{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T08:19:01Z","timestamp":1780474741438,"version":"3.54.1"},"reference-count":30,"publisher":"The Angle Orthodontist (EH Angle Education & Research Foundation)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,9]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objective:<\/jats:title>\n To evaluate the effect of corticotomy and corticision, with and without a full mucoperiosteal flap, on the rate of tooth movement and alveolar response in a rat model.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n Sixty male, 6-week-old Wistar rats were divided into five groups based on surgical procedure, as follows: control (no tooth movement), orthodontic tooth movement (OTM) only, corticotomy, corticision, and corticision with full mucoperiosteal flap (corticision + flap). A force of 10\u201315g was applied from the maxillary left first molar to the maxillary incisors using nickel-titanium springs. Surgery was performed at the time of appliance placement (day 0), and tooth movement occurred for 21 days. Micro\u2013computed tomography was performed on day 21 to evaluate the amount of tooth movement and alveolar bone parameters. Histomorphometry, including tartrate-resistant acid phosphatase staining, was performed to quantify the osteoclast parameters at day 21.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n No statistical differences in the amount of OTM, bone volume fraction, and tissue density and the osteoclast parameters were found among all experimental groups.<\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Corticotomy and corticision, with or without a full mucoperiosteal flap, did not show a significant effect on either the OTM magnitude or alveolar bone response.<\/jats:p>\n <\/jats:sec>","DOI":"10.2319\/123016-940.1","type":"journal-article","created":{"date-parts":[[2017,6,8]],"date-time":"2017-06-08T10:09:54Z","timestamp":1496916594000},"page":"717-724","source":"Crossref","is-referenced-by-count":20,"title":["Comparison of the effects of three surgical techniques on the rate of orthodontic tooth movement in a rat model"],"prefix":"10.2319","volume":"87","author":[{"given":"Zachary","family":"Librizzi","sequence":"first","affiliation":[{"name":"Private Practice, Burlington, Vt."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zana","family":"Kalajzic","sequence":"additional","affiliation":[{"name":"Instructor in Basic Sciences, Department of Oral Health and Diagnostic Sciences, University of Connecticut School of Dental Medicine, Farmington, Conn."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Camacho","sequence":"additional","affiliation":[{"name":"Dental Student, University of Connecticut School of Dental Medicine, Farmington, Conn."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumit","family":"Yadav","sequence":"additional","affiliation":[{"name":"Assistant Professor, Division of Orthodontics, Department of Craniofacial Sciences, University of Connecticut School of Dental Medicine, Farmington, Conn."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravindra","family":"Nanda","sequence":"additional","affiliation":[{"name":"Professor and Head, Division of Orthodontics, Department of Craniofacial Sciences, Alumni Endowed Chair, University of Connecticut School of Dental Medicine, Farmington, Conn."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavio","family":"Uribe","sequence":"additional","affiliation":[{"name":"Associate Professor and Program Director, Charles Burstone Professor, Division of Orthodontics, Department of Craniofacial Sciences, University of Connecticut School of Dental Medicine, Farmington, Conn."