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Kiyono H, Azegami T (2015) The mucosal immune system: from dentistry to vaccine development. Proc Jpn Acad Ser B Phys Biol Sci 91, 423-439.","DOI":"10.2183\/pjab.91.423"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Dawes C, Pedersen AM, Villa A, Ekstr\u00f6m J, Proctor GB, Vissink A et al. (2015) The functions of human saliva: a review sponsored by the World Workshop on Oral Medicine VI.Arch Oral Biol 60, 863-874.","DOI":"10.1016\/j.archoralbio.2015.03.004"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Caball\u00e9-Serrano J, Cvikl B, Bosshardt DD, Buser D, Lussi A, Gruber R (2015) Saliva suppresses osteoclastogenesis in murine bone marrow cultures. J Dent Res 94, 192-200.","DOI":"10.1177\/0022034514553977"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Williams RC, Gibbons RJ (1972) Inhibition of bacterial adherence by secretory immunoglobulin A: a mechanism of antigen disposal. Science 177, 697-699.","DOI":"10.1126\/science.177.4050.697"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Hanson LA, Ahlstedt S, Andersson B, Carlsson B, Cole MF, Cruz JR et al. (1983) Mucosal immunity. Ann N Y Acad Sci 409, 1-21.","DOI":"10.1111\/j.1749-6632.1983.tb26855.x"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Oliver SJ, Laing SJ, Wilson S, Bilzon JL, Walters R, Walsh NP (2007) Salivary immunoglobulin A response at rest and after exercise following a 48 h period of fluid and\/or energy restriction. Br J Nutr 97, 1109-1116.","DOI":"10.1017\/S0007114507682919"},{"key":"7","unstructured":"7. MacKinnon LT, Jenkins DG (1993) Decreased salivary immunoglobulins after intense interval exercise before and after training. Med Sci Sports Exerc 25, 678-683."},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Fahlman MM, Engels HJ (2005) Mucosal IgA and URTI in American college football players: a year longitudinal study. Med Sci Sports Exerc 37, 374-380.","DOI":"10.1249\/01.MSS.0000155432.67020.88"},{"key":"9","unstructured":"9. Ostergaard PA (1980) Clinical and immunological features of transient IgA deficiency in children. Clin Exp Immunol 40, 561-565."},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Shimizu K, Sato H, Suga Y, Yamahira S, Toba M, Hamuro K et al. (2014) The effects of Lactobacillus pentosus strain b240 and appropriate physical training on salivary secretory IgA levels in elderly adults with low physical fitness: a randomized, double-blind, placebo-controlled trial. J Clin Biochem Nutr 54, 61-66.","DOI":"10.3164\/jcbn.13-62"},{"key":"11","unstructured":"11. Schley PD, Field CJ (2002) The immune-enhancing effects of dietary fibres and prebiotics. Br J Nutr 87, Suppl 2, S221-230."},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. R\u00f6nnau K, Guth D, von Engelhardt W (1989) Absorption of dissociated and undissociated short-chain fatty acids across the colonic epithelium of guinea-pig. Q J Exp Physiol 74, 511-519.","DOI":"10.1113\/expphysiol.1989.sp003298"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Verbeke KA, Boobis AR, Chiodini A, Edwards CA, Franck A, Kleerebezem M et al. (2015) Towards microbial fermentation metabolites as markers for health benefits of prebiotics. Nutr Res Rev 28, 42-66.","DOI":"10.1017\/S0954422415000037"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Patil DH, Grimble GK, Silk DB (1987) Lactitol, a new hydrogenated lactose derivative: intestinal absorption and laxative threshold in normal human subjects. Br J Nutr 57, 195-199.","DOI":"10.1079\/BJN19870025"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Probert HM, Apajalahti JH, Rautonen N, Stowell J, Gibson GR (2004) Polydextrose, lactitol, and fructo-oligosaccharide fermentation by colonic bacteria in a three-stage continuous culture system. Appl Environ Microbiol 70, 4505-4511.","DOI":"10.1128\/AEM.70.8.4505-4511.2004"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Fava