{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T00:37:25Z","timestamp":1794357445136,"version":"4.9.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Oral Biosciences"],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1016\/s1349-0079(11)80006-x","type":"journal-article","created":{"date-parts":[[2013,8,14]],"date-time":"2013-08-14T16:51:41Z","timestamp":1376499101000},"page":"233-240","source":"Crossref","is-referenced-by-count":122,"title":["Immune Evasion Strategies of Porphyromonas gingivalis"],"prefix":"10.1016","volume":"53","author":[{"given":"George","family":"Hajishengallis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/S1349-0079(11)80006-X_bib1","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1016\/S0140-6736(05)67728-8","article-title":"Periodontal diseases","volume":"366","author":"Pihlstrom","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/S1349-0079(11)80006-X_bib2","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1177\/154405910808700908","article-title":"A new inflammatory cytokine on the block: re-thinking periodontal disease and the Th1\/Th2 paradigm in the context of Th17 cells and IL-17","volume":"87","author":"Gaffen","year":"2008","journal-title":"J. Dent. Res."},{"key":"10.1016\/S1349-0079(11)80006-X_bib3","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1600-051X.1998.tb02419.x","article-title":"Microbial complexes in subgingival plaque","volume":"25","author":"Socransky","year":"1998","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/S1349-0079(11)80006-X_bib4","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nrmicro2337","article-title":"Periodontitis: a polymicrobial disruption of host homeostasis","volume":"8","author":"Darveau","year":"2010","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/S1349-0079(11)80006-X_bib5","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1089\/dna.2009.0864","article-title":"The oral microbial consortium's interaction with the periodontal innate defense system","volume":"28","author":"Darveau","year":"2009","journal-title":"DNA Cell Biol."},{"key":"10.1016\/S1349-0079(11)80006-X_bib6","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/nrrheum.2010.139","article-title":"Periodontitis in RA-the citrullinated enolase connection","volume":"6","author":"Lundberg","year":"2010","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/S1349-0079(11)80006-X_bib7","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1177\/0022034510375281","article-title":"Gum bug leave my heart alone -Epidemiologic and mechanistic evidence linking periodontal infections and atherosclerosis","volume":"89","author":"Kebschull","year":"2010","journal-title":"J. Dent. Res."},{"key":"10.1016\/S1349-0079(11)80006-X_bib8","first-page":"112","article-title":"Surface components of Porphyromonas gingivalis","volume":"44","author":"Yoshimura","year":"2008","journal-title":"J. Periodontal Res."},{"key":"10.1016\/S1349-0079(11)80006-X_bib9","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1034\/j.1399-302x.2000.150601.x","article-title":"Subgingival colonization by Porphyromonas gingivalis","volume":"15","author":"Lamont","year":"2000","journal-title":"Oral Microbiol. Immunol."},{"key":"10.1016\/S1349-0079(11)80006-X_bib10","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.micinf.2009.03.009","article-title":"Porphyromonas gingivalis-host interactions: open war or intelligent guerilla tactics?","volume":"11","author":"Hajishengallis","year":"2009","journal-title":"Microbes Infect."},{"key":"10.1016\/S1349-0079(11)80006-X_bib11","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/nrmicro1824","article-title":"Complement evasion by human pathogens","volume":"6","author":"Lambris","year":"2008","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/S1349-0079(11)80006-X_bib12","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/nrmicro2128","article-title":"Antimicrobial mechanisms of phagocytes and bacterial evasion strategies","volume":"7","author":"Flannagan","year":"2009","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/S1349-0079(11)80006-X_bib13","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/nature06246","article-title":"Recognition of microorganisms and activation of the immune response","volume":"449","author":"Medzhitov","year":"2007","journal-title":"Nature"},{"key":"10.1016\/S1349-0079(11)80006-X_bib14","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/ni.1923","article-title":"Complement: a key system for immune surveillance and homeostasis","volume":"11","author":"Ricklin","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/S1349-0079(11)80006-X_bib15","first-page":"1587","article-title":"Human Toll-like receptor 4 responses to P","volume":"11","author":"Coats","year":"2009","journal-title":"gingivalis are regulated by lipid A land 4' -phosphatase activities. Cell Microbiol."},{"key":"10.1016\/S1349-0079(11)80006-X_bib16","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.micinf.2010.05.008","article-title":"Outer membrane vesicles function as offensive weapons in hostparasite interactions","volume":"12","author":"Amano","year":"2010","journal-title":"Microbes Infect."