{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:40:38Z","timestamp":1787845238789,"version":"build-2784847793"},"reference-count":54,"publisher":"The Angle Orthodontist (EH Angle Education & Research Foundation)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objective:<\/jats:title>\n To evaluate the function of Piezo1, an evolutionarily conserved mechanically activated channel, in periodontal ligament (PDL) tissue homeostasis under compressive loading.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n Primary human PDL cells (hPDLCs) were isolated, cultured, and then subjected to 2.0\u00a0g\/cm\n 2<\/jats:sup>\n static compressive loading for 0.5, 3, 6, and 12\u00a0hours, respectively. The expressions of Piezo1 and osteoclastogenesis marker gene were assessed by semiquantitative reverse transcription\u2013polymerase chain reaction. In addition, Piezo1 inhibitor, GsMTx4, was used to block the function of Piezo1, and tumor necrosis factor\u2013\u03b1 was also used as a positive control. After 12\u00a0hours of compressive loading the PDLCs were co-cultured with murine monocytic cell line RAW264.7. Immunofluorescence, western blot, enzyme-linked immunosorbent assay, and tartrate-resistant acid phosphatase staining were also used to test the potency of PDLCs to induce osteoclastogenesis and the activation of nuclear factor (NF)-\u03baB.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n Piezo1, cyclooxygenase-2, receptor activator of NF-\u03baB ligand, and prostaglandin E2 were significantly upregulated under static compressive stimuli. GsMTx4 repressed osteoclastogenesis in the mechanical stress\u2013pretreated PDLCs-RAW264.7 co-culture system. Furthermore, NF-\u03baB signaling pathway was involved in the mechanical stress\u2013induced osteoclastogenesis.<\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Piezo1 exerts a transduction role in mechanical stress\u2013induced osteoclastogenesis in hPDLCs.<\/jats:p>\n <\/jats:sec>","DOI":"10.2319\/123113-955.1","type":"journal-article","created":{"date-parts":[[2014,5,8]],"date-time":"2014-05-08T09:40:52Z","timestamp":1399542052000},"page":"87-94","source":"Crossref","is-referenced-by-count":102,"title":["Functional role of mechanosensitive ion channel Piezo1 in human periodontal ligament cells"],"prefix":"10.2319","volume":"85","author":[{"given":"Ying","family":"Jin","sequence":"first","affiliation":[{"name":"PhD Candidate, Department of Orthodontics, State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, West China School of Stomatology, Sichuan University, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Li","sequence":"additional","affiliation":[{"name":"Associate Professor, Department of Orthodontics, State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, West China School of Stomatology, Sichuan University, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yating","family":"Wang","sequence":"additional","affiliation":[{"name":"Lecturer, Department of Orthodontics, State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, West China School of Stomatology, Sichuan University, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Ye","sequence":"additional","affiliation":[{"name":"Lecturer, Department of Orthodontics, State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, West China School of Stomatology, Sichuan University, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxia","family":"Feng","sequence":"additional","affiliation":[{"name":"PhD Candidate, Department of Orthodontics, State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, West China School of Stomatology, Sichuan University, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Jing","sequence":"additional","affiliation":[{"name":"MS Candidate, Department of Orthodontics, State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, West China School of Stomatology, Sichuan University, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihe","family":"Zhao","sequence":"additional","affiliation":[{"name":"Professor, Department of Orthodontics, State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, West China School of Stomatology, Sichuan University, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1164","reference":[{"key":"angl-86-04-06-b01","series-title":"Bone","first-page":"1089","article-title":"The TRPV1 ion channel antagonist capsazepine inhibits osteoclast and osteoblast differentiation in vitro and ovariectomy induced bone loss in vivo","volume":"46","author":"Idris\n AI,","year":"2010","unstructured":"Idris\n AI, \n \n Landao-Bassonga\n E, \n \n Ralston\n SH. \n \n The TRPV1 ion channel antagonist capsazepine inhibits osteoclast and osteoblast differentiation in vitro and ovariectomy induced bone loss in vivo. Bone. 2010;46:1089\u20131099."},{"key":"angl-86-04-06-b02","series-title":"J Periodont Res","first-page":"169","article-title":"Mechanical stress-induced interleukin-1beta expression through adenosine triphosphate\/P2X7 receptor activation in human periodontal ligament cells","volume":"48","author":"Kanjanamekanant\n K,","year":"2013","unstructured":"Kanjanamekanant\n K, \n \n Luckprom\n P, \n \n Pavasant\n P. \n \n Mechanical stress-induced interleukin-1beta expression through adenosine triphosphate\/P2X7 receptor activation in human periodontal ligament cells. J Periodont Res. 2013;48:169\u2013176."},{"key":"angl-86-04-06-b03","series-title":"J Bone Miner Res Off J Am Soc Bone Miner Res","first-page":"210","article-title":"Periodontal ligament cells under mechanical stress induce osteoclastogenesis by receptor activator of nuclear factor kappaB ligand up-regulation via prostaglandin E2 synthesis","volume":"17","author":"Kanzaki\n H,","year":"2002","unstructured":"Kanzaki\n H, \n \n Chiba\n M, \n \n Shimizu\n Y, \n \n Mitani\n H. \n \n Periodontal ligament cells under mechanical stress induce osteoclastogenesis by receptor activator of nuclear factor kappaB ligand up-regulation via prostaglandin E2 synthesis. J Bone Miner Res Off J Am Soc Bone Miner Res. 2002;17:210\u2013220."},{"key":"angl-86-04-06-b04","series-title":"Arch Oral Biol","first-page":"707","article-title":"Compressive stress induced the up-regulation of M-CSF, RANKL, TNF-alpha expression and the down-regulation of OPG expression in PDL cells via the integrin-FAK pathway","volume":"58","author":"Kim\n SJ,","year":"2013","unstructured":"Kim\n SJ, \n \n Park\n KH, \n \n Park\n YG, \n \n Lee\n SW, \n \n Kang\n YG. \n \n Compressive stress induced the up-regulation of M-CSF, RANKL, TNF-alpha expression and the down-regulation of OPG expression in PDL cells via the integrin-FAK pathway. Arch Oral Biol. 2013;58:707\u2013716."},{"key":"angl-86-04-06-b05","series-title":"J Dent Res","first-page":"115","article-title":"Expression of osteoclastogenesis inducers in a tissue model of periodontal ligament under compression","volume":"90","author":"Li\n Y,","year":"2011","unstructured":"Li\n Y, \n \n Zheng\n W, \n \n Liu\n JS, \n et al. \n Expression of osteoclastogenesis inducers in a tissue model of periodontal ligament under compression. J Dent Res. 2011;90:115\u2013120."