{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:50:41Z","timestamp":1790682641060,"version":"4.1.0"},"reference-count":30,"publisher":"Nihon University School of Dentistry","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Sci","Journal of Oral Science"],"published-print":{"date-parts":[[2021]]},"DOI":"10.2334\/josnusd.19-0504","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T22:06:11Z","timestamp":1603922771000},"page":"22-26","source":"Crossref","is-referenced-by-count":34,"title":["Variability of salivary metabolite levels in patients with Sj\u00f6gren\u2019s syndrome"],"prefix":"10.2334","volume":"63","author":[{"given":"Maria","family":"Herrala","sequence":"first","affiliation":[{"name":"Research Group of Oral Health Sciences, Faculty of Medicine, University of Oulu and Oulu University Hospital"},{"name":"Institute of Dentistry, Faculty of Health Sciences, University of Eastern Finland"},{"name":"Medical Research Center Oulu, University of Oulu and Oulu University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jopi J. W.","family":"Mikkonen","sequence":"additional","affiliation":[{"name":"SIB Labs and Department of Applied Physics, Faculty of Science and Forestry, University of Eastern Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Pesonen","sequence":"additional","affiliation":[{"name":"Infrastructure for Population Studies, Faculty of Medicine, University of Oulu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reijo","family":"Lappalainen","sequence":"additional","affiliation":[{"name":"SIB Labs and Department of Applied Physics, Faculty of Science and Forestry, University of Eastern Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo","family":"Tj\u00e4derhane","sequence":"additional","affiliation":[{"name":"Medical Research Center Oulu, University of Oulu and Oulu University Hospital"},{"name":"Department of Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raija K.","family":"Niemel\u00e4","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Oulu University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubertus","family":"Seitsalo","sequence":"additional","affiliation":[{"name":"Private practice"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuula","family":"Salo","sequence":"additional","affiliation":[{"name":"Medical Research Center Oulu, University of Oulu and Oulu University Hospital"},{"name":"Department of Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sami","family":"Myllymaa","sequence":"additional","affiliation":[{"name":"SIB Labs and Department of Applied Physics, Faculty of Science and Forestry, University of Eastern Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arja M.","family":"Kullaa","sequence":"additional","affiliation":[{"name":"Research Group of Oral Health Sciences, Faculty of Medicine, University of Oulu and Oulu University Hospital"},{"name":"Institute of Dentistry, Faculty of Health Sciences, University of Eastern Finland"},{"name":"Educational Dental Clinic, Kuopio University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1160","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Goules AV, Tzioufas AG (2016) Primary Sj\u00f6gren\u2019s syndrome: clinical phenotypes, outcome and the development of biomarkers. Autoimmun Rev 15, 695-703.","DOI":"10.1016\/j.autrev.2016.03.004"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Hakala M, Niemel\u00e4 RK (2000) Does autonomic nervous impairment have a role in pathophysiology of sj\u00f6gren\u2019s syndrome. The Lancet 355, 1032-1033.","DOI":"10.1016\/S0140-6736(00)02030-4"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. van der Meulen TA, Harmsen HJM, Bootsma H, Liefers SC, Vich Vila A, Zhernakova A et al. (2018) Dysbiosis of the buccal mucosa microbiome in primary Sj\u00f6gren\u2019s syndrome patients. Rheumatology 57, 2225-2234.","DOI":"10.1093\/rheumatology\/key215"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Wakamatsu