},{"key":"10.1016\/S1349-0079(11)80006-X_bib17","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1111\/j.1462-5822.2006.00730.x","article-title":"Differential interactions of fimbriae and lipopolysaccharide from Porphyromonas gingivalis with the Toll-like receptor 2-centred pattern recognition apparatus","volume":"8","author":"Hajishengallis","year":"2006","journal-title":"Cell. Microbiol."},{"key":"10.1016\/S1349-0079(11)80006-X_bib18","doi-asserted-by":"crossref","first-page":"8296","DOI":"10.4049\/jimmunol.177.12.8296","article-title":"Cutting Edge: TLR2 is required for the innate response to Porphyromonas gingivalis: Activation leads to bacterial persistence and TLR2 deficiency attenuates induced alveolar bone resorption","volume":"177","author":"Burns","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/S1349-0079(11)80006-X_bib19","doi-asserted-by":"crossref","first-page":"6690","DOI":"10.4049\/jimmunol.0900524","article-title":"Induction of distinct TLR2-mediated proinflammatory and proadhesive signaling pathways in response to Porphyromonas gingivalis fimbriae","volume":"182","author":"Hajishengallis","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/S1349-0079(11)80006-X_bib20","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1002\/eji.200425883","article-title":"Integrin activation by bacterial fimbriae through a pathway involving CD14, Toll-like receptor 2, and phosphatidylinosi tol-3-kinase","volume":"35","author":"Harokopakis","year":"2005","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/S1349-0079(11)80006-X_bib21","doi-asserted-by":"crossref","first-page":"7645","DOI":"10.4049\/jimmunol.176.12.7645","article-title":"TLR2 transmodulates monocyte adhesion and transmigration via Racl- and PI3K mediated inside-out signaling in response to Porphyromonas gingivalis fimbriae","volume":"176","author":"Harokopakis","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/S1349-0079(11)80006-X_bib22","doi-asserted-by":"crossref","first-page":"5658","DOI":"10.1128\/IAI.00784-06","article-title":"Porphyromonas gingivalis fimbriae proactively modulate z integrin adhe sive activity and promote binding to and internalization by macrophages","volume":"74","author":"Hajishengallis","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/S1349-0079(11)80006-X_bib23","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.4049\/jimmunol.179.4.2349","article-title":"Fimbrial proteins of Porphyromo nas gingivalis mediate in vivo virulence and exploit TLR2 and complement receptor 3 to persist in macrophages","volume":"179","author":"Wang","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/S1349-0079(11)80006-X_bib24","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.4049\/jimmunol.179.4.2359","article-title":"Complement receptor 3 blockade promotes IL-12-mediated clearance of Porphyromonas gingivalis and negates its virulence in vivo","volume":"179","author":"Hajishengallis","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/S1349-0079(11)80006-X_bib25","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1099\/mic.0.2008\/021220-0","article-title":"The chronicles of Porphyromonas gingivalis: the microbium, the human oral epithelium and their interplay","volume":"154","author":"Yilmaz","year":"2008","journal-title":"Microbiology"},{"key":"10.1016\/S1349-0079(11)80006-X_bib26","doi-asserted-by":"crossref","first-page":"13532","DOI":"10.1073\/pnas.0803852105","article-title":"Pathogen induction of CXCR4\/TLR2 cross-talk impairs host defense function","volume":"105","author":"Hajishengallis","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S1349-0079(11)80006-X_bib27","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1126\/scisignal.2000697","article-title":"Microbial hijacking of complement-Toll-like receptor crosstalk","volume":"3","author":"Wang","year":"2010","journal-title":"Sci. Signal."},{"key":"10.1016\/S1349-0079(11)80006-X_bib28","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1159\/000181144","article-title":"Corruption of innate immunity by bacterial proteases","volume":"1","author":"Potempa","year":"2009","journal-title":"J. Innate Immun."},{"key":"10.1016\/S1349-0079(11)80006-X_bib29","doi-asserted-by":"crossref","first-page":"869","DOI":"10.4049\/jimmunol.1003252","article-title":"The C5a receptor impairs IL-12-dependent clearance of Porphyromonas gingivalis and is required for induction of periodontal bone loss","volume":"186","author":"Liang","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/S1349-0079(11)80006-X_bib30","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1126\/scisignal.3120pe15","article-title":"Complementing toll signaling","volume":"3","author":"Kagan","year":"2010","journal-title":"Sci. Signal."},{"key":"10.1016\/S1349-0079(11)80006-X_bib31","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1600-0757.2009.00324.x","article-title":"Complementary Tolls in the periodontium: how periodontal bacteria modify complement and Toll-like receptor responses to prevail in the host","volume":"52","author":"Krauss","year":"2010","journal-title":"Periodontol. 