},{"key":"angl-86-04-06-b06","series-title":"Arch Oral Biol","first-page":"511","article-title":"Analysis of time-course gene expression profiles of a periodontal ligament tissue model under compression","volume":"58","author":"Li\n Y,","year":"2013","unstructured":"Li\n Y, \n \n Li\n M, \n \n Tan\n L, \n et al. \n Analysis of time-course gene expression profiles of a periodontal ligament tissue model under compression. Arch Oral Biol. 2013;58:511\u2013522."},{"key":"angl-86-04-06-b07","series-title":"Med Sci","first-page":"1056","article-title":"Piezo proteins form a new class of mechanically activated ion channels","volume":"28","author":"Coste\n B.","year":"2012","unstructured":"Coste\n B. \n \n Piezo proteins form a new class of mechanically activated ion channels. Med Sci. 2012;28:1056\u20131057."},{"key":"angl-86-04-06-b08","series-title":"Nature","first-page":"176","article-title":"Piezo proteins are pore-forming subunits of mechanically activated channels","volume":"483","author":"Coste\n B,","year":"2012","unstructured":"Coste\n B, \n \n Xiao\n B, \n \n Santos\n JS, \n et al. \n Piezo proteins are pore-forming subunits of mechanically activated channels. Nature. 2012;483:176\u2013181."},{"key":"angl-86-04-06-b09","series-title":"Nat Commun","first-page":"1682","article-title":"A role for Piezo2 in EPAC1-dependent mechanical allodynia","volume":"4","author":"Eijkelkamp\n N,","year":"2013","unstructured":"Eijkelkamp\n N, \n \n Linley\n JE, \n \n Torres\n JM, \n et al. \n A role for Piezo2 in EPAC1-dependent mechanical allodynia. Nat Commun. 2013;4:1682."},{"key":"angl-86-04-06-b10","series-title":"Nature","first-page":"546","article-title":"Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia","volume":"484","author":"Eisenhoffer\n GT,","year":"2012","unstructured":"Eisenhoffer\n GT, \n \n Loftus\n PD, \n \n Yoshigi\n M, \n et al. \n Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia. Nature. 2012;484:546\u2013549."},{"key":"angl-86-04-06-b11","series-title":"Channels","first-page":"214","article-title":"Piezo1: properties of a cation selective mechanical channel","volume":"6","author":"Gottlieb\n PA,","year":"2012","unstructured":"Gottlieb\n PA, \n \n Sachs\n F. \n \n Piezo1: properties of a cation selective mechanical channel. Channels. 2012;6:214\u2013219."},{"key":"angl-86-04-06-b12","series-title":"Nature","first-page":"209","article-title":"The role of Drosophila Piezo in mechanical nociception","volume":"483","author":"Kim\n SE,","year":"2012","unstructured":"Kim\n SE, \n \n Coste\n B, \n \n Chadha\n A, \n \n Cook\n B, \n \n Patapoutian\n A. \n \n The role of Drosophila Piezo in mechanical nociception. Nature. 2012;483:209\u2013212."},{"key":"angl-86-04-06-b13","series-title":"Nat Rev Mol Cell Biol","first-page":"49","article-title":"Integrating cell-signalling pathways with NF-kappaB and IKK function","volume":"8","author":"Perkins\n ND.","year":"2007","unstructured":"Perkins\n ND. \n \n Integrating cell-signalling pathways with NF-kappaB and IKK function. Nat Rev Mol Cell Biol. 2007;8:49\u201362."},{"key":"angl-86-04-06-b14","series-title":"FASEB J","first-page":"899","article-title":"A central role for the nuclear factor-kappaB pathway in anti-inflammatory and proinflammatory actions of mechanical strain","volume":"17","author":"Agarwal\n S,","year":"2003","unstructured":"Agarwal\n S, \n \n Long\n P, \n \n Seyedain\n A, \n \n Piesco\n N, \n \n Shree\n A, \n \n Gassner\n R. \n \n A central role for the nuclear factor-kappaB pathway in anti-inflammatory and proinflammatory actions of mechanical strain. FASEB J. 2003;17:899\u2013901."