{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:44:26Z","timestamp":1773290666833,"version":"3.50.1"},"reference-count":58,"publisher":"Nihon University School of Dentistry","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Sci"],"published-print":{"date-parts":[[2008]]},"DOI":"10.2334\/josnusd.50.151","type":"journal-article","created":{"date-parts":[[2008,6,30]],"date-time":"2008-06-30T05:51:47Z","timestamp":1214805107000},"page":"151-159","source":"Crossref","is-referenced-by-count":32,"title":["Interleukin-1 and tumor necrosis factor-\u03b1 gene polymorphisms in Turkish patients with localized aggressive periodontitis"],"prefix":"10.2334","volume":"50","author":[{"given":"Esra","family":"Guzeldemir","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meral","family":"Gunhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Onur","family":"Ozcelik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hakki","family":"Tastan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1160","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Van Dyke TE, Schweinebraten M, Cianciola LJ, Offenbacher S, Genco RJ (1985) Neutrophil chemotaxis in families with localized juvenil periodontitis. J Periodont Res 20, 503-514","DOI":"10.1111\/j.1600-0765.1985.tb00834.x"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Haffajee AD, Socransky SS (1994) Microbial etiological agents of destructive periodontal diseases. Periodontol 2000 5, 78-111","DOI":"10.1111\/j.1600-0757.1994.tb00020.x"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Hodge P, Michalowicz B (2001) Genetic predisposition to periodontitis in children and young adults. Periodontol 2000 26, 113-134","DOI":"10.1034\/j.1600-0757.2001.2260106.x"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Nunn ME (2003) Understanding the etiology of periodontitis: an overview of periodontal risk factors. Periodontol 2000 32, 11-23","DOI":"10.1046\/j.0906-6713.2002.03202.x"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Okada H, Murakami S (1998) Cytokine expression in periodontal health and disease. Crit Rev Oral Biol Med 9, 248-266","DOI":"10.1177\/10454411980090030101"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Stashenko P, Jandinski JJ, Fujiyoshi P, Rynar J, Socransky SS (1991) Tissue levels of bone resorptive cytokines in periodontal disease. J Periodontol 62, 504-509","DOI":"10.1902\/jop.1991.62.8.504"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1989.tb00883.x"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Dinarello CA (1996) Biologic basis for interleukin-1 in disease. Blood 87, 2095-2147","DOI":"10.1182\/blood.V87.6.2095.bloodjournal8762095"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Gemmell E, Marshall RI, Seymour GJ (1997) Cytokines and prostaglandins in immune homeostasis and tissue destruction in periodontal disease. Periodontol 2000 14, 112-143","DOI":"10.1111\/j.1600-0757.1997.tb00194.x"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb01187.x"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1993.tb02113.x"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Hart TC, Kornman KS (1997) Genetic factors in the pathogenesis of periodontitis. Periodontol 2000 14, 202-215","DOI":"10.1111\/j.1600-0757.1997.tb00198.x"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1994.1076"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Offenbacher S (1996) Periodontal diseases: pathogenesis. Ann Periodontol 1, 821-878","DOI":"10.1902\/annals.1996.1.1.821"},{"key":"15","unstructured":"15. Alexander MB, Damoulis PD (1994) The role of cytokines in the pathogenesis of periodontal disease. Curr Opin Periodontol 2, 39-53"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Wilson AG, di Giovine FS, Blakemore AL, Duff GW (1992) Single base polymorphism in the human tumour necrosis factor alpha (TNF-α) gene detectable by Nco1 restriction of PCR product. Hum Mol Genet 1, 353","DOI":"10.1093\/hmg\/1.5.353"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Kornman KS, Di Giovine FS (1998) Genetic variations in cytokine expression: a risk factor severity of adult periodontitis. Ann Periodontol 3, 327-338","DOI":"10.1902\/annals.1998.3.1.327"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Diehl SR, Wang Y, Brooks CN, Burmeister JA, Califano JV, Wang S, Schenkein HA (1999) Linkage disequilibrium of interleukin-1 genetic polymorphisms with early-onset periodontitis. J Periodontol 70, 418-430","DOI":"10.1902\/jop.1999.70.4.418"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Walker SJ, Van Dyke, TE, Rich S, Kornman KS, di Giovine FS, Hart TC (2000) Genetic polymorphisms of the IL-1α and IL-1β genes in African-American LJP patients and an African-American control population. J Periodontol 71, 723-728","DOI":"10.1902\/jop.2000.71.5.723"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Parkhill JM, Hennig BJ, Chapple IL, Heasman PA, Taylor JJ (2000) Association