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1164","reference":[{"key":"i0003-3219-87-5-717-b01","series-title":"Am J Orthod Dentofacial Orthop","first-page":"469.e1","article-title":"Cellular, molecular, and tissue-level reactions to orthodontic force","volume":"129","author":"Krishnan \n V,","year":"2006","unstructured":"Krishnan \n V, \n \n \n Davidovitch \n Z. \n \n \n Cellular, molecular, and tissue-level reactions to orthodontic force. Am J Orthod Dentofacial Orthop. 2006;129:469.e1\u201332."},{"key":"i0003-3219-87-5-717-b02","series-title":"Henry Ford Hosp Med J","first-page":"3","article-title":"The regional acceleratory phenomenon: a review","volume":"31","author":"Frost \n HM.","year":"1983","unstructured":"Frost \n HM. \n \n \n The regional acceleratory phenomenon: a review. Henry Ford Hosp Med J. 1983;31:3\u20139."},{"key":"i0003-3219-87-5-717-b03","series-title":"J Oral Maxillofac Surg","first-page":"2149","article-title":"Accelerated osteogenic orthodontics technique: a 1-stage surgically facilitated rapid orthodontic technique with alveolar augmentation","volume":"67","author":"Wilcko \n MT,","year":"2009","unstructured":"Wilcko \n MT, \n \n \n Wilcko \n WM, \n \n \n Pulver \n JJ, \n \n \n Bissada \n NF, \n \n \n Bouquot \n JE. \n \n \n Accelerated osteogenic orthodontics technique: a 1-stage surgically facilitated rapid orthodontic technique with alveolar augmentation. J Oral Maxillofac Surg. 2009;67:2149\u20132159."},{"key":"i0003-3219-87-5-717-b04","series-title":"Angle Orthod","first-page":"284","article-title":"Effects of corticision on paradental remodeling in orthodontic tooth movement","volume":"79","author":"Kim \n SJ,","year":"2009","unstructured":"Kim \n SJ, \n \n \n Park \n YG, \n \n \n Kang \n SG. \n \n \n Effects of corticision on paradental remodeling in orthodontic tooth movement. Angle Orthod. 2009;79:284\u2013291."},{"key":"i0003-3219-87-5-717-b05","series-title":"Int J Periodontics Restorative Dent","first-page":"487","article-title":"Rapid treatment of Class II malocclusion with piezocision: two case reports","volume":"30","author":"Dibart \n S,","year":"2010","unstructured":"Dibart \n S, \n \n \n Surmenian \n J, \n \n \n Sebaoun \n JD, \n \n \n Montesani \n L. \n \n \n Rapid treatment of Class II malocclusion with piezocision: two case reports. Int J Periodontics Restorative Dent. 2010;30:487\u2013493."},{"key":"i0003-3219-87-5-717-b06","series-title":"Lasers Surg Med","first-page":"524","article-title":"Effects of low-level laser therapy after corticision on tooth movement and paradental remodeling","volume":"41","author":"Kim \n SJ,","year":"2009","unstructured":"Kim \n SJ, \n \n \n Moon \n SU, \n \n \n Kang \n SG, \n \n \n Park \n YG. \n \n \n Effects of low-level laser therapy after corticision on tooth movement and paradental remodeling. Lasers Surg Med. 2009;41:524\u2013533."},{"key":"i0003-3219-87-5-717-b07","series-title":"Am J Orthod Dentofacial Orthop","first-page":"547","article-title":"Flapless cortical bone damage has no effect on medullary bone mesial to teeth being moved","volume":"147","author":"Swapp \n A,","year":"2015","unstructured":"Swapp \n A, \n \n \n Campbell \n PM, \n \n \n Spears \n R, \n \n \n Buschang \n PH. \n \n \n Flapless cortical bone damage has no effect on medullary bone mesial to teeth being moved. Am J Orthod Dentofacial Orthop. 2015;147:547\u2013558."},{"key":"i0003-3219-87-5-717-b08","series-title":"J Periodontol","first-page":"79","article-title":"Regional accelerated phenomenon in the mandible following mucoperiosteal flap surgery","volume":"65","author":"Yaffe \n A,","year":"1994","unstructured":"Yaffe \n A, \n \n \n Fine \n N, \n \n \n Binderman \n I. \n \n \n Regional accelerated phenomenon in the mandible following mucoperiosteal flap surgery. J Periodontol. 1994;65:79\u201383."