},{"key":"angl-86-04-06-b15","series-title":"Cell Tissue Res","first-page":"537","article-title":"Elevated expression of genes assigned to NF-kappaB and apoptotic pathways in human periodontal ligament fibroblasts following mechanical stretch","volume":"328","author":"Ritter\n N,","year":"2007","unstructured":"Ritter\n N, \n \n Mussig\n E, \n \n Steinberg\n T, \n \n Kohl\n A, \n \n Komposch\n G, \n \n Tomakidi\n P. \n \n Elevated expression of genes assigned to NF-kappaB and apoptotic pathways in human periodontal ligament fibroblasts following mechanical stretch. Cell Tissue Res. 2007;328:537\u2013548."},{"issue":"suppl","key":"angl-86-04-06-b16","series-title":"Cell","first-page":"S81","article-title":"Missing pieces in the NF-kappaB puzzle","volume":"109","author":"Ghosh\n S,","year":"2002","unstructured":"Ghosh\n S, \n \n Karin\n M. \n \n Missing pieces in the NF-kappaB puzzle. Cell. 2002;109(suppl):S81\u2013S96."},{"key":"angl-86-04-06-b17","series-title":"Nat Immunol","first-page":"221","article-title":"NF-kappaB at the crossroads of life and death","volume":"3","author":"Karin\n M,","year":"2002","unstructured":"Karin\n M, \n \n Lin\n A. \n \n NF-kappaB at the crossroads of life and death. Nat Immunol. 2002;3:221\u2013227."},{"key":"angl-86-04-06-b18","series-title":"J Periodont Res","first-page":"168","article-title":"Effects of compression force on fibroblast growth factor-2 and receptor activator of nuclear factor kappa B ligand production by periodontal ligament cells in vitro","volume":"43","author":"Nakajima\n R,","year":"2008","unstructured":"Nakajima\n R, \n \n Yamaguchi\n M, \n \n Kojima\n T, \n \n Takano\n M, \n \n Kasai\n K. \n \n Effects of compression force on fibroblast growth factor-2 and receptor activator of nuclear factor kappa B ligand production by periodontal ligament cells in vitro. J Periodont Res. 2008;43:168\u2013173."},{"key":"angl-86-04-06-b19","series-title":"Arch Med Sci","first-page":"422","article-title":"Up-regulated osteogenic transcription factors during early response of human periodontal ligament stem cells to cyclic tensile strain","volume":"8","author":"Tang\n N,","year":"2012","unstructured":"Tang\n N, \n \n Zhao\n Z, \n \n Zhang\n L. \n et al. \n Up-regulated osteogenic transcription factors during early response of human periodontal ligament stem cells to cyclic tensile strain. Arch Med Sci. 2012;8:422\u2013430."},{"key":"angl-86-04-06-b20","series-title":"Biochemistry","first-page":"6295","article-title":"The mechanosensitive ion channel Piezo1 is inhibited by the peptide GsMTx4","volume":"50","author":"Bae\n C,","year":"2011","unstructured":"Bae\n C, \n \n Sachs\n F, \n \n Gottlieb\n PA. \n \n The mechanosensitive ion channel Piezo1 is inhibited by the peptide GsMTx4. Biochemistry. 2011;50:6295\u20136300."},{"key":"angl-86-04-06-b21","series-title":"J Comp Neurol","first-page":"863","article-title":"Localization and comparative analysis of acid-sensing ion channel (ASIC1, 2, and 3) mRNA expression in mouse colonic sensory neurons within thoracolumbar dorsal root ganglia","volume":"500","author":"Hughes\n PA,","year":"2007","unstructured":"Hughes\n PA, \n \n Brierley\n SM, \n \n Young\n RL, \n \n Blackshaw\n LA. \n \n Localization and comparative analysis of acid-sensing ion channel (ASIC1, 2, and 3) mRNA expression in mouse colonic sensory neurons within thoracolumbar dorsal root ganglia. J Comp Neurol. 2007;500:863\u2013875."},{"key":"angl-86-04-06-b22","series-title":"Heart Rhythm Off J Heart Rhythm Soc","first-page":"1415","article-title":"Left versus right atrial difference in dominant frequency, K(+) channel transcripts, and fibrosis in patients developing atrial fibrillation after cardiac surgery","volume":"6","author":"Swartz\n MF,","year":"2009","unstructured":"Swartz\n MF, \n \n Fink\n GW, \n \n Lutz\n CJ, \n et al. \n Left versus right atrial difference in dominant frequency, K(+) channel transcripts, and fibrosis in patients developing atrial fibrillation after cardiac surgery. Heart Rhythm Off J Heart Rhythm Soc. 2009;6:1415\u20131422."