{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:46:38Z","timestamp":1792003598237,"version":"4.4.0"},"reference-count":32,"publisher":"Japanese Society of Allergology","issue":"2","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,4,29]],"date-time":"2015-04-29T00:00:00Z","timestamp":1430265600000},"content-version":"vor","delay-in-days":1214,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergology International"],"published-print":{"date-parts":[[2012]]},"DOI":"10.2332\/allergolint.11-oa-0349","type":"journal-article","created":{"date-parts":[[2015,3,12]],"date-time":"2015-03-12T16:51:18Z","timestamp":1426179078000},"page":"275-282","source":"Crossref","is-referenced-by-count":33,"title":["Blood Level of Tacrolimus in Patients with Severe Allergic Conjunctivitis Treated by 0.1% Tacrolimus Ophthalmic Suspension"],"prefix":"10.2332","volume":"61","author":[{"given":"Nobuyuki","family":"Ebihara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Ohashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Fujishima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuki","family":"Fukushima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yayoi","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Namba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeki","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Shoji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etsuko","family":"Takamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiichi","family":"Uchio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dai","family":"Miyazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1154","reference":[{"key":"10.2332\/allergolint.11-OA-0349_bb0005","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/0002-9394(88)90595-8","article-title":"Intraocular pressure response to topical dexamethasone as a predictor for the development of primary open-angle glaucoma","volume":"106","author":"Lewis","year":"1988","journal-title":"Am J Ophthalmol"},{"key":"10.2332\/allergolint.11-OA-0349_bb0010","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/S0002-9394(14)76256-7","article-title":"Marked intraocular pressure response to instillation of corticosteroids in children","volume":"112","author":"Ohji","year":"1991","journal-title":"Am J Ophthalmol"},{"key":"10.2332\/allergolint.11-OA-0349_bb0015","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/S0161-6420(02)00963-6","article-title":"Indecision about corticosteroids for bacterial keratitis: an evidence-based update","volume":"109","author":"Wilhelmus","year":"2002","journal-title":"Ophthalmology"},{"key":"10.2332\/allergolint.11-OA-0349_bb0020","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/j.1440-1592.2004.00349.x","article-title":"Possibility of non-steroidal treatment in allergic conjunctival diseases","volume":"53","author":"Uchio","year":"2004","journal-title":"Allergol Int"},{"key":"10.2332\/allergolint.11-OA-0349_bb0025","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.7164\/antibiotics.40.1249","article-title":"FK-506, a novel immunosuppressant isolated from a Sterptomyces I. fermentation, isolation, and physico-chemical and biological characteristics","volume":"40","author":"Kino","year":"1987","journal-title":"J Antibiot"},{"key":"10.2332\/allergolint.11-OA-0349_bb0030","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1097\/ICO.0b013e31812dfab3","article-title":"Management of severe allergic conjunctivitis with topical cyclosporine A 0.05% eyedrops","volume":"26","author":"Ozcan","year":"2007","journal-title":"Cornea"},{"key":"10.2332\/allergolint.11-OA-0349_bb0035","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1089\/jop.2008.0103","article-title":"A large prospective observational study of novel cyclosporine 0.1% aqueous ophthalmic solution in the treatment of severe allergic conjunctivitis","volume":"25","author":"Ebihara","year":"2009","journal-title":"J Ocul Pharmacol Ther"},{"key":"10.2332\/allergolint.11-OA-0349_bb0040","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.jaci.2003.10.065","article-title":"Vernal keratoconjunctivitis: Result of a novel therapy with 0.1% topical ophthalmic FK-506 