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To explore the role of SGK1 in salt-dependent glucose uptake, SGK1 knockout mice (sgk1\u2212\/\u2212) and their wild-type littermates (sgk1+\/+) were allowed free access to either tap water (control) or 1% saline (high salt). According to Western blotting, high salt decreased and deoxycorticosterone acetate (DOCA; 35 mg\/kg body wt) increased SGK1 protein abundance in skeletal muscle and fat tissue of sgk1+\/+ mice. Intraperitoneal injection of glucose (3 g\/kg body wt) into sgk1+\/+ mice transiently increased plasma glucose concentration approaching significantly higher values ([glucose]p,max) in high salt (281 \u00b1 39 mg\/dl) than in control (164 \u00b1 23 mg\/dl) animals. DOCA did not significantly modify [glucose]p,max in control sgk1+\/+ mice but significantly decreased [glucose]p,max in high-salt sgk1+\/+ mice, an effect reversed by spironolactone (50 mg\/kg body wt). [Glucose]p,max was in sgk1\u2212\/\u2212 mice insensitive to high salt and significantly higher than in control sgk1+\/+ mice. Uptake of 2-deoxy-d-[1,2-3H]glucose into skeletal muscle and fat tissue was significantly smaller in sgk1\u2212\/\u2212 mice than in sgk1+\/+ mice and decreased by high salt in sgk1+\/+ mice. Transfection of HEK-293 cells with active S422DSGK1, but not inactive K127NSGK, stimulated phloretin-sensitive glucose uptake. In conclusion, high salt decreases SGK1-dependent cellular glucose uptake. SGK1 thus participates in the link between salt intake and glucose tolerance.<\/jats:p>","DOI":"10.2337\/db05-1038","type":"journal-article","created":{"date-parts":[[2006,6,27]],"date-time":"2006-06-27T18:39:44Z","timestamp":1151433584000},"page":"2059-2066","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":35,"title":["Serum- and Glucocorticoid-Inducible Kinase 1 Mediates Salt Sensitivity of Glucose Tolerance"],"prefix":"10.2337","volume":"55","author":[{"given":"Krishna M.","family":"Boini","sequence":"first","affiliation":[{"name":"Department of Physiology, University of Tu\u0308bingen, Tu\u0308bingen, Germany"},{"name":"Department of Pharmacology and Toxicology, University of Tu\u0308bingen, Tu\u0308bingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita M.","family":"Hennige","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 4, University of Tu\u0308bingen, Tu\u0308bingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan Yang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, University of Tu\u0308bingen, Tu\u0308bingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bjo\u0308rn","family":"Friedrich","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 4, University of Tu\u0308bingen, Tu\u0308bingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Palmada","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Tu\u0308bingen, Tu\u0308bingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Boehmer","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Tu\u0308bingen, Tu\u0308bingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Grahammer","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Tu\u0308bingen, Tu\u0308bingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferruh","family":"Artunc","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Tu\u0308bingen, Tu\u0308bingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Ullrich","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Tu\u0308bingen, Tu\u0308bingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Avram","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Tu\u0308bingen, Tu\u0308bingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hartmut","family":"Osswald","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, University of Tu\u0308bingen, Tu\u0308bingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peer","family":"Wulff","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurobiology, University Hospital of Neurology, Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dietmar","family":"Kuhl","sequence":"additional","affiliation":[{"name":"Department of Biology, Chemistry, and Pharmacy, Free University Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volker","family":"Vallon","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, University of Tu\u0308bingen, Tu\u0308bingen, Germany"},{"name":"Departments of Medicine and Pharmacology, University of California San Diego and Veterans\u2019 Administration San Diego Health Care System, San Diego, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-Ulrich","family":"Ha\u0308ring","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 4, University of Tu\u0308bingen, Tu\u0308bingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Lang","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Tu\u0308bingen, Tu\u0308bingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","reference":[{"key":"2022031209353137200_R1","doi-asserted-by":"crossref","unstructured":"Cheng ZJ, Vaskonen T, Tikkanen I, Nurminen K, Ruskoaho H, Vapaatalo H, Muller D, Park JK, Luft FC, Mervaala EM: Endothelial dysfunction and salt-sensitive hypertension in spontaneously diabetic Goto-Kakizaki rats. 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