},{"key":"angl-86-04-06-b23","series-title":"Clin Oral Invest","first-page":"941","article-title":"PTH(1-34)-induced changes in RANKL and OPG expression by human PDL cells modify osteoclast biology in a co-culture model with RAW 264.7 cells","volume":"15","author":"Lossdorfer\n S,","year":"2011","unstructured":"Lossdorfer\n S, \n \n Gotz\n W, \n \n Jager\n A. \n \n PTH(1-34)-induced changes in RANKL and OPG expression by human PDL cells modify osteoclast biology in a co-culture model with RAW 264.7 cells. Clin Oral Invest. 2011;15:941\u2013952."},{"key":"angl-86-04-06-b24","series-title":"J Dent Res","first-page":"664","article-title":"Single-channel recordings of TREK-1 K+ channels in periodontal ligament fibroblasts","volume":"85","author":"Ohara\n A,","year":"2006","unstructured":"Ohara\n A, \n \n Saeki\n Y, \n \n Nishikawa\n M, \n \n Yamamoto\n Y, \n \n Yamamoto\n G. \n \n Single-channel recordings of TREK-1 K+ channels in periodontal ligament fibroblasts. J Dent Res. 2006;85:664\u2013669."},{"key":"angl-86-04-06-b25","series-title":"Drug Metab Rev","first-page":"457","article-title":"The presence of arachidonic acid-activated K+ channel, TREK-1, in human periodontal ligament fibroblasts","volume":"39","author":"Saeki\n Y,","year":"2007","unstructured":"Saeki\n Y, \n \n Ohara\n A, \n \n Nishikawa\n M, \n \n Yamamoto\n T, \n \n Yamamoto\n G. \n \n The presence of arachidonic acid-activated K+ channel, TREK-1, in human periodontal ligament fibroblasts. Drug Metab Rev. 2007;39:457\u2013465."},{"issue":"9","key":"angl-86-04-06-b26","series-title":"Clin Oral Invest","first-page":"2041","article-title":"Endotoxins potentiate COX-2 and RANKL expression in compressed PDL cells","volume":"17","author":"Romer\n P,","year":"2013","unstructured":"Romer\n P, \n \n Kostler\n J, \n \n Koretsi\n V, \n \n Proff\n P. \n \n Endotoxins potentiate COX-2 and RANKL expression in compressed PDL cells. Clin Oral Invest. 2013;17(9):2041\u20132048."},{"key":"angl-86-04-06-b27","series-title":"J Periodontol","first-page":"249","article-title":"Regulatory effects of interleukin-1\u03b2 and prostaglandin E2 on expression of receptor activator of nuclear factor-\u03baB ligand in human periodontal ligament cells","volume":"75","author":"Nukaga\n J,","year":"2004","unstructured":"Nukaga\n J, \n \n Kobayashi\n M, \n \n Shinki\n T, \n et al. \n Regulatory effects of interleukin-1\u03b2 and prostaglandin E2 on expression of receptor activator of nuclear factor-\u03baB ligand in human periodontal ligament cells. J Periodontol. 2004;75:249\u2013259."},{"key":"angl-86-04-06-b01","series-title":"Bone","first-page":"1089","article-title":"The TRPV1 ion channel antagonist capsazepine inhibits osteoclast and osteoblast differentiation in vitro and ovariectomy induced bone loss in vivo","volume":"46","author":"Idris\n AI,","year":"2010","unstructured":"Idris\n AI, \n \n Landao-Bassonga\n E, \n \n Ralston\n SH. \n \n The TRPV1 ion channel antagonist capsazepine inhibits osteoclast and osteoblast differentiation in vitro and ovariectomy induced bone loss in vivo. Bone. 2010;46:1089\u20131099."},{"key":"angl-86-04-06-b02","series-title":"J Periodont Res","first-page":"169","article-title":"Mechanical stress-induced interleukin-1beta expression through adenosine triphosphate\/P2X7 receptor activation in human periodontal ligament cells","volume":"48","author":"Kanjanamekanant\n K,","year":"2013","unstructured":"Kanjanamekanant\n K, \n \n Luckprom\n P, \n \n Pavasant\n P. \n \n Mechanical stress-induced interleukin-1beta expression through adenosine triphosphate\/P2X7 receptor activation in human periodontal ligament cells. J Periodont Res. 2013;48:169\u2013176."