TH, Dogru M, Matsumoto Y, Kojima T, Kaido M, Ibrahim OM et al. (2013) Evaluation of lipid oxidative stress status in Sj\u00f6gren syndrome patients. Invest Ophthalmol Vis Sci 54, 201-210.","DOI":"10.1167\/iovs.12-10325"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Kageyama G, Saegusa J, Irino Y, Tanaka S, Tsuda K, Takahashi S et al. (2015) Metabolomics analysis of saliva from patients with primary Sj\u00f6gren\u2019s syndrome. Clin Exp Immunol 182, 149-153.","DOI":"10.1111\/cei.12683"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Fragkioudaki S, Mavragani CP, Moutsopoulos HM (2016) Predicting the risk for lymphoma development in Sjogren syndrome: an easy tool for clinical use. Medicine 95, 3766-3766.","DOI":"10.1097\/MD.0000000000003766"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Garc\u00eda-Villaescusa A, Morales-Tatay J, Monle\u00f3n-Salvad\u00f3 D, Gonz\u00e1lez-Darder JM, Bellot-Arcis C, Montiel-Company JM et al. (2018) Using NMR in saliva to identify possible biomarkers of glioblastoma and chronic periodontitis. PloS One 13, e0188710.","DOI":"10.1371\/journal.pone.0188710"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Dame ZT, Aziat F, Mandal R, Krishnamurthy R, Bouatra S, Borzouie S et al. (2015) The human saliva metabolome. Metabolomics 11, 1864-1883.","DOI":"10.1007\/s11306-015-0840-5"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Mikkonen J, Singh S, Herrala M, Lappalainen R, Myllymaa S, Kullaa A (2016) Salivary metabolomics in the diagnosis of oral cancer and periodontal diseases. J Periodont Res 51, 431-437.","DOI":"10.1111\/jre.12327"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Grimaldi M, Palisi A, Rossi G, Stillitano I, Faiella F, Montoro P et al. (2018) Saliva of patients affected by salivary gland tumour: an NMR metabolomics analysis. J Pharm Biomed Anal 160, 436-442.","DOI":"10.1016\/j.jpba.2018.08.015"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Gardner A, Parkes HG, Carpenter GH, So PW (2018) Developing and standardizing a protocol for quantitative proton nuclear magnetic resonance (<sup>(1)<\/sup>H NMR) spectroscopy of saliva. J Proteome Res 17, 1521-1531.","DOI":"10.1021\/acs.jproteome.7b00847"},{"key":"12","unstructured":"12. Mikkonen JJ, Herrala M, Soininen P, Lappalainen R, Tj\u00e4derhane L, Seitsalo H et al. (2013) Metabolic profiling of saliva in patients with primary Sj\u00f6gren\u2019s syndrome. Metabolomics: Open Access 3, 128 doi:10.4172\/2153-0769.100012"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. De Almeida PDL, Gregio A, Machado M, De Lima A, Azevedo LR (2008) Saliva composition and functions: a comprehensive review. J Contemp Dent Pract 9, 72-80.","DOI":"10.5005\/jcdp-9-3-72"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Vitali C, Bombardieri S, Jonsson R, Moutsopoulos HM, Alexander EL, Carsons SE et al. (2002) Classification criteria for Sj\u00f6gren\u2019s syndrome: a revised version of the European criteria proposed by the American-European consensus group. Ann Rheum Dis 61, 554-558.","DOI":"10.1136\/ard.61.6.554"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Niemela RK, Takalo R, Paakko E, Suramo I, Paivansalo M, Salo T et al. (2004) Ultrasonography of salivary glands in primary Sj\u00f6gren\u2019s syndrome. A comparison with magnetic resonance imaging and magnetic resonance sialography of parotid glands. Rheumatology (Oxford) 43, 875-879.","DOI":"10.1093\/rheumatology\/keh187"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Seitsalo H, Niemel\u00e4 RK, Marinescu-Gava M, Vuotila T, Tj\u00e4derhane L, Salo T (2007) Effectiveness of low-dose doxycycline (LDD) on clinical symptoms of Sj\u00f6gren\u2019s syndrome: A randomized, double-blind, placebo controlled cross-over study. J Negat Results Biomed 6, 11.","DOI":"10.1186\/1477-5751-6-11"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Navazesh M (1993) Methods for collecting saliva. Ann N Y Acad Sci 694, 