{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:11:06Z","timestamp":1792656666641,"version":"4.5.0"},"reference-count":38,"publisher":"Nihon University School of Dentistry","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Sci"],"published-print":{"date-parts":[[2010]]},"DOI":"10.2334\/josnusd.52.431","type":"journal-article","created":{"date-parts":[[2010,9,24]],"date-time":"2010-09-24T06:55:20Z","timestamp":1285311320000},"page":"431-437","source":"Crossref","is-referenced-by-count":15,"title":["Interleukin-6 promoter polymorphism (-174 G\/C) in Indian patients with chronic periodontitis"],"prefix":"10.2334","volume":"52","author":[{"given":"Nagaraj B.","family":"Kalburgi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aman","family":"Bhatia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivaprasad","family":"Bilichodmath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudhir R.","family":"Patil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin B.","family":"Mangalekar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kishore","family":"Bhat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1160","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.8.1.253"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Akira S, Taga T, Kishimoto T (1993) Interleukin 6 in biology and medicine. Adv Immunol 54, 1-78.","DOI":"10.1016\/S0065-2776(08)60532-5"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.16.6367"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310614"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Hirano T, Akira S, Taga T, Kishimoto T (1990) Biological and clinical aspects of interleukin 6. Immunol Today 11, 443-449.","DOI":"10.1016\/0167-5699(90)90173-7"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(99)00463-3"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1210\/jc.82.12.4196"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1368"},{"issue":"4","key":"9","doi-asserted-by":"crossref","first-page":"163","DOI":"10.2334\/josnusd.41.163","volume":"41","author":"KURTIS B","year":"1999","ISSN":"https:\/\/id.crossref.org\/issn\/1343-4934","issn-type":"print"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Dongari-Bagtzoglou AI, Ebersole JL (1998) Increased presence of interleukin-6 (IL-6) and IL-8 secreting fibroblast subpopulations in adult periodontitis. J Periodontol 69, 899-910.","DOI":"10.1902\/jop.1998.69.8.899"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Geivelis M, Turner DW, Pederson ED, Lamberts BL (1993) Measurements of interleukin-6 in gingival crevicular fluid from adults with destructive periodontal disease. J Periodontol 64, 980-983.","DOI":"10.1902\/jop.1993.64.10.980"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1993.tb00348.x"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Kono Y, Beagley KW, Fujihashi K, McGhee JR, Taga T, Hirano T, Kishimoto T, Kiyono H (1991) Cytokine regulation of localized inflammation. Induction of activated B cells and IL-6 mediated polyclonal IgG and IgA synthesis in inflamed human gingiva. J Immunol 146, 1812-1821.","DOI":"10.4049\/jimmunol.146.6.1812"},{"issue":"1","key":"14","first-page":"42","volume":"76","year":"1992","ISSN":"https:\/\/id.crossref.org\/issn\/0019-2805","issn-type":"print"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Takahashi K, Takashiba S, Nagai A, Takigawa M, Myoukai F, Kurihara H, Murayama Y (1994) Assessment of interleukin-6 in the pathogenesis of periodontal disease. J Periodontol 65, 147-153.","DOI":"10.1902\/jop.1994.65.2.147"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Prabhu A, Michalowicz BS, Mathur A (1996) Detection of local and systemic cytokines in adult periodontitis. J Periodontol 67, 515-522.","DOI":"10.1902\/jop.1996.67.5.515"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200108)31:8<2357::AID-IMMU2357>3.3.CO;2-O"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1172\/JCI2629"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Kiszel P, Fust G, Pessi T, Hurme M, Proh&aacute;szka Z (2006) Associations between interleukin-6 genetic polymorphisms and levels of autoantibodies to 60-kDa heat-shock proteins. Hum Hered 62, 77-83.","DOI":"10.1159\/000096095"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Michalowicz BS, Aeppli D, Virag JG, Klump DG, Hinrichs JE, Segal NL, Bouchard TJ Jr, Pihlstrom BL (1991) Periodontal findings in adult twins. J Periodontol 62, 293-299.","DOI":"10.1902\/jop.1991.62.5.293"},{"key":"21","unstructured":"21. Beaty TH, Boughman JA, Yang P, Astemborski JA, Suzuki JB (1987) Genetic analysis of juvenile periodontitis in families ascertained through an affected proband. Am J Hum Genet 40, 443-452."