ointment","volume":"113","author":"Vichyanond","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.2332\/allergolint.11-OA-0349_bb0045","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1080\/02713680802149115","article-title":"Topical tacrolimus 0.03% ointment for intractable allergic conjunctivitis: an open-label pilot study","volume":"33","author":"Attas-Fox","year":"2008","journal-title":"Curr Eye Res"},{"key":"10.2332\/allergolint.11-OA-0349_bb0050","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.ophtha.2007.07.025","article-title":"Therapeutic effects of tacrolimus ointment for refractory ocular surface inflammatory diseases","volume":"115","author":"Miyazaki","year":"2008","journal-title":"Ophthalmology"},{"key":"10.2332\/allergolint.11-OA-0349_bb0055","first-page":"136","article-title":"Effect of FK506 and cyclosporine A on cytokine production studied in vitro at a single-cell level","volume":"75","author":"Anderson","year":"1992","journal-title":"Immunology"},{"key":"10.2332\/allergolint.11-OA-0349_bb0060","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1089\/jop.2009.0087","article-title":"A randomized, placebo-controlled clinical trial of tacrolimus ophthalmic suspension 0.1% in severe allergic conjunctivitis","volume":"26","author":"Ohashi","year":"2010","journal-title":"J Ocul Pharmacol Ther"},{"key":"10.2332\/allergolint.11-OA-0349_bb0065","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1053\/bbmt.1999.v5.pm10371361","article-title":"Relationship of tacrolimus whole blood levels to efficacy and safety outcomes after unrelated donor marrow transplantation","volume":"5","author":"Przepiorka","year":"1999","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.2332\/allergolint.11-OA-0349_bb0070","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1001\/archderm.136.8.999","article-title":"Safety and efficasy of 1 year of tacrolimus ointment monotherapy in adults with atopic dermatitis","volume":"136","author":"Sakari","year":"2000","journal-title":"Arch Drematol"},{"key":"10.2332\/allergolint.11-OA-0349_bb0075","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1345\/aph.1M278","article-title":"Association between exposure to topical tacrolimus or pimecrolimus and cancers","volume":"43","author":"Rita","year":"2009","journal-title":"Ann Pharmaco- ther"},{"key":"10.2332\/allergolint.11-OA-0349_bb0080","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1093\/clinchem\/42.2.279","article-title":"Sensitive, specific quantitative analysis of tacrolimus (FK506) in blood by liquid chromatography-electrospray tandem mass spectrometry","volume":"42","author":"Taylor","year":"1996","journal-title":"Clin Chem"},{"key":"10.2332\/allergolint.11-OA-0349_bb0085","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/S1567-5769(01)00059-5","article-title":"Tacrolimus suppressed the production of cytokines involved in atopic dermatitis by direct stimulation of human PBMC system. (Comparison with steroids)","volume":"1","author":"Sakuma","year":"2001","journal-title":"Int Immunopharmacol"},{"key":"10.2332\/allergolint.11-OA-0349_bb0090","doi-asserted-by":"crossref","first-page":"S165","DOI":"10.1016\/j.jaad.2005.04.059","article-title":"The efficacy and safety of tacrolimus ointment: a clinical review","volume":"53","author":"Beck","year":"2005","journal-title":"J Am Acad Dermatol"},{"key":"10.2332\/allergolint.11-OA-0349_bb0095","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1358\/dot.2006.42.7.1003316","article-title":"Tacrolimus: focusing on atopic dermatitis","volume":"42","author":"Carroll","year":"2006","journal-title":"Drugs Today (Barc)"},{"key":"10.2332\/allergolint.11-OA-0349_bb0100","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1159\/000086431","article-title":"Consensus statement on the safety profile of topical calcineurin inhibitors","volume":"211","author":"Bieber","year":"2005","journal-title":"Dermatology"},{"key":"10.2332\/allergolint.11-OA-0349_bb0105","article-title":"Topical pimecrolimus, tacrolimus, and the risk for cancer: an expert interview with Lawrence Eichenfield, MD","volume":"6","author":"Richardson","year":"2005","journal-title":"Medscape Dermatol"},{"key":"10.2332\/allergolint.11-OA-0349_bb0110","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.jaci.2005.04.006","article-title":"Report