},{"key":"i0003-3219-87-5-717-b09","series-title":"Eur J Orthod","first-page":"613","article-title":"Bone response to buccal tooth movements\u2014with and without flapless alveolar decortication","volume":"36","author":"Ruso \n S,","year":"2014","unstructured":"Ruso \n S, \n \n \n Campbell \n PM, \n \n \n Rossmann \n J, \n \n \n Opperman \n LA, \n \n \n Taylor \n RW, \n \n \n Buschang \n PH. \n \n \n Bone response to buccal tooth movements\u2014with and without flapless alveolar decortication. Eur J Orthod. 2014;36:613\u2013623."},{"key":"i0003-3219-87-5-717-b10","series-title":"Am J Orthod Dentofacial Orthop","first-page":"55","article-title":"Effect of corticision and different force magnitudes on orthodontic tooth movement in a rat model","volume":"146","author":"Murphy \n CA,","year":"2014","unstructured":"Murphy \n CA, \n \n \n Chandhoke \n T, \n \n \n Kalajzic \n Z, \n \n et al. \n Effect of corticision and different force magnitudes on orthodontic tooth movement in a rat model. Am J Orthod Dentofacial Orthop. 2014;146:55\u201366."},{"key":"i0003-3219-87-5-717-b11","series-title":"J Dent Res","first-page":"1135","article-title":"Cytokine expression and accelerated tooth movement","volume":"89","author":"Teixeira \n CC,","year":"2010","unstructured":"Teixeira \n CC, \n \n \n Khoo \n E, \n \n \n Tran \n J, \n \n et al. \n Cytokine expression and accelerated tooth movement. J Dent Res. 2010;89:1135\u20131141."},{"key":"i0003-3219-87-5-717-b12","series-title":"Angle Orthod","first-page":"558","article-title":"Comparison of the effects of micro-osteoperforation and corticision on the rate of orthodontic tooth movement in rats","volume":"86","author":"Tsai \n CY,","year":"2016","unstructured":"Tsai \n CY, \n \n \n Yang \n TK, \n \n \n Hsieh \n HY, \n \n \n Yang \n LY. \n \n \n Comparison of the effects of micro-osteoperforation and corticision on the rate of orthodontic tooth movement in rats. Angle Orthod. 2016;86:558\u2013564."},{"key":"i0003-3219-87-5-717-b13","series-title":"Eur J Orthod","article-title":"Increasing the amount of corticotomy does not affect orthodontic tooth movement or root resorption, but accelerates alveolar bone resorption in rats","author":"Kurohama \n T,","year":"2016","unstructured":"Kurohama \n T, \n \n \n Hotokezaka \n H, \n \n \n Hashimoto \n M, \n \n et al. \n Increasing the amount of corticotomy does not affect orthodontic tooth movement or root resorption, but accelerates alveolar bone resorption in rats. Eur J Orthod. 2016."},{"key":"i0003-3219-87-5-717-b14","series-title":"Angle Orthod","first-page":"118","article-title":"Tissue responses resulting from tooth movement surgically assisted by corticotomy and corticision in rats","volume":"87","author":"Peron \n AP,","year":"2017","unstructured":"Peron \n AP, \n \n \n Johann \n AC, \n \n \n Papalexiou \n V, \n \n et al. \n Tissue responses resulting from tooth movement surgically assisted by corticotomy and corticision in rats. Angle Orthod. 2017;87:118\u2013124."},{"key":"i0003-3219-87-5-717-b15","series-title":"J Dent Res","first-page":"38","article-title":"Age effect on orthodontic tooth movement in rats","volume":"82","author":"Ren \n Y,","year":"2003","unstructured":"Ren \n Y, \n \n \n Maltha \n JC, \n \n \n Van't Hof \n MA, \n \n \n Kuijpers-Jagtman \n AM. \n \n \n Age effect on orthodontic tooth movement in rats. J Dent Res. 2003;82:38\u201342."},{"key":"i0003-3219-87-5-717-b01","series-title":"Am J Orthod Dentofacial Orthop","first-page":"469.e1","article-title":"Cellular, molecular, and tissue-level reactions to orthodontic force","volume":"129","author":"Krishnan \n V,","year":"2006","unstructured":"Krishnan \n V, \n \n \n Davidovitch \n Z. \n \n \n Cellular, molecular, and tissue-level reactions to orthodontic force. Am J Orthod Dentofacial Orthop. 2006;129:469.e1\u201332."