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Gabriel SE (2001) The epidemiology of rheumatoid arthritis. Rheum Dis Clin North Am 27, 269-281.","DOI":"10.1016\/S0889-857X(05)70201-5"},{"key":"2","unstructured":"2. Silman AJ, Pearson JE (2002) Epidemiology and genetics of rheumatoid arthritis. Arthritis Res 4, S265-272."},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Alamanos Y, Voulgari PV, Drosos AA (2006) Incidence and prevalence of rheumatoid arthritis, based on the 1987 American College of Rheumatology criteria: a systematic review. Semin Arthritis Rheum 36, 182-188.","DOI":"10.1016\/j.semarthrit.2006.08.006"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Tob\u00f3n GJ, Youinou P, Saraux A (2010) The environment, geo-epidemiology, and autoimmune disease: rheumatoid arthritis. J Autoimmun 35, 10-14.","DOI":"10.1016\/j.jaut.2009.12.009"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Mercado F, Marshall RI, Klestov AC, Bartold PM (2000) Is there a relationship between rheumatoid arthritis and periodontal disease? J Clin Periodontol 27, 267-272.","DOI":"10.1034\/j.1600-051x.2000.027004267.x"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Demmer RT, Molitor JA, Jacobs DR Jr, Michalowicz BS (2011) Periodontal disease, tooth loss and incident rheumatoid arthritis: results from the First National Health and Nutrition Examination Survey and its epidemiological follow-up study. J Clin Periodontol 38, 998-1006.","DOI":"10.1111\/j.1600-051X.2011.01776.x"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Berthelot JM, Le Goff B (2010) Rheumatoid arthritis and periodontal disease. Joint Bone Spine 77, 537-541.","DOI":"10.1016\/j.jbspin.2010.04.015"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Lee JY, Choi IA, Kim JH, Kim KH, Lee EY, Lee EB et al. (2015) Association between anti-Porphyromonas gingivalis or anti-\u03b1-enolase antibody and severity of periodontitis or rheumatoid arthritis (RA) disease activity in RA. BMC Musculoskelet Disord 16, 190.","DOI":"10.1186\/s12891-015-0647-6"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. K\u00e4sser UR, Gleissner C, Dehne F, Michel A, Willershausen-Z\u00f6nnchen B, Bolten WW (1997) Risk for periodontal disease in patients with longstanding rheumatoid arthritis. Arthritis Rheum 40, 2248-2251.","DOI":"10.1002\/art.1780401221"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Pischon N, Pischon T, Kr\u00f6ger J, G\u00fclmez E, Kleber BM, Bernimoulin JP et al. (2008) Association among rheumatoid arthritis, oral hygiene, and periodontitis. J Periodontol 79, 979-986.","DOI":"10.1902\/jop.2008.070501"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Bartold PM, Marshall RI, Haynes DR (2005) Periodontitis and rheumatoid arthritis: a review. 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(2010) Serum cytokine and periodontal profiles in relation to disease activity of rheumatoid arthritis in Japanese adults. J Periodontol 81, 650-657.","DOI":"10.1902\/jop.2010.090688"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Graves DT, Cochran D (2003) The contribution of interleukin-1 and tumor necrosis factor to periodontal tissue destruction. J Periodontol 74, 391-401.","DOI":"10.1902\/jop.2003.74.3.391"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. McInnes IB, Schett G (2007) Cytokines in the pathogenesis of rheumatoid arthritis. Nat Rev Immunol 7, 429-442.","DOI":"10.1038\/nri2094"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Assuma R, Oates T, Cochran D, Amar S, Graves DT (1998) IL-1 and TNF antagonists inhibit the inflammatory response and bone loss in experimental periodontitis. J Immunol 160, 403-409.","DOI":"10.4049\/jimmunol.160.1.403"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Delima AJ, Oates T, Assuma R, Schwartz Z, Cochran D, Amar S et al. (2001) Soluble antagonists to interleukin-1 (IL-1) and tumor necrosis factor (TNF) inhibits loss of tissue attachment in experimental periodontitis. J Clin