopedic treatment of craniomandibular pain dysfunction. Part 2: posterior condylar displacement.J Craniomandib Pract1984. 2:333\u2013349."},{"key":"i0003-3219-81-6-975-b11","series-title":"J Prosthet Dent","first-page":"532","article-title":"The role of stress, occlusion, and condyle position in TMJ dysfunction-pain.","volume":"49","author":"Weinberg, L. A.","year":"1983","unstructured":"Weinberg, L. A.\n          \n          The role of stress, occlusion, and condyle position in TMJ dysfunction-pain.\n          J Prosthet Dent\n          1983. 49:532\u2013545."},{"key":"i0003-3219-81-6-975-b12","series-title":"Int J Prosthodont","first-page":"46","article-title":"Changes in the rabbit temporomandibular joint associated with posterior displacement of the mandible.","volume":"9","author":"Desai, S.","year":"1996","unstructured":"Desai, S., D. L.Johnson, R. I.Howes, and M. D.Rohrer. Changes in the rabbit temporomandibular joint associated with posterior displacement of the mandible.Int J Prosthodont1996. 9:46\u201357."},{"key":"i0003-3219-81-6-975-b13","series-title":"J Bone Miner Metab","first-page":"276","article-title":"Effect of compressive force on extracellular matrix in rat mandibular condylar cartilage.","volume":"21","author":"Teramoto, M.","year":"2003","unstructured":"Teramoto, M., S.Kaneko, S.Shibata, M.Yanagishita, and K.Soma. Effect of compressive force on extracellular matrix in rat mandibular condylar cartilage.J Bone Miner Metab2003. 21:276\u2013286."},{"key":"i0003-3219-81-6-975-b14","series-title":"Angle Orthod","first-page":"677","article-title":"Alteration of the rat temporomandibular joint in functional posterior displacement of the mandible.","volume":"74","author":"Cholasueksa, P.","year":"2004","unstructured":"Cholasueksa, P., H.Warita, and K.Soma. Alteration of the rat temporomandibular joint in functional posterior displacement of the mandible.Angle Orthod2004. 74:677\u2013683."},{"key":"i0003-3219-81-6-975-b15","series-title":"The Law of Bone Remodeling [in German]","author":"Wolff, J.","year":"1986","unstructured":"Wolff, J.\n          \n          The Law of Bone Remodeling [in German]. Berlin, GermanySpringer Verlag. 1986."},{"key":"i0003-3219-81-6-975-b16","series-title":"J Struct Biol","first-page":"126","article-title":"Structural development of the mineralized tissue in the human L4 vertebral body.","volume":"136","author":"Roschger, P.","year":"2001","unstructured":"Roschger, P., B. M.Grabner, S.Rinnerthaler, W.Tesch, M.Kneissel, A.Berzlanovich, K.Klaushofer, and P. J.Fratzl. Structural development of the mineralized tissue in the human L4 vertebral body.J Struct Biol2001. 136:126\u2013136."},{"key":"i0003-3219-81-6-975-b17","series-title":"Bone","first-page":"650","article-title":"Increase in bone volume fraction precedes architectural adaptation in growing bone.","volume":"28","author":"Tank, E.","year":"2001","unstructured":"Tank, E., J.Homminga, G. H.Van Lenthe, and R.Huiskes. Increase in bone volume fraction precedes architectural adaptation in growing bone.Bone2001. 28:650\u2013654."},{"key":"i0003-3219-81-6-975-b18","series-title":"J Bone Miner Res","first-page":"1167","article-title":"Direct three-dimensional morphometric analysis of human cancellous bone: microstructural data from spine, femur, iliac crest, and calcaneus.","volume":"14","author":"Hildebrand, T.","year":"1999","unstructured":"Hildebrand, T., A.Laib, R.Muller, J.Dequeker, and P.Ruegsegger. Direct three-dimensional morphometric analysis of human cancellous bone: microstructural data from spine, femur, iliac crest, and calcaneus.J Bone Miner Res1999. 14:1167\u20131174."},{"key":"i0003-3219-81-6-975-b19","series-title":"J Dent Res","first-page":"957","article-title":"The three-dimensional cancellous bone architecture of the human mandibular condyle.","volume":"79","author":"Giesen, E. B. W.","year":"2000","unstructured":"Giesen, E. B. W. and T. M. G. J.van Eijden. The three-dimensional cancellous bone architecture of the human mandibular condyle.J Dent Res2000. 79:957\u2013963."},{"key":"i0003-3219-81-6-975-b20","series-title":"Arch Oral Biol","first-page":"155","article-title":"Age- and sex-related changes of mandibular condylar cartilage and subchondral bone: a histomorphometric and micro-CT study in rats.","volume":"55","author":"Jiao, K.","year":"2010","unstructured":"Jiao, K., J.Dai, M. Q.Wang, L. N.Niu, S. B.Yu, and X. D.Liu. Age- and sex-related changes of mandibular condylar cartilage and subchondral bone: a histomorphometric and micro-CT study in rats.Arch Oral Biol2010. 55:155\u2013163."