of interleukin-1 gene polymorphisms with early-onset periodontitis. J Clin Periodontol 27, 682-689","DOI":"10.1034\/j.1600-051x.2000.027009682.x"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Hodge PJ, Riggio MP, Kinane DF (2001) Failure to detect an association with IL1 genotypes in European Caucasians with generalised early onset periodontitis. J Clin Periodontol 28, 430-436","DOI":"10.1034\/j.1600-051x.2001.028005430.x"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Fassmann A, Holla LI, Buckova D, Vasku A, Znojil V, Vanek J (2003) Polymorphisms in the +252(A\/G) lymphotoxin-alpha and the -308(A\/G) tumor necrosis factor-alpha genes and susceptibility to chronic periodontitis in a Czech population. J Periodontal Res 38, 394-399","DOI":"10.1034\/j.1600-0765.2003.00661.x"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Kinane DF, Hodge P, Eskdale J, Ellis R, Gallagher G (1999) Analysis of genetic polymorphisms at the interleukin-10 and tumour necrosis factor loci in early-onset periodontitis. J Periodontal Res 34, 379-386","DOI":"10.1111\/j.1600-0765.1999.tb02270.x"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Endo M, Tai H, Tabeta K, Kobayashi T, Yamazaki K, Yoshie H (2001) Analysis of single nucleotide polymorphisms in the 5'-flanking region of tumor necrosis factor-alpha gene in Japanese patients with early-onset periodontitis. J Periodontol 72, 1554-1559","DOI":"10.1902\/jop.2001.72.11.1554"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Shapira L, Stabholz A, Rieckmann P, Kruse N (2001) Genetic polymorphism of the tumor necrosis factor (TNF)-α promotor region in families with localized early-onset periodontitis. J Periodontal Res 36, 183-186","DOI":"10.1034\/j.1600-0765.2001.360307.x"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Craandijk J, van Krugten MV, Verweij CL, van der Velden U, Loos BG (2002) Tumor necrosis factor-α gene polymorphisms in relation to periodontitis. J Clin Periodontol 29, 28-34","DOI":"10.1034\/j.1600-051x.2002.290105.x"},{"key":"27","unstructured":"27. Guzeldemir E, Toygar HU (2006) From alveolar diffuse atrophy to aggressive periodontitis: a brief history. J Hist Dent 54, 96-99"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Butler JH (1969) A familial pattern of juvenile periodontitis (periodontosis). J Periodontol 40, 115-118","DOI":"10.1902\/jop.1969.40.2.115"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Saxén L (1980) Heredity of juvenil periodontitis. J Clin Periodontol 7, 276-288","DOI":"10.1111\/j.1600-051X.1980.tb01970.x"},{"key":"30","unstructured":"30. Saribay A, Eres G, Akkaya M (1999) Prevalance of juvenile periodontitis among students aged 13-19 in Ankara, Turkey. J Dent Res 78, Spec, 187 (abstract)"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Kinane DF, Hart TC (2003) Genes and gene polymorphisms associated with periodontal disease. Crit Rev Oral Biol Med 14, 430-449","DOI":"10.1177\/154411130301400605"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Gonzales JR, Michel J, Rodriguez EL, Herrmann JM, Bodeker RH, Meyle J (2003) Comparison of interleukin-1 genotypes in two populations with aggressive periodontitis. Eur J Oral Sci 111, 395-399","DOI":"10.1034\/j.1600-0722.2003.00071.x"},{"key":"33","unstructured":"33. Miller SC, Wolf W, Seidler BB (1941) Systemic aspects of precocious advanced alveolar bone destruction: preliminary report. J Dent Res 20, 386 (abstract)"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Marshall-Day CD, Stephens RG, Quigley LF Jr (1955) Periodontal disease: prevalence and incidence. J Periodontol 26, 185-203","DOI":"10.1902\/jop.1955.26.3.185"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Rao SS, Tewani SV (1968) Prevalence of periodontosis among Indians. J Periodontol 39, 27-34","DOI":"10.1902\/jop.1968.39.1.27"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Baer PN (1971) The case for periodontosis as a clinical entity. J Periodontol 42, 516-520","DOI":"10.1902\/jop.1971.42.8.516"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Russell AL (1971) The prevalence of periodontal disease in different populations during the circumpubertal period. J Periodontol 42, 508-512","DOI":"10.1902\/jop.1971.42.8.508"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Liljenberg B, Lindhe J (1980) Juvenile periodontitis. Some microbiological, histopathological and clinical characteristics. J Clin Periodontol 7, 48-61","DOI":"10.1111\/j.1600-051X.1980.tb01948.x"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Barnett ML, Baker RL, Yancey JM (1982) The prevalence of juvenile periodontitis (“periodontosis”) in a dental school patient population. J Dent Res 61, 391-392","DOI":"10.1177\/00220345820610020401"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Burmeister JA, Best AM, Palcanis KG, Caine FA, Ranney RR (1984) Localized juvenile periodontitis and generalized severe periodontitis: clinical