72-77.","DOI":"10.1111\/j.1749-6632.1993.tb18343.x"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Silwood CJL, Lynch E, Claxson AWD, Grootveld MC (2002) <sup>1<\/sup>H and <sup>13<\/sup>C NMR spectroscopic analysis of human saliva. J Dent Res 81, 422-427.","DOI":"10.1177\/154405910208100613"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Aimetti M, Cacciatore S, Graziano A, Tenori L (2012) Metabonomic analysis of saliva reveals generalized chronic periodontitis signature. Metabolomics 8, 465-474.","DOI":"10.1007\/s11306-011-0331-2"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Soininen P, Haarala J, Veps\u00e4l\u00e4inen J, Niemitz M, Laatikainen R (2005) Strategies for organic impurity quantification by 1H NMR spectroscopy: constrained total-line-shape fitting. Anal Chim Acta 542, 178-185.","DOI":"10.1016\/j.aca.2005.03.060"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Mikkonen, JJ, Singh, SP, Akhi R, Salo T, Lappalainen R, Gonz\u00e1lez Arriagada et al. (2018) Potential role of nuclear magnetic resonance spectroscopy to identify salivary metabolite alterations in patients with head and neck cancer. Oncol Lett 16, 6795-6800.","DOI":"10.3892\/ol.2018.9419"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Kettunen J, Demirkan A, Wrtz P, Draisma HHM, Haller T, Rawal R et al. (2016) Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA. Nat Commun 7, 11122.","DOI":"10.1038\/ncomms11122"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Pedersen AML, S\u00f8rensen CE, Proctor GB, Carpenter GH, Ekstr\u00f6m J (2018) Salivary secretion in health and disease. J Oral Rehabil 45, 730-746.","DOI":"10.1111\/joor.12664"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Glunde K, Bhujwalla ZM, Ronen SM (2011) Choline metabolism in malignant transformation. Nat Rev Cancer 11, 835-848.","DOI":"10.1038\/nrc3162"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Ohshima M, Sugahara K, Kasahara K, Katakura A (2017) Metabolomic analysis of the saliva of japanese patients with oral squamous cell carcinoma. Oncol Rep 37, 2727-2734.","DOI":"10.3892\/or.2017.5561"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Wang Q, Gao P, Wang X, Duan Y (2014) Investigation and identification of potential biomarkers in human saliva for the early diagnosis of oral squamous cell carcinoma. Clin Chim Acta 427, 79-85.","DOI":"10.1016\/j.cca.2013.10.004"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Mozaffari MS, Borke JL (2002) Taurine in submandibular gland of the rat: effect of muscarinic drugs. J Histochem Cytochem 50, 527-532.","DOI":"10.1177\/002215540205000409"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Porto-Mascarenhas EC, Assad DX, Chardin H, Gozal D, De Luca Canto G, Acevedo AC et al. (2017) Salivary biomarkers in the diagnosis of breast cancer: a review. Crit Rev Oncol Hematol 110, 62-73.","DOI":"10.1016\/j.critrevonc.2016.12.009"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. P\u00e9rez-Torres I, Zuniga-Munoz AM, Guarner-Lans V (2017) Beneficial effects of the amino acid glycine. Mini Rev Med Chem 17, 15-32.","DOI":"10.2174\/1389557516666160609081602"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Malicka B, Skoskiewicz-Malinowska K, Kaczmarek U (2016) Salivary lactate dehydrogenase and aminotransferases in diabetic patients. Medicine 95, e5211.","DOI":"10.1097\/MD.0000000000005211"}],"container-title":["Journal of Oral Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/josnusd\/63\/1\/63_19-0504\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,26]],"date-time":"2020-12-26T03:45:04Z","timestamp":1608954304000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/josnusd\/63\/1\/63_19-0504\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.2334\/josnusd.19-0504","relation":{},"ISSN":["1343-4934","1880-4926"],"issn-type":[{"value":"1343-4934","type":"print"},{"value":"1880-4926","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}