Periodontol 28, 233-240.","DOI":"10.1034\/j.1600-051x.2001.028003233.x"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Ahmed N, Petersson A, Catrina AI, Mustafa H, Alstergren P (2015) Tumor necrosis factor mediates temporomandibular joint bone tissue resorption in rheumatoid arthritis. Acta Odontol Scand 73, 232-240.","DOI":"10.3109\/00016357.2014.994561"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Bostanci N, Ilgenli T, Emingil G, Afacan B, Han B, T\u00f6z H et al. (2007) Differential expression of receptor activator of nuclear factor-kappaB ligand and osteoprotegerin mRNA in periodontal diseases. J Periodontol Res 42, 287-293.","DOI":"10.1111\/j.1600-0765.2006.00946.x"},{"key":"21","unstructured":"21. Luo J, Wen H, Guo H, Cai Q, Li S, Li X (2013) 1,25-dihydroxyvitamin D3 inhibits the RANKL pathway and impacts on the production of pathway-associated cytokines in early rheumatoid arthritis. Biomed Res Int 101805."},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Liu K, Meng H, Tang X, Xu L, Zhang L, Chen Z et al. (2009) Elevated plasma calcifediol is associated with aggressive periodontitis. J Periodontol 80, 1114-1120.","DOI":"10.1902\/jop.2009.080675"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Liu K, Meng H, Lu R, Xu L, Zhang L, Chen Z et al. (2010) Initial periodontal therapy reduced systemic and local 25-hydroxy vitamin D3 and interleukin-1\u03b2 in patients with aggressive periodontitis. J Periodontol 81, 260-266.","DOI":"10.1902\/jop.2009.090355"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Zhang X, Meng H, Sun X, Xu L, Zhang L, Shi D et al. (2013) Elevation of vitamin D-binding protein levels in the plasma of patients with generalized aggressive periodontitis. J Periodontal Res 48, 74-79.","DOI":"10.1111\/j.1600-0765.2012.01505.x"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Liu K, Meng H, Hou J (2012) Activity of 25-hydroxylase in human gingival fibroblasts and periodontal ligament cells. PloS One 7, e52053.","DOI":"10.1371\/journal.pone.0052053"},{"key":"26","doi-asserted-by":"publisher","unstructured":"26. Loyola-Rodriguez JP, Martinez-Martinez RE, Abud-Mendoza C, Pati\u00f1o-Marin N, Seymour GJ (2010) Rheumatoid arthritis and the role of oral bacteria. J Oral Microbiol 2, doi: 10.3402\/jom.v2i0.5784.","DOI":"10.3402\/jom.v2i0.5784"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Reichert S, Schlumberger W, D\u00e4hnrich C, Hornig N, Altermann W, Schaller HG et al. (2015) Association of levels of antibodies against citrullinated cyclic peptides and citrullinated \u03b1-enolase in chronic and aggressive periodontitis as a risk factor of rheumatoid arthritis: a case control study. J Transl Med 13, 283.","DOI":"10.1186\/s12967-015-0625-7"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Kobayashi T, Yoshie H (2015) Host responses in the link between periodontitis and rheumatoid arthritis. Curr Oral Health Rep 2, 1-8.","DOI":"10.1007\/s40496-014-0039-2"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Mirrielees J, Crofford LJ, Lin Y, Kryscio RJ, Dawson DR 3rd, Ebersole JL et al. (2010) Rheumatoid arthritis and salivary biomarkers of periodontal disease. J Clin Periodontol 37, 1068-1074.","DOI":"10.1111\/j.1600-051X.2010.01625.x"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Kaur S, Bright R, Proudman SM, Bartold PM (2014) Does periodontal treatment influence clinical and biochemical measures for rheumatoid arthritis? A systematic review and meta-analysis. Semin Arthritis Rheum 44, 113-122.","DOI":"10.1016\/j.semarthrit.2014.04.009"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Mayer Y, Balbir-Gurman A, Machtei EE (2009) Anti-tumor necrosis factor-alpha therapy and periodontal parameters in patients with rheumatoid arthritis. J Periodontol 80, 1414-1420.","DOI":"10.1902\/jop.2009.090015"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Kawai T, Matsuyama T, Hosokawa Y, Makihira S, Seki M, Karimbux NY et al. (2006) B and T lymphocytes are the primary sources of RANKL in the bone resorptive lesion of periodontal disease. Am J Pathol 169, 987-998.","DOI":"10.2353\/ajpath.2006.060180"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Kotake S, Udagawa N, Hakoda M, Mogi M, Yano K, Tsuda E et al. 