findings. J Clin Periodontol 11, 181-192","DOI":"10.1111\/j.1600-051X.1984.tb01322.x"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Saxby MS (1987) Juvenil periodontitis: an epidemiologic study in the west Midlands of the United Kingdom. J Clin Periodontol 14, 594-598","DOI":"10.1111\/j.1600-051X.1987.tb01521.x"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Melvin WL, Sandifer JB, Gray JL (1991) The prevalence and sex ratio of juvenile periodontitis in a young racially mixed population. J Periodontol 62, 330-334","DOI":"10.1902\/jop.1991.62.5.330"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43. Nassar M, Afifi O, Deprez RD (1994) The prevalence of localized juvenile periodontitis in Saudi subjects. J Periodontol 65, 698-701","DOI":"10.1902\/jop.1994.65.7.698"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44. Löe H, Brown LJ (1991) Early onset periodontitis in the United States of America. J Periodontol 62, 608-616","DOI":"10.1902\/jop.1991.62.10.608"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45. Kronauer E, Borsa G, Lang NP (1986) Prevalence of incipient juvenile periodontitis at age 16 years in Switzerland. J Clin Periodontol 13, 103-108","DOI":"10.1111\/j.1600-051X.1986.tb01441.x"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46. Campbell P (2001) Everyone's genome. Nature 409, 813","DOI":"10.1038\/35057264"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47. Burchard EG, Ziv E, Coyle N, Gomez SL, Tang H, Karter AJ, Mountain JL, Pérez-Stable EJ, Sheppard D, Risch N (2003) The importance of race and ethnic background in biomedical research and clinical practice. N Engl J Med 348, 1170-1175","DOI":"10.1056\/NEJMsb025007"},{"key":"48","unstructured":"48. Risch N, Burchard E, Ziv E, Tang H (2002) Categorization of humans in biomedical research: genes, race and disease. Genome Biol 3, comment2007"},{"key":"49","unstructured":"49. U.S. Census Bureau (2007) Overview of race and Hispanic origin. In Census 2000 briefs, available online at www.census.gov\/prod\/2001pubs\/c2kbr01-1.pdf"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50. Coskun M, Bacanli A, Sallakci N, Alpsoy E, Yavuzer U, Yegin O (2005) Specific interleukin-1 gene polymorphisms in Turkish patients with Behcet's disease. Exp Dermatol 14, 124-129","DOI":"10.1111\/j.0906-6705.2005.00253.x"},{"key":"51","doi-asserted-by":"crossref","unstructured":"51. Sallakci N, Akcurin G, Köksoy S, Kardelen F, Uguz A, Coskun M, Ertug H, Yegin O (2005) TNF-alpha G-308A polymorphism is associated with rheumatic fever and correlates with increased TNF-alpha production. J Autoimmun 25, 150-154","DOI":"10.1016\/j.jaut.2005.05.005"},{"key":"52","doi-asserted-by":"crossref","unstructured":"52. Celik Y, Dagli U, Kiliç MY, Törüner M, Ozen SC, Ozkan M, Soykan I, Cetinkaya H, Ulker A, Ozden A, Bozdayi AM (2006) Cytokine gene polymorphisms in Turkish patients with inflammatory bowel disease. Scand J Gastroenterol 41, 559-565","DOI":"10.1080\/00365520500349523"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1992.tb01480.x"},{"key":"54","doi-asserted-by":"crossref","unstructured":"54. Quappe L, Jara L, Lopez NJ (2004) Association of interleukin-1 polymorphisms with aggressive periodontitis. J Periodontol 75, 1509-1515","DOI":"10.1902\/jop.2004.75.11.1509"},{"key":"55","doi-asserted-by":"crossref","unstructured":"55. Tai H, Endo M, Shimada Y, Gou E, Orima K, Kobayashi T, Yamazaki K, Yoshie H (2002) Association of interleukin-1 receptor antagonist gene polymorphisms with early onset periodontitis in Japanese. J Clin Periodontol 29, 882-888","DOI":"10.1034\/j.1600-051X.2002.291002.x"},{"key":"56","doi-asserted-by":"crossref","unstructured":"56. Cox A, Camp NJ, Nicklin MJH, di Giovine FS, Duff GW (1998) An analysis of linkage disequilibrium in the interleukin-1 gene cluster, using a novel grouping method for multiallelic markers. Am J Hum Genet 62, 1180-1188","DOI":"10.1086\/301817"},{"key":"57","doi-asserted-by":"crossref","unstructured":"57. Shapira L, Warbington M, Van Dyke TE (1994) TNF-α and IL-1β in serum of LJP patients with normal and defective neutrophil chemotaxis. J Periodontol Res 29, 371-373","DOI":"10.1111\/j.1600-0765.1994.tb01236.x"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.03.126"}],"container-title":["Journal of Oral Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/josnusd\/50\/2\/50_2_151\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T02:15:31Z","timestamp":1656555331000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jstage.jst.go.jp\/article\/josnusd\/50\/2\/50_2_151\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":58,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008]]}},"URL":"https:\/\/doi.org\/10.2334\/josnusd.50.151","relation":{},"ISSN":["1880-4926","1343-4934"],"issn-type":[{"value":"1880-4926","type":"electronic"},{"value":"1343-4934","type":"print"}],"subject":[],"published":{"date-parts":[[2008]]}}}