},{"key":"i0003-3219-87-5-717-b02","series-title":"Henry Ford Hosp Med J","first-page":"3","article-title":"The regional acceleratory phenomenon: a review","volume":"31","author":"Frost \n HM.","year":"1983","unstructured":"Frost \n HM. \n \n \n The regional acceleratory phenomenon: a review. Henry Ford Hosp Med J. 1983;31:3\u20139."},{"key":"i0003-3219-87-5-717-b03","series-title":"J Oral Maxillofac Surg","first-page":"2149","article-title":"Accelerated osteogenic orthodontics technique: a 1-stage surgically facilitated rapid orthodontic technique with alveolar augmentation","volume":"67","author":"Wilcko \n MT,","year":"2009","unstructured":"Wilcko \n MT, \n \n \n Wilcko \n WM, \n \n \n Pulver \n JJ, \n \n \n Bissada \n NF, \n \n \n Bouquot \n JE. \n \n \n Accelerated osteogenic orthodontics technique: a 1-stage surgically facilitated rapid orthodontic technique with alveolar augmentation. J Oral Maxillofac Surg. 2009;67:2149\u20132159."},{"key":"i0003-3219-87-5-717-b04","series-title":"Angle Orthod","first-page":"284","article-title":"Effects of corticision on paradental remodeling in orthodontic tooth movement","volume":"79","author":"Kim \n SJ,","year":"2009","unstructured":"Kim \n SJ, \n \n \n Park \n YG, \n \n \n Kang \n SG. \n \n \n Effects of corticision on paradental remodeling in orthodontic tooth movement. Angle Orthod. 2009;79:284\u2013291."},{"key":"i0003-3219-87-5-717-b05","series-title":"Int J Periodontics Restorative Dent","first-page":"487","article-title":"Rapid treatment of Class II malocclusion with piezocision: two case reports","volume":"30","author":"Dibart \n S,","year":"2010","unstructured":"Dibart \n S, \n \n \n Surmenian \n J, \n \n \n Sebaoun \n JD, \n \n \n Montesani \n L. \n \n \n Rapid treatment of Class II malocclusion with piezocision: two case reports. Int J Periodontics Restorative Dent. 2010;30:487\u2013493."},{"key":"i0003-3219-87-5-717-b06","series-title":"Lasers Surg Med","first-page":"524","article-title":"Effects of low-level laser therapy after corticision on tooth movement and paradental remodeling","volume":"41","author":"Kim \n SJ,","year":"2009","unstructured":"Kim \n SJ, \n \n \n Moon \n SU, \n \n \n Kang \n SG, \n \n \n Park \n YG. \n \n \n Effects of low-level laser therapy after corticision on tooth movement and paradental remodeling. Lasers Surg Med. 2009;41:524\u2013533."},{"key":"i0003-3219-87-5-717-b07","series-title":"Am J Orthod Dentofacial Orthop","first-page":"547","article-title":"Flapless cortical bone damage has no effect on medullary bone mesial to teeth being moved","volume":"147","author":"Swapp \n A,","year":"2015","unstructured":"Swapp \n A, \n \n \n Campbell \n PM, \n \n \n Spears \n R, \n \n \n Buschang \n PH. \n \n \n Flapless cortical bone damage has no effect on medullary bone mesial to teeth being moved. Am J Orthod Dentofacial Orthop. 2015;147:547\u2013558."},{"key":"i0003-3219-87-5-717-b08","series-title":"J Periodontol","first-page":"79","article-title":"Regional accelerated phenomenon in the mandible following mucoperiosteal flap surgery","volume":"65","author":"Yaffe \n A,","year":"1994","unstructured":"Yaffe \n A, \n \n \n Fine \n N, \n \n \n Binderman \n I. \n \n \n Regional accelerated phenomenon in the mandible following mucoperiosteal flap surgery. J Periodontol. 1994;65:79\u201383."},{"key":"i0003-3219-87-5-717-b09","series-title":"Eur J Orthod","first-page":"613","article-title":"Bone response to buccal tooth movements\u2014with and without flapless alveolar decortication","volume":"36","author":"Ruso \n S,","year":"2014","unstructured":"Ruso \n S, \n \n \n Campbell \n PM, \n \n \n Rossmann \n J, \n \n \n Opperman \n LA, \n \n \n Taylor \n RW, \n \n \n Buschang \n PH. \n \n \n Bone response to buccal tooth movements\u2014with and without flapless alveolar decortication. Eur J Orthod. 2014;36:613\u2013623."