},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb01187.x"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Trevilatto PC, Scarel-Caminaga RM, de Brito RB Jr, de Souza AP, Line SRP (2003) Polymorphism at position -174 of IL-6 gene is associated with susceptibility to chronic periodontitis in a Caucasian Brazilian population. J Clin Periodontol 30, 438-442.","DOI":"10.1034\/j.1600-051X.2003.20016.x"},{"key":"24","unstructured":"24. Meiser H, Sch&ouml;ttler D, Genius J, Lichy C, Grau AJ, D&ouml;rfer CE (2003) Polymorphism in the promoter of interleukin-6 gene and periodontitis in a South German population. J Dent Res 82, Spec B, Abstract #2818."},{"key":"25","unstructured":"25. Jansson H, Lyssenko V, Gustavsson A, Hamberg K, S&ouml;derfeldt B, Groop L, Bratthall G (2006) Analysis of the interleukin-1 and interleukin-6 polymorphisms in patients with chronic periodontitis. A pilot study. Swed Dent J 30, 17-23."},{"key":"26","unstructured":"26. Groessner-Schreiber B, Jepsen S, Scholz C, Schaefer C, Schenck K, Vander Velden U (2004) Polymorphism in the IL-6 and Fc&gamma;RIIIa genes in aggressive periodontitis. J Dent Res 83, Spec B, Abstract #0478."},{"key":"27","unstructured":"27. Newton CR, Graham A (1997) PCR. 2nd ed, BIOS Scientific, Oxford, 46-67."},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Tervonen T, Raunio T, Knuuttila M, Karttunen R (2007) Polymorphism in the CD14 and IL-6 genes associated with periodontal disease. J Clin Periodontol 34, 377-383.","DOI":"10.1111\/j.1600-051X.2007.01067.x"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Costa AM, Guimar&atilde;es MC, de Souza ER, N&oacute;brega OT, Bezerra AC (2010) Interleukin-6 (G-174C) and tumor necrosis factor-alpha (G-308A) gene polymorphisms in geriatric patients with chronic periodontitis. Gerodontology 27, 70-75.","DOI":"10.1111\/j.1741-2358.2009.00291.x"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2008.10.016"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Babel N, Cherepnev G, Babel D, Tropmann A, Hammer M, Volk HD, Reinke P (2006) Analysis of tumor necrosis factor-&alpha;, transforming growth factor-&beta;, interleukin-10, IL-6, and interferon-&gamma; gene polymorphisms in patients with chronic periodontitis. J Periodontol 77, 1978-1983.","DOI":"10.1902\/jop.2006.050315"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. D'Aiuto F, Parker M, Brett PM, Ready D, Tonetti MS (2004) Gene polymorphisms in pro-inflammatory cytokines are associated with systemic inflammation in patients with severe periodontal infections. Cytokine 28, 29-34.","DOI":"10.1016\/j.cyto.2004.06.005"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Harding D, Dhamrait S, Millar A, Humphries S, Marlow N, Whitelaw A, Montgomery H (2003) Is interleukin-6 -174 genotype associated with the development of septicemia in preterm infants? Pediatrics 112, 800-803.","DOI":"10.1542\/peds.112.4.800"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Holla LI, Fassmann A, Stejskalov&aacute; A, Znojil V, Vanek J, Vacha J (2004) Analysis of the interleukin-6 gene promoter polymorphism in Czech patients with chronic periodontitis. J Periodontol 75, 30-36.","DOI":"10.1902\/jop.2004.75.1.30"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Brett PM, Zygogianni P, Griffiths GS, Tomaz M, Parkar M, D'Aiuto F, Tonetti M (2005) Functional gene polymorphisms in aggressive and chronic periodontitis. J Dent Res 84, 1149-1153.","DOI":"10.1177\/154405910508401211"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Moreira PR, Lima PMA, Sathler KOB, Imanishi SA, Costa JE, Gomes RS, Gollob KJ, Dutra WO (2007) Interleukin-6 expression and gene polymorphism are associated with severity of periodontal disease in a sample of Brazilian individuals. Clin Exp Immunol 148, 119-126.","DOI":"10.1111\/j.1365-2249.2007.03327.x"},{"issue":"12","key":"37","doi-asserted-by":"crossref","first-page":"5537","DOI":"10.1128\/MCB.9.12.5537","volume":"9","year":"1989","ISSN":"https:\/\/id.crossref.org\/issn\/0270-7306","issn-type":"print"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Kinane DF, Hart TC (2003) Genes and gene polymorphisms associated with periodontal disease. Crit Rev Oral Biol Med 14, 430-449.","DOI":"10.1177\/154411130301400605"}],"container-title":["Journal of Oral Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/josnusd\/52\/3\/52_3_431\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,3]],"date-time":"2023-06-03T13:23:16Z","timestamp":1685798596000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jstage.jst.go.jp\/article\/josnusd\/52\/3\/52_3_431\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.2334\/josnusd.52.431","relation":{},"ISSN":["1880-4926","1343-4934"],"issn-type":[{"value":"1880-4926","type":"electronic"},{"value":"1343-4934","type":"print"}],"subject":[],"published":{"date-parts":[[2010]]}}}