},{"key":"i0003-3219-81-6-975-b21","series-title":"Ann Biomedic Eng","first-page":"1617","article-title":"Effect of food consistency on the degree of mineralization in the rat mandible.","volume":"35","author":"Tanaka, E.","year":"2007","unstructured":"Tanaka, E., R.Sano, N. Kawai, G. E. J.Langenbach, P.Brugman, K.Tanne, T. M. G. J.van Eijden, et al. Effect of food consistency on the degree of mineralization in the rat mandible.Ann Biomedic Eng2007. 35:1617\u20131621."},{"key":"i0003-3219-81-6-975-b22","series-title":"Osteoarthritis Cartilage","first-page":"354","article-title":"Altered functional loading causes differential effects in the subchondral bone and condylar cartilage in the temporomandibular joint from young mice.","volume":"17","author":"Chen, J.","year":"2008","unstructured":"Chen, J., K. P.Sorensen, T.Gupta, and T.Kilts. Altered functional loading causes differential effects in the subchondral bone and condylar cartilage in the temporomandibular joint from young mice.Osteoarthritis Cartilage2008. 17:354\u2013361."},{"key":"i0003-3219-81-6-975-b23","series-title":"J Prosthet Dent","first-page":"539","article-title":"Anatomic and clinical evaluation of the relationship between the temporomandibular joint and occlusion.","volume":"38","author":"Mongini, F.","year":"1977","unstructured":"Mongini, F.\n          \n          Anatomic and clinical evaluation of the relationship between the temporomandibular joint and occlusion.\n          J Prosthet Dent\n          1977. 38:539\u2013551."},{"key":"i0003-3219-81-6-975-b24","series-title":"Arch Oral Biol","first-page":"299","article-title":"Effects of compressive forces on proliferation and matrix synthesis in mandibular condylar cartilage of the rat in vitro.","volume":"30","author":"Copray, J. C.","year":"1985","unstructured":"Copray, J. C., H. W.Jansen, and H. S.Duterloo. Effects of compressive forces on proliferation and matrix synthesis in mandibular condylar cartilage of the rat in vitro.Arch Oral Biol1985. 30:299\u2013304."},{"key":"i0003-3219-81-6-975-b25","series-title":"Calcif Tissue Int","first-page":"176","article-title":"Rat hindlimb unloading by tail suspension reduces osteoblast differentiation, induces IL-6 secretion, and increases bone resorption in ex vivo cultures.","volume":"70","author":"Grano, M.","year":"2002","unstructured":"Grano, M., G.Mori, V.Minielli, et al. Rat hindlimb unloading by tail suspension reduces osteoblast differentiation, induces IL-6 secretion, and increases bone resorption in ex vivo cultures.Calcif Tissue Int2002. 70:176\u2013185."},{"key":"i0003-3219-81-6-975-b26","series-title":"Bone","first-page":"315","article-title":"Three-dimensional methods for quantification of cancellous bone architecture.","volume":"20","author":"Odgaard, A.","year":"1997","unstructured":"Odgaard, A.\n          \n          Three-dimensional methods for quantification of cancellous bone architecture.\n          Bone\n          1997. 20:315\u2013328."},{"key":"i0003-3219-81-6-975-b27","series-title":"J Orthop Res","first-page":"23","article-title":"Relationships between bone morphology and bone elastic properties can be accurately quantified using high-resolution computer reconstruction.","volume":"16","author":"Van Rietbergen, B.","year":"1998","unstructured":"Van Rietbergen, B., A.Odgaard, J.Kabel, and R.Huiskes. Relationships between bone morphology and bone elastic properties can be accurately quantified using high-resolution computer reconstruction.J Orthop Res1998. 16:23\u201328."},{"key":"i0003-3219-81-6-975-b28","series-title":"J Biomech Eng","first-page":"640","article-title":"A global relationship between trabecular bone morphology and homogenized elastic properties.","volume":"120","author":"Zysset, P. K.","year":"1998","unstructured":"Zysset, P. K., R. W.Goulet, and S. J.Hollister. A global relationship between trabecular bone morphology and homogenized elastic properties.J Biomech Eng1998. 120:640\u2013646."}],"container-title":["The Angle Orthodontist"],"original-title":[],"link":[{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/view\/journals\/angl\/81\/6\/article-p975.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/downloadpdf\/journals\/angl\/81\/6\/article-p975.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/downloadpdf\/journals\/angl\/81\/6\/article-p975.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:55:20Z","timestamp":1747356920000},"score":1,"resource":{"primary":{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/view\/journals\/angl\/81\/6\/article-p975.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11]]},"references-count":28,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.2319\/122810-749.1","relation":{},"ISSN":["0003-3219","1945-7103"],"issn-type":[{"type":"print","value":"0003-3219"},{"type":"electronic","value":"1945-7103"}],"subject":[],"published":{"date-parts":[[2011,11]]}}}