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J Periodontal Res 38, 380-387.","DOI":"10.1034\/j.1600-0765.2003.00615.x"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Holding CA, Findlay DM, Stamenkov R, Neale SD, Lucas H, Dharmapatni AS et al. (2006) The correlation of RANK, RANKL and TNF\u03b1 expression with bone loss volume and polyethylene wear debris around hip implants. Biomaterials 27, 5212-5219.","DOI":"10.1016\/j.biomaterials.2006.05.054"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Jiang C, Li Z, Quan H, Xiao L, Zhao J, Jiang C et al. (2015) Osteoimmunology in orthodontic tooth movement. Oral Dis 21, 694-704.","DOI":"10.1111\/odi.12273"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Crotti TN, Dharmapatni AA, Alias E, Haynes DR (2015) Osteoimmunology: major and costimulatory pathway expression associated with chronic inflammatory induced bone loss. J Immunol Res 2015, 281287.","DOI":"10.1155\/2015\/281287"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. van Tuyl LH, Voskuyl AE, Boers M, Geusens P, Landew\u00e9 RB, Dijkmans BA et al. (2010) Baseline RANKL:OPG ratio and markers of bone and cartilage degradation predict annual radiological progression over 11 years in rheumatoid arthritis. Ann Rheum Dis 69, 1623-1628.","DOI":"10.1136\/ard.2009.121764"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Zhang X, Meng H, Xu L, Zhang L, Shi D, Feng X et al. (2014) Vitamin D-binding protein levels in plasma and gingival crevicular fluid of patients with generalized aggressive periodontitis. Int J Endocrinol 783575.","DOI":"10.1155\/2014\/783575"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Guillot X, Semerano L, Saidenberg-Kermanac\u2019h N, Falgarone G, Boissier MC (2010) Vitamin D and inflammation. Joint Bone Spine 77, 552-557.","DOI":"10.1016\/j.jbspin.2010.09.018"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Tang X, Pan Y, Zhao Y (2013) Vitamin D inhibits the expression of interleukin-8 in human periodontal ligament cells stimulated with Porphyromonas gingivalis. Arch Oral Biol 58, 397-407.","DOI":"10.1016\/j.archoralbio.2012.09.010"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43. Mathieu C, Adorini L (2002) The coming of age of 1,25-dihydroxyvitamin D3 analogs as immunomodulatory agents. Trends Mol Med 8, 174-179.","DOI":"10.1016\/S1471-4914(02)02294-3"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44. Teles FR, Teles RP, Martin L, Socransky SS, Haffajee AD (2012) Relationships among interleukin-6, tumor necrosis factor-\u03b1, adipokines, vitamin D, and chronic periodontitis. J Periodontol 83, 1183-1191.","DOI":"10.1902\/jop.2011.110346"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45. Cantorna MT, Hayes CE, DeLuca HF (1998) 1,25-Dihydroxycholecalciferol inhibits the progression of arthritis in murine models of human arthritis. J Nutr 128, 68-72.","DOI":"10.1093\/jn\/128.1.68"},{"key":"46","unstructured":"46. Andjelkovic Z, Vojinovic J, Pejnovic N, Popovic M, Dujic A, Mitrovic D, et al. (1999) Disease modifying and immunomodulatory effects of high dose 1\u03b1(OH) D3 in rheumatoid arthritis patients. Clin Exp Rheumatol 17, 453-456."},{"key":"47","doi-asserted-by":"crossref","unstructured":"47. Mercado FB, Marshall RI, Bartold PM (2003) Inter-relationships between rheumatoid arthritis and periodontal disease. A review. J Clin Periodontol 30, 761-772.","DOI":"10.1034\/j.1600-051X.2003.00371.x"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48. Orozco A, Gemmell E, Bickel M, Seymour GJ (2006) Interleukin-1\u03b2, interleukin-12 and interleukin-18 levels in gingival fluid and serum of patients with gingivitis and periodontitis. 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