},{"key":"i0003-3219-87-5-717-b10","series-title":"Am J Orthod Dentofacial Orthop","first-page":"55","article-title":"Effect of corticision and different force magnitudes on orthodontic tooth movement in a rat model","volume":"146","author":"Murphy \n CA,","year":"2014","unstructured":"Murphy \n CA, \n \n \n Chandhoke \n T, \n \n \n Kalajzic \n Z, \n \n et al. \n Effect of corticision and different force magnitudes on orthodontic tooth movement in a rat model. Am J Orthod Dentofacial Orthop. 2014;146:55\u201366."},{"key":"i0003-3219-87-5-717-b11","series-title":"J Dent Res","first-page":"1135","article-title":"Cytokine expression and accelerated tooth movement","volume":"89","author":"Teixeira \n CC,","year":"2010","unstructured":"Teixeira \n CC, \n \n \n Khoo \n E, \n \n \n Tran \n J, \n \n et al. \n Cytokine expression and accelerated tooth movement. J Dent Res. 2010;89:1135\u20131141."},{"key":"i0003-3219-87-5-717-b12","series-title":"Angle Orthod","first-page":"558","article-title":"Comparison of the effects of micro-osteoperforation and corticision on the rate of orthodontic tooth movement in rats","volume":"86","author":"Tsai \n CY,","year":"2016","unstructured":"Tsai \n CY, \n \n \n Yang \n TK, \n \n \n Hsieh \n HY, \n \n \n Yang \n LY. \n \n \n Comparison of the effects of micro-osteoperforation and corticision on the rate of orthodontic tooth movement in rats. Angle Orthod. 2016;86:558\u2013564."},{"key":"i0003-3219-87-5-717-b13","series-title":"Eur J Orthod","article-title":"Increasing the amount of corticotomy does not affect orthodontic tooth movement or root resorption, but accelerates alveolar bone resorption in rats","author":"Kurohama \n T,","year":"2016","unstructured":"Kurohama \n T, \n \n \n Hotokezaka \n H, \n \n \n Hashimoto \n M, \n \n et al. \n Increasing the amount of corticotomy does not affect orthodontic tooth movement or root resorption, but accelerates alveolar bone resorption in rats. Eur J Orthod. 2016."},{"key":"i0003-3219-87-5-717-b14","series-title":"Angle Orthod","first-page":"118","article-title":"Tissue responses resulting from tooth movement surgically assisted by corticotomy and corticision in rats","volume":"87","author":"Peron \n AP,","year":"2017","unstructured":"Peron \n AP, \n \n \n Johann \n AC, \n \n \n Papalexiou \n V, \n \n et al. \n Tissue responses resulting from tooth movement surgically assisted by corticotomy and corticision in rats. Angle Orthod. 2017;87:118\u2013124."},{"key":"i0003-3219-87-5-717-b15","series-title":"J Dent Res","first-page":"38","article-title":"Age effect on orthodontic tooth movement in rats","volume":"82","author":"Ren \n Y,","year":"2003","unstructured":"Ren \n Y, \n \n \n Maltha \n JC, \n \n \n Van't Hof \n MA, \n \n \n Kuijpers-Jagtman \n AM. \n \n \n Age effect on orthodontic tooth movement in rats. J Dent Res. 2003;82:38\u201342."}],"container-title":["The Angle Orthodontist"],"original-title":[],"link":[{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/view\/journals\/angl\/87\/5\/article-p717.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/angle-orthodontist\/article-pdf\/87\/5\/717\/1389241\/123016-940_1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/downloadpdf\/journals\/angl\/87\/5\/article-p717.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/downloadpdf\/journals\/angl\/87\/5\/article-p717.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T15:21:02Z","timestamp":1780068062000},"score":1,"resource":{"primary":{"URL":"https:\/\/angle-orthodontist.kglmeridian.com\/view\/journals\/angl\/87\/5\/article-p717.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":30,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.2319\/123016-940.1","relation":{},"ISSN":["0003-3219","1945-7103"],"issn-type":[{"value":"0003-3219","type":"print"},{"value":"1945-7103","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9]]}}}