2000"},{"key":"10.1016\/S1349-0079(11)80006-X_bib32","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.fsi.2008.12.004","article-title":"LPS response and tolerance in the zebrafish (Danio rerio)","volume":"26","author":"Novoa","year":"2009","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/S1349-0079(11)80006-X_bib33","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1038\/ni1528","article-title":"Pathogen subversion of cell-intrinsic innate immunity","volume":"8","author":"Roy","year":"2007","journal-title":"Nat. Immunol."},{"key":"10.1016\/S1349-0079(11)80006-X_bib34","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/nri2918","article-title":"Microbial manipulation of receptor crosstalk in innate immunity","volume":"11","author":"Hajishengallis","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/S1349-0079(11)80006-X_bib35","first-page":"4547","article-title":"Porphyromonas gingivalis interactions with complement receptor 3 (CR3): innate immunity or immune evasion? Front","volume":"12","author":"Hajishengallis","year":"2007","journal-title":"Biosci."},{"key":"10.1016\/S1349-0079(11)80006-X_bib36","doi-asserted-by":"crossref","first-page":"7242","DOI":"10.4049\/jimmunol.178.11.7242","article-title":"Biphasic effect of gingipains from Porphyromonas gingivalis on the human complement system","volume":"178","author":"Popadiak","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/S1349-0079(11)80006-X_bib37","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1371\/journal.ppat.1000316","article-title":"Interpain A, a cysteine proteinase from Prevotella intermedia, inhibits complement by degrading complement factor C3","volume":"5","author":"Potempa","year":"2009","journal-title":"PLoS Pathog."},{"key":"10.1016\/S1349-0079(11)80006-X_bib38","doi-asserted-by":"crossref","first-page":"5352","DOI":"10.1128\/IAI.00304-06","article-title":"Mechanisms of resistance of Porphyromonas gingivalis to killing by serum complement","volume":"74","author":"Slaney","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/S1349-0079(11)80006-X_bib39","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.1128\/JB.01868-07","article-title":"Identification of a second lipopoly saccharide in Porphyromonas gingivalis W50","volume":"190","author":"Rangarajan","year":"2008","journal-title":"J. Bacteriol."},{"key":"10.1016\/S1349-0079(11)80006-X_bib40","doi-asserted-by":"crossref","first-page":"5537","DOI":"10.4049\/jimmunol.181.8.5537","article-title":"Binding of complement inhibitor C4b-binding protein contributes to serum resistance of Porphyromonas gingivalis","volume":"181","author":"Potempa","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/S1349-0079(11)80006-X_bib41","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1111\/j.1399-302X.2009.00532.x","article-title":"Porphyromonas gingivalis mediates the shedding and proteolysis of complement regulatory protein CD46 expressed by oral epithelial cells","volume":"24","author":"Mahtout","year":"2009","journal-title":"Oral Microbiol. Immunol."},{"key":"10.1016\/S1349-0079(11)80006-X_bib42","doi-asserted-by":"crossref","first-page":"4490","DOI":"10.4049\/jimmunol.175.7.4490","article-title":"MD-2 mediates the ability of tetra-acylated and penta-acylated lipopolysaccha rides to antagonize Escherichia coli lipopolysaccharide at the TLR4 signaling complex","volume":"175","author":"Coats","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/S1349-0079(11)80006-X_bib43","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1189\/jlb.0607432","article-title":"Early and preferential induction of IL1 receptor-associated kinase-M in THP-1 cells by LPS derived from Porphyromonas gingivalis","volume":"83","author":"Domon","year":"2008","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/S1349-0079(11)80006-X_bib44","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1371\/journal.ppat.0020076","article-title":"Roles of the host oxidative immune response and bacterial antioxidant rubrerythrin during Porphyromonas gingivalis infection","volume":"2","author":"Mydel","year":"2006","journal-title":"PLoS Pathog."},{"key":"10.1016\/S1349-0079(11)80006-X_bib45","doi-asserted-by":"crossref","first-page":"3215","DOI":"10.2741\/2922","article-title":"Gingipaindependent interactions with the host are important for survival of Porphyromonas gingivalis","volume":"13","author":"Sheets","year":"2008","journal-title":"Front. Biosci."}],"container-title":["Journal of Oral Biosciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S134900791180006X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S134900791180006X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,20]],"date-time":"2019-07-20T20:31:08Z","timestamp":1563654668000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S134900791180006X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":45,"aliases":["10.2330\/joralbiosci.53.233"],"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["S134900791180006X"],"URL":"https:\/\/doi.org\/10.1016\/s1349-0079(11)80006-x","relation":{},"ISSN":["1349-0079"],"issn-type":[{"value":"1349-0079","type":"print"}],"subject":[],"published":{"date-parts":[[2011,1]]}}}