F, M\u00e4kivuokko H, Siljander-Rasi H, Putaala H, Tiihonen K, Stowell J et al. (2007) Effect of polydextrose on intestinal microbes and immune functions in pigs. Br J Nutr 98, 123-133.","DOI":"10.1017\/S0007114507691818"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Peuranen S, Tiihonen K, Apajalahti J, Kettunen A, Saarinen M, Rautonen N (2004) Combination of polydextrose and lactitol affects microbial ecosystem and immune responses in rat gastrointestinal tract. Br J Nutr 91, 905-914.","DOI":"10.1079\/BJN20041114"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Yamamoto Y, To M, Hayashi T, Shimizu T, Kamata Y, Saruta J et al. (2015) Intake of indigestible carbohydrates influences IgA response and polymeric Ig receptor expression in the rat submandibular gland. Br J Nutr 113, 1895-1902.","DOI":"10.1017\/S0007114515001403"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Yamamoto Y, Takahashi T, To M, Nakagawa Y, Hayashi T, Shimizu T et al. (2016) The salivary IgA flow rate is increased by high concentrations of short-chain fatty acids in the cecum of rats ingesting fructooligosaccharides. Nutrients 8, pii: E500.","DOI":"10.3390\/nu8080500"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Frost GS, Walton GE, Swann JR, Psichas A, Costabile A, Johnson LP et al. (2014) Impacts of plant-based foods in ancestral hominin diets on the metabolism and function of gut microbiota in vitro. MBio 5, e00853-14.","DOI":"10.1128\/mBio.00853-14"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Otles S, Ozgoz S (2014) Health effects of dietary fiber. Acta Sci Pol Technol Aliment 13, 191-202.","DOI":"10.17306\/J.AFS.2014.2.8"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Cresci A, Orpianesi C, Silvi S, Mastrandrea V, Dolara P (1999) The effect of sucrose or starch-based diet on short-chain fatty acids and faecal microflora in rats. J Appl Microbiol 86, 245-250.","DOI":"10.1046\/j.1365-2672.1999.00668.x"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Tsukahara T, Matsukawa N, Tomonaga S, Inoue R, Ushida K, Ochiai K (2014) High-sensitivity detection of short-chain fatty acids in porcine ileal, cecal, portal and abdominal blood by gas chromatography-mass spectrometry. Anim Sci J 85, 494-498.","DOI":"10.1111\/asj.12188"},{"key":"24","doi-asserted-by":"crossref","unstructured":"25. Kudoh K, Shimizu J, Ishiyama A, Wada M, Takita T, Kanke Y et al. (1999) Secretion and excretion of immunoglobulin A to cecum and feces differ with type of indigestible saccharides. J Nutr Sci Vitaminol (Tokyo) 45, 173-181.","DOI":"10.3177\/jnsv.45.173"},{"key":"25","doi-asserted-by":"crossref","unstructured":"26. Li M, Bauer LL, Chen X, Wang M, Kuhlenschmidt TB, Kuhlenschmidt MS et al. (2012) Microbial composition and in vitro fermentation patterns of human milk oligosaccharides and prebiotics differ between formula-fed and sow-reared piglets. J Nutr 142, 681-689.","DOI":"10.3945\/jn.111.154427"},{"key":"26","doi-asserted-by":"crossref","unstructured":"27. Busserolles J, Gueux E, Rock E, Demign\u00e9 C, Mazur A, Rayssiguier Y (2003) Oligofructose protects against the hypertriglyceridemic and pro-oxidative effects of a high fructose diet in rats. J Nutr 133, 1903-1908.","DOI":"10.1093\/jn\/133.6.1903"},{"key":"27","doi-asserted-by":"crossref","unstructured":"28. Inagaki A, Sakata T (2005) Dose-dependent stimulatory and inhibitory effects of luminal and serosal n-butyric acid on epithelial cell proliferation of pig distal colonic mucosa. J Nutr Sci Vitaminol (Tokyo) 51, 156-160.","DOI":"10.3177\/jnsv.51.156"},{"key":"28","doi-asserted-by":"crossref","unstructured":"29. Sakata T, von Engelhardt W (1983) Stimulatory effect of short chain fatty acids on the epithelial cell proliferation in rat large intestine. Comp Biochem Physiol A Comp Physiol 74, 459-462.","DOI":"10.1016\/0300-9629(83)90631-X"},{"key":"29","doi-asserted-by":"crossref","unstructured":"30. Sakata T (1987) Stimulatory