of the Topical Calcineurin Inhibitor Task Force of the American College of Allergy, Asthma and Immunology and the American Academy of Allergy, Asthma and Immunology","volume":"115","author":"Fonacier","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"10.2332\/allergolint.11-OA-0349_bb0115","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1111\/j.1365-2133.2005.06899.x","article-title":"Topical tacrolimus and pimecrolimus and the risk of cancer: how much cause for concern?","volume":"153","author":"Ormerod","year":"2005","journal-title":"Br J Dermatol"},{"key":"10.2332\/allergolint.11-OA-0349_bb0120","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.jaad.2006.01.054","article-title":"Frieden IJ; American Academy of Dermatology Association Task Force. The use of topical calcineurin inhibitors in dermatology: safety concerns. Report of the American Academy of Dermatology Association Task Force","volume":"54","author":"Berger","year":"2006","journal-title":"J Am Acad Dermatol"},{"key":"10.2332\/allergolint.11-OA-0349_bb0125","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/S0037-6337(05)70200-X","article-title":"Show me the signal","volume":"36","author":"Fleischer","year":"2005","journal-title":"FDA. Skin Allergy News"},{"key":"10.2332\/allergolint.11-OA-0349_bb0130","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1001\/archderm.139.9.1184","article-title":"The safety and efficacy of tacrolimus therapy in patients younger than 2 years with atopic dermatitis","volume":"139","author":"Patel","year":"2003","journal-title":"Arch Dermatol"},{"key":"10.2332\/allergolint.11-OA-0349_bb0135","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0190-9622(98)70541-9","article-title":"Tacrolimus (FK506) ointment for atopic dermatitis: a phase I study in adults and children","volume":"38","author":"Alaiti","year":"1998","journal-title":"J Am Acad Dermatol"},{"key":"10.2332\/allergolint.11-OA-0349_bb0140","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.0022-202X.2005.23644.x","article-title":"A multicenter study of the pharmacokinetics of tacrolimus ointment after first and repeated application to children with atopic dermatitis","volume":"124","author":"Harper","year":"2005","journal-title":"J Invest Dermatol"},{"key":"10.2332\/allergolint.11-OA-0349_bb0145","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/j.0022-202X.2005.23754.x","article-title":"Pharmacokinetics of 0.1% tacrolimus ointment after first and repeated application to adults with moderate to severe atopic dermatitis","volume":"125","author":"Rubins","year":"2005","journal-title":"J Invest Dermatol"},{"issue":"Suppl 2","key":"10.2332\/allergolint.11-OA-0349_bb0150","first-page":"150","article-title":"Tacrolimus blood levels after 3 months repeated application to children with atopic dermatitis [abstract]","volume":"19","author":"Tonin","year":"2005","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.2332\/allergolint.11-OA-0349_bb0155","first-page":"613","article-title":"Does prolonged topical application of tacrolimus in children result in systemic accumulation?","volume":"125","author":"Tonin","year":"2005","journal-title":"J Invest Dermatol"},{"key":"10.2332\/allergolint.11-OA-0349_bb0160","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1097\/01.ico.0000151507.49565.6e","article-title":"Topical tacrolimus ointment for treatment of refractory anterior segment inflammatory disorders","volume":"4","author":"Joseph","year":"2005","journal-title":"Cornea"}],"container-title":["Allergology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S1323893015302215?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S1323893015302215?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,30]],"date-time":"2020-08-30T19:51:15Z","timestamp":1598817075000},"score":1,"resource":{"primary":{"URL":"http:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1323893015302215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012]]}},"alternative-id":["S1323893015302215"],"URL":"https:\/\/doi.org\/10.2332\/allergolint.11-oa-0349","relation":{},"ISSN":["1323-8930"],"issn-type":[{"value":"1323-8930","type":"print"}],"subject":[],"published":{"date-parts":[[2012]]}}}