},{"key":"angl-86-04-06-b03","series-title":"J Bone Miner Res Off J Am Soc Bone Miner Res","first-page":"210","article-title":"Periodontal ligament cells under mechanical stress induce osteoclastogenesis by receptor activator of nuclear factor kappaB ligand up-regulation via prostaglandin E2 synthesis","volume":"17","author":"Kanzaki\n H,","year":"2002","unstructured":"Kanzaki\n H, \n \n Chiba\n M, \n \n Shimizu\n Y, \n \n Mitani\n H. \n \n Periodontal ligament cells under mechanical stress induce osteoclastogenesis by receptor activator of nuclear factor kappaB ligand up-regulation via prostaglandin E2 synthesis. J Bone Miner Res Off J Am Soc Bone Miner Res. 2002;17:210\u2013220."},{"key":"angl-86-04-06-b04","series-title":"Arch Oral Biol","first-page":"707","article-title":"Compressive stress induced the up-regulation of M-CSF, RANKL, TNF-alpha expression and the down-regulation of OPG expression in PDL cells via the integrin-FAK pathway","volume":"58","author":"Kim\n SJ,","year":"2013","unstructured":"Kim\n SJ, \n \n Park\n KH, \n \n Park\n YG, \n \n Lee\n SW, \n \n Kang\n YG. \n \n Compressive stress induced the up-regulation of M-CSF, RANKL, TNF-alpha expression and the down-regulation of OPG expression in PDL cells via the integrin-FAK pathway. Arch Oral Biol. 2013;58:707\u2013716."},{"key":"angl-86-04-06-b05","series-title":"J Dent Res","first-page":"115","article-title":"Expression of osteoclastogenesis inducers in a tissue model of periodontal ligament under compression","volume":"90","author":"Li\n Y,","year":"2011","unstructured":"Li\n Y, \n \n Zheng\n W, \n \n Liu\n JS, \n et al. \n Expression of osteoclastogenesis inducers in a tissue model of periodontal ligament under compression. J Dent Res. 2011;90:115\u2013120."},{"key":"angl-86-04-06-b06","series-title":"Arch Oral Biol","first-page":"511","article-title":"Analysis of time-course gene expression profiles of a periodontal ligament tissue model under compression","volume":"58","author":"Li\n Y,","year":"2013","unstructured":"Li\n Y, \n \n Li\n M, \n \n Tan\n L, \n et al. \n Analysis of time-course gene expression profiles of a periodontal ligament tissue model under compression. Arch Oral Biol. 2013;58:511\u2013522."},{"key":"angl-86-04-06-b07","series-title":"Med Sci","first-page":"1056","article-title":"Piezo proteins form a new class of mechanically activated ion channels","volume":"28","author":"Coste\n B.","year":"2012","unstructured":"Coste\n B. \n \n Piezo proteins form a new class of mechanically activated ion channels. Med Sci. 2012;28:1056\u20131057."},{"key":"angl-86-04-06-b08","series-title":"Nature","first-page":"176","article-title":"Piezo proteins are pore-forming subunits of mechanically activated channels","volume":"483","author":"Coste\n B,","year":"2012","unstructured":"Coste\n B, \n \n Xiao\n B, \n \n Santos\n JS, \n et al. \n Piezo proteins are pore-forming subunits of mechanically activated channels. Nature. 2012;483:176\u2013181."},{"key":"angl-86-04-06-b09","series-title":"Nat Commun","first-page":"1682","article-title":"A role for Piezo2 in EPAC1-dependent mechanical allodynia","volume":"4","author":"Eijkelkamp\n N,","year":"2013","unstructured":"Eijkelkamp\n N, \n \n Linley\n JE, \n \n Torres\n JM, \n et al. \n A role for Piezo2 in EPAC1-dependent mechanical allodynia. Nat Commun. 2013;4:1682."},{"key":"angl-86-04-06-b10","series-title":"Nature","first-page":"546","article-title":"Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia","volume":"484","author":"Eisenhoffer\n GT,","year":"2012","unstructured":"Eisenhoffer\n GT, \n \n Loftus\n PD, \n \n Yoshigi\n M, \n et al. \n Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia. Nature. 2012;484:546\u2013549."},{"key":"angl-86-04-06-b11","series-title":"Channels","first-page":"214","article-title":"Piezo1: properties of a cation selective mechanical channel","volume":"6","author":"Gottlieb\n PA,","year":"2012","unstructured":"Gottlieb\n PA, \n \n Sachs\n F. \n \n Piezo1: properties of a cation selective mechanical channel. Channels. 2012;6:214\u2013219."},{"key":"angl-86-04-06-b12","series-title":"Nature","first-page":"209","article-title":"The role of Drosophila Piezo in mechanical nociception","volume":"483","author":"Kim\n SE,","year":"2012","unstructured":"Kim\n SE, \n \n Coste\n B, \n \n Chadha\n A, \n \n Cook\n B, \n \n Patapoutian\n A. \n \n The role of Drosophila Piezo in mechanical nociception. Nature. 2012;483:209\u2013212."},{"key":"angl-86-04-06-b13","series-title":"Nat Rev Mol Cell Biol","first-page":"49","article-title":"Integrating cell-signalling pathways with NF-kappaB and IKK function","volume":"8","author":"Perkins\n ND.","year":"2007","unstructured":"Perkins\n ND. \n \n Integrating cell-signalling pathways with NF-kappaB and IKK function. Nat Rev Mol Cell Biol. 2007;8:49\u201362."},{"key":"angl-86-04-06-b14","series-title":"FASEB J","first-page":"899","article-title":"A central role for the nuclear factor-kappaB pathway in anti-inflammatory and proinflammatory actions of mechanical strain","volume":"17","author":"Agarwal\n S,","year":"2003","unstructured":"Agarwal\n S, \n \n Long\n P, \n \n Seyedain\n A, \n \n Piesco\n N, \n \n Shree\n A, \n \n Gassner\n R. \n \n A central role for the nuclear factor-kappaB pathway in anti-inflammatory and proinflammatory actions of mechanical strain. FASEB J. 2003;17:899\u2013901."},{"key":"angl-86-04-06-b15","series-title":"Cell Tissue Res","first-page":"537","article-title":"Elevated expression of genes assigned to NF-kappaB and apoptotic pathways in human periodontal ligament fibroblasts following mechanical stretch","volume":"328","author":"Ritter\n N,","year":"2007","unstructured":"Ritter\n N, \n \n Mussig\n E, \n \n Steinberg\n T, \n \n Kohl\n A, \n \n Komposch\n G, \n \n Tomakidi\n P. \n \n Elevated expression of genes assigned to NF-kappaB and apoptotic pathways in human periodontal ligament fibroblasts following mechanical stretch. Cell Tissue Res. 2007;328:537\u2013548."},{"issue":"suppl","key":"angl-86-04-06-b16","series-title":"Cell","first-page":"S81","article-title":"Missing pieces in the NF-kappaB puzzle","volume":"109","author":"Ghosh\n S,","year":"2002","unstructured":"Ghosh\n S, \n \n Karin\n M. \n \n Missing pieces in the NF-kappaB puzzle. Cell. 2002;109(suppl):S81\u2013S96."},{"key":"angl-86-04-06-b17","series-title":"Nat Immunol","first-page":"221","article-title":"NF-kappaB at the crossroads of life and death","volume":"3","author":"Karin\n M,","year":"2002","unstructured":"Karin\n M, \n \n Lin\n A. \n \n NF-kappaB at the crossroads of life and death. Nat Immunol. 2002;3:221\u2013227."},{"key":"angl-86-04-06-b18","series-title":"J Periodont Res","first-page":"168","article-title":"Effects of compression force on fibroblast growth factor-2 and receptor activator of nuclear factor kappa B ligand production by periodontal ligament cells in vitro","volume":"43","author":"Nakajima\n R,","year":"2008","unstructured":"Nakajima\n R, \n \n Yamaguchi\n M, \n \n Kojima\n T, \n \n Takano\n M, \n \n Kasai\n K. \n \n Effects of compression force on fibroblast growth factor-2 and receptor activator of nuclear factor kappa B ligand production by periodontal ligament cells in vitro. 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