effect of short-chain fatty acids on epithelial cell proliferation in the rat intestine: a possible explanation for trophic effects of fermentable fibre, gut microbes and luminal trophic factors. Br J Nutr 58, 95-103.","DOI":"10.1079\/BJN19870073"},{"key":"30","doi-asserted-by":"crossref","unstructured":"31. Ouwehand AC, Tiihonen K, Saarinen M, Putaala H, Rautonen N (2009) Influence of a combination of Lactobacillus acidophilus NCFM and lactitol on healthy elderly: intestinal and immune parameters. Br J Nutr 101, 367-375.","DOI":"10.1017\/S0007114508003097"},{"key":"31","doi-asserted-by":"crossref","unstructured":"32. Beards E, Tuohy K, Gibson G (2010) Bacterial, SCFA and gas profiles of a range of food ingredients following in vitro fermentation by human colonic microbiota. Anaerobe 16, 420-425.","DOI":"10.1016\/j.anaerobe.2010.05.006"},{"key":"32","doi-asserted-by":"crossref","unstructured":"33. Beloshapka AN, Wolff AK, Swanson KS (2012) Effects of feeding polydextrose on faecal characteristics, microbiota and fermentative end products in healthy adult dogs. Br J Nutr 108, 638-644.","DOI":"10.1017\/S0007114511005927"},{"key":"33","doi-asserted-by":"crossref","unstructured":"34. Hara H, Suzuki T, Aoyama Y (2000) Ingestion of the soluble dietary fibre, polydextrose, increases calcium absorption and bone mineralization in normal and total-gastrectomized rats. Br J Nutr 84, 655-661.","DOI":"10.1017\/S0007114500001999"},{"key":"34","doi-asserted-by":"crossref","unstructured":"35. Ichikawa H, Sakata T (1997) Effect of L-lactic acid, short-chain fatty acids, and pH in cecal infusate on morphometric and cell kinetic parameters of rat cecum. Dig Dis Sci 42, 1598-1610.","DOI":"10.1023\/A:1018884625737"},{"key":"35","doi-asserted-by":"crossref","unstructured":"36. McRorie J, Brown S, Cooper R, Givaruangsawat S, Scruggs D, Boring G (2000) Effects of dietary fibre and olestra on regional apparent viscosity and water content of digesta residue in porcine large intestine. Aliment Pharmacol Ther 14, 471-477.","DOI":"10.1046\/j.1365-2036.2000.00734.x"},{"key":"36","doi-asserted-by":"crossref","unstructured":"37. Schepens MA, ten Bruggencate SJ, Schonewille AJ, Brummer RJ, van der Meer R, Bovee-Oudenhoven IM (2012) The protective effect of supplemental calcium on colonic permeability depends on a calcium phosphate-induced increase in luminal buffering capacity. Br J Nutr 107, 950-956.","DOI":"10.1017\/S0007114511003977"},{"key":"37","doi-asserted-by":"crossref","unstructured":"38. von Engelhardt W, Burmester M, Hansen K, Becker G, Rechkemmer G (1993) Effects of amiloride and ouabain on short-chain fatty acid transport in guinea-pig large intestine. J Physiol 460, 455-466.","DOI":"10.1113\/jphysiol.1993.sp019481"},{"key":"38","doi-asserted-by":"crossref","unstructured":"39. Takahashi T (2011) Flow behavior of digesta and the absorption of nutrients in the gastrointestine. J Nutr Sci Vitaminol (Tokyo) 57, 265-273.","DOI":"10.3177\/jnsv.57.265"},{"key":"39","doi-asserted-by":"crossref","unstructured":"40. Maglogiannis I, Zafiropoulos E, Platis A, Lambrinoudakis C (2006) Risk analysis of a patient monitoring system using Bayesian Network modeling. J Biomed Inform 39, 637-647.","DOI":"10.1016\/j.jbi.2005.10.003"},{"key":"40","doi-asserted-by":"crossref","unstructured":"42. Carpenter GH, Proctor GB, Ebersole LE, Garrett JR (2004) Secretion of IgA by rat parotid and submandibular cells in response to autonomimetic stimulation in vitro. Int Immunopharmacol 4, 1005-1014.","DOI":"10.1016\/j.intimp.2004.03.013"},{"key":"41","doi-asserted-by":"crossref","unstructured":"43. Cuche G, Malbert CH (1999) Short-chain fatty acids present in the ileum inhibit fasting gastrointestinal motility in conscious pigs. Neurogastroenterol Motil 219-225.","DOI":"10.1046\/j.1365-2982.1999.00149.x"},{"key":"42","doi